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Sodium Thiosulfate
Also known as: 7772-98-7, Sodiumthiosulfate, Disodium thiosulfate, Hypo, Chlorine control, Thiosulfuric acid, disodium salt
Molecular Formula
Na2O3S2
Molecular Weight
158.11  g/mol
InChI Key
AKHNMLFCWUSKQB-UHFFFAOYSA-L
FDA UNII
L0IYT1O31N

1 2D Structure

Sodium Thiosulfate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;dioxido-oxo-sulfanylidene-6-sulfane
2.1.2 InChI
InChI=1S/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
2.1.3 InChI Key
AKHNMLFCWUSKQB-UHFFFAOYSA-L
2.1.4 Canonical SMILES
[O-]S(=O)(=S)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
L0IYT1O31N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Pentahydrate Of Sodium Thiosulfate

2. Sodium Thiosulfate (usan)

3. Sodium Thiosulfate Anhydrous

4. Sodium Thiosulfate Pentahydrate

5. Thiosulfuric Acid, Disodium Salt

2.3.2 Depositor-Supplied Synonyms

1. 7772-98-7

2. Sodiumthiosulfate

3. Disodium Thiosulfate

4. Hypo

5. Chlorine Control

6. Thiosulfuric Acid, Disodium Salt

7. Sodium Thiosulfate, Anhydrous

8. Disodium Sulfurothioate

9. Mfcd00003499

10. Na2s2o3

11. L0iyt1o31n

12. Thiosulfuric Acid (h2s2o3), Disodium Salt

13. Sodothiol

14. Sodium Sulfothioate

15. Sodothiol; Sulfactol; Sulfothiorine

16. Chlorine Cure

17. Declor-it

18. Hypo (van)

19. Hsdb 592

20. Einecs 231-867-5

21. Unii-l0iyt1o31n

22. Sodium Thiosulfate Concentrate

23. Ai3-01237

24. Sodium Thiosulfat

25. Sodium Thio-sulfate

26. Sodium Oxide Sulfide

27. Hypo Alcohol, In Ethanol

28. Anhydrous Sodium Thiosulfate

29. Ec 231-867-5

30. Disodium Thiosulphate

31. Sodium Thiosulfate (anhydrous)

32. Sodium Thiosulfate [mi]

33. Chembl3753202

34. Dtxsid9042417

35. Sodium Thiosulfate [hsdb]

36. Chebi:132112

37. Sodium Thiosulfate Solution, 1 M

38. Sodium Thiosulfate, Ar, >=98%

39. Sodium Thiosulfate, Lr, >=97%

40. Sodium Thiosulfate [who-dd]

41. Sodium Thiosulfate Solution, 0.1 M

42. Sodium Thiosulfate, P.a., 98.0%

43. Akos015856704

44. Akos016372312

45. Sodium Thiosulfate Solution, 0.01 M

46. Sodium Thiosulfate Solution, 0.025 M

47. Sodium Thiosulfate Anhydrous [ii]

48. Bp-21059

49. Sodium Thiosulfate, Reagentplus(r), 99%

50. Ft-0696570

51. O0522

52. Sodium Thiosulfate, 0.1n Volumetric Solution

53. D78333

54. Sodium Thiosulfate, 0.1n Standardized Solution

55. Sodium Thiosulfate, 1.0n Standardized Solution

56. Sodium Thiosulfate, 0.01n Standardized Solution

57. Sodium Thiosulfate, Saj First Grade, >=90.0%

58. Disodium;dioxido-oxo-sulfanylidene-lambda6-sulfane

59. Q339866

60. Sodium Thiosulfate, >=99.99% Trace Metals Basis

61. Sodium Thiosulfate, Vetec(tm) Reagent Grade, 99%

62. Thiosulfuric Acid (h2s2o3), Sodium Salt (1:2)

63. Sodium Thiosulfate Solution, 2 G/dl In Deionized Water

64. Sodium Thiosulfate, Anhydrous, Trace Metals Grade 99.99%

65. Sodium Thiosulfate, Purum P.a., Anhydrous, >=98.0% (rt)

66. Sodium Thiosulfate, Anhydrous, >=98% (calc. To The Dried Substance)

67. Sodium Thiosulfate, Acculute Standard Volumetric Solution, Final Concentration 0.1n

68. Sodium Thiosulfate 2.5m Solution (+/- 0.1m) Ph 7.0 - 9.0 (sodium Carbonate Added As A Preservative)

69. Sodium Thiosulfate Solution, Silver Stain Kit Component, 0.5 % (w/v) Sodium Thiosulfate In H2o

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 158.11 g/mol
Molecular Formula Na2O3S2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass157.90842477 g/mol
Monoisotopic Mass157.90842477 g/mol
Topological Polar Surface Area104 Ų
Heavy Atom Count7
Formal Charge0
