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Chemistry

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Also known as: 26628-22-8, Azide, sodium, Hydrazoic acid sodium salt, Natriumazid, Sodiumazide, Sodium;azide
Molecular Formula
N3Na
Molecular Weight
65.010  g/mol
InChI Key
PXIPVTKHYLBLMZ-UHFFFAOYSA-N
FDA UNII
968JJ8C9DV

Sodium Azide
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
1 2D Structure

Sodium Azide

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;azide
2.1.2 InChI
InChI=1S/N3.Na/c1-3-2;/q-1;+1
2.1.3 InChI Key
PXIPVTKHYLBLMZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
[N-]=[N+]=[N-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
968JJ8C9DV
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Azide, Sodium

2. Nan3

2.3.2 Depositor-Supplied Synonyms

1. 26628-22-8

2. Azide, Sodium

3. Hydrazoic Acid Sodium Salt

4. Natriumazid

5. Sodiumazide

6. Sodium;azide

7. Azoture De Sodium

8. Hydrazoic Acid, Sodium Salt

9. Azidosodium

10. Sodium Trinitride

11. Chembl89295

12. 968jj8c9dv

13. Chebi:278547

14. Nemazyd

15. Dsstox_cid_121

16. Dsstox_rid_75383

17. Dsstox_gsid_20121

18. Natriumazid [german]

19. Natriummazide [dutch]

20. Azydek Sodu [polish]

21. Caswell No. 744a

22. Natriummazide

23. Azydek Sodu

24. Nsc 3072

25. Rcra Waste Number P105

26. Azoture De Sodium [french]

27. Sodium, Azoture De

28. Sodium, Azoturo Di

29. Sodium, Azoture De [french]

30. Sodium, Azoturo Di [italian]

31. Cas-26628-22-8

32. Ccris 1261

33. Hsdb 695

34. Nan3

35. Nci-c06462

36. Einecs 247-852-1

37. Un1687

38. Rcra Waste No. P105

39. Epa Pesticide Chemical Code 107701

40. Unii-968jj8c9dv

41. Azido Sodium

42. Sodium Azid

43. Sodium-azide

44. Natrium Azide

45. Ai3-50436

46. Sodium Azid E

47. U-3886

48. Mfcd00003536

49. Azide, 2% Solution

50. Sodium Azide [mi]

51. Ec 247-852-1

52. Sodium Azide [hsdb]

53. Dtxsid8020121

54. Tox21_202461

55. Tox21_300024

56. Sodium Azide [un1687] [poison]

57. Akos015833396

58. Akos015951264

59. Ncgc00090996-01

60. Ncgc00254054-01

61. Ncgc00260010-01

62. S0489

63. Sodium Azide Solution In Water, 10% Wt/volume

64. Q407577

65. J-016500

2.4 Create Date
2005-08-01
3 Chemical and Physical Properties
Molecular Weight 65.010 g/mol
Molecular Formula N3Na
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass64.99899129 g/mol
Monoisotopic Mass64.99899129 g/mol
Topological Polar Surface Area3 Ų
Heavy Atom Count4
Formal Charge0
Complexity15.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Minimum/Potential Fatal Human Dose

... The body of a laboratory assistant, was discovered by his colleagues in the laboratory, seated on a chair located near a digital computer displaying information about sodium azide. Moreover, a half empty 99% sodium azide flask was found near the corpse. ... The elevated sodium azide concentration found in the gastric sample and the amount of gastric content allowed to conclude that sodium azide intake was more than 6 g which was above the lethal dose, i.e. approximately 1 g. ...

PMID:22559996 Le Blanc-Louvry I et al; Forensic Sci Int 221 (1-3): e17-20 (2012)


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant and Hackh's Chemical Dictionary, 5th ed, p301, p499) (See all compounds classified as Indicators and Reagents.)


