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ACTIVE PHARMA INGREDIENTS

59 API Suppliers, 20 USDMF, 2 CEP/COS, 1 JDMF, 11 EU WC, 8 KDMF, 10 NDC API, 42 Listed Suppliers, $ API Reference Price

59 API Suppliers
20 USDMF
2 CEP/COS
1 JDMF
11 EU WC
8 KDMF
10 NDC API
42 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

7 Drugs in Development

7 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

30 FDF Dossiers, 6 FDA Orange Book, 7 Europe, 1 Canada, 3 Australia, 2 South Africa, 11 Listed Dossiers

30 FDF Dossiers
6 FDA Orange Book
7 Europe
1 Canada
3 Australia
2 South Africa
11 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma, 2 Seqens, 2 DKSH, 1 Jai Radhe Sales, 3 Faran Shimi Pharmaceutical, 7 Gangwal Healthcare, 1 ACG Worldwide, 3 Actylis, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 13 BASF, 10 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 5 Gangwal Chemicals, 5 Ideal Cures Pvt Ltd, 1 Ingredion Pharma Solutions, 15 Kerry, 3 Kima Chemical, 6 Lonza Capsugel, 8 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Qualicaps, 10 Roquette, 6 Seppic, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 2 The Dow Chemical Company, 3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

45 Coating Systems & Additives, 25 Controlled & Modified Release, 25 Fillers, Diluents & Binders, 16 Direct Compression, 15 Thickeners and Stabilizers, 15 Disintegrants & Superdisintegrants, 13 Granulation, 12 Lubricants & Glidants, 8 Co-Processed Excipients, 8 Topical, 7 Film Formers & Plasticizers, 6 Taste Masking, 5 Empty Capsules, 5 Solubilizers, 4 Vegetarian Capsules, 4 Coloring Agents, 3 Rheology Modifiers, 3 Chewable & Orodispersible Aids, 3 API Stability Enhancers, 2 Parenteral, 2 Emulsifying Agents, 1 Surfactant & Foaming Agents

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 103 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
103 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 5 Finished Drug Prices, 9 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
5 Finished Drug Prices
9 Annual Reports

MARKET PLACE

8 APIs, 11 FDF Dossiers

marketPlace
8 APIs
11 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents, 9 Health Canada Patents

patents
4 US Patents
9 Health Canada Patents

REF. STANDARDS & IMPURITIES

13 Others

otherSolutions
13 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 4,355

MARKET PLACE

API

FDF

19INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

7DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

103

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

63,601,663

Annual Reports (USD Million)

5,913

Finished Drug Prices

141 RELATED EXCIPIENT COMPANIES

227EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 475207-59-1, Nexavar, Sorafenib tosylate [usan], Sorafenib (tosylate), Sorafenib tosilate, Bay 54-9085

Molecular Formula

C₂₈H₂₄ClF₃N₄O₆S

Molecular Weight

637.0 g/mol

InChI Key

IVDHYUQIDRJSTI-UHFFFAOYSA-N

FDA UNII

5T62Q3B36J

A niacinamide and phenylurea derivative that inhibits multiple intracellular and cell surface kinases thought to be involved in ANGIOGENESIS, including RAF KINASES and VEGF RECEPTORS. It is used in the treatment of advanced RENAL CELL CARCINOMA and HEPATOCELLULAR CARCINOMA, and for treatment of THYROID CARCINOMA refractory to radioactive iodine therapy.

1 2D Structure

Sorafenib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide;4-methylbenzenesulfonic acid

2.1.2 InChI

InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

2.1.3 InChI Key

IVDHYUQIDRJSTI-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F

2.2 Other Identifiers

2.2.1 UNII

5T62Q3B36J

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxylic Acid Methyamide-4-methylbenzenesulfonate

2. Bay 43 9006

3. Bay 43-9006

4. Bay 439006

5. Bay 545 9085

6. Bay 545-9085

7. Bay 5459085

8. Bay 673472

9. Bay-545-9085

10. Bay-673472

11. Bay5459085

12. Nexavar

13. Sorafenib

14. Sorafenib N Oxide

15. Sorafenib N-oxide

2.3.2 Depositor-Supplied Synonyms

1. 475207-59-1

2. Nexavar

3. Sorafenib Tosylate [usan]

4. Sorafenib (tosylate)

5. Sorafenib Tosilate

6. Bay 54-9085

7. 475207-59-1 (tosylate)

