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Sofosbuvir And Velpatasvir

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CHEMISTRY
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FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 1 Europe, 3 Australia

4 FDF Dossiers
1 Europe
3 Australia

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 42 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
42 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 Finished Drug Prices, 6 Annual Reports

globalSalesInformation
1 Finished Drug Prices
6 Annual Reports

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

3 Health Canada Patents

patents
3 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

11,085

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Sofosbuvir & velpatasvir, Sofosbuvir + velpatasvir, Epclusa tablet, Sofosbuvir / velpatasvir, Velpatasvir / sofosbuvir, Sofosbuvir and velpatasvir

Molecular Formula

C₇₁H₈₃FN₁₁O₁₇P

Molecular Weight

1412.5 g/mol

InChI Key

HCOFYZXVHCYVAU-OTBOHSEESA-N

1 2D Structure

Sofosbuvir / Velpatasvir

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate;propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate

2.1.2 InChI

InChI=1S/C49H54N8O8.C22H29FN3O9P/c1-26(2)41(54-48(60)63-5)47(59)57-27(3)12-17-38(57)45-51-36-16-14-30-20-35-33-15-13-31(19-32(33)25-65-40(35)21-34(30)43(36)53-45)37-22-50-44(52-37)39-18-28(24-62-4)23-56(39)46(58)42(55-49(61)64-6)29-10-8-7-9-11-29;1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h7-11,13-16,19-22,26-28,38-39,41-42H,12,17-18,23-25H2,1-6H3,(H,50,52)(H,51,53)(H,54,60)(H,55,61);5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t27-,28-,38-,39-,41-,42+;14-,16+,18+,20+,22+,36+/m00/s1

2.1.3 InChI Key

HCOFYZXVHCYVAU-OTBOHSEESA-N

2.1.4 Canonical SMILES

CC1CCC(N1C(=O)C(C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)C8CC(CN8C(=O)C(C9=CC=CC=C9)NC(=O)OC)COC.CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

2.1.5 Isomeric SMILES

C[C@H]1CC[C@H](N1C(=O)[C@H](C(C)C)NC(=O)OC)C2=NC3=C(N2)C=CC4=CC5=C(C=C43)OCC6=C5C=CC(=C6)C7=CN=C(N7)[C@@H]8C[C@@H](CN8C(=O)[C@@H](C9=CC=CC=C9)NC(=O)OC)COC.C[C@@H](C(=O)OC(C)C)N[P@@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Sofosbuvir Velpatasvir Drug Combination

2. Sofosbuvir, Velpatasvir Drug Combination

3. Sofosbuvir-velpatasvir Drug Combination

2.2.2 Depositor-Supplied Synonyms

1. Sofosbuvir & Velpatasvir

2. Sofosbuvir + Velpatasvir

3. Epclusa Tablet

4. Sofosbuvir / Velpatasvir

5. Velpatasvir / Sofosbuvir

6. Sofosbuvir And Velpatasvir

7. Sof / Vlp

8. Sofosbuvir Mixture With Velpatasvir

9. S900007160

2.3 Create Date

2015-09-26

3 Chemical and Physical Properties

Molecular Formula	C₇₁H₈₃FN₁₁O₁₇P
Molecular Weight	1412.5 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	21
Rotatable Bond Count	24
Exact Mass	1411.56900538 g/mol
Monoisotopic Mass	1411.56900538 g/mol
Topological Polar Surface Area	346 Å²
Heavy Atom Count	101
Formal Charge	0
Complexity	2600
Isotope Atom Count	0
Defined Atom Stereocenter Count	12
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Epclusa is indicated for the treatment of chronic hepatitis C virus (HCV) infection in patients 3 years of age and older (see sections 4. 2, 4. 4 and 5. 1).

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiviral Agents

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

5.2 ATC Code

J05A

J - Antiinfectives for systemic use

J05 - Antivirals for systemic use

J05A - Direct acting antivirals

J05AP - Antivirals for treatment of hcv infections

J05AP55 - Sofosbuvir and velpatasvir

FDF Dossiers