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Chemistry

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Also known as: 1218778-77-8, Lde225 diphosphate, Sonidegib diphosphate, Erismodegib phosphate, Sonidegib (diphosphate), W421ai34uw
Molecular Formula
C26H32F3N3O11P2
Molecular Weight
681.5  g/mol
InChI Key
RWIVSVMMGFFZIJ-VWDRLOGHSA-N
FDA UNII
W421AI34UW

Sonidegib Phosphate
1 2D Structure

Sonidegib Phosphate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[6-[(2R,6S)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide;phosphoric acid
2.1.2 InChI
InChI=1S/C26H26F3N3O3.2H3O4P/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29;2*1-5(2,3)4/h4-13,16-17H,14-15H2,1-3H3,(H,31,33);2*(H3,1,2,3,4)/t16-,17+;;
2.1.3 InChI Key
RWIVSVMMGFFZIJ-VWDRLOGHSA-N
2.1.4 Canonical SMILES
CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F.OP(=O)(O)O.OP(=O)(O)O
2.1.5 Isomeric SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F.OP(=O)(O)O.OP(=O)(O)O
2.2 Other Identifiers
2.2.1 UNII
W421AI34UW
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1218778-77-8

2. Lde225 Diphosphate

3. Sonidegib Diphosphate

4. Erismodegib Phosphate

5. Sonidegib (diphosphate)

6. W421ai34uw

7. 1218778-77-8 (phosphate)

8. Nvp-lde225 Diphosphate

9. Sonidegib Phosphate (usan)

10. (1,1'-biphenyl)-3-carboxamide, N-(6-((2r,6s)-2,6-dimethyl-4-morpholinyl)-3-pyridinyl)-2-methyl-4'-(trifluoromethoxy)-, Rel-, Phosphate (1:2)

11. N-(6-((2r,6s)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide Bis(phosphate)

12. Sonidegib Phosphate [usan]

13. Lde225 (diphosphate)

14. Unii-w421ai34uw

15. Sonidegib Phosphate [usan:inn]

16. Odomzo (tn)

17. Sonidegib Bisphosphate

18. Erismodegib Diphosphate

19. Nvp-lde 225 Diphosphate

20. Nvp-lde225 Diphosphate Salt

21. Chembl3137317

22. Sonidegib Phosphate [mi]

23. Chebi:90864

24. Dtxsid90669468

25. Bcp11860

26. Ex-a1556

27. Sonidegib Phosphate [who-dd]

28. Akos015994565

29. Cs-1175

30. Fe-0016

31. Sonidegib Diphosphate [ema Epar]

32. Sonidegib Phosphate [orange Book]

33. Hy-16582

34. Nvp-lde 225 Diphosphatesonidegib Diphosphate

35. D10729

36. A907209

37. Q27162838

38. Erismodegib Diphosphate, Nvp-lde225 (diphosphate Salt)

39. N-(6-((2r,6s)-2,6-dimethylmorpholin-4-yl)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-(1,1'-biphenyl)-3-carboxamide Diphosphate

40. N-[6-[(2r,6s)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide;phosphoric Acid

41. N-{6-[(2r,6s)-2,6-dimethyl-4-morpholinyl]-3-pyridinyl}-2-methyl-4'-(trifluoromethoxy)-3-biphenylcarboxamide Phosphate (1:2)

42. Phosphoric Acid--n-{6-[(2r,6s)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide (2/1)

43. Rel-n-(6-((2r,6s)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide Bis(phosphate)

44. Rel-n-{6-[(2r,6s)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl}-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide Bis(phosphate)

2.3.2 Other Synonyms

1. Erismodegib

2. Sonidegib

3. Lde 225

4. Sonidegib Phospate

2.4 Create Date
2010-04-26
3 Chemical and Physical Properties
Molecular Weight 681.5 g/mol
Molecular Formula C26H32F3N3O11P2
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count16
Rotatable Bond Count5
Exact Mass681.14641733 g/mol
Monoisotopic Mass681.14641733 g/mol
Topological Polar Surface Area219 Ų
Heavy Atom Count45
Formal Charge0
Complexity741
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Odomzo is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (BCC) who are not amenable to curative surgery or radiation therapy.


