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Synopsis

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107 RELATED EXCIPIENT COMPANIES

195EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 86472-71-1, Rgrf 43, Hpgrf(1-43)oh, Rhgrf(1-43), Rgrf(1-43)-oh, Grf(1-43)-oh

Molecular Formula

C₂₂₅H₃₆₀N₇₆O₆₇S

Molecular Weight

5234 g/mol

InChI Key

ORNDKVCWLUZAQL-FOWIMTFFSA-N

1 2D Structure

Somatropin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-3-amino-1-carboxy-3-oxopropyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-oxopentanoic acid

2.1.2 InChI

InChI=1S/C225H360N76O67S/c1-20-111(12)174(298-180(329)116(17)264-201(350)154(96-172(323)324)282-179(328)114(15)262-181(330)126(227)92-122-98-249-105-260-122)215(364)293-151(89-119-40-27-24-28-41-119)210(359)301-177(117(18)305)217(366)297-159(104-304)213(362)296-158(103-303)212(361)288-150(91-121-52-56-125(307)57-53-121)205(354)272-129(44-32-77-252-220(237)238)185(334)271-134(49-37-82-257-225(247)248)198(347)299-176(113(14)22-3)216(365)292-144(84-107(4)5)183(332)259-101-168(316)265-136(59-67-161(229)309)192(341)284-146(86-109(8)9)203(352)287-148(90-120-50-54-124(306)55-51-120)200(349)263-115(16)178(327)267-128(43-31-76-251-219(235)236)184(333)268-127(42-29-30-75-226)187(336)283-145(85-108(6)7)202(351)285-147(87-110(10)11)204(353)289-152(93-123-99-250-106-261-123)207(356)280-142(65-73-171(321)322)199(348)300-175(112(13)21-2)214(363)281-143(74-83-369-19)197(346)291-155(97-173(325)326)209(358)273-130(45-33-78-253-221(239)240)186(335)276-139(61-69-163(231)311)194(343)275-135(58-66-160(228)308)182(331)258-100-167(315)266-137(63-71-169(317)318)191(340)269-131(46-34-79-254-222(241)242)189(338)290-153(94-165(233)313)208(357)279-140(62-70-164(232)312)195(344)278-141(64-72-170(319)320)196(345)277-138(60-68-162(230)310)193(342)270-133(48-36-81-256-224(245)246)190(339)295-157(102-302)211(360)274-132(47-35-80-255-223(243)244)188(337)286-149(88-118-38-25-23-26-39-118)206(355)294-156(218(367)368)95-166(234)314/h23-28,38-41,50-57,98-99,105-117,126-159,174-177,302-307H,20-22,29-37,42-49,58-97,100-104,226-227H2,1-19H3,(H2,228,308)(H2,229,309)(H2,230,310)(H2,231,311)(H2,232,312)(H2,233,313)(H2,234,314)(H,249,260)(H,250,261)(H,258,331)(H,259,332)(H,262,330)(H,263,349)(H,264,350)(H,265,316)(H,266,315)(H,267,327)(H,268,333)(H,269,340)(H,270,342)(H,271,334)(H,272,354)(H,273,358)(H,274,360)(H,275,343)(H,276,335)(H,277,345)(H,278,344)(H,279,357)(H,280,356)(H,281,363)(H,282,328)(H,283,336)(H,284,341)(H,285,351)(H,286,337)(H,287,352)(H,288,361)(H,289,353)(H,290,338)(H,291,346)(H,292,365)(H,293,364)(H,294,355)(H,295,339)(H,296,362)(H,297,366)(H,298,329)(H,299,347)(H,300,348)(H,301,359)(H,317,318)(H,319,320)(H,321,322)(H,323,324)(H,325,326)(H,367,368)(H4,235,236,251)(H4,237,238,252)(H4,239,240,253)(H4,241,242,254)(H4,243,244,255)(H4,245,246,256)(H4,247,248,257)/t111-,112-,113-,114-,115-,116-,117+,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,174-,175-,176-,177-/m0/s1

2.1.3 InChI Key

ORNDKVCWLUZAQL-FOWIMTFFSA-N

2.1.4 Canonical SMILES

CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)CC)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC4=CN=CN4)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CC=CC=C5)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC6=CN=CN6)N

2.1.5 Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC4=CN=CN4)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC5=CC=CC=C5)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC6=CN=CN6)N

