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Sodium Iodide I 123

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Chemistry

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Also known as: 7681-82-5, Ioduril, Sodium monoiodide, Soiodin, Iodure de sodium, Sodium iodide (nai)

Molecular Formula

INa

Molecular Weight

149.8942 g/mol

InChI Key

FVAUCKIRQBBSSJ-UHFFFAOYSA-M

FDA UNII

F5WR8N145C

A compound forming white, odorless deliquescent crystals and used as iodine supplement, expectorant or in its radioactive (I-131) form as an diagnostic aid, particularly for thyroid function tests.

1 2D Structure

Sodium Iodide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;iodide

2.1.2 InChI

InChI=1S/HI.Na/h1H;/q;+1/p-1

2.1.3 InChI Key

FVAUCKIRQBBSSJ-UHFFFAOYSA-M

2.1.4 Canonical SMILES

[Na+].[I-]

2.2 Other Identifiers

2.2.1 UNII

F5WR8N145C

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 7681-82-5

2. Ioduril

3. Sodium Monoiodide

4. Soiodin

5. Iodure De Sodium

6. Sodium Iodide (nai)

7. Sodiumiodide

8. Jodid Sodny

9. Sodium;iodide

10. Mfcd00003532

11. Nsc-77388

12. Iodide (as Sodium Iodide)

13. Fdy-5301

14. F5wr8n145c

15. Chembl1644695

16. Chebi:33167

17. Natriumjodid

18. Natrii Iodidum

19. Sodium Iodide, Ultra Dry

20. Jodid Sodny [czech]

21. Caswell No. 777

22. Natriumjodid [german]

23. Hsdb 750

24. Einecs 231-679-3

25. Nsc 77388

26. Epa Pesticide Chemical Code 075702

27. Sodium Iodide [usp:jan]

28. Unii-f5wr8n145c

29. Sodium-iodide

30. Iodeto De Sodio

31. Ioduro Di Sodio

32. Yoduro De Sodio

33. Sodium Iodide-

34. Sodium Iodide,99%

35. Sodium Iodide Solution

36. Sodium Iodide, Anhydrous

37. Sodium Iodide, Acs Grade

38. Wln: Na I

39. Ec 231-679-3

40. Sodium Iodide [ii]

41. Sodium Iodide [mi]

42. Sodium Iodine-131(1-)

43. Dsstox_cid_21125

44. Dsstox_rid_79629

45. Sodium Iodide [jan]

46. Dsstox_gsid_41125

47. Sodium Iodide [hsdb]

48. Sodium Iodide [inci]

49. Sodium Iodide (jp17/usp)

50. Sodium Iodide [vandf]

51. Sodium Iodide [mart.]

52. Sodium Iodide [who-dd]

53. Dtxsid2041125

54. Sodium Iodide, Trace Metals Grade

55. Bcp22179

56. Nsc77388

57. Tox21_301379

58. Sodium Iodide [ep Monograph]

59. Sodium Iodide [usp Monograph]

60. Akos015950612

61. Akos016015354

62. Db11119

63. Ncgc00255631-01

64. Cas-7681-82-5

65. Iodide (as Sodium Iodide) [vandf]

66. Cs-0013799

67. Ft-0645131

68. S0564

69. D04874

70. Q390305

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	INa
Molecular Weight	149.8942 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	149.89424 g/mol
Monoisotopic Mass	149.89424 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	2
Formal Charge	0
Complexity	2
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Sodium iodide i 123
PubMed Health	Sodium Iodide I 123 (By mouth)
Drug Classes	Diagnostic Agent
Active Ingredient	Sodium iodide i-123
Dosage Form	Capsule
Route	Oral
Strength	100uci; 200uci
Market Status	Prescription
Company	Cardinal Hlth 414; Mallinckrodt

2 of 2
Drug Name	Sodium iodide i 123
PubMed Health	Sodium Iodide I 123 (By mouth)
Drug Classes	Diagnostic Agent
Active Ingredient	Sodium iodide i-123
Dosage Form	Capsule
Route	Oral
Strength	100uci; 200uci
Market Status	Prescription
Company	Cardinal Hlth 414; Mallinckrodt

4.2 Therapeutic Uses

...CAN BE USED INTERCHANGEABLY WITH POTASSIUM IODIDE, AS A THERAPEUTIC AGENT, EXCEPT WHERE SODIUM ION IS CONTRAINDICATED.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

VET: HAS BEEN USED FOR RINGWORM, HYPERPLASTIC FIBROUS LESIONS, PARAPLEGIA FROM PACHYMENINGITIS OF DOGS.

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1116

VET: ...IT MAY BE USEFUL IV FOR OTHER MYCOSES, CHRONIC JOINT SWELLINGS, LARYNGITIS, BRONCHITIS, & PLEURITIS IN MANY SPECIES; LUNGWORM INFECTIONS IN CATS; TO IMMOBILIZE THALLIUM IN THE BODY; BY CATHETER INTO THE BLADDER AS AN X-RAY CONTRAST MEDIA...

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 541

DOSE--ORAL, 300 MG TO 2 G DAILY; USUAL, 300 MG 2-4 TIMES A DAY; IV INFUSION, 1-3 G DAILY; USUAL, 1 G.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 802

For more Therapeutic Uses (Complete) data for SODIUM IODIDE (15 total), please visit the HSDB record page.

