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Chemistry

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Also known as: 37300-21-3, Pentosan sulfuric polyester, Polypentose sulfate, [(2r,3r,4s,5r)-2-hydroxy-5-[(2s,3r,4s,5r)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate, Xylan, hydrogen sulfate, Unii-f59p8b75r4
Molecular Formula
C10H18O21S4
Molecular Weight
602.5  g/mol
InChI Key
FCCNSUIJIOOXEZ-SJYYZXOBSA-N

Pentosan Polysulfate Sodium
A sulfated pentosyl polysaccharide with heparin-like properties.
1 2D Structure

Pentosan Polysulfate Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate
2.1.2 InChI
InChI=1S/C10H18O21S4/c11-3-1-26-10(8(31-35(22,23)24)5(3)28-32(13,14)15)27-4-2-25-9(12)7(30-34(19,20)21)6(4)29-33(16,17)18/h3-12H,1-2H2,(H,13,14,15)(H,16,17,18)(H,19,20,21)(H,22,23,24)/t3-,4-,5+,6+,7-,8-,9-,10+/m1/s1
2.1.3 InChI Key
FCCNSUIJIOOXEZ-SJYYZXOBSA-N
2.1.4 Canonical SMILES
C1C(C(C(C(O1)OC2COC(C(C2OS(=O)(=O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)O
2.1.5 Isomeric SMILES
C1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2CO[C@H]([C@@H]([C@H]2OS(=O)(=O)O)OS(=O)(=O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Bay 946

2. Bay-946

3. Elmiron

4. Fibrocid

5. Hemoclar

6. Hoe 946

7. Hoe Bay 946

8. Hoe-946

9. Hoe-bay 946

10. Hoe-bay-946

11. Pentosan Polysulfate Sodium

12. Pentosan Polysulphate Sodium

13. Pentosan Sulfuric Polyester

14. Pentosane Sulfuric Polyester

15. Polyester, Pentosan Sulfuric

16. Polyester, Pentosane Sulfuric

17. Polypentose Sulfate

18. Polysulfate Sodium, Pentosan

19. Polysulfate, Pentosan

20. Polysulfated Xylan

21. Polysulphate Sodium, Pentosan

22. Pz 68

23. Pz-68

24. Pz68

25. Sodium, Pentosan Polysulfate

26. Sodium, Pentosan Polysulphate

27. Sp 54

28. Sp 54, Tavan

29. Sp-54

30. Sp54

31. Sp54, Xylan

32. Sulfate, Polypentose

33. Sulfate, Xylan

34. Sulfuric Polyester, Pentosan

35. Sulfuric Polyester, Pentosane

36. Tavan Sp 54

37. Xylan Sp54

38. Xylan Sulfate

39. Xylan, Polysulfated

2.2.2 Depositor-Supplied Synonyms

1. 37300-21-3

2. Pentosan Sulfuric Polyester

3. Polypentose Sulfate

4. [(2r,3r,4s,5r)-2-hydroxy-5-[(2s,3r,4s,5r)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] Hydrogen Sulfate

5. Xylan, Hydrogen Sulfate

6. Unii-f59p8b75r4

7. Schembl157354

8. Chembl4073796

9. Chebi:184555

10. F59p8b75r4

11. Db00686

12. Q7165276

13. [(2r,3r,4s,5r)-2-hydroxy-5-[(2s,3r,4s,5r)-5-hydroxy-3,4-disulooxyoxan-2-yl]oxy-3-sulooxyoxan-4-yl] Hydrogen Sulate

14. [(2r,3r,4s,5r)-2-hydroxy-5-{[(2s,3r,4s,5r)-5-hydroxy-3,4-bis(sulfooxy)oxan-2-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic Acid

15. [(2s,3r,4s,5r)-5-hydroxy-2-{[(3r,4s,5r,6r)-6-hydroxy-4,5-bis(sulfooxy)oxan-3-yl]oxy}-4-(sulfooxy)oxan-3-yl]oxidanesulfonic Acid

16. 11096-31-4

2.3 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 602.5 g/mol
Molecular Formula C10H18O21S4
XLogP3-5.6
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count21
Rotatable Bond Count10
Exact Mass601.92234227 g/mol
Monoisotopic Mass601.92234227 g/mol
Topological Polar Surface Area356 Ų
Heavy Atom Count35
Formal Charge0
Complexity1140
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameElmiron
PubMed HealthPentosan Polysulfate Sodium (By mouth)
Drug ClassesCystitis Agent, Urinary Stone Agent
Drug LabelPentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water...
Active IngredientPentosan polysulfate sodium
Dosage FormCapsule
RouteOral
Strength100mg
Market StatusPrescription
CompanyJanssen Pharms

