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    Chemistry

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    Also known as: 7757-82-6, Disodium sulfate, Sodium sulfate, anhydrous, Sodium sulfate anhydrous, Sodium sulphate, Salt cake
    Molecular Formula
    Na2O4S
    Molecular Weight
    142.04  g/mol
    InChI Key
    PMZURENOXWZQFD-UHFFFAOYSA-L
    FDA UNII
    36KCS0R750
    Sodium Sulfate
    Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate anhydrous is an electrolyte replenisher and is used in isosmotic solutions so that administration does not disturb normal electrolyte balance and does not lead to absorption or excretion of water and ions.
    1 2D Structure

    Sodium Sulfate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;sulfate
    2.1.2 InChI
    InChI=1S/2Na.H2O4S/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
    2.1.3 InChI Key
    PMZURENOXWZQFD-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    [O-]S(=O)(=O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    36KCS0R750
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Disodium Sulfate

    2. Mangxiao

    3. Mirabilitum

    4. Natrii Sulphas

    5. Puxiao

    6. Sodium Bisulfate

    7. Sodium Bisulfate, Monohydrate

    8. Sodium Hydrosulfate

    9. Sodium Sulfate, 35s-labeled Cpd

    10. Sodium Sulfate, Decahydrate

    11. Sulfuric Acid, Monosodium Salt

    12. Thenardite

    2.3.2 Depositor-Supplied Synonyms

    1. 7757-82-6

    2. Disodium Sulfate

    3. Sodium Sulfate, Anhydrous

    4. Sodium Sulfate Anhydrous

    5. Sodium Sulphate

    6. Salt Cake

    7. Sodiumsulfate

    8. Sulfuric Acid Disodium Salt

    9. Disodium Sulphate

    10. Disodium;sulfate

    11. 15124-09-1

    12. Sulfuric Acid, Sodium Salt

    13. Sulfate, Sodium

    14. Sodium Sulphate Anhydrous

    15. Sodium Sulfate, Dried [jan]

    16. Sodium Sulfate, Dried

    17. Na2so4

    18. Mfcd00003504

    19. Sodium Sulphate, Anhydrous

    20. Chebi:32149

    21. 36kcs0r750

    22. Nsc-403914

    23. Sulfuric Acid, Mono-c14-18-alkyl Esters, Sodium Salts

    24. 13759-07-4

    25. Sodium Sulfate, Dried (jan)

    26. Dibasic Sodium Sulfate

    27. Natriumsulfat (german)

    28. Na Sulphate

    29. Caswell No. 793

    30. Hsdb 5042

    31. Sodium Sulfate Anyhdrous

    32. Sulfuric Acid Sodium Salt (1:2)

    33. Sodium Sulfate (solution)

    34. Thenardite (na2(so4))

    35. Natriumsulfat

    36. Sodium Tallow Alcohol Sulfate

    37. Unii-36kcs0r750

    38. Einecs 231-820-9

    39. Einecs 268-366-6

    40. Einecs 268-773-9

    41. Einecs 270-211-2

    42. Epa Pesticide Chemical Code 005604

    43. Nsc 403914

    44. Sodium Sulfate Acs He

    45. Ai3-02398

    46. Sda 17-062-04

    47. Sulfuric Acid Sodium Salt

    48. Dsstox_cid_1291

    49. Ec 231-820-9

    50. Dsstox_rid_76063

    51. Sodium Sulfate [mi]

    52. Dsstox_gsid_21291

    53. Sodium Sulfate, Acs Reagent

    54. Sodium Sulfate, Dried (tn)

    55. Sodium Sulfate [hsdb]

    56. Chembl233406

    57. Dtxsid1021291

    58. Anhydous Sodium Sulfate (jp17)

    59. Sodium Sulfate - Drilling Grade

    60. Bcp13313

    61. Sodium Sulfate, For Residue Analysis

    62. Tox21_201045

    63. Sodium Sulfate Anhydrous [ii]

    64. Akos015833463

    65. Anhydrous Sodium Sulfate [jan]

    66. Sodium Sulfate Anhydrous Granular Acs

    67. Sodium Sulfate, Bioxtra, >=99.0%

    68. Sulfuric Acid Disodium Salt, Anhydrous

    69. Db09472

    70. Anhydrous Sodium Sulfate [mart.]

    71. Ncgc00258598-01

    72. Sodium Sulfate, Lr, Anhydrous, >=99%

    73. E514

    74. Sodium Sulfate Anhydrous [usp-rs]

    75. Sodium Sulfate Anhydrous [who-dd]

    76. Sodium Sulfate Anhydrous; Sodium Sulphate

    77. Cas-7757-82-6

    78. Sodium Sulfate, Anhydrous [who-ip]