Vasodilator Agents

Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Mutagens

Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)


5.2 Absorption, Distribution and Excretion

... Sodium azide appeared in rat plasma 5 minutes after a single oral dose at 40 mg/kg and ... by 24 hours, no azide could be detected in either blood or peripheral tissues. A small fraction (7.9 ug) of the administered dose was eliminated in rat urine, but no azide was detected in expired air or feces.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 2-3


When rats were given daily doses of 23 mg/kg sodium azide in their drinking water for 147 days, no azide could be found in their blood.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 3


... For treatment of foot rot /in the bovine hoof/ ... the penetration rate ... of sodium azide /is/ less than 0.05 to 0.24 mm per hr. ... Inclusion of sodium lauryl sulfate in treatments enhanced the penetration rate of ... azide approx 6-fold.

Malecki JC, McCausland IP; Res Vet Sci 3(2): 192-7 (1982)


5.3 Metabolism/Metabolites

... Hepatic biotransformation was considered to be the primary route of detoxification based on in vitro data.

American Conference of Governmental Industrial Hygienists. Documentation of the TLVs and BEIs with Other World Wide Occupational Exposure Values. 7th Ed. CD-ROM Cincinnati, OH 45240-1634 2013., p. 2-3


5.4 Biological Half-Life

A case of fatal sodium azide poisoning induced by suicidal ingestion was reported. When the patient arrived, her vital signs such as consciousness and blood pressure, were normal. But 25 hours after ingestion, she died from metabolic acidosis, ARDS (acute respiratory distress syndrome) and acute cardiac failure. We detected the azide ion in patient's serum using GCMS method and measured the blood concentration of sodium azide using the GC/NPD method. The half-life period of sodium azide in blood was calculated as about 2.5 hours.

PMID:11806101 Senda T et al; Chudoku Kenkyu 14 (4): 339-42 (2001)


5.5 Mechanism of Action

Sodium azide /is/ an inhibitor of mitochondrial ATPase. ...

Doucet A, Katz AI; Am J Physiol 242 (4): F346-52 (1982)


ABOUT THIS PAGE

Looking for 26628-22-8 / Sodium Azide API manufacturers, exporters & distributors?

Sodium Azide manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Sodium Azide API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Sodium Azide manufacturer or Sodium Azide supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Sodium Azide manufacturer or Sodium Azide supplier.

PharmaCompass also assists you with knowing the Sodium Azide API Price utilized in the formulation of products. Sodium Azide API Price is not always fixed or binding as the Sodium Azide Price is obtained through a variety of data sources. The Sodium Azide Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Sodium Azide

Synonyms

26628-22-8, Azide, sodium, Hydrazoic acid sodium salt, Natriumazid, Sodiumazide, Sodium;azide

Cas Number

26628-22-8

Unique Ingredient Identifier (UNII)

968JJ8C9DV

About Sodium Azide

A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)

Sodium trinitride Manufacturers

A Sodium trinitride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sodium trinitride, including repackagers and relabelers. The FDA regulates Sodium trinitride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sodium trinitride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sodium trinitride Suppliers

A Sodium trinitride supplier is an individual or a company that provides Sodium trinitride active pharmaceutical ingredient (API) or Sodium trinitride finished formulations upon request. The Sodium trinitride suppliers may include Sodium trinitride API manufacturers, exporters, distributors and traders.

click here to find a list of Sodium trinitride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sodium trinitride USDMF

A Sodium trinitride DMF (Drug Master File) is a document detailing the whole manufacturing process of Sodium trinitride active pharmaceutical ingredient (API) in detail. Different forms of Sodium trinitride DMFs exist exist since differing nations have different regulations, such as Sodium trinitride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sodium trinitride DMF submitted to regulatory agencies in the US is known as a USDMF. Sodium trinitride USDMF includes data on Sodium trinitride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sodium trinitride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sodium trinitride suppliers with USDMF on PharmaCompass.

Sodium trinitride GMP

Sodium trinitride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sodium trinitride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sodium trinitride GMP manufacturer or Sodium trinitride GMP API supplier for your needs.

Sodium trinitride CoA

A Sodium trinitride CoA (Certificate of Analysis) is a formal document that attests to Sodium trinitride's compliance with Sodium trinitride specifications and serves as a tool for batch-level quality control.

Sodium trinitride CoA mostly includes findings from lab analyses of a specific batch. For each Sodium trinitride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sodium trinitride may be tested according to a variety of international standards, such as European Pharmacopoeia (Sodium trinitride EP), Sodium trinitride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sodium trinitride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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