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Synopsis

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Chemistry

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Also known as: Spi-1620, Deeavyfahldiiw, C86h117n17o27, Suc[glu9,ala11,15]et-110-21, (asp-1 = suc-asp), Spi 1620

Molecular Formula

C₈₆H₁₁₇N₁₇O₂₇

Molecular Weight

1820.9 g/mol

InChI Key

DXPHNGAMYPPTBJ-TZMIJSMNSA-N

Sovateltide is a highly selective peptide agonist of the endothelin-B receptor. Sovateltide binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle. This agent may induce a transient, selective increase in blood flow to a tumor, which may result in an increase in the delivery of anticancer agents to the tumor and, so, an increase in anticancer agent efficacy.

1 2D Structure

Sovateltide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4S)-4-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-(3-carboxypropanoylamino)propanoyl]amino]butanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

2.1.2 InChI

InChI=1S/C86H117N17O27/c1-11-44(7)71(84(127)100-63(86(129)130)35-50-39-88-54-21-17-16-20-53(50)54)103-85(128)72(45(8)12-2)102-82(125)62(38-69(114)115)98-78(121)57(32-42(3)4)96-80(123)60(36-51-40-87-41-89-51)95-73(116)46(9)91-77(120)58(33-48-18-14-13-15-19-48)97-79(122)59(34-49-22-24-52(104)25-23-49)99-83(126)70(43(5)6)101-74(117)47(10)90-75(118)55(26-29-65(106)107)93-76(119)56(27-30-66(108)109)94-81(124)61(37-68(112)113)92-64(105)28-31-67(110)111/h13-25,39-47,55-63,70-72,88,104H,11-12,26-38H2,1-10H3,(H,87,89)(H,90,118)(H,91,120)(H,92,105)(H,93,119)(H,94,124)(H,95,116)(H,96,123)(H,97,122)(H,98,121)(H,99,126)(H,100,127)(H,101,117)(H,102,125)(H,103,128)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H,129,130)/t44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,70-,71-,72-/m0/s1

2.1.3 InChI Key

DXPHNGAMYPPTBJ-TZMIJSMNSA-N

2.1.4 Canonical SMILES

CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC3=CNC=N3)NC(=O)C(C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O

2.1.5 Isomeric SMILES

CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](C)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC5=CC=C(C=C5)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Endothelin-1 (8-21), Succinyl-(glu(9),ala(11,15))-

2. Irl 1620

3. Irl-1620

4. Spi-1620

5. Succinyl-(glu(9),ala(11,15))-endothelin-1 (8-21)

6. Succinyl-(glutamyl(9)-alanyl(11,15))-endothelin-1 (8-21)

2.2.2 Depositor-Supplied Synonyms

1. Spi-1620

2. Deeavyfahldiiw

3. C86h117n17o27

4. Suc[glu9,ala11,15]et-110-21

5. (asp-1 = Suc-asp)

6. Spi 1620

7. Gtpl3886

8. Chembl3188091

9. Irl1620

10. Irl2620

11. Mfcd00214284

12. Akos024456459

13. Suc-asp-glu-glu-ala-val-tyr-phe-ala-his-leu-asp-ile-ile-trp-oh

14. Succinyl-(glu9,ala11 Inverted Exclamation Mark Currency15)-endothelin-1 (8-21)

15. Succinyl-(glu9,ala11?15)-endothelin-1 (8-21) (suc-asp-glu-glu-ala-val-tyr-phe-ala-his-leu-asp-ile-ile-trp)

2.3 Create Date

2007-07-04

3 Chemical and Physical Properties

Molecular Formula	C₈₆H₁₁₇N₁₇O₂₇
Molecular Weight	1820.9 g/mol
XLogP3	2.1
Hydrogen Bond Donor Count	23
Hydrogen Bond Acceptor Count	28
Rotatable Bond Count	56
Exact Mass	1819.83048152 g/mol
Monoisotopic Mass	1819.83048152 g/mol
Topological Polar Surface Area	696 Å²
Heavy Atom Count	130
Formal Charge	0
Complexity	3920
Isotope Atom Count	0
Defined Atom Stereocenter Count	16
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

Drugs in Development

01 Pharmazz

U.S.A

Duphat

Not Confirmed

02 Pharmazz

U.S.A

Duphat

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U.S.A

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U.S.A

Duphat

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U.S.A

Duphat

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Duphat

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07 Pharmazz

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Duphat

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08 Pharmazz

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Duphat

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09 Pharmazz

U.S.A

Duphat

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10 Pharmazz

U.S.A

Duphat

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Sovateltide Manufacturers

A Sovateltide manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sovateltide, including repackagers and relabelers. The FDA regulates Sovateltide manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sovateltide API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sovateltide Suppliers

A Sovateltide supplier is an individual or a company that provides Sovateltide active pharmaceutical ingredient (API) or Sovateltide finished formulations upon request. The Sovateltide suppliers may include Sovateltide API manufacturers, exporters, distributors and traders.

Sovateltide GMP

Sovateltide Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sovateltide GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sovateltide GMP manufacturer or Sovateltide GMP API supplier for your needs.

Sovateltide CoA

A Sovateltide CoA (Certificate of Analysis) is a formal document that attests to Sovateltide's compliance with Sovateltide specifications and serves as a tool for batch-level quality control.

Sovateltide CoA mostly includes findings from lab analyses of a specific batch. For each Sovateltide CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sovateltide may be tested according to a variety of international standards, such as European Pharmacopoeia (Sovateltide EP), Sovateltide JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sovateltide USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

Find Sovateltide manufacturers, exporters & distributors on PharmaCompass

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Sovateltide Manufacturers

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