Complexity82.6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameSodium thiosulfate
PubMed HealthSodium Thiosulfate (Intravenous)
Drug ClassesCyanide Antidote
Drug LabelSodium thiosulfate has the chemical name thiosulfuric acid, disodium salt, pentahydrate. The chemical formula is Na2S2O3 5H2O and the molecular weight is 248.17. The structural formula is:Structure of Sodium Thiosulfate PentahydrateSodium Thiosulf...
Active IngredientSodium thiosulfate
Dosage FormSolution
RouteIntravenous
Strength12.5gm/50ml (250mg/ml)
Market StatusPrescription
CompanyHope Pharms

2 of 2  
Drug NameSodium thiosulfate
PubMed HealthSodium Thiosulfate (Intravenous)
Drug ClassesCyanide Antidote
Drug LabelSodium thiosulfate has the chemical name thiosulfuric acid, disodium salt, pentahydrate. The chemical formula is Na2S2O3 5H2O and the molecular weight is 248.17. The structural formula is:Structure of Sodium Thiosulfate PentahydrateSodium Thiosulf...
Active IngredientSodium thiosulfate
Dosage FormSolution
RouteIntravenous
Strength12.5gm/50ml (250mg/ml)
Market StatusPrescription
CompanyHope Pharms

4.2 Therapeutic Uses

Antidotes; Antitubercular Agents; Antioxidants; Chelating Agents

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


SODIUM THIOSULFATE, USP, IS INTENDED FOR PARENTERAL USE IN TREATMENT OF CYANIDE POISONING, BUT IT MAY BE APPLIED TO SKIN IN VARIOUS FORMS. CUTANEOUS INFECTIONS CAUSED BY STAPH AUREUS & STAPH EPIDERMIDIS MAY RESPOND TO CONCN AS LOW AS 0.5%. CONCN OF 2-8%...USED TO TREAT ACNE; THEY ARE ALSO ANTIFUNGAL.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1005


/SODIUM THIOSULFATE USP/...IS USEFUL IN TOPICAL TREATMENT OF TINEA VERSICOLOR, TINEA CRURIS, & POSSIBLY MOST OTHER DERMATOPHYTOSES.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1168


MEDICATION (VET): IN CYANIDE POISONING; HAS BEEN USED...EXTERNALLY IN RINGWORM, MANGE.

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1122


For more Therapeutic Uses (Complete) data for SODIUM THIOSULFATE (6 total), please visit the HSDB record page.


4.3 Drug Warning

PHYSICALLY INCOMPATIBLE WITH IV CALCIUM SALTS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 548


4.4 Minimum/Potential Fatal Human Dose

3(?). 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-86


4.5 Drug Indication

Prevention of platinum-induced ototoxic hearing loss


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)


Antioxidants

Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)


Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)


5.2 Absorption, Distribution and Excretion

POORLY ABSORBED FROM BOWEL. ... THIOSULFATE ION DISTRIBUTES ITSELF IN EXTRACELLULAR FLUID.

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-86


5.3 Mechanism of Action

/ANTIFUNGAL ACTION OF SODIUM THIOSULFATE, USP,/...IS PROBABLY ATTRIBUTABLE TO SLOW RELEASE OF COLLOIDAL SULFUR.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1168


IN CYANIDE POISONING, SODIUM NITRITE IS INJECTED IV...TO PRODUCE METHEMOGLOBIN WHICH COMBINES WITH...CYANIDE ION & RENDERS IT TEMPORARILY INACTIVE IN FORM OF CYANMETHEMOGLOBIN. SODIUM THIOSULFATE /USP/ IS THEN INJECTED IV TO FORM NONTOXIC THIOCYANATE.

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 779


THIOSULFATE SERVES AS SUBSTRATE FOR ENZYME RHODANESE, WHICH MEDIATES CONVERSION OF CYANIDE TO MUCH LESS TOXIC THIOCYANATE, WHICH IS EXCRETED IN URINE.

Casarett, L.J., and J. Doull. Toxicology: The Basic Science of Poisons. New York: MacMillan Publishing Co., 1975., p. 239


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