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    Chemistry

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    Also known as: Chlorine base compound, 7681-52-9, Antiformin, Clorox, Hypochlorous acid, sodium salt, Sodium oxychloride
    Molecular Formula
    ClNaO
    Molecular Weight
    74.44  g/mol
    InChI Key
    SUKJFIGYRHOWBL-UHFFFAOYSA-N
    FDA UNII
    DY38VHM5OD
    Sodium Hypochlorite
    It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant and Hackh's Chemical Dictionary, 5th ed)
    1 2D Structure

    Sodium Hypochlorite

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;hypochlorite
    2.1.2 InChI
    InChI=1S/ClO.Na/c1-2;/q-1;+1
    2.1.3 InChI Key
    SUKJFIGYRHOWBL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    [O-]Cl.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    DY38VHM5OD
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Antiformin

    2. Clorox

    3. Hypochlorite, Sodium

    4. Sodium Hypochlorite (solution)

    2.3.2 Depositor-Supplied Synonyms

    1. Chlorine Base Compound

    2. 7681-52-9

    3. Antiformin

    4. Clorox

    5. Hypochlorous Acid, Sodium Salt

    6. Sodium Oxychloride

    7. Household Bleach

    8. Dakin's Solution

    9. Chlorox

    10. Javex

    11. Javelle Water

    12. Hypochlorite Sodium

    13. Sodium Hypochlorite Solution

    14. Sodiumhypochlorite

    15. Sodium;hypochlorite

    16. Texant

    17. Dental Antiformin

    18. Naclo

    19. Naocl

    20. Sodium Hypochloride

    21. Natrum Hypochlorosum

    22. Dy38vhm5od

    23. Hypochlorous Acid, Sodium Salt (1:1)

    24. Chebi:32146

    25. Ncgc00091027-01

    26. Carrel-dakin Solution

    27. Chloros

    28. Cloralex

    29. Cloropool

    30. Dispatch

    31. Hyclorite

    32. Klorocin

    33. Parozone

    34. Surchlor

    35. Youxiaolin

    36. Deosan

    37. Hypure

    38. Milton

    39. Dakins Solution

    40. Hospital Milton

    41. Milton Crystals

    42. Neo-cleaner

    43. Neoseptal Cl

    44. Hypure N

    45. Sodium Hypochlorite [solution, Diluted]

    46. Purin B

    47. B-k Liquid

    48. Modified Dakin's Solution

    49. Hyposan And Voxsan

    50. Solutions, Dakin's

    51. Ad Gel

    52. Clorox Liquid Bleach

    53. Sunnysol 150

    54. Caswell No. 776

    55. Dakins Quarter

    56. Sodium Hypochlorite Solution (available Chlorine 10-15 Per Cent)

    57. Dakins Half

    58. Di-dak-sol

    59. Sodium Hypochlorite (naclo)

    60. Sodium Hypochlorite (naocl)

    61. Ccris 708

    62. Deosan Green Label Steriliser

    63. Hsdb 748

    64. Xy 12

    65. Einecs 231-668-3

    66. Unii-dy38vhm5od

    67. Epa Pesticide Chemical Code 014703

    68. Un 1791

    69. Sodium Hypochlorite [usp:jan]

    70. Sodium Hypochiorite

    71. Sodium Hypo Chlorite

    72. Mfcd00011120

    73. Texant (tn)

    74. Chlorinated Water (sodium Hypochlorite)

    75. Sodium Hypochlorite [hypochloride Salts]

    76. Sodium Hypochlorite Solution (15% Or Less)

    77. Antiformin, Dental

    78. Dsstox_cid_1276

    79. Ec 231-668-3

    80. Dsstox_rid_76052

    81. Dsstox_gsid_21276

    82. Sodium Hypochlorite (jan/usp)

    83. Chembl1334078

    84. Dtxsid8021276

    85. Sodium Hypochlorite [ii]

    86. Sodium Hypochlorite [mi]

    87. Sodium Hypochlorite [jan]

    88. Sodium Hypochlorite [hsdb]

    89. Sodium Hypochlorite [inci]

    90. Natrum Hypochlorosum [hpus]

    91. Sodium Hypochlorite [vandf]

    92. Sodium Hypochlorite [mart.]

    93. Str00665

    94. Sodium Hypochlorite Solution 6-14%

    95. Tox21_111062

    96. Sodium Hypochlorite [who-dd]

    97. Akos015950665

    98. Sodium Hypochlorite [usp Impurity]

    99. Cas-7681-52-9

    100. S0939

    101. 7681-52-910022-70-5(pentahydrate)

    102. D01711

    103. Q407204

    104. Q-200732

    105. Sodium Hypochlorite, Aqueous Solution, 12-15% Available Chlorine

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 74.44 g/mol
    Molecular Formula ClNaO
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count0
    Exact Mass73.9535366 g/mol
    Monoisotopic Mass73.9535366 g/mol
    Topological Polar Surface Area23.1 Ų
    Heavy Atom Count3
    Formal Charge0
    Complexity4.8
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Disinfectants; Oxidants

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    For surgical purposes, diluted sodium hypochlorite soln is used; it contains 0.45 to 0.5% sodium hypochlorite and it may be further diluted 1:3. ... It is used to loosen and help dissolve and deodorize necrotic tissue. ... Diluted sodium hypochlorite soln may be used to irrigate ragged or dirty wounds, as an antiseptic in certain peritoneal dialysis system.

    Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 964

    IT WAS ONCE WIDELY USED TO TREAT SUPPURATING WOUNDS, BUT HAS A SOLVENT ACTION ON BLOOD CLOTS AND THUS DELAYS CLOTTING.

    American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 1526

    For prophylaxis of epidermophytosis, diluted sodium hypochlorite soln is ... used as a foot bath. Soln is also a deodorant. /Sodium hypochlorite soln, diluted/

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1112

    MEDICATION (VET): Antiseptic for wound irrigation /Sodium hypochlorite, diluted/

    The Merck Index. 10th ed. Rahway, New Jersey: Merck Co., Inc., 1983., p. 1236

    4.2 Drug Warning

    For surgical purposes, diluted sodium hypochlorite soln is used; it contains 0.45 to 0.5% sodium hypochlorite and it may be further diluted 1:3. ... It is used to loosen and help dissolve and deodorize necrotic tissue. ... It is irritating to the skin unless rinsed off promptly.

    Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 964

    Topically applied hypochlorites may dissolve blood clots and cause bleeding. Sodium hypochlorite could interfere with the Clinistix and Labstix qualitative urine tests for glucose to produce false positive results. ... Traces of sodium hypochlorite soln adhering to utensils for preparing feeds of pooled human milk for premature infants incr dietary sodium intake by 50% in a series of 9 paired estimations.

    Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982., p. 574

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Disinfectants

    Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) (See all compounds classified as Disinfectants.)

    Oxidants

    Electron-accepting molecules in chemical reactions in which electrons are transferred from one molecule to another (OXIDATION-REDUCTION). (See all compounds classified as Oxidants.)

    5.2 ATC Code

    D - Dermatologicals

    D08 - Antiseptics and disinfectants

    D08A - Antiseptics and disinfectants

    D08AX - Other antiseptics and disinfectants

    D08AX07 - Sodium hypochlorite

    5.3 Metabolism/Metabolites

    Trichloroacetic acid was found in the gut contents & plasma of fasted & nonfasted rats 1 hr after dosing with sodium hypochlorite. Thus, the formation is not dependent on the interaction of sodium hypochlorite with foreign organic material in the gut. Dichloroacetic acid was also found in all treated animals. Chloroform generally was present when trichloroacetic acid was detected. Dichloroacetonitrile was found in the gut contents of 2 of 3 nonfasted rats treated with sodium hypochlorite. Addition of 8 mg sodium hypochlorite/ml to nonfasted rat gut contents in vitro produced dichloroacetic acid, trichloroacetic acid, dichloroacetonitrile, & trichloroacetonitrile.

    PMID:6850127 Mink FL et al; Bull Environ Contam Toxicol 30 (4): 394-9 (1983)

    5.4 Mechanism of Action

    ITS TOXIC EFFECT IS DUE TO PRESENCE OF CHLORINE.

    International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 299

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    [{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1626201000,"product":"SODIUM HYPOCHLORITE SOLUTION 6-14","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"OAKWOOD PRODUCTS. INC","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"LTR","unitRateFc":"38.9","totalValueFC":"157.3","currency":"USD","unitRateINR":"2931.5","date":"14-Jul-2021","totalValueINR":"11726","totalValueInUsd":"157.3","indian_port":"Biocon-SEZ","hs_no":"29420090","bill_no":"1009766","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"N\/A","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1706812200,"product":"SODIUM HYPOCHLORITE SOLUTION 6-14% - 101471-500ML","address":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3","city":"","supplier":"OAKWOOD PRODUCTS, INC.,","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"SYNGENE INTERNATIONAL LIMITED","customerCountry":"INDIA","quantity":"4.00","actualQuantity":"4","unit":"LTR","unitRateFc":"35.7","totalValueFC":"175","currency":"USD","unitRateINR":"3630.1","date":"02-Feb-2024","totalValueINR":"14520.54","totalValueInUsd":"175","indian_port":"Bangalore Air","hs_no":"29339990","bill_no":"9940410","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"P.O.BOX 457, ESTILL, SC 29918 Columbia, , UNITED STATESSDNF UNITED STATES","customerAddress":"BIOCON SEZ, BIOCON PARK,PLOT NO.2 3"}]
    14-Jul-2021
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    ABOUT THIS PAGE

    Sodium Hypochlorite Manufacturers

    A Sodium Hypochlorite manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Hypochlorite, including repackagers and relabelers. The FDA regulates Sodium Hypochlorite manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Hypochlorite API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Sodium Hypochlorite manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Sodium Hypochlorite Suppliers

    A Sodium Hypochlorite supplier is an individual or a company that provides Sodium Hypochlorite active pharmaceutical ingredient (API) or Sodium Hypochlorite finished formulations upon request. The Sodium Hypochlorite suppliers may include Sodium Hypochlorite API manufacturers, exporters, distributors and traders.

    click here to find a list of Sodium Hypochlorite suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Sodium Hypochlorite GMP

    Sodium Hypochlorite Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Sodium Hypochlorite GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Hypochlorite GMP manufacturer or Sodium Hypochlorite GMP API supplier for your needs.

    Sodium Hypochlorite CoA

    A Sodium Hypochlorite CoA (Certificate of Analysis) is a formal document that attests to Sodium Hypochlorite's compliance with Sodium Hypochlorite specifications and serves as a tool for batch-level quality control.

    Sodium Hypochlorite CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Hypochlorite CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Sodium Hypochlorite may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Hypochlorite EP), Sodium Hypochlorite JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Hypochlorite USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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