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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers, $ API Reference Price

1 API Suppliers
1 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 1 Europe, 2 Canada, 1 South Africa

4 FDF Dossiers
1 Europe
2 Canada
1 South Africa

RELATED EXCIPIENT COMPANIES

2 Rochem International Inc, 2 SPI Pharma, 1 Gangwal Healthcare, 1 Nanjing Well Pharmaceutical, 2 Actylis, 2 Gangwal Chemicals, 1 Ideal Cures Pvt Ltd, 11 Roquette, 1 Shijiazhuang Huaxu Pharmaceutical, 2 Zhejiang Huakang Pharmaceutical

relatedExcipients
2 Rochem International Inc
2 SPI Pharma
1 Gangwal Healthcare
1 Nanjing Well Pharmaceutical
2 Actylis
2 Gangwal Chemicals
1 Ideal Cures Pvt Ltd
11 Roquette
1 Shijiazhuang Huaxu Pharmaceutical
2 Zhejiang Huakang Pharmaceutical

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9 Film Formers & Plasticizers, 7 Taste Masking, 6 Coating Systems & Additives, 6 Fillers, Diluents & Binders, 5 Chewable & Orodispersible Aids, 3 Parenteral, 2 Disintegrants & Superdisintegrants, 1 Soft Gelatin, 1 Topical, 1 Controlled & Modified Release, 1 Co-Processed Excipients, 1 Direct Compression

excipientsByApplications
9 Film Formers & Plasticizers
7 Taste Masking
6 Coating Systems & Additives
6 Fillers, Diluents & Binders
5 Chewable & Orodispersible Aids
3 Parenteral
2 Disintegrants & Superdisintegrants
1 Soft Gelatin
1 Topical
1 Controlled & Modified Release
1 Co-Processed Excipients
1 Direct Compression

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2 EXCIPIENTS

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Synopsis

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$ 3

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43EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sodium pyrophosphate, 7722-88-5, Tspp, Tetrasodium diphosphate, Phosphotex, Diphosphoric acid, tetrasodium salt

Molecular Formula

Na₄O₇P₂

Molecular Weight

265.90 g/mol

InChI Key

FQENQNTWSFEDLI-UHFFFAOYSA-J

FDA UNII

O352864B8Z

1 2D Structure

Sodium Pyrophosphate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

tetrasodium;phosphonato phosphate

2.1.2 InChI

InChI=1S/4Na.H4O7P2/c;;;;1-8(2,3)7-9(4,5)6/h;;;;(H2,1,2,3)(H2,4,5,6)/q4*+1;/p-4

2.1.3 InChI Key

FQENQNTWSFEDLI-UHFFFAOYSA-J

2.1.4 Canonical SMILES

[O-]P(=O)([O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

O352864B8Z

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Anhydrous Sodium Pyrophosphate

2. Disodium Pyrophosphate

3. Sodium Diphosphate

4. Sodium Pyrophosphate

5. Tetrasodium Pyrophosphate, 32p2-labeled Cpd

6. Tetrasodium Pyrophosphate, Decahydrate

7. Trisodium Pyrophosphate

2.3.2 Depositor-Supplied Synonyms

1. Sodium Pyrophosphate

2. 7722-88-5

3. Tspp

4. Tetrasodium Diphosphate

5. Phosphotex

6. Diphosphoric Acid, Tetrasodium Salt

7. Sodium Diphosphate

8. Victor Tspp

9. Caswell No. 847

10. Sodium Pyrophosphate [usan]

11. Sodium Pyrophosphate Tetrabasic

12. Natrium Pyrophosphat

13. Pyrophosphoric Acid Tetrasodium Salt

14. Sodium Diphosphate, Anhydrous

15. Natrium Pyrophosphat [german]

16. Sodium Phosphate (na4p2o7)

17. Hsdb 854

18. Mfcd00003513

19. Na4p2o7

20. Chebi:71240

21. O352864b8z

22. Sodium Pyrophosphate (usan)

23. Sodium Pyrophosphate, Tetrabasic

24. Tetranatriumpyrophosphat [german]

25. Einecs 231-767-1

26. Nsc 56751

27. Epa Pesticide Chemical Code 076405

28. Sodium Diphosphate Tetrabasic

29. Tetrasodium Phosphonato Phosphate

30. Unii-o352864b8z

31. Tetrasodium Pyrophosphate, Anhydride

32. Sodiumpyrophosphate

33. Tetra Sodium Pyrophosphate

34. Ec 231-767-1

35. Dsstox_cid_22465

36. Dsstox_rid_80032

37. Dsstox_gsid_42465

38. Diphosphoric Acid Sodium Salt

39. Dtxsid9042465

40. Sodium Pyrophosphate [ii]

41. Sodium Diphosphate (na4(p2o7))

42. Sodium Pyrophosphate [fcc]

43. Tetrasodium Pyrophosphate Anhydrous

44. Sodium Pyrophosphate [hsdb]

45. Cs-b1771

46. Sodium Pyrophosphate [vandf]

47. Tox21_110033

48. Sodium Pyrophosphate [mart.]

49. Sodium Pyrophosphate [who-dd]

50. Tetrasodium Pyrophosphate [mi]

51. Akos015914004

52. Akos024418778

53. Diphosphoric Acid, Sodium Salt (1:4)

54. Tetrasodium Pyrophosphate [inci]

55. Ncgc00013687-01

56. Cas-7722-88-5

57. Ft-0689073

58. D05873

59. E75941

60. Q418504

61. 1004291-85-3

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	Na₄O₇P₂
Molecular Weight	265.90 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	0
Exact Mass	265.87100346 g/mol
Monoisotopic Mass	265.87100346 g/mol
Topological Polar Surface Area	136 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	124
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	5

4 Drug and Medication Information

4.1 Minimum/Potential Fatal Human Dose

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ AND 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB). ... SOME ANIMAL DATA SUGGEST THAT PYROPHOSPHATE IS CONSIDERABLY (AND UNACCOUNTABLY) MORE TOXIC THAN IMPLIED BY TOXICITY RATING OF 3.

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-121

5 Pharmacology and Biochemistry

5.1 Metabolism/Metabolites

Pyrophosphate is hydrolyzed to the orthophosphate in the gut.

American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, 1991., p. 1529

5.2 Mechanism of Action

ARSONIC ACID HERBICIDES ARE NOT GROWTH REGULATORS IN SENSE OF PLANT HORMONES. THEY ... ACT THROUGH ENZYME SYSTEMS TO INHIBIT GROWTH. THEY KILL ... SLOWLY; FIRST SYMPTOMS ARE ... CHLOROSIS, CESSATION OF GROWTH, & GRADUAL YELLOWING, THEN BROWNING FOLLOWED BY DEHYDRATION & DEATH. /ORGANOARSENICAL HERBICIDES/

Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 763

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