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Grf(1-43)-oh

2. Growth Hormone Releasing Factor 43

3. Hpgrf(1-43)oh

4. Rat Growth Hormone-releasing Factor(1-43)

5. Rgrf 43

6. Rgrf(1-43)-oh

7. Rgrf(1-43)oh

8. Rhgrf(1-43)

9. Somaotropin Releasing Hormone (1-43)oh

10. Somatotropin Releasing Factor 43

2.2.2 Depositor-Supplied Synonyms

1. 86472-71-1

2. Rgrf 43

3. Hpgrf(1-43)oh

4. Rhgrf(1-43)

5. Rgrf(1-43)-oh

6. Grf(1-43)-oh

7. Somatotropin Releasing Factor 43

8. Growth Hormone Releasing Factor 43

9. Somatropin Recombinant

10. Somaotropin Releasing Hormone (1-43)oh

11. Rat Growth Hormone-releasing Factor(1-43)

12. Dtxsid30235580

13. Somatoliberin (human Pancreatic Islet), 1-l-histidine-8-l-serine -12-l-arginine-13-l-isoleucine-18-l-tyrosine-24-l-histidine-25-l-glutamic Acid-28-l-asparagine-34-l-arginine-38-l-glutamine-39-l-arginine-40-l-serine-42-l-phenylalanine-43-l-asparagine-44-de-l-leucinamide-

2.3 Create Date

2007-07-03

3 Chemical and Physical Properties

Molecular Formula	C₂₂₅H₃₆₀N₇₆O₆₇S
Molecular Weight	5234 g/mol
XLogP3	-23.5
Hydrogen Bond Donor Count	86
Hydrogen Bond Acceptor Count	79
Rotatable Bond Count	189
Exact Mass	5232.6886961 g/mol
Monoisotopic Mass	5230.6819865 g/mol
Topological Polar Surface Area	2440 Å²
Heavy Atom Count	369
Formal Charge	0
Complexity	13100
Isotope Atom Count	0
Defined Atom Stereocenter Count	45
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

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ZONE, CHANGCHUN, JILIN 130012 CN","customerAddress":"12\/12, SHAKTI NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1719858600,"product":"HUMAN GROWTH HORMONE (SOMATROPIN) (110 GRAMS)","address":"12\/12, SHAKTI NAGAR,","city":"DELHI","supplier":"CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD.","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"COOPER LAB","customerCountry":"INDIA","quantity":"0.11","actualQuantity":"110","unit":"GMS","unitRateFc":"620","totalValueFC":"70553.3","currency":"USD","unitRateINR":"53614.8","date":"02-Jul-2024","totalValueINR":"5897628","totalValueInUsd":"70553.3","indian_port":"Delhi Air","hs_no":"29371900","bill_no":"4292673","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"1718 YUEDA ROAD CHANGCHUN HIGH TECHIND DEV ZONE CHANOCHUN JILINSDNF CN","customerAddress":"12\/12, SHAKTI NAGAR,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724005800,"product":"HUMAN GROWTH HORMONE (SOMATROPIN) (134 GRAMS)","address":"12\/12, SHAKTI NAGAR,","city":"DELHI","supplier":"CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD.","supplierCountry":"CHINA","foreign_port":"BEIJING","customer":"COOPER LAB","customerCountry":"INDIA","quantity":"0.13","actualQuantity":"134","unit":"GMS","unitRateFc":"828","totalValueFC":"113321.4","currency":"USD","unitRateINR":"70934.6","date":"19-Aug-2024","totalValueINR":"9505236.4","totalValueInUsd":"113321.4","indian_port":"Delhi Air","hs_no":"29371900","bill_no":"5127433","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"BEIJING","supplierAddress":"1718 YUEDA ROAD, CHANGCHUN HIGH-TECH INDUSTRIAL DEVELOPMENT ZONE, CHANGCHUN, JILIN 130012, CN","customerAddress":"12\/12, SHAKTI NAGAR,"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Somatropin

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers

1 NDC API

2 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

333 FDF Dossiers

58 FDA Orange Book

162 Europe

32 Canada

71 Australia

7 South Africa

3 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

37 Fillers, Diluents & Binders

24 Direct Compression

15 Parenteral

15 Thickeners and Stabilizers

14 Topical

13 Co-Processed Excipients

11 Granulation

11 Taste Masking

11 Chewable & Orodispersible Aids

11 Lubricants & Glidants

6 Disintegrants & Superdisintegrants

6 Solubilizers

6 Controlled & Modified Release

4 Film Formers & Plasticizers

4 Coating Systems & Additives

3 Emulsifying Agents

2 Surfactant & Foaming Agents

1 API Stability Enhancers

1 Rheology Modifiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow

12 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

97 Finished Drug Prices

25 Annual Reports

MARKET PLACE

5 APIs

3 FDF Dossiers