8. 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-n-methylpicolinamide 4-methylbenzenesulfonate

9. Chebi:50928

10. 5t62q3b36j

11. Mfcd08235032

12. Bay-54-9085

13. Sorafenib Tosilate (jan)

14. Sorafenib (nexavar)

15. Sorafenib Tosylate (usan)

16. Nexavar(r)

17. Dsstox_cid_27817

18. Dsstox_rid_82581

19. Dsstox_gsid_47839

20. 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)urea Mono(4-methylbenzenesulfonate)

21. 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-n2-methylpyridine-2-carboxamide Mono (4-methylbenzenesulfonate)

22. 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide;4-methylbenzenesulfonic Acid

23. Sorafenib Tosilate [jan]

24. Bay 43-9006 Tosylate

25. 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-n-methylpicolinamide 4-methylbenzenesulfonate.

26. 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-n-methylpyridine-2-carboxamide; 4-methylbenzene-1-sulfonic Acid

27. Cas-475207-59-1

28. Nsc-724772

29. Ncgc00167488-01

30. Unii-5t62q3b36j

31. Sr-00000000529

32. Orafenib Tosylate

33. Bay43-9006 Mono-p-tosylate

34. Bay 43-9006 Mono-p-tosylate

35. 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)phenoxy)-n-methylpyridine-2-carboxamide 4-methylbenzenesulfonate

36. 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-n-methylpyridine-2-carboxamide 4-methylbenzenesulfonate

37. Nexavar (tn)

38. Nsc724772

39. Sorafenib - Nexavar

40. Sorafenib Tsoh Salt

41. Mls002415564

42. Sorafenib Tosylate [mi]

43. Chembl1200485

44. Dtxsid9047839

45. Sorafenib (bay-43-9006)

46. Hms2219e08

47. Hms3654i09

48. Sorafenib, P-toluenesulfonate Salt

49. Sorafenib Tosilate [mart.]

50. Sorafenib Tosilate [who-dd]

51. Sorafenib Tosylate [usp-rs]

52. Tox21_112489

53. Hy-10201a

54. S1040

55. Akos015924650

56. Akos027469919

57. Tox21_112489_1

58. Ac-6799

59. Ccg-208000

60. Cs-0164

61. Nd-0228

62. Sorafenib Tosylate [orange Book]

63. Ncgc00167488-08

64. Sorafenib Tosilate [ep Monograph]

65. 2-pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-n-methyl-, Mono(4-methylbenzenesulfonate)

66. Bs164414

67. Smr001339079

68. Sorafenib Tosylate [usp Monograph]

69. Sy012324

70. Bcp0726000112

71. Am20090612

72. Ft-0650737

73. Ft-0698449

74. Sw202562-3

75. Ec-000.2356

76. A25518

77. D06272

78. S-8502

79. 207s591

80. Q-201729

81. Sr-00000000529-5

82. 2,5-dioxo-1,4-cyclohexanedicarboxylicaciddimethylester

83. Q27122250

84. 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-n-methylpicolinamide Tosylate

85. 2-pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-n-methyl-, 4-methylbenzenesulfonate (1:1)

86. 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)phenoxy)-n-methylpyridine-2-carboxamide 4-methylbenzenesulphonate

87. 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-n-methylpicolinamide4-methylbenzenesulfonate

88. 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-2-pyridinecarboxamide Tosylate

89. 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide;hydron;4-methylbenzenesulfonate

90. 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)-amino]phenoxy}-n-methylpyridine-2-carboxamide Tosylate

91. 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n -methylpyridine-2-carboxamide Tosylate

92. 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide Tosylate

93. 4-{4-[3-(4-chloro-3-trifluoromethyl-phenyl)-ureido]-phenoxy} -pyridine-2-carboxylic Acid Methylamide-4-methylbenzenesulfonate

94. 4-{4-[3-(4-cl-3-trifluoromethyl-phenyl)-ureido]-phenoxy}-pyridine-2-carboxylic Acid Methylamide 4-methylbenzenesulfonate

95. 4-methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-n-(5-(4-methyl-1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide Monomethanesulfonate

