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Sodium Valproate

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ACTIVE PHARMA INGREDIENTS

30 API Suppliers, 10 USDMF, 11 CEP/COS, 6 JDMF, 4 EU WC, 5 KDMF, 7 NDC API, 14 Listed Suppliers, $ API Reference Price

30 API Suppliers
10 USDMF
11 CEP/COS
6 JDMF
4 EU WC
5 KDMF
7 NDC API
14 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

4 Drugs in Development

4 Drugs in Development

FINISHED DOSAGE FORMULATIONS

130 FDF Dossiers, 5 FDA Orange Book, 61 Europe, 11 Canada, 19 South Africa, 34 Listed Dossiers

130 FDF Dossiers
5 FDA Orange Book
61 Europe
11 Canada
19 South Africa
34 Listed Dossiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 15 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
15 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 37 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
1 US Medicaid Prescriptions
37 Finished Drug Prices
8 Annual Reports

MARKET PLACE

16 APIs, 11 FDF Dossiers

marketPlace
16 APIs
11 FDF Dossiers

REF. STANDARDS & IMPURITIES

2 EDQM

otherSolutions
2 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

130

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

18,980

Annual Reports (USD Million)

782

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sodium 2-propylpentanoate, 1069-66-5, Valproate sodium, Valproic acid sodium salt, Valproic acid sodium, Depacon

Molecular Formula

C₈H₁₅NaO₂

Molecular Weight

166.19 g/mol

InChI Key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

FDA UNII

5VOM6GYJ0D

A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.

1 2D Structure

Sodium Valproate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;2-propylpentanoate

2.1.2 InChI

InChI=1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1

2.1.3 InChI Key

AEQFSUDEHCCHBT-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CCCC(CCC)C(=O)[O-].[Na+]