2 of 2  
Drug NameElmiron
PubMed HealthPentosan Polysulfate Sodium (By mouth)
Drug ClassesCystitis Agent, Urinary Stone Agent
Drug LabelPentosan polysulfate sodium is a semi-synthetically produced heparin-like macromolecular carbohydrate derivative, which chemically and structurally resembles glycosaminoglycans. It is a white odorless powder, slightly hygroscopic and soluble in water...
Active IngredientPentosan polysulfate sodium
Dosage FormCapsule
RouteOral
Strength100mg
Market StatusPrescription
CompanyJanssen Pharms

4.2 Drug Indication

For the relief of bladder pain or discomfort associated with interstitial cystitis.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Pentosan polysulfate sodium is a low molecular weight heparin-like compound. It has anticoagulant and fibrinolytic effects.


5.2 MeSH Pharmacological Classification

Anticoagulants

Agents that prevent BLOOD CLOTTING. (See all compounds classified as Anticoagulants.)


5.3 Absorption, Distribution and Excretion

Absorption

Slow


5.4 Biological Half-Life

4.8 hours


5.5 Mechanism of Action

Pentosan polysulfate is a polymer of xylose hydrogen sulfate and contains two sulfate groups per carbohydrate monomer. It binds Fibroblast growth factors (FGFs) as well as other heparin-binding growth factors. It has been shown to interact also with the heparin-binding site of FGFR-1. It inhibits the growth of SW13 adrenocortical cells transfected with FGF-4 and tumorigenicity of MCF-7 breast carcinoma cells transfected with FGF-1 or FGF-4.


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NO.37","city":"BOMBAY ,MAHARASHTRA","supplier":"TRICON ENTERPRISES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"BARCELONA","customer":"A.L.S.A","customerCountry":"SPAIN","quantity":"12.00","actualQuantity":"12","unit":"KGS","unitRateFc":"2725","totalValueFC":"32034.9","currency":"USD","unitRateINR":226830.95583333334,"date":"04-Dec-2024","totalValueINR":"2721971.47","totalValueInUsd":"32034.9","indian_port":"Madras Air","hs_no":"29339990","bill_no":"6171398","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"KAMALA BHUVAN NO.2, 1ST FLR. NO.37, BOMBAY ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1733855400,"product":"PENTOSAN POLYSULFATE SODIUM - BCH NO:BPPS2412008 AND BPPS2412009 MFG DT NOV 2024RETEST DT OCT 2027","address":"KAMALA BHUVAN NO.2, 1ST FLR. NO.37","city":"BOMBAY ,MAHARASHTRA","supplier":"TRICON ENTERPRISES PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"PKN","customerCountry":"REPUBLIC OF KOREA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"2840","totalValueFC":"560606.9","currency":"USD","unitRateINR":238171,"date":"11-Dec-2024","totalValueINR":"47634200","totalValueInUsd":"560606.9","indian_port":"Madras Air","hs_no":"29339990","bill_no":"6358209","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Madras Air","supplierAddress":"KAMALA BHUVAN NO.2, 1ST FLR. NO.37, BOMBAY ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1734719400,"product":"PENTOSAN POLYSULFATE SODIUM ( BATCH NO:PNT3O24002 ) ( KG ) ( QTY- 6.000 )","address":"NO 31, RACE COURSE ROAD,BANGALORE","city":"BENGALURU,KARNATAKA","supplier":"MICRO LABS LIMITED","supplierCountry":"INDIA","foreign_port":"SEOUL - INCHEON INT\\'","customer":"L TEC PHARMACHEM ","customerCountry":"REPUBLIC OF KOREA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"5000","totalValueFC":"29678.7","currency":"USD","unitRateINR":420295.16666666669,"date":"21-Dec-2024","totalValueINR":"2521771","totalValueInUsd":"29678.7","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"6644679","productDescription":"API","marketType":"REGULATED MARKET","country":"REPUBLIC OF KOREA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"NO 31, RACE COURSE ROAD,BANGALORE, BENGALURU,KARNATAKA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1652898600,"product":"PENTOSAN POLYSULFATE SODIUM. FV0973 PPS HD. BATCH NO. 116\/1243. SAMPLE FOR R & D PURPOSE.","address":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE","city":"AHMEDABAD","supplier":"ITALFARMACO S.P.A","supplierCountry":"ITALY","foreign_port":"NA","customer":"ZYDUS LIFESCIENCES","customerCountry":"INDIA","quantity":"1.30","actualQuantity":"1.3","unit":"KGS","unitRateFc":"3900","totalValueFC":"5408.8","currency":"EUR","unitRateINR":"321555","date":"19-May-2022","totalValueINR":"418021.5","totalValueInUsd":"5408.8","indian_port":"AHMEDABAD AIR","hs_no":"29339990","bill_no":"8741456","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"ZYDUS CORPORATE PARK, SCHEME NO 63, KHORAJ (GANDHINAGAR), NR. VAISHNODE"}]
14-Jan-2021
21-Dec-2024
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ABOUT THIS PAGE

