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    Chemistry

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    Also known as: 54-21-7, Sodium 2-hydroxybenzoate, Enterosalicyl, Kerasalicyl, Clin, Alysine
    Molecular Formula
    C7H5NaO3
    Molecular Weight
    160.10  g/mol
    InChI Key
    ABBQHOQBGMUPJH-UHFFFAOYSA-M
    FDA UNII
    WIQ1H85SYP
    Sodium Salicylate
    A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)
    1 2D Structure

    Sodium Salicylate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-hydroxybenzoate
    2.1.2 InChI
    InChI=1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1
    2.1.3 InChI Key
    ABBQHOQBGMUPJH-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1=CC=C(C(=C1)C(=O)[O-])O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    WIQ1H85SYP
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Salicylate, Sodium

    2.3.2 Depositor-Supplied Synonyms

    1. 54-21-7

    2. Sodium 2-hydroxybenzoate

    3. Enterosalicyl

    4. Kerasalicyl

    5. Clin

    6. Alysine

    7. Salsonin

    8. Benzoic Acid, 2-hydroxy-, Monosodium Salt

    9. Enterosalil

    10. Entrosalyl

    11. Glutosalyl

    12. Magsalyl

    13. Aroall

    14. Kerosal

    15. Nadisal

    16. Salisod

    17. Idocyl Novum

    18. Neo-salicyl

    19. Natrum Salicylicum

    20. Monosodium Salicylate

    21. Salicylic Acid Sodium Salt

    22. Diuretin

    23. Parbocyl-rev

    24. Sodium;2-hydroxybenzoate

    25. Salicylate Sodium

    26. Salicylic Acid, Sodium Salt

    27. Sodium O-hydroxybenzoate

    28. Salicylic Acid Sodium

    29. Wiq1h85syp

    30. O-hydroxybenzoic Acid, Sodium Salt

    31. Chebi:9180

    32. Nsc-202167

    33. 90218-97-6

    34. Benzoic Acid, 2-hydroxy-, Monosodium Salt, Coupled With 4-amino-1-naphthalenesulfonic Acid And Diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine, Sodium Salt

    35. Salicylic Acid Sodium Salt;2-hydroxybenzoic Acid Sodium Salt

    36. Natrium Salicylat [german]

    37. Ccris 6715

    38. Einecs 200-198-0

    39. Unii-wiq1h85syp

    40. Nsc 202167

    41. Sodium Salicylate [usp:jan]

    42. Natrii Salicylas

    43. Mfcd00002440

    44. Sodium;2-carboxyphenolate

    45. Sodium Salicylate, 99%

    46. Spectrum2_001945

    47. Spectrum3_000900

    48. Spectrum4_000995

    49. Spectrum5_001120

    50. Dsstox_cid_1708

    51. Ec 200-198-0

    52. Schembl4603

    53. Dsstox_rid_76287

    54. Dsstox_gsid_21708

    55. Kbiogr_001429

    56. 90218-94-3

    57. Spectrum1500533

    58. Spbio_002009

    59. Chembl447868

    60. Sodium Salicylate [jan]

    61. Dtxsid5021708

    62. Sodium Salicylate (jp17/usp)

    63. Sodium Salicylate [inci]

    64. Hy-b0167a

    65. Kbio3_001820

    66. Natrum Salicylicum [hpus]

    67. Sodium Salicylate [vandf]

    68. Sodium Salicylate [mart.]

    69. Hms1920p16

    70. Hms2092g17

    71. Salicylate Sodium [who-dd]

    72. Sodium Salicylate [usp-rs]

    73. Sodium Salicylate [who-ip]

    74. Sodium Salicylate, P.a., 99.5%

    75. Tox21_200411

    76. 2-hydroxy Benzoic Acid, Sodium Salt

    77. Ccg-39474

    78. Akos003051698

    79. Akos005766021

    80. Cs-2008

    81. Cas-54-21-7

    82. Natrii Salicylas [who-ip Latin]

    83. Salicylic Acid Sodium Salt [mi]

    84. Sodium Salicylate [ep Monograph]

    85. Ncgc00094780-01

    86. Ncgc00094780-02

    87. Ncgc00257965-01

    88. Sodium Salicylate [usp Monograph]

    89. Db-052516

    90. Ft-0631235

    91. C07587

    92. D00566

    93. D83111

    94. Sodium Salicylate, Reagentplus(r), >=99.5%

    95. Sodium Salicylate, Saj First Grade, >=99.5%

    96. Sodium Salicylate, Tested According To Ph.eur.

    97. Sodium Salicylate, Saj Special Grade, >=99.5%

    98. 2,4-dimethoxyphenylboronicacid,pinacolester

    99. Q414547

    100. Sodium Salicylate, Vetec(tm) Reagent Grade, 99%

    101. Sodium Salicylate, Meets Usp Testing Specifications

    102. Sodium Salicylate, Puriss. P.a., >=99.5% (nt)

    103. Sodium Salicylate, European Pharmacopoeia (ep) Reference Standard

    104. Sodium Salicylate, United States Pharmacopeia (usp) Reference Standard

    105. Benzoic Acid,2-hydroxy-,monosodium Salt,coupled With 4-amino-5-hydroxy-2,7-naphthalenedisulfonic Acid,diazotized 2-(4-aminophenyl)-1h-benzimidazol-5-amine And Diazotized 4-nitrobenzenamine,sodium

