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Solriamfetol Hydrochloride

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ACTIVE PHARMA INGREDIENTS

9 API Suppliers, 6 USDMF, 2 EU WC, 4 NDC API, 5 Listed Suppliers, $ API Reference Price

9 API Suppliers
6 USDMF
2 EU WC
4 NDC API
5 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

10 Drugs in Development

10 Drugs in Development

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 2 FDA Orange Book, 2 Europe

4 FDF Dossiers
2 FDA Orange Book
2 Europe

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 24 NEWS #PharmaBuzz

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2 DATA COMPILATION #PharmaFlow
24 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 2 Finished Drug Prices, 5 Annual Reports

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1 US Medicaid Prescriptions
2 Finished Drug Prices
5 Annual Reports

MARKET PLACE

2 APIs

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2 APIs

PATENTS & EXCLUSIVITIES

69 US Patents, 4 US Exclusivities

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69 US Patents
4 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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API REF. PRICE (USD/KG)

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FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

13,749,335

Annual Reports (USD Million)

119

Finished Drug Prices

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Chemistry

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Also known as: Jzp-110 hydrochloride, 178429-65-7, Solriamfetol (hydrochloride), K7ro88sp7a, Solriamfetol hydrochloride [usan], Solriamfetol hydrochloride (usan)

Molecular Formula

C₁₀H₁₅ClN₂O₂

Molecular Weight

230.69 g/mol

InChI Key

KAOVAAHCFNYXNJ-SBSPUUFOSA-N

FDA UNII

K7RO88SP7A

1 2D Structure

Solriamfetol Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

[(2R)-2-amino-3-phenylpropyl] carbamate;hydrochloride

2.1.2 InChI

InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1

2.1.3 InChI Key

KAOVAAHCFNYXNJ-SBSPUUFOSA-N

2.1.4 Canonical SMILES

C1=CC=C(C=C1)CC(COC(=O)N)N.Cl

2.1.5 Isomeric SMILES

C1=CC=C(C=C1)C[C@H](COC(=O)N)N.Cl

2.2 Other Identifiers

2.2.1 UNII

K7RO88SP7A

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (2r)-2-amino-3-phenylpropyl Carbamate

2. (r)-2-amino-3-phenylpropylcarbamate Hydrochloride

3. Adx-n05

4. Benzenepropanol, Beta-amino-, Carbamate (ester), (betar)-

5. Jzp-110

6. Solriamfetol

7. Sunosi

2.3.2 Depositor-Supplied Synonyms

1. Jzp-110 Hydrochloride

2. 178429-65-7

3. Solriamfetol (hydrochloride)

4. K7ro88sp7a

5. Solriamfetol Hydrochloride [usan]

6. Solriamfetol Hydrochloride (usan)

7. R-228060

8. Sunosi (tn)

9. Unii-k7ro88sp7a

10. Adx-n05 Hydrochloride

11. Ykp-10a Hydrochloride

12. Schembl8430382

13. Adx-n-05 Hydrochloride

14. Skl-n-05 Hydrochloride

15. Chembl4297212

16. Dtxsid101027927

17. R-228060 Hydrochloride

18. Hy-109043a

19. Solriamfetol Hydrochloride [mi]

20. Solriamfetol Hydrochloride [who-dd]

21. Cs-0112102

22. O-carbamoyl-(d)-phenylalaninol Hydrochloride

23. D11328

24. Solriamfetol Hydrochloride [orange Book]

25. (d)-o-carbamoylphenylalaninol Hydrochloride Salt

26. R228060;jzp-110;adx-n05;skl-n05;ykp-10

27. (2r)-2-amino-3-phenylpropyl Carbamate, Monohydrochloride

28. (betar)-beta-amino-benzenepropanol 1-carbamate Hydrochloride (1:1)

29. (r)-(+)-2-amino-1-carbamoyloxy-3-phenylpropane Hydrochloride

30. Benzenepropanol, .beta.-amino-, 1-carbamate, Hydrochloride (1:1), (.beta.r)-

31. 561069-23-6

2.4 Create Date

2012-11-30

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₅ClN₂O₂
Molecular Weight	230.69 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	230.0822054 g/mol
Monoisotopic Mass	230.0822054 g/mol
Topological Polar Surface Area	78.3 Å²
Heavy Atom Count	15
Formal Charge	0
Complexity	179
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Sunosi is indicated to improve wakefulness and reduce excessive daytime sleepiness in adult patients with narcolepsy (with or without cataplexy).

Sunosi is indicated to improve wakefulness and reduce excessive daytime sleepiness (EDS) in adult patients with obstructive sleep apnoea (OSA) whose EDS has not been satisfactorily treated by primary OSA therapy, such as continuous positive airway pressure (CPAP).

5 Pharmacology and Biochemistry

5.1 ATC Code

N06BA14

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