Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 Listed Suppliers

1 API Suppliers
1 Listed Suppliers

DEVELOPMENTS

7 Drugs in Development

7 Drugs in Development

DIGITAL CONTENT

5 NEWS #PharmaBuzz

media
5 NEWS #PharmaBuzz

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

7DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: Sovleplenib [inn], 9cl6353kho, 1415792-84-5, (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido(4,3-b)pyrazin-5-amine, Pyrido[3,4-b]pyrazin-5-amine, 7-[4-[1-(methylsulfonyl)-4-piperidinyl]phenyl]-n-[(2s)-2-morpholinylmethyl]-, Unii-9cl6353kho

Molecular Formula

C₂₄H₃₀N₆O₃S

Molecular Weight

482.6 g/mol

InChI Key

NJIAKNWTIVDSDA-FQEVSTJZSA-N

FDA UNII

9CL6353KHO

Sovleplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential immunomodulating and antineoplastic activities. Upon oral administration of sovleplenib, this agent binds to and inhibits the activity of Syk. This inhibits B-cell receptor (BCR) signaling, which leads to the inhibition of B-cell activation, and prevents tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies; it plays a key role in B-cell receptor signaling.

1 2D Structure

Sovleplenib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-[4-(1-methylsulfonylpiperidin-4-yl)phenyl]-N-[[(2S)-morpholin-2-yl]methyl]pyrido[3,4-b]pyrazin-5-amine

2.1.2 InChI

InChI=1S/C24H30N6O3S/c1-34(31,32)30-11-6-18(7-12-30)17-2-4-19(5-3-17)21-14-22-23(27-9-8-26-22)24(29-21)28-16-20-15-25-10-13-33-20/h2-5,8-9,14,18,20,25H,6-7,10-13,15-16H2,1H3,(H,28,29)/t20-/m0/s1

2.1.3 InChI Key

NJIAKNWTIVDSDA-FQEVSTJZSA-N

2.1.4 Canonical SMILES

CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NCC5CNCCO5

2.1.5 Isomeric SMILES

CS(=O)(=O)N1CCC(CC1)C2=CC=C(C=C2)C3=CC4=NC=CN=C4C(=N3)NC[C@@H]5CNCCO5

2.2 Other Identifiers

2.2.1 UNII

9CL6353KHO

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Sovleplenib [inn]

2. 9cl6353kho

3. 1415792-84-5

4. (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido(4,3-b)pyrazin-5-amine

5. Pyrido[3,4-b]pyrazin-5-amine, 7-[4-[1-(methylsulfonyl)-4-piperidinyl]phenyl]-n-[(2s)-2-morpholinylmethyl]-

6. Unii-9cl6353kho

7. Hmpl523

8. Hmpl-523

9. Hmpl-523 [who-dd]

10. Schembl14242080

11. Gtpl11886

12. Zinc143715528

13. Compound 225 [wo2012167733a1]

14. Hy-145598

15. Cs-0376654

16. F78019

17. (s)-7-(4-(1-(methylsulfonyl)piperidin-4-yl)phenyl)-n-(morpholin-2-ylmethyl)pyrido[3,4-b]pyrazin-5-amine

2.4 Create Date

2013-03-21

3 Chemical and Physical Properties

Molecular Formula	C₂₄H₃₀N₆O₃S
Molecular Weight	482.6 g/mol
XLogP3	1.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	6
Exact Mass	482.21001001 g/mol
Monoisotopic Mass	482.21001001 g/mol
Topological Polar Surface Area	118 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	748
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1