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Sodium Propionate

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ACTIVE PHARMA INGREDIENTS

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Synopsis

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Chemistry

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Also known as: 137-40-6, Sodium propanoate, Propionic acid sodium salt, Propanoic acid, sodium salt, Sodium;propanoate, Sodiumpropionate

Molecular Formula

C₃H₅NaO₂

Molecular Weight

96.06 g/mol

InChI Key

JXKPEJDQGNYQSM-UHFFFAOYSA-M

FDA UNII

DK6Y9P42IN

Sodium Propionate is the sodium salt form of propionic acid, a short chain fatty acid (SCFA) and food additive, with potential gastrointestinal (GI) protective activity. Upon oral administration of sodium propionate, it converts to propionic acid which may protect the GI tract and reduce incidence and severity of GI toxicity from radiation therapy.

1 2D Structure

Sodium Propionate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;propanoate

2.1.2 InChI

InChI=1S/C3H6O2.Na/c1-2-3(4)5;/h2H2,1H3,(H,4,5);/q;+1/p-1

2.1.3 InChI Key

JXKPEJDQGNYQSM-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CCC(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

DK6Y9P42IN

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Prophyllin

2.3.2 Depositor-Supplied Synonyms

1. 137-40-6

2. Sodium Propanoate

3. Propionic Acid Sodium Salt

4. Propanoic Acid, Sodium Salt

5. Sodium;propanoate

6. Sodiumpropionate

7. Propionic Acid, Sodium Salt

8. Sodium Propionate Anhydrous

9. Natriumpropionat

10. Mycoban

11. Propanoic Acid, Sodium Salt (1:1)

12. Dk6y9p42in

13. Mycoban; Napropion; Ocuseptine

14. Ocuseptine

15. Napropion

16. Bioban-s

17. Deketon

18. E281

19. Impedex

20. Keenate

21. Propiofar

22. Propisol

23. Sodium Dipropionate

24. Propi-ophtal

25. Whit-pro

26. Dsstox_cid_1996

27. Dsstox_rid_76449

28. Dsstox_gsid_21996

29. Caswell No. 707a

30. Propionan Sodny

31. Propionan Sodny [czech]

32. Natriumpropionat [german]

33. Chembl500826

34. Cas-137-40-6

35. Ccris 1896

36. Hsdb 766

37. Propanoic Acid, Sodium Salt (2:1)

38. Ncgc00159468-02

39. Einecs 205-290-4

40. Epa Pesticide Chemical Code 077703

41. Propionic Acid Sodium

42. Unii-dk6y9p42in

43. Sodium Propionate [ii]

44. Sodium Propionate [mi]

45. Ins No.281

46. Sodium Propionate [fcc]

47. Dtxsid7021996

48. Sodium Propionate [inci]

49. Ins-281

50. Sodium Propionate [vandf]

51. Anhydrous Sodium Propionate

52. Chebi:132106

53. Sodium Propionate [mart.]

54. 391o0po49r

55. Sodium Propionate [usp-rs]

56. Sodium Propionate [who-dd]

57. Amy22300

58. Natriumpropionat [veterinary] (tn)

59. Einecs 264-460-6

60. Tox21_113044

61. Tox21_202735

62. Mfcd00002759

63. Akos003051488

64. Akos015892835

65. Sodium Propionate [ep Monograph]

66. Ncgc00260283-01

67. Sodium Propionate Anhydrous [hsdb]

68. Anhydrous Sodium Propionate [mart.]

69. E-281

70. Ft-0655038

71. P0512

72. D08440

73. A807253

74. Q420130

75. J-007019

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₃H₅NaO₂
Molecular Weight	96.06 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	96.01872368 g/mol
Monoisotopic Mass	96.01872368 g/mol
Topological Polar Surface Area	40.1 Å²
Heavy Atom Count	6
Formal Charge	0
Complexity	44.1
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Therapeutic Uses

MANY PROPRIETARY PREPARATIONS ARE AVAILABLE FOR TREATING DERMATOPHYTIC INFECTIONS, ESPECIALLY TINEA PEDIS (ATHLETE'S FOOT). THESE INCLUDE ... SODIUM PROPIONATE ...

American Medical Association, AMA Department of Drugs, AMA Drug Evaluations. 3rd ed. Littleton, Massachusetts: PSG Publishing Co., Inc., 1977., p. 822

CLINICALLY, MEDICATION: SODIUM PROPIONATE IS USED IN TREATMENT OF OTOMYCOSIS. IT IS ALSO USED IN TREATMENT OF EPIDERMOPHYTOSIS, BUT IT IS NOT AS EFFECTIVE AS MOST OTHER AGENTS FOR THIS CONDITION. IT IS NOT FUNGICIDAL, SO THAT OTHER HYGIENE MEASURES MUST BE EMPHASIZED. ... DOSE--TOPICAL, IN DOSAGE FORMS CONTAINING 0.5-10% OF SODIUM PROPIONATE.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1177

MEDICATION (VET): ALTHOUGH SOME COWS FIND HIGH DOSAGE (250 G) UNPALATABLE & IT MAY LACK SUBSTANTIAL EFFECTIVENESS AS PROPHYLACTIC & THERAPEUTIC AGENT IN ACETONEMIA, IT IS A USEFUL ADJUNCT TO THERAPY & ITS BENEFICIAL EFFECTS ON MILK PRODUCTION HAVE BEEN ATTRIBUTED TO CONTROL OF SUBCLINICAL KETOSIS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 545

MEDICATION (VET): EFFECTIVE IN EARLY TREATMENT OF KETOSIS OF CATTLE OR AS FOLLOWUP TREATMENT AFTER DEXTROSE THERAPY OF THIS DISEASE.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1168

For more Therapeutic Uses (Complete) data for SODIUM PROPIONATE (6 total), please visit the HSDB record page.

5 Pharmacology and Biochemistry

5.1 ATC Code

S - Sensory organs

S01 - Ophthalmologicals

S01A - Antiinfectives

S01AX - Other antiinfectives

S01AX10 - Sodium propionate

5.2 Absorption, Distribution and Excretion

SRP: In an acidic medium propionic acid is rapidly absorbed.

5.3 Metabolism/Metabolites

INCORPORATION RATE OF SPECIFICALLY LABELED SODIUM PROPIONATE INTO METHYLMALONATE & TRICARBOXYLIC ACID CYCLE INTERMEDIATES STUDIED. INCORPORATION OF (14)C FROM SODIUM PROPIONATE INTO METABOLIC INTERMEDIATES BEYOND METHYLMALONATE WAS POSITIVELY CORRELATED WITH LIVER VITAMIN B-12 CONCN.

PMID:6070000 MATHIAS MM, ELLIOT JM; J DAIRY SCI 50 (12): 1935-40 (1967)

MICE RECEIVED IV LABELED SODIUM PROPIONATE. ANALYSIS OF TOTAL BODY FATTY ACIDS 12 MIN LATER SHOWED 89 & 11 OF THE LABELS TO BE INCORPORATED INTO ODD-NUMBERED & EVEN-NUMBERED FATTY ACIDS, RESPECTIVELY. RESULTS CONFIRMED PROPOSED DEMETHYLATION OF PROPIONIC ACID IN VIVO.

FAVARGER P, GERLACH J; HELV CHIM ACTA 49 (1): 506-9 (1966)

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