4.3 Drug Warning

VET: ...MONITOR IODISM. AVOID UNNECESSARY USE IN ADVANCED PREGNANCY...IT MAY PRODUCE GOITER IN NEWBORN. .../AVOID/ USE OF MILK FROM TREATED ANIMALS FOR AT LEAST 72 HR & 6 MILKINGS AFTER SUCH TREATMENT. MAY POTENTIATE BARBITURATE ANESTHESIA IN RATS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 541

IODIDES MAY PPT THYROTOXICOSIS WHEN GIVEN TO PT WITH NODULAR GOITERS, OR IN EUTHYROID PT WITH AUTONOMOUS THYROID FUNCTION...DURING REMISSION OF HYPERTHYROIDISM FOLLOWING A COURSE OF THIONAMIDES... IN PT WITH CHRONIC THYROIDITIS, PREVIOUS RADIOIODINE THERAPY OR THYROIDECTOMY, IODIDES MAY INDUCE HYPOTHYROIDISM. /IODIDES/

Miller, R. R., and D. J. Greenblatt. Handbook of Drug Therapy. New York: Elsevier North Holland, 1979., p. 918

CONTRAINDICATIONS (VET): HYPERTHYROIDISM & PREGNANCY. WARNING: ANIMALS VARY IN SUSCEPTIBILITY TO IODIDES. ADMIN WITH CAUTION UNTIL TOLERANCE IS DETERMINED. DISCONTINUE TREATMENT IMMEDIATELY IF SYMPTOMS OF IODISM APPEAR... /SODIUM IODIDE 20%/

Aronson, C.E. (ed.). Veterinary Pharmaceuticals & Biologicals, 1980-1981. Media, Pa.: Harwal Publishing Co., 1980., p. 16/30

POTENTIAL ADVERSE EFFECTS ON FETUS: Goiters, fetal encephalopathy. POTENTIAL SIDE EFFECTS ON BREAST-FED INFANT: May cause skin rash and thyroid suppression in infant. FDA Category:D (D = There is no evidence of human fetal risk but the potential benefits from use in pregnant women may be acceptable despite the potential risks (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective.) /Iodides/ /from table II/

Stockton, D.L. and A.S. Paller. J Am Acad Dermatol 23 (1):87-103 (1990)

4.4 Minimum/Potential Fatal Human Dose

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OUNCE & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). /IODIDE SALTS/

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-78

4.5 Drug Indication

Indicated for use as a supplement to intravenous solutions given for total parenteral nutrition (TPN).

5 Pharmacology and Biochemistry

5.1 Pharmacology

When intravenously administered for total parental nutrition, sodium iodide prevents the depletion of endogenous stores of iodine and subsequent deficiency symptoms.

5.2 Absorption, Distribution and Excretion

Absorption

Iodide salts are readily absorbed in the gastrointestinal tract.

Route of Elimination

Iodides are expected to be renal excreted.

Volume of Distribution

Iodides are distributed widely throughout extracellular fluid of thyroid gland.

5.3 Mechanism of Action

RESPONSE TO IODIDE IN HYPERTHYROIDISM: /IN THYROID GLAND/...VASCULARITY IS REDUCED, GLAND BECOMES MUCH FIRMER & EVEN HARD TO THE TOUCH, CELLS BECOME SMALLER, COLLOID REACCUMULATES IN FOLLICLES, & QUANTITY OF BOUND IODINE INCREASES. /IODIDES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1412

HIGH CONCN OF IODIDE APPEAR TO INFLUENCE ALL IMPORTANT ASPECTS OF IODINE METABOLISM BY THE THYROID GLAND. CAPACITY OF IODIDE TO LIMIT ITS OWN TRANSPORT... ACUTE INHIBITION OF SYNTHESIS OF IODOTYROSINE & IODOTHYRONINE BY IODIDE IS ALSO WELL KNOWN (THE WOLFF-CHAIKOFF EFFECT)... /IODIDES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1413

THIS INHIBITION /WOLFF-CHAIKOFF EFFECT/ IS OBSERVED ONLY ABOVE CRITICAL CONCN OF IODIDE, & THE INTRACELLULAR...CONCN OF ANION APPEARS TO BE MAJOR DETERMINANT. WITH TIME THERE IS "ESCAPE" FOR THIS INHIBITION...ASSOCIATED WITH AN ADAPTIVE DECR IN IODIDE TRANSPORT & LOWERED INTRACELLULAR IODIDE CONCN. /IODIDES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1413

THE MOST IMPORTANT CLINICAL EFFECT OF HIGH IODIDE CONCN IS AN INHIBITION OF THE RELEASE OF THYROID HORMONE. THIS ACTION IS RAPID & EFFICACIOUS IN SEVERE THYROTOXICOSIS. THE EFFECT IS EXERTED DIRECTLY ON THE THYROID GLAND, & IT CAN BE DEMONSTRATED IN EUTHYROID SUBJECT & EXPTL ANIMALS AS WELL AS IN HYPERTHYROID PT. /IODIDES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1413

IODIDE ANTAGONIZES THE ABILITY OF BOTH THYROTROPIN & CYCLIC AMP TO STIMULATE ENDOCYTOSIS OF COLLOID, PROTEOLYSIS, & HORMONE SECRETION. /REPORTEDLY/... IODIDE ATTENUATES THE EFFECT OF TSH ON CYCLIC AMP IN VIVO & IN ISOLATED TISSUES. /IODIDES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 1413

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