    79. Sodium Sulfate, Ar, Anhydrous, >=99.5%

    80. Ft-0645112

    81. S0566

    82. Sodium Sulfate, 99.9955% (metals Basis)

    83. Sodium Sulfate, Reagentplus(r), >=99.0%

    84. Sodium Sulfate Anhydrous [orange Book]

    85. Sodium Sulfate, For Pesticide Residue Analysis

    86. Sodium Sulfate, Trace Metals Grade, 99.99%

    87. D01732

    88. Natrii Sulfas Anhydricus [who-ip Latin]

    89. Sodium Sulfate, >=99.99% Trace Metals Basis

    90. Sodium Sulfate, Jis Special Grade, >=99.0%

    91. Sodium Sulfate, Vetec(tm) Reagent Grade, 99%

    92. Sodium Sulfate Anhydrous [usp Monograph]

    93. Sodium Sulfate, Anhydrous [ep Monograph]

    94. Sodium Sulfate, Meets Usp Testing Specifications

    95. Q211737

    96. Sodium Sulfate, For Hplc, 99.0-101.0% (t)

    97. Sodium Sulfate, Purum, Anhydrous, >=99.0% (t)

    98. Sodium Sulfate, Saj First Grade, >=99.0%, Beads

    99. Sodium Sulfate, Saj First Grade, >=99.0%, Powder

    100. Sodium Sulfate, >=99.0%, Plant Cell Culture Tested

    101. Sodium Sulfate, Bioultra, Anhydrous, >=99.0% (t)

    102. Sodium Sulfate, P.a., 99.0-101.0%, Reag. Iso

    103. Sodium Sulfate, For Pesticide Residue Analysis, 99.0%

    104. Sodium Sulfate, Tested According To Ph.eur., Anhydrous

    105. Sulfuric Acid Disodium Salt, Anhydrous [who-ip]

    106. Sodium Sulfate, Acs Reagent, >=99.0%, Anhydrous, Powder

    107. Sodium Sulfate, Acs Reagent, >=99.0%, Anhydrous, Granular

    108. Sodium Sulfate, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99%

    109. Sodium Sulfate Anhydrous, United States Pharmacopeia (usp) Reference Standard

    110. Sodium Sulfate, Anhydrous, Free-flowing, Redi-dri(tm), Reagentplus(r), >=99%

    111. Sodium Sulfate, Anhydrous, Granular, Free-flowing, Redi-dri(tm), Acs Reagent, >=99%

    112. Sodium Sulfate, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., Anhydrous, >=99.0%

    113. Sodium Sulfate, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, Anhydrous, 99.0-100.5% (calc. To The Dried Substance)

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 142.04 g/mol
    Molecular Formula Na2O4S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass141.93126821 g/mol
    Monoisotopic Mass141.93126821 g/mol
    Topological Polar Surface Area88.6 Ų
    Heavy Atom Count7
    Formal Charge0
    Complexity62.2
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Cathartics

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    EXPL THER /The purpose of the study was/ to evaluate the early bone response to a nanotextured dental implant treated with sodium sulfate (Na2SO4), using a rabbit model. Twelve animals were randomly divided into group 1 (Control) - machined implants and group 2 (Test) - nanotextured implants. Extra-oral incision was performed to provide access to intended surgical site where the dental implant was inserted immediately after the extraction of the mandibular first premolar. Implant surface characterization was performed by scanning electron microscopy attached to energy dispersive spectroscopy and interferometry. Three weeks after surgery, the animals were induced to death and undecalcified sections of the samples were prepared for histological and histomorphometrical analysis. Surface characterization of the implant demonstrated enhanced surface area of anodized group compared to Control group with 19.2% +/- 6.2 versus 1.6 +/- 0.7, respectively. Histological evaluation demonstrated new bone formation starting from the buccal and lingual cortical walls on both groups. After three weeks, significant higher bone contact of 27% (p<0.05) was observed to nanotextured compared to machined implants (Control group). The anodization with sodium sulfate nanostructures to the implant surface that resulted in faster osseointegration.