Sodium, Pentosan Polysulphate Manufacturers

A Sodium, Pentosan Polysulphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium, Pentosan Polysulphate, including repackagers and relabelers. The FDA regulates Sodium, Pentosan Polysulphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium, Pentosan Polysulphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sodium, Pentosan Polysulphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sodium, Pentosan Polysulphate Suppliers

A Sodium, Pentosan Polysulphate supplier is an individual or a company that provides Sodium, Pentosan Polysulphate active pharmaceutical ingredient (API) or Sodium, Pentosan Polysulphate finished formulations upon request. The Sodium, Pentosan Polysulphate suppliers may include Sodium, Pentosan Polysulphate API manufacturers, exporters, distributors and traders.

click here to find a list of Sodium, Pentosan Polysulphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sodium, Pentosan Polysulphate USDMF

A Sodium, Pentosan Polysulphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium, Pentosan Polysulphate active pharmaceutical ingredient (API) in detail. Different forms of Sodium, Pentosan Polysulphate DMFs exist exist since differing nations have different regulations, such as Sodium, Pentosan Polysulphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sodium, Pentosan Polysulphate DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium, Pentosan Polysulphate USDMF includes data on Sodium, Pentosan Polysulphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium, Pentosan Polysulphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sodium, Pentosan Polysulphate suppliers with USDMF on PharmaCompass.

Sodium, Pentosan Polysulphate KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Sodium, Pentosan Polysulphate Drug Master File in Korea (Sodium, Pentosan Polysulphate KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Sodium, Pentosan Polysulphate. The MFDS reviews the Sodium, Pentosan Polysulphate KDMF as part of the drug registration process and uses the information provided in the Sodium, Pentosan Polysulphate KDMF to evaluate the safety and efficacy of the drug.

After submitting a Sodium, Pentosan Polysulphate KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Sodium, Pentosan Polysulphate API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Sodium, Pentosan Polysulphate suppliers with KDMF on PharmaCompass.

Sodium, Pentosan Polysulphate WC

A Sodium, Pentosan Polysulphate written confirmation (Sodium, Pentosan Polysulphate WC) is an official document issued by a regulatory agency to a Sodium, Pentosan Polysulphate manufacturer, verifying that the manufacturing facility of a Sodium, Pentosan Polysulphate active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Sodium, Pentosan Polysulphate APIs or Sodium, Pentosan Polysulphate finished pharmaceutical products to another nation, regulatory agencies frequently require a Sodium, Pentosan Polysulphate WC (written confirmation) as part of the regulatory process.

click here to find a list of Sodium, Pentosan Polysulphate suppliers with Written Confirmation (WC) on PharmaCompass.

Sodium, Pentosan Polysulphate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sodium, Pentosan Polysulphate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sodium, Pentosan Polysulphate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sodium, Pentosan Polysulphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sodium, Pentosan Polysulphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sodium, Pentosan Polysulphate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sodium, Pentosan Polysulphate suppliers with NDC on PharmaCompass.

Sodium, Pentosan Polysulphate GMP

Sodium, Pentosan Polysulphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sodium, Pentosan Polysulphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium, Pentosan Polysulphate GMP manufacturer or Sodium, Pentosan Polysulphate GMP API supplier for your needs.

Sodium, Pentosan Polysulphate CoA

A Sodium, Pentosan Polysulphate CoA (Certificate of Analysis) is a formal document that attests to Sodium, Pentosan Polysulphate's compliance with Sodium, Pentosan Polysulphate specifications and serves as a tool for batch-level quality control.

Sodium, Pentosan Polysulphate CoA mostly includes findings from lab analyses of a specific batch. For each Sodium, Pentosan Polysulphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sodium, Pentosan Polysulphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium, Pentosan Polysulphate EP), Sodium, Pentosan Polysulphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium, Pentosan Polysulphate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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