5 Pharmacology and Biochemistry
5.1 ATC Code

L01XJ02


API Reference Price

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29-May-2021
29-May-2021
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Drugs in Development

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Details:

ODOMZO (sonidegib) works by inhibiting a molecular pathway, known as the hedgehog signaling pathway, which is indicated for the treatment of adult patients with locally advanced basal cell carcinoma.


Lead Product(s): Sonidegib Phosphate

Therapeutic Area: Oncology Brand Name: Odomzo

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 12, 2020

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01

Biotech Digital Meet
Not Confirmed
Biotech Digital Meet
Not Confirmed

Details : ODOMZO (sonidegib) works by inhibiting a molecular pathway, known as the hedgehog signaling pathway, which is indicated for the treatment of adult patients with locally advanced basal cell carcinoma.

Product Name : Odomzo

Product Type : Small molecule

Upfront Cash : Not Applicable

June 12, 2020

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ABOUT THIS PAGE

Looking for 1218778-77-8 / Lde225 Diphosphate API manufacturers, exporters & distributors?

Lde225 Diphosphate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lde225 Diphosphate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lde225 Diphosphate manufacturer or Lde225 Diphosphate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lde225 Diphosphate manufacturer or Lde225 Diphosphate supplier.

PharmaCompass also assists you with knowing the Lde225 Diphosphate API Price utilized in the formulation of products. Lde225 Diphosphate API Price is not always fixed or binding as the Lde225 Diphosphate Price is obtained through a variety of data sources. The Lde225 Diphosphate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lde225 Diphosphate

Synonyms

1218778-77-8, Sonidegib diphosphate, Erismodegib phosphate, Sonidegib (diphosphate), W421ai34uw, 1218778-77-8 (phosphate)

Cas Number

1218778-77-8

Unique Ingredient Identifier (UNII)

W421AI34UW

Sonidegib Phosphate Manufacturers

A Sonidegib Phosphate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sonidegib Phosphate, including repackagers and relabelers. The FDA regulates Sonidegib Phosphate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sonidegib Phosphate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sonidegib Phosphate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sonidegib Phosphate Suppliers

A Sonidegib Phosphate supplier is an individual or a company that provides Sonidegib Phosphate active pharmaceutical ingredient (API) or Sonidegib Phosphate finished formulations upon request. The Sonidegib Phosphate suppliers may include Sonidegib Phosphate API manufacturers, exporters, distributors and traders.

click here to find a list of Sonidegib Phosphate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sonidegib Phosphate USDMF

A Sonidegib Phosphate DMF (Drug Master File) is a document detailing the whole manufacturing process of Sonidegib Phosphate active pharmaceutical ingredient (API) in detail. Different forms of Sonidegib Phosphate DMFs exist exist since differing nations have different regulations, such as Sonidegib Phosphate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Sonidegib Phosphate DMF submitted to regulatory agencies in the US is known as a USDMF. Sonidegib Phosphate USDMF includes data on Sonidegib Phosphate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Sonidegib Phosphate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Sonidegib Phosphate suppliers with USDMF on PharmaCompass.

Sonidegib Phosphate NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Sonidegib Phosphate as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Sonidegib Phosphate API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Sonidegib Phosphate as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Sonidegib Phosphate and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Sonidegib Phosphate NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Sonidegib Phosphate suppliers with NDC on PharmaCompass.

Sonidegib Phosphate GMP

Sonidegib Phosphate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sonidegib Phosphate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sonidegib Phosphate GMP manufacturer or Sonidegib Phosphate GMP API supplier for your needs.

Sonidegib Phosphate CoA

A Sonidegib Phosphate CoA (Certificate of Analysis) is a formal document that attests to Sonidegib Phosphate's compliance with Sonidegib Phosphate specifications and serves as a tool for batch-level quality control.

Sonidegib Phosphate CoA mostly includes findings from lab analyses of a specific batch. For each Sonidegib Phosphate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sonidegib Phosphate may be tested according to a variety of international standards, such as European Pharmacopoeia (Sonidegib Phosphate EP), Sonidegib Phosphate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sonidegib Phosphate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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