    PMID:24919046 Pinheiro FA et al; Acta Cir Bras 29 (6): 376-82 (2014)

    /EXPL THER/ ... 2-16 mmol/kg of sodium sulfate and sulfur-containing amino acids (cysteine or methionine) were infused intravenously for 2 hr into pentobarbital-anesthetized rats. ... Hepatic 3'-phosphoadenosine 5'-phosphosulfate concentrations increased significantly (30-35%) only when infused with the higher doses (8 or 16 mmol/kg/2 hr) of sodium sulfate.

    PMID:7493551 Kim HJ et al; Drug Metab Dispos 23 (8): 840-5 (1995)

    VET: Cathartic

    O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Cambridge, UK: Royal Society of Chemistry, 2013., p. 1607

    For more Therapeutic Uses (Complete) data for Sodium sulfate (12 total), please visit the HSDB record page.

    4.2 Drug Warning

    Sodium sulfate used in treatment of hypercalcemia may result in hypokalemia and hypernatremia. Thus, the progress of patients with cardiovascular disease should be watched closely when ... infusions are administered.

    Hansten, P.D. Drug Interactions. 4th ed. Philadelphia: Lea and Febiger, 1979., p. 396

    4.3 Drug Indication

    indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Induces catharsis by the osmotic effects of the unabsorbed sulfate salts and polyethylene glycol (PEG) in the GI tract. Specifically, sulfate salts provide sulfate anions, which are poorly absorbed, and PEG, which is primarily unabsorbed, causes water to be retained in the GI tract resulting in watery diarrhea.

    5.2 MeSH Pharmacological Classification

    Cathartics

    Agents that are used to stimulate evacuation of the bowels. (See all compounds classified as Cathartics.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Increased Large Intestinal Motility [PE]
    5.4 ATC Code

    A - Alimentary tract and metabolism

    A06 - Drugs for constipation

    A06A - Drugs for constipation

    A06AD - Osmotically acting laxatives

    A06AD13 - Sodium sulfate

    A - Alimentary tract and metabolism

    A12 - Mineral supplements

    A12C - Other mineral supplements

    A12CA - Sodium

    A12CA02 - Sodium sulfate

    5.5 Absorption, Distribution and Excretion

    Absorption

    Absorption of sodium sulfate after ingestion in rats was investigated. 35)S-Radioactivity excreted in urine during 24 hr indicated almost complete absorption from GI tract. Determination in serum 2 hr after admin revealed 3-fold increase in sulfate concentration rapid and almost complete absorption of inorganic sulfate occurs after oral admin in rats.

    Route of Elimination

    Rectal effluent if unabsorbed sulfates ; urine (predominant route for absorbed sulfates )

    The importance of tissue sulfate concentrations in regulating 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthesis is not known. Therefore, this study was conducted to determine the influence of increased availability of inorganic sulfate on steady-state PAPS concentrations in various tissues. To increase tissue sulfate concentrations, 2-16 mmol/kg of sodium sulfate and sulfur-containing amino acids (cysteine or methionine) were infused intravenously for 2 hr into pentobarbital-anesthetized rats. Serial blood samples were taken during the infusion and analyzed for sulfate concentrations. After 2 hr of infusion, liver, kidney, and brain were removed for quantification of tissue PAPS and sulfate concentrations. Infusion of sodium sulfate, cysteine, and methionine increased serum and tissue sulfate concentrations in a dose- and time-dependent manner. Serum sulfate concentrations increased from 0.8 to 14 mM during the infusion of sodium sulfate, whereas infusions of cysteine and methionine increased serum sulfate concentrations to 4.8 and 2.0 mM, respectively. Tissue sulfate concentrations also increased during sulfate infusion. Liver sulfate concentration increased from 0.8 to 4.8 mM, kidney concentration increased from 0.6 to 31 mM, and brain concentration increased from 0.1 to 0.6 mM. Similar to the serum sulfate concentrations, sulfate infusion was the most effective in increasing tissue sulfate concentrations, cysteine was intermediate, and methionine the least effective. Although sulfate concentrations in liver, kidney, and brain increased 6-, 50-, and 6-fold by infusing sulfate, respectively; tissue PAPS levels were not altered markedly. Hepatic PAPS concentrations increased significantly (30-35%) only when infused with the higher doses (8 or 16 mmol/kg/2 hr) of sodium sulfate.

