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Chemistry

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Also known as: 252920-94-8, (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic acid, Solabegron [inn], Gw427353, 451470-34-1, Gw 427353
Molecular Formula
C23H23ClN2O3
Molecular Weight
410.9  g/mol
InChI Key
LLDXOPKUNJTIRF-QFIPXVFZSA-N
FDA UNII
55P6YH9O6N

Solabegron
Solabegron (GW-427,353) is a selective 3 adrenoceptor agonist being developed for the treatment of overactive bladder and irritable bowel syndrome.
1 2D Structure

Solabegron

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[3-[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethylamino]phenyl]benzoic acid
2.1.2 InChI
InChI=1S/C23H23ClN2O3/c24-20-8-2-6-18(13-20)22(27)15-25-10-11-26-21-9-3-5-17(14-21)16-4-1-7-19(12-16)23(28)29/h1-9,12-14,22,25-27H,10-11,15H2,(H,28,29)/t22-/m0/s1
2.1.3 InChI Key
LLDXOPKUNJTIRF-QFIPXVFZSA-N
2.1.4 Canonical SMILES
C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNCC(C3=CC(=CC=C3)Cl)O
2.1.5 Isomeric SMILES
C1=CC(=CC(=C1)C(=O)O)C2=CC(=CC=C2)NCCNC[C@@H](C3=CC(=CC=C3)Cl)O
2.2 Other Identifiers
2.2.1 UNII
55P6YH9O6N
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

2. 3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

3. Gw 427353

4. Gw-427353

5. Gw427353

6. Solabegron Hydrochloride

2.3.2 Depositor-Supplied Synonyms

1. 252920-94-8

2. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic Acid

3. Solabegron [inn]

4. Gw427353

5. 451470-34-1

6. Gw 427353

7. Gw-427353

8. 55p6yh9o6n

9. 3-[3-[2-[[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethylamino]phenyl]benzoic Acid

10. [1,1'-biphenyl]-3-carboxylicacid,3'-[[2-[[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-

11. (1,1'-biphenyl)-3-carboxylic Acid, 3'-((2-(((2r)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-

12. (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-(1,1'-biphenyl)-3-carboxylic Acid

13. Solabegronum

14. Unii-55p6yh9o6n

15. Solabegron-13c6

16. (r)-3'-[[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3-carboxylic Acid

17. Solabegron [who-dd]

18. Chembl208427

19. Gtpl9512

20. Schembl2596555

21. Dtxsid50179932

22. Chebi:141346

23. Cka92094

24. Zinc1547346

25. Bdbm50002595

26. Db06190

27. Compound 38 [pmid: 16640337]

28. As-74724

29. Hy-19436

30. Cs-0015536

31. Gw 427353gw 427353

32. D93408

33. (r)-3'-(2-(2-(3-chlorophenyl)-2-hydroxyethylamino)ethylamino)biphenyl-3-carboxylic Acid

34. 3'-((2-(((2r)-2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)biphenyl-3-carboxylic Acid

35. 3'-[(2-{[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino]-[1,1'-biphenyl]-3-carboxylic Acid

36. 3'-[(2-{[(2r)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)amino][biphenyl]-3-carboxylic Acid

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 410.9 g/mol
Molecular Formula C23H23ClN2O3
XLogP31.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass410.1397203 g/mol
Monoisotopic Mass410.1397203 g/mol
Topological Polar Surface Area81.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Investigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Adrenergic beta-3 Receptor Agonists

Compounds that bind to and activate ADRENERGIC BETA-3 RECEPTORS. (See all compounds classified as Adrenergic beta-3 Receptor Agonists.)


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Looking for 252920-94-8 / Solabegron API manufacturers, exporters & distributors?

Solabegron manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Solabegron API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Solabegron manufacturer or Solabegron supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Solabegron manufacturer or Solabegron supplier.

PharmaCompass also assists you with knowing the Solabegron API Price utilized in the formulation of products. Solabegron API Price is not always fixed or binding as the Solabegron Price is obtained through a variety of data sources. The Solabegron Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Solabegron

Synonyms

252920-94-8, (r)-3'-((2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)ethyl)amino)-[1,1'-biphenyl]-3-carboxylic acid, Solabegron [inn], Gw427353, 451470-34-1, Gw 427353

Cas Number

252920-94-8

Unique Ingredient Identifier (UNII)

55P6YH9O6N

About Solabegron

Solabegron (GW-427,353) is a selective 3 adrenoceptor agonist being developed for the treatment of overactive bladder and irritable bowel syndrome.

Solabegron Manufacturers

A Solabegron manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Solabegron, including repackagers and relabelers. The FDA regulates Solabegron manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Solabegron API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Solabegron Suppliers

A Solabegron supplier is an individual or a company that provides Solabegron active pharmaceutical ingredient (API) or Solabegron finished formulations upon request. The Solabegron suppliers may include Solabegron API manufacturers, exporters, distributors and traders.

Solabegron GMP

Solabegron Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Solabegron GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Solabegron GMP manufacturer or Solabegron GMP API supplier for your needs.

Solabegron CoA

A Solabegron CoA (Certificate of Analysis) is a formal document that attests to Solabegron's compliance with Solabegron specifications and serves as a tool for batch-level quality control.

Solabegron CoA mostly includes findings from lab analyses of a specific batch. For each Solabegron CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Solabegron may be tested according to a variety of international standards, such as European Pharmacopoeia (Solabegron EP), Solabegron JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Solabegron USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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