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ACTIVE PHARMA INGREDIENTS

75 API Suppliers, 31 USDMF, 25 CEP/COS, 6 JDMF, 23 EU WC, 25 KDMF, 16 NDC API, 42 Listed Suppliers, $ API Reference Price

75 API Suppliers
31 USDMF
25 CEP/COS
6 JDMF
23 EU WC
25 KDMF
16 NDC API
42 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

8 Drugs in Development

8 Drugs in Development

INTERMEDIATES

23 Intermediates Suppliers

23 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

289 FDF Dossiers, 53 FDA Orange Book, 139 Europe, 30 Canada, 24 South Africa, 43 Listed Dossiers

289 FDF Dossiers
53 FDA Orange Book
139 Europe
30 Canada
24 South Africa
43 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 10MG, TABLET;ORAL - 5MG

drugProductComposition
TABLET;ORAL - 10MG
TABLET;ORAL - 5MG

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 41 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
41 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 US Medicaid Prescriptions, 77 Finished Drug Prices, 8 Annual Reports

globalSalesInformation
3 US Medicaid Prescriptions
77 Finished Drug Prices
8 Annual Reports

MARKET PLACE

9 APIs, 5 FDF Dossiers

marketPlace
9 APIs
5 FDF Dossiers

PATENTS & EXCLUSIVITIES

1 US Patents, 2 Health Canada Patents

patents
1 US Patents
2 Health Canada Patents

REF. STANDARDS & IMPURITIES

4 Others

otherSolutions
4 Others

ANALYTICAL

2 BioAnalytical Methods

otherMethods
2 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

289

FDF Dossiers

FDA Orange Book

139

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

93,068,124

Annual Reports (USD Million)

5,259

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 242478-38-2, Vesicare, Solifenacin (succinate), Solifenacin succinate [usan], Ym-905, Ym 905

Molecular Formula

C₂₇H₃₂N₂O₆

Molecular Weight

480.6 g/mol

InChI Key

RXZMMZZRUPYENV-VROPFNGYSA-N

FDA UNII

KKA5DLD701

A quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

1 2D Structure

Solifenacin Succinate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate;butanedioic acid

2.1.2 InChI

InChI=1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21-,22-;/m0./s1

2.1.3 InChI Key

RXZMMZZRUPYENV-VROPFNGYSA-N

2.1.4 Canonical SMILES

C1CN2CCC1C(C2)OC(=O)N3CCC4=CC=CC=C4C3C5=CC=CC=C5.C(CC(=O)O)C(=O)O

2.1.5 Isomeric SMILES

C1CN2CCC1[C@H](C2)OC(=O)N3CCC4=CC=CC=C4[C@@H]3C5=CC=CC=C5.C(CC(=O)O)C(=O)O

2.2 Other Identifiers

2.2.1 UNII

KKA5DLD701

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2(1h)-isoquinolinecarboxylic Acid, 3,4-dihydro-1-phenyl-,1- Azabicyclo(2.2.2)oct-3-yl Ester, (r-(r*,s*))-

2. 905, Ym

3. Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate Monosuccinate

4. Solifenacin

5. Succinate, Solifenacin

6. Vesicare

7. Ym 905

8. Ym905

2.3.2 Depositor-Supplied Synonyms

1. 242478-38-2

2. Vesicare

3. Solifenacin (succinate)

4. Solifenacin Succinate [usan]

5. Ym-905

6. Ym 905

7. Ym905

8. 1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Butanedioic Acid

9. Ym67905

10. Kka5dld701

11. Ym-67905

12. [(3r)-1-azabicyclo[2.2.2]octan-3-yl] (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate;butanedioic Acid

13. Vesikur

14. (s)-(r)-quinuclidin-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate Succinate