    106. Sodium Salicylate, Puriss. P.a., Reag. Ph. Eur., 99.5-101.0% (calc. To The Dried Substance)

    2.4 Create Date
    2007-11-13
    3 Chemical and Physical Properties
    Molecular Weight 160.10 g/mol
    Molecular Formula C7H5NaO3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count1
    Exact Mass160.01363830 g/mol
    Monoisotopic Mass160.01363830 g/mol
    Topological Polar Surface Area60.4 Ų
    Heavy Atom Count11
    Formal Charge0
    Complexity138
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Inflammatory Agents, Non-Steroidal

    Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

    Cyclooxygenase Inhibitors

    Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

    4.2 ATC Code

    N - Nervous system

    N02 - Analgesics

    N02B - Other analgesics and antipyretics

    N02BA - Salicylic acid and derivatives

    N02BA04 - Sodium salicylate

    API Reference Price

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    02-Jan-2021
    28-Feb-2025
    KGS
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    ABOUT THIS PAGE

    Looking for 54-21-7 / Sodium Salicylate API manufacturers, exporters & distributors?

    Sodium Salicylate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Sodium Salicylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Salicylate manufacturer or Sodium Salicylate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Salicylate manufacturer or Sodium Salicylate supplier.

    PharmaCompass also assists you with knowing the Sodium Salicylate API Price utilized in the formulation of products. Sodium Salicylate API Price is not always fixed or binding as the Sodium Salicylate Price is obtained through a variety of data sources. The Sodium Salicylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Sodium Salicylate

    Synonyms

    54-21-7, Sodium 2-hydroxybenzoate, Enterosalicyl, Kerasalicyl, Clin, Alysine

    Cas Number

    54-21-7

    Unique Ingredient Identifier (UNII)

    WIQ1H85SYP

    About Sodium Salicylate

    A non-steroidal anti-inflammatory agent that is less effective than equal doses of ASPIRIN in relieving pain and reducing fever. However, individuals who are hypersensitive to ASPIRIN may tolerate sodium salicylate. In general, this salicylate produces the same adverse reactions as ASPIRIN, but there is less occult gastrointestinal bleeding. (From AMA Drug Evaluations Annual, 1992, p120)

    Sodium Salicylate Manufacturers

    A Sodium Salicylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium Salicylate, including repackagers and relabelers. The FDA regulates Sodium Salicylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium Salicylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Sodium Salicylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Sodium Salicylate Suppliers

    A Sodium Salicylate supplier is an individual or a company that provides Sodium Salicylate active pharmaceutical ingredient (API) or Sodium Salicylate finished formulations upon request. The Sodium Salicylate suppliers may include Sodium Salicylate API manufacturers, exporters, distributors and traders.

    click here to find a list of Sodium Salicylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Sodium Salicylate USDMF

    A Sodium Salicylate DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium Salicylate active pharmaceutical ingredient (API) in detail. Different forms of Sodium Salicylate DMFs exist exist since differing nations have different regulations, such as Sodium Salicylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Sodium Salicylate DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium Salicylate USDMF includes data on Sodium Salicylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium Salicylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Sodium Salicylate suppliers with USDMF on PharmaCompass.

    Sodium Salicylate JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Sodium Salicylate Drug Master File in Japan (Sodium Salicylate JDMF) empowers Sodium Salicylate API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Sodium Salicylate JDMF during the approval evaluation for pharmaceutical products. At the time of Sodium Salicylate JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Sodium Salicylate suppliers with JDMF on PharmaCompass.

    Sodium Salicylate NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sodium Salicylate as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Sodium Salicylate API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Sodium Salicylate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Sodium Salicylate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sodium Salicylate NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Sodium Salicylate suppliers with NDC on PharmaCompass.

    Sodium Salicylate GMP

    Sodium Salicylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Sodium Salicylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium Salicylate GMP manufacturer or Sodium Salicylate GMP API supplier for your needs.

    Sodium Salicylate CoA

    A Sodium Salicylate CoA (Certificate of Analysis) is a formal document that attests to Sodium Salicylate's compliance with Sodium Salicylate specifications and serves as a tool for batch-level quality control.

    Sodium Salicylate CoA mostly includes findings from lab analyses of a specific batch. For each Sodium Salicylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Sodium Salicylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium Salicylate EP), Sodium Salicylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium Salicylate USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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