Find Sovleplenib manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: Sovleplenib [inn], 9cl6353kho, 1415792-84-5, (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido(4,3-b)pyrazin-5-amine, Pyrido[3,4-b]pyrazin-5-amine, 7-[4-[1-(methylsulfonyl)-4-piperidinyl]phenyl]-n-[(2s)-2-morpholinylmethyl]-, Unii-9cl6353kho
Molecular Formula
C24H30N6O3S
Molecular Weight
482.6  g/mol
InChI Key
NJIAKNWTIVDSDA-FQEVSTJZSA-N
FDA UNII
9CL6353KHO

Sovleplenib
Sovleplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential immunomodulating and antineoplastic activities. Upon oral administration of sovleplenib, this agent binds to and inhibits the activity of Syk. This inhibits B-cell receptor (BCR) signaling, which leads to the inhibition of B-cell activation, and prevents tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies; it plays a key role in B-cell receptor signaling.
1 2D Structure

Sovleplenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-[4-(1-methylsulfonylpiperidin-4-yl)phenyl]-N-[[(2S)-morpholin-2-yl]methyl]pyrido[3,4-b]pyrazin-5-amine
2.1.2 InChI
InChI=1S/C24H30N6O3S/c1-34(31,32)30-11-6-18(7-12-30)17-2-4-19(5-3-17)21-14-22-23(27-9-8-26-22)24(29-21)28-16-20-15-25-10-13-33-20/h2-5,8-9,14,18,20,25H,6-7,10-13,15-16H2,1H3,(H,28,29)/t20-/m0/s1
2.1.3 InChI Key
NJIAKNWTIVDSDA-FQEVSTJZSA-N
2.1.4 Canonical SMILES
CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NCC5CNCCO5
2.1.5 Isomeric SMILES
CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NC[C@@H]5CNCCO5
2.2 Other Identifiers
2.2.1 UNII
9CL6353KHO
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sovleplenib [inn]

2. 9cl6353kho

3. 1415792-84-5

4. (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido(4,3-b)pyrazin-5-amine

5. Pyrido[3,4-b]pyrazin-5-amine, 7-[4-[1-(methylsulfonyl)-4-piperidinyl]phenyl]-n-[(2s)-2-morpholinylmethyl]-

6. Unii-9cl6353kho

7. Hmpl523

8. Hmpl-523

9. Hmpl-523 [who-dd]

10. Schembl14242080

11. Gtpl11886

12. Zinc143715528

13. Compound 225 [wo2012167733a1]

14. Hy-145598

15. Cs-0376654

16. F78019

17. (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido[3,4-b]pyrazin-5-amine

2.4 Create Date
2013-03-21
3 Chemical and Physical Properties
Molecular Weight 482.6 g/mol
Molecular Formula C24H30N6O3S
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass482.21001001 g/mol
Monoisotopic Mass482.21001001 g/mol
Topological Polar Surface Area118 Ų
Heavy Atom Count34
Formal Charge0
Complexity748
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Sovleplenib Manufacturers

A Sovleplenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sovleplenib, including repackagers and relabelers. The FDA regulates Sovleplenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sovleplenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Sovleplenib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Sovleplenib Suppliers

A Sovleplenib supplier is an individual or a company that provides Sovleplenib active pharmaceutical ingredient (API) or Sovleplenib finished formulations upon request. The Sovleplenib suppliers may include Sovleplenib API manufacturers, exporters, distributors and traders.

click here to find a list of Sovleplenib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Sovleplenib GMP

Sovleplenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sovleplenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sovleplenib GMP manufacturer or Sovleplenib GMP API supplier for your needs.

Sovleplenib CoA

A Sovleplenib CoA (Certificate of Analysis) is a formal document that attests to Sovleplenib's compliance with Sovleplenib specifications and serves as a tool for batch-level quality control.

Sovleplenib CoA mostly includes findings from lab analyses of a specific batch. For each Sovleplenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sovleplenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Sovleplenib EP), Sovleplenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sovleplenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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