15. Chembl1200803

16. Solifenacin Succinate Salt

17. Unii-kka5dld701

18. Vesicare Od

19. Vesicare (tn)

20. Isoprenalinoe Sulfate

21. Vesicare Ls

22. Solifenacin Succinate- Bio-x

23. Mls006010416

24. Schembl109333

25. Chebi:32151

26. Dtxsid30947075

27. Hms3887a13

28. Solifenacin Succinate [mi]

29. Solifenacin Succinate [jan]

30. Ex-a4170

31. Hy-a0002

32. Mfcd00954234

33. S3048

34. Solifenacin Succinate [vandf]

35. Solifenacin Succinate [mart.]

36. Akos015994745

37. Solifenacin Succinate [usp-rs]

38. Solifenacin Succinate [who-dd]

39. Am84825

40. Ccg-269551

41. Cs-0371

42. Ks-1286

43. Solifenacin Succinate (jan/usan/inn)

44. Solifenacin Succinate, >=98% (hplc)

45. [(3r)-1-azabicyclo[2.2.2]octan-3-yl] (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate; Butanedioic Acid

46. 2(1h)-isoquinolinecarboxylic Acid, 3,4-dihydro-1-phenyl-, (3r)-1-azabicyclo(2.2.2)oct-3-yl Ester, (1s)-, Butanedioate (1:1)

47. As-35288

48. Bs164410

49. Butanedioic Acid, Cmpd. With (1s)-(3r)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate (1:1)

50. Butanedioic Acid, Compd With (1s)-(3r)-1-azabicyclo(2.2.2)oct-3-yl 3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate (1:1)

51. Smr004701445

52. Ym-53705

53. Solifenacin Succinate [orange Book]

54. Solifenacin Succinate [ep Monograph]

55. S0944

56. Sw219141-1

57. D01269

58. A819262

59. A881133

60. Q374826

61. Solifenacin Succinate, Europepharmacopoeia (ep) Reference Standard

62. Solifenacin Succinate, United States Pharmacopeia (usp) Reference Standard

63. (r)-quinuclidin-3-yl (s)-1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate

64. (s)-(r)-quinuclidin-3-yl1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylatesuccinate

65. Quinuclidin-3'-yl-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylatemonosuccinate

66. Solifenacin For System Suitability, Europepharmacopoeia (ep) Reference Standard

67. (1s)-(3r)-1-azabicyclo[2.2.2]oct-3-yl-3,4-dihydro-1-phenyl-2(1h)-isoquinolinecarboxylate Succinate

68. 1-azabicyclo[2.2.2]octan-8-yl (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylate Butanedioic Acid (solifenacin?succinate)

69. Butanedioic Acid--1-azabicyclo[2.2.2]octan-3-yl 1-phenyl-3,4-dihydroisoquinoline-2(1h)-carboxylate (1/1)

70. Butanedioic Acid; (1s)-1-phenyl-3,4-dihydro-1h-isoquinoline-2-carboxylic Acid [(3r)-1-azabicyclo[2.2.2]octan-3-yl] Ester

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₂₇H₃₂N₂O₆
Molecular Weight	480.6 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	480.22603674 g/mol
Monoisotopic Mass	480.22603674 g/mol
Topological Polar Surface Area	107 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	617
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Solifenacin succinate
Drug Label	VESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
Active Ingredient	Solifenacin succinate
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Teva Pharms Usa

2 of 4
Drug Name	Vesicare
PubMed Health	Solifenacin (By mouth)
Drug Classes	Urinary Antispasmodic
Drug Label	VESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
Active Ingredient	Solifenacin succinate
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Astellas

3 of 4
Drug Name	Solifenacin succinate
Drug Label	VESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
Active Ingredient	Solifenacin succinate
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Teva Pharms Usa

4 of 4
Drug Name	Vesicare
PubMed Health	Solifenacin (By mouth)
Drug Classes	Urinary Antispasmodic
Drug Label	VESIcare (solifenacin succinate) is a muscarinic receptor antagonist. Chemically, solifenacin succinate is butanedioic acid, compounded with (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate (1:1) having an e...
Active Ingredient	Solifenacin succinate
Dosage Form	Tablet
Route	Oral
Strength	5mg; 10mg
Market Status	Prescription
Company	Astellas

4.2 Drug Indication

Treatment of neurogenic detrusor overactivity

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

Muscarinic Antagonists

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Cholinergic Muscarinic Antagonists [MoA]; Cholinergic Muscarinic Antagonist [EPC]

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API Reference Price

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