    PMID:7493551 Kim HJ et al; Drug Metab Dispos 23 (8): 840-5 (1995)

    The absorption of inorganic sulfate after ingestion was investigated in rats. After oral administration of Na235SO4, 35S radioactivity was measurable in plasma already after 15 min and its plasma concentration reached a peak after about 1.5-2 hr. The 35S-radioactivity excreted in urine during 24 hr after ingestion of Na235SO4 together with varying amounts of unlabelled Na2SO4 (0.25-5.0 mmol Na2SO4 per rat) indicated an almost complete absorption of inorganic sulfate from the gastrointestinal tract. Determination of the inorganic sulfate concentration in rat serum 2 hr after oral administration of 5.0 mmol Na2SO4 revealed a three-fold increase in serum sulfate concentration. The data suggest a rapid and almost complete absorption of inorganic sulfate after oral administration in the rat. Its importance in relation to the sulfate availability for sulfate conjugation of drugs is discussed.

    PMID:476150 Krijgsheld KR et al; Biochim Biophys Acta 586 (3): 492-500 (1979)

    Sodium sulfate can be used to enhance the conjugation of phenolic drugs with sulfate and to treat hypercalcemia. It is thought that sulfate in is absorbed slowly and incompletely from the digestive tract. The purposes of this investigation were to determine the absorption of large amount of sodium sulfate(18.1 g as the decahydrate, equivalent to 8.0 g of the anhydrous salt) and to compare the bioavailability when this amount is administered orally to normal subjects as a single dose and as four equally divided hourly doses. The 72-hr urinary recovery of free sulfate following single and divided doses was 53.4 +/- 15.8 and 61.8 +/- 7.8%, respectively (mean +/- SD, n=5, p > 0.2). The single dose produced severe diarrhea while the divided doses caused only mild or no diarrhea. Thus, a large amount of sodium sulfate, when administered orally in divided doses over 3 hr, is well tolerated and is absorbed to a significant extent. Orally administered sodium sulfate may be useful for the early treatment of acetaminophen overdose.

    PMID:7264905 Cocchetto DM, Levy G; J Pharm Sci 70 (3): 331-3 (1981)

    The renal excretion of potassium by unanesthetized sheep was studied in clearance studies in which water and sodium excretion were elevated by intravenous infusion of isotonic sodium chloride, hypertonic sodium phosphate, or hypertonic sodium sulfate. Aldosterone was infused at 10 ug/hr in some experiments with sodium sulfate. Sodium excretion increased in all experiments, rising at times to equal 25% of the filtered load. Urine flow increased in most experiments. Glomerular filtration rate increased only with infusion of isotonic saline. No consistent change in potassium excretion occurred under any of these loading conditions. This finding contrasts with the increase in potassium excretion commonly seen in man, dogs, and rats intravenously loaded with sodium salts.

    PMID:645906 Rabinowitz L, Gunther RA; Am J Physiol 234 (5): F371-5 (1978)

    5.6 Biological Half-Life

    Serum sulfate: 8.5 hours

    5.7 Mechanism of Action

    MoviPrep produces a watery stool leading to cleansing of the colon. The osmotic activity of polyethylene glycol 3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid, when taken with 1 liter of additional clear fluid, usually results in no net absorption or excretion of ions or water.

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SCHIPHOL","customer":"ALPHAMED FORMULATIONS PRIVATE ","customerCountry":"INDIA","quantity":"0.00","actualQuantity":"0.5","unit":"GMS","unitRateFc":"200","totalValueFC":"111.5","currency":"EUR","unitRateINR":"18540","date":"17-Jan-2024","totalValueINR":"9270","totalValueInUsd":"111.5","indian_port":"Hyderabad Air","hs_no":"29372300","bill_no":"9695680","productDescription":"API","marketType":"REGULATED MARKET","country":"NETHERLANDS","selfForZScoreResived":"Pharma Grade","supplierPort":"AMSTERDAM, SCHIPHOL","supplierAddress":"NETHERLANDSSDNFSDNF NL","customerAddress":"ASURVEY NO.225, SAMPANBOLE VILLAGE"}]
    22-May-2021
    17-Jan-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - POWDER;ORAL - 1.6GM/BOT;3.13GM/BOT;1...DOSAGE - POWDER;ORAL - 1.6GM/BOT;3.13GM/BOT;17.5GM/BOT

    USFDA APPLICATION NUMBER - 204553

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    DOSAGE - TABLET;ORAL - 0.225GM;0.188GM;1.479G...DOSAGE - TABLET;ORAL - 0.225GM;0.188GM;1.479GM

    USFDA APPLICATION NUMBER - 213135

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