2.4 Create Date

2005-03-26

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₂₄ClF₃N₄O₆S
Molecular Weight	637.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	636.1057179 g/mol
Monoisotopic Mass	636.1057179 g/mol
Topological Polar Surface Area	155 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	853
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Nexavar
PubMed Health	Sorafenib (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib. Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2-methylpyridine-2-carboxamide 4-methylbenzenesulfonate and its structural formula is...
Active Ingredient	Sorafenib tosylate
Dosage Form	Tablet
Route	Oral
Strength	eq 200mg base
Market Status	Prescription
Company	Bayer Hlthcare

2 of 2
Drug Name	Nexavar
PubMed Health	Sorafenib (By mouth)
Drug Classes	Antineoplastic Agent
Drug Label	NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib. Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)N2-methylpyridine-2-carboxamide 4-methylbenzenesulfonate and its structural formula is...
Active Ingredient	Sorafenib tosylate
Dosage Form	Tablet
Route	Oral
Strength	eq 200mg base
Market Status	Prescription
Company	Bayer Hlthcare

4.2 Drug Indication

* Hepatocellular carcinoma:

Nexavar is indicated for the treatment of hepatocellular carcinoma.

* Renal cell carcinoma:

Nexavar is indicated for the treatment of patients with advanced renal cell carcinoma who have failed prior interferon-alpha or interleukin-2 based therapy or are considered unsuitable for such therapy.

* Differentiated thyroid carcinoma:

Nexavar is indicated for the treatment of patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hrthle cell) thyroid carcinoma, refractory to radioactive iodine.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

5.2 ATC Code

L01EX02

API SUPPLIERS

01

Minakem

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich

Attending

Minakem delivers API, HPAPI, steroids & CDMO services for generics with FDA/GMP certification, regulatory know-how & proven success.

Contact Supplier

France

Virtual Booth

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USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Minakem (formerly Delmar Chemicals...

Canada

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

Minakem is manufacturing small molecules APIs including corticosteroids

Contact Supplier

Canada

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Portfolio PDF

Corporate PDF

03

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BioFlorida Conference

Attending

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Faran Shimi Pharmaceutical

Iran

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

Faran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

Contact Supplier

Iran

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Corporate PDF

05

Shandong Loncom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

Shandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Shandong Loncom Pharmaceutical company banner

06

Granules India Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI India 2024

Attending

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

India

Virtual Booth

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC

KDMF VMF Others AUDIT

07

Yabao Pharmaceutical Group Co. Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

08

Teva API

Israel

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

09

Sichuan Xieli Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

10

Zhejiang Jiuzhou Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Coating Systems & Additives

Controlled & Modified Release

Fillers, Diluents & Binders

Direct Compression

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Disintegrants & Superdisintegrants

Granulation

Lubricants & Glidants

Co-Processed Excipients

Topical

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Taste Masking

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Solubilizers

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Rheology Modifiers

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ABOUT THIS PAGE

Find Sorafenib manufacturers, exporters & distributors on PharmaCompass

ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

59 API Suppliers

20 USDMF

2 CEP/COS

1 JDMF

11 EU WC

8 KDMF

10 NDC API

42 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

7 Drugs in Development

INTERMEDIATES

19 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

30 FDF Dossiers

6 FDA Orange Book

7 Europe

1 Canada

3 Australia

2 South Africa

11 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 SPI Pharma

2 Seqens

2 DKSH

1 Jai Radhe Sales

3 Faran Shimi Pharmaceutical

7 Gangwal Healthcare

1 ACG Worldwide

3 Actylis

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

13 BASF

10 Corel Pharma Chem

3 DFE Pharma

1 Finar

5 Gangwal Chemicals

5 Ideal Cures Pvt Ltd

1 Ingredion Pharma Solutions

15 Kerry

3 Kima Chemical

6 Lonza Capsugel

8 Microlex e.U

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

3 Prachin Chemical

1 Qianhao Chemical (Hebei) Co., Ltd

1 Qualicaps

10 Roquette

6 Seppic

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

9 Sigachi Industries

2 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

45 Coating Systems & Additives

25 Controlled & Modified Release

25 Fillers, Diluents & Binders

16 Direct Compression

15 Thickeners and Stabilizers

15 Disintegrants & Superdisintegrants

13 Granulation

12 Lubricants & Glidants

8 Co-Processed Excipients

8 Topical

7 Film Formers & Plasticizers

6 Taste Masking

5 Empty Capsules

5 Solubilizers

4 Vegetarian Capsules

4 Coloring Agents

3 Rheology Modifiers

3 Chewable & Orodispersible Aids