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    Sodium Tripolyphosphate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 7758-29-4, Pentasodium triphosphate, Sodium triphosphate, Stpp, Pentasodium tripolyphosphate, Triphosphoric acid, pentasodium salt
    Molecular Formula
    Na5O10P3
    Molecular Weight
    367.86  g/mol
    InChI Key
    HWGNBUXHKFFFIH-UHFFFAOYSA-I
    FDA UNII
    9SW4PFD2FZ
    Sodium tripolyphosphate is an inorganic compound with formula Na5P3O10 and the sodium salt of the polyphosphate penta-anion. It is used as a component of a wide range domestic and industrial products, particularly detergents.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    pentasodium;[oxido(phosphonatooxy)phosphoryl] phosphate
    2.1.2 InChI
    InChI=1S/5Na.H5O10P3/c;;;;;1-11(2,3)9-13(7,8)10-12(4,5)6/h;;;;;(H,7,8)(H2,1,2,3)(H2,4,5,6)/q5*+1;/p-5
    2.1.3 InChI Key
    HWGNBUXHKFFFIH-UHFFFAOYSA-I
    2.1.4 Canonical SMILES
    [O-]P(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    9SW4PFD2FZ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Pentapotassium Triphosphate

    2. Potassium Triphosphate

    3. Sodium Triphosphate

    4. Sodium Tripolyphosphate Anhydrous

    5. Tetrasodium Tripolyphosphate

    6. Triphosphate

    7. Triphosphoric Acid

    8. Triphosphoric Acid, 99tc-labeled Cpd

    9. Triphosphoric Acid, Pentapotassium Salt

    10. Triphosphoric Acid, Pentasodium Salt

    11. Triphosphoric Acid, Sodium Salt

    12. Triphosphoric Acid, Sodium, Potassium Salt

    13. Tripolyphosphate

    2.3.2 Depositor-Supplied Synonyms

    1. 7758-29-4

    2. Pentasodium Triphosphate

    3. Sodium Triphosphate

    4. Stpp

    5. Pentasodium Tripolyphosphate

    6. Triphosphoric Acid, Pentasodium Salt

    7. Triphosphoric Acid, Sodium Salt

    8. 9sw4pfd2fz

    9. Sodium Tripolyphosphate Anhydrous

    10. Thermphos

    11. Mfcd00003514

    12. Pentasodium;[oxido(phosphonatooxy)phosphoryl] Phosphate

    13. Armofos

    14. Polygon

    15. Tripoly

    16. Rhodiaphos Lv

    17. Thermphos N

    18. Empiphos Stp-d

    19. Thermphos Spr

    20. Thermphos L 50

    21. Caswell No. 799

    22. Natriumtripolyphosphat

    23. Natriumtripolyphosphat [german]

    24. Sodium Phosphate (na5p3o10)

    25. Hsdb 1099

    26. Sodium Tripolyphosphate, Anhydrous

    27. Sodium Triphosphate (na5p3o10)

    28. Einecs 231-838-7

    29. Unii-9sw4pfd2fz

    30. Sodium Tripolyphosphate (na5p3o10)

    31. Epa Pesticide Chemical Code 076404

    32. Na5p3o10

    33. S 400

    34. Ec 231-838-7

    35. Dtxsid9036307

    36. Sodium Tripolyphosphate [mi]

    37. Sodium Triphosphate (na5(p3o10))

    38. Akos015902309

    39. Akos015951376

    40. Db11493

    41. Pentasodium Triphosphate [inci]

    42. Triphosphoric Acid, Sodium Salt (1:5)

    43. Pentasodium Tripolyphosphate [hsdb]

    44. Sodium Tripolyphosphate [green Book]

    45. Ft-0689070

    46. Sodium Tripolyphosphate, Technical Grade, 85%

    47. Q29145

    48. Sodium Triphosphate Pentabasic, Purum P.a., >=98.0% (t)

    49. Sodium Triphosphate Pentabasic, Vetec(tm) Reagent Grade, 98%

    50. Sodium Tripolyphosphate, Saj First Grade, 56.0-61.0% P2o5 Basis

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 367.86 g/mol
    Molecular Formula Na5O10P3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count2
    Exact Mass367.8192786 g/mol
    Monoisotopic Mass367.8192786 g/mol
    Topological Polar Surface Area185 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity241
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count6
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    MEDICATION (VET): USED IN WATER SOL DISPERSIBLE PREMIXES OR IN LIQ FEED SUPPLEMENTS AS PHOSPHORUS SOURCE FOR CATTLE. ... AS CALCIUM & MAGNESIUM CHELATOR, IT NOT ONLY FINDS WIDESPREAD USE IN WATER SOFTENING BUT AS ADJUNCTIVE ORAL PROPHYLAXIS AGAINST SUCH MINERAL BASED URINARY CALCULI IN CATS.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 548

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    If ingested in large amounts nausea, vomiting and diarrhea are probable. Thought to be hydrolyzed to (ortho)phosphates before absorption. If appreciable amounts of the intact polymer are absorbed from the alimentary tract, hypocalcemic tetany may be a danger due to the binding (chelation) of ionized calcium. Hypocalcemic tetany apparently occurred in one ingestion episode. /Tripolyphosphate/

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-121

    5.2 Metabolism/Metabolites

    THOUGHT TO BE HYDROLYZED TO (ORTHO)PHOSPHATES BEFORE ABSORPTION. /TRIPOLYPHOSPHATE/

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-121

    In the body, phosphorus is converted to phosphates. /Phosphorus/

    Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2122

    5.3 Mechanism of Action

    The effects of condensed phosphate ( ... sodium tripolyphosphate ... ) on the growth of Streptococcus mutans, sugar metabolism in vitro, and S mutans-induced caries of hamsters were studied. All condensed phosphates depressed the growth of S mutans. This growth inhibition was reversed by divalent metal ions. Thus, the chelating capacity of condensed phosphate is responsible for their antibacterial actions. Condensed phosphates depressed lactate production from glucose and sucrose by the S mutans.

    PMID:7308964 Shibata H; Fukuoka Igaku Zasshi 72 (6): 379-91 (1981)