2.2 Other Identifiers

2.2.1 UNII

5VOM6GYJ0D

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2 Propylpentanoic Acid

2. 2-propylpentanoic Acid

3. Calcium Valproate

4. Convulsofin

5. Depakene

6. Depakine

7. Depakote

8. Dipropyl Acetate

9. Divalproex

10. Divalproex Sodium

11. Ergenyl

12. Magnesium Valproate

13. Propylisopropylacetic Acid

14. Semisodium Valproate

15. Valproate

16. Valproate Calcium

17. Valproate Sodium

18. Valproic Acid

19. Valproic Acid, Sodium Salt (2:1)

20. Vupral

2.3.2 Depositor-Supplied Synonyms

1. Sodium 2-propylpentanoate

2. 1069-66-5

3. Valproate Sodium

4. Valproic Acid Sodium Salt

5. Valproic Acid Sodium

6. Depacon

7. Sodium 2-propylvalerate

8. Epilim

9. Valproic Acid, Sodium Salt

10. Pentanoic Acid, 2-propyl-, Sodium Salt

11. 2-propylvaleric Acid Sodium Salt

12. Valerin

13. 2-propylpentanoic Acid Sodium Salt

14. Valproic Acid Sodium Salt (1:1)

15. Valproic Acid (sodium Salt)

16. Selenica

17. Abbott 44090

18. Valproate Sodium [usan]

19. Valproate

20. Valproic Acid, Sodium

21. Valproic Acid Sodium Salt (sodium Valproate)

22. Sodium;2-propylpentanoate

23. Mfcd00078604

24. 5vom6gyj0d

25. Abbott-44090

26. Chebi:9925

27. Eurekene

28. Labazene

29. Orfiril

30. Kw-6066n

31. Nsc-732626

32. Nsc-757376

33. Depakene (tn)

34. Natrium Valproat

35. Valproate Sodium (usan)

36. A-44090

37. Dipropylacetate Sodium

38. Sodium Dipropylacetate

39. Sodium Bispropylacetate

40. Chembl433

41. Valproinsaeure, Natrium

42. Sodium N-dipropylacetate

43. 2-propylpentanoic Acid Sodium

44. Smr000875243

45. Sodium 2-n-propyl-pentanoate

46. Kw 6066n

47. Einecs 213-961-8

48. Unii-5vom6gyj0d

49. Valeric Acid, 2-propyl-, Sodium Salt

50. Natrii Valproas

51. Valproate Sodium [usan:usp]

52. Valproicacidsodium

53. Selenica (tn)

54. Valproic Acid (sodium)

55. Lopac-p-4543

56. Sodium Valproate (jp17)

57. Dsstox_cid_17072

58. Dsstox_rid_79301

59. Dsstox_gsid_37072

60. Schembl35027

61. Mls001332431

62. Mls001332432

63. Mls002153189

64. Spectrum1500606

65. Sodium Valproate [jan]

66. Dtxsid5037072

67. Valproate Sodium [vandf]

68. Hms500n15

69. Valproic Acid Sodium Salt, 98%

70. Sodium Valproate [mart.]

71. Sodium Valproate [who-ip]

72. Valproate Sodium [who-dd]

73. Hms1921i21

74. Hms2092c12

75. Hms2230e16

76. Hms3262b20

77. Hms3369l11

78. Hms3648a12

79. Hms3654i14

80. Hms3872g13

81. Hms3884e05

82. Bcp02888

83. Tox21_302623

84. Tox21_500889

85. Ccg-40071

86. Hy-10585a

87. S1168

88. 2-propyl-pentanoic Acid, Sodium Salt

89. Akos005066057

90. Valproate Sodium [orange Book]

91. Ac-8391

92. Ccg-208088

93. Ccg-266330

94. Cs-1764

95. Lp00889

96. Natrii Valproas [who-ip Latin]

97. Nsc 732626

98. Nsc 757376

99. Sodium Valproate [ep Monograph]

100. Valproate Sodium [usp Impurity]

101. Ncgc00016192-01

102. Ncgc00016192-02

103. Ncgc00016192-03

104. Ncgc00016192-04

105. Ncgc00094208-01

106. Ncgc00094208-02

107. Ncgc00094208-03

108. Ncgc00167849-01

109. Ncgc00256651-01

110. Ncgc00261574-01

111. As-13150

112. Sy058189

113. 2-propylpentanoic Acid Sodium Salt (1:1)

114. Bcp0726000316

115. Cas-1069-66-5

116. Db-059527

117. Sodium 2-propylpentanoate [who-ip]

118. Eu-0100889

119. Ft-0633278

120. S0894

121. Sw219169-2

122. D00710

123. H11308

124. P 4543

125. Valproic Acid Sodium Salt (1:1) [mi]

126. Pentanoic Acid, 2-propyl-, Sodium Salt (1:1)

127. Valproic Acid, Sodium Salt - Cas 1069-66-5

128. Q-201918

129. Q4347890

130. Sodium Valproate, British Pharmacopoeia (bp) Reference Standard

131. Sodium Valproate, European Pharmacopoeia (ep) Reference Standard

132. Sodium Valproate, 2-propylpentanoic Acid . Na, Sodium 2-propylpentanoate

2.4 Create Date

2007-11-13

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₅NaO₂
Molecular Weight	166.19 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	166.09697400 g/mol
Monoisotopic Mass	166.09697400 g/mol
Topological Polar Surface Area	40.1 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	98.3
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Depacon
PubMed Health	Valproate Sodium (Injection)
Drug Classes	Anticonvulsant
Drug Label	Depacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
Active Ingredient	Valproate sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/ml
Market Status	Prescription
Company	Abbvie

2 of 4
Drug Name	Valproate sodium
PubMed Health	Valproate Sodium (Injection)
Drug Classes	Anticonvulsant
Drug Label	Valproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
Active Ingredient	Valproate sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/ml
Market Status	Prescription
Company	Bedford; Hikma Farmaceutica; Fresenius Kabi Usa

3 of 4
Drug Name	Depacon
PubMed Health	Valproate Sodium (Injection)
Drug Classes	Anticonvulsant
Drug Label	Depacon (valproate sodium) is the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorless, cry...
Active Ingredient	Valproate sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/ml
Market Status	Prescription
Company	Abbvie

4 of 4
Drug Name	Valproate sodium
PubMed Health	Valproate Sodium (Injection)
Drug Classes	Anticonvulsant
Drug Label	Valproate sodium injection, USPis the sodium salt of valproic acid designated as sodium 2-propylpentanoate. Valproate sodium has the following structure:Valproate sodium has a molecular weight of 166.2. It occurs as an essentially white and odorles...
Active Ingredient	Valproate sodium
Dosage Form	Injectable
Route	Injection
Strength	eq 100mg base/ml
Market Status	Prescription
Company	Bedford; Hikma Farmaceutica; Fresenius Kabi Usa

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

Antimanic Agents

Agents that are used to treat bipolar disorders or mania associated with other affective disorders. (See all compounds classified as Antimanic Agents.)

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

GABA Agents

Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function. (See all compounds classified as GABA Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Decreased Central Nervous System Disorganized Electrical Activity [PE]; Mood Stabilizer [EPC]; Anti-epileptic Agent [EPC]

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API Reference Price

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