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4 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 71-44-3, Musculamine, Neuridine, Gerontine, Spermin, 4,9-diaza-1,12-dodecanediamine
Molecular Formula
C10H26N4
Molecular Weight
202.34  g/mol
InChI Key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
FDA UNII
2FZ7Y3VOQX

Spermine
A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure.
1 2D Structure

Spermine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N'-bis(3-aminopropyl)butane-1,4-diamine
2.1.2 InChI
InChI=1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
2.1.3 InChI Key
PFNFFQXMRSDOHW-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C(CCNCCCN)CNCCCN
2.2 Other Identifiers
2.2.1 UNII
2FZ7Y3VOQX
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 71-44-3

2. Musculamine

3. Neuridine

4. Gerontine

5. Spermin

6. 4,9-diaza-1,12-dodecanediamine

7. N,n'-bis(3-aminopropyl)-1,4-butanediamine

8. Diaminopropyltetramethylenediamine

9. Spermine, Puriss

10. 1,4-butanediamine, N,n'-bis(3-aminopropyl)-

11. 4,9-diazadodecamethylenediamine

12. N,n'-bis(3-aminopropyl)butane-1,4-diamine

13. 1,4-bis(aminopropyl)butanediamine

14. Gerotine

15. 4,9-diazadodecane-1,12-diamine

16. 68956-56-9

17. Polyspermine

18. Nsc 268508

19. 1,4-bis(aminopropyl) Butanediamine

20. N1,n1'-(butane-1,4-diyl)bis(propane-1,3-diamine)

21. Spermine Free Base

22. Actilip Sp-91

23. 1,4-diaminobutane, N,n'-bis(3-aminopropyl)-

24. Brn 1750791

25. Ai3-26633

26. 1,5,10,14-tetraazatetradecane

27. 2fz7y3voqx

28. Nsc-268508

29. Nsc 268508; Neuridine

30. Chembl23194

31. Hydrocarbons, Terpene Processing By-products

32. 71052-31-8

33. Chebi:15746

34. N1,n4-bis(3-aminopropyl)-1,4-butanediamine

35. Nsc268508

36. 71-44-3 (free Base)

37. Spermidine 3hcl

38. 1,4-butanediamine, N1,n4-bis(3-aminopropyl)-

39. Spm

40. (3-aminopropyl)({4-[(3-aminopropyl)amino]butyl})amine

41. 1,4-butanediamine, N1,n4-bis(3-aminopropyl)-, Homopolymer

42. Spermina

43. Mls002472980

44. Diaminopropyl-tetramethylenediamine

45. Spermina [italian]

46. Smr001397086

47. Einecs 200-754-2

48. Unii-2fz7y3voqx

49. Mfcd00008215

50. Spermine Puriss

51. N,n'-bis(3-aminopropyl)-1,4-diaminobutane

52. Terpene Hydrocarbons, By Product

53. Einecs 273-309-3

54. 4,12-diamine

55. Spermine, >=97%

56. Tocris-0958

57. Gerotine [inci]

58. Spermine [mi]

59. Lopac-s-2876

60. Biomol-nt_000213

61. Bmse000117

62. Ec 273-309-3

63. Ncimech_000206

64. Spermine, Min. 98.0%

65. Lopac0_001077

66. Schembl14965

67. Wln: Z3m4m3z

68. Gtpl710

69. Spermine, Analytical Standard

70. 4-04-00-01301 (beilstein Handbook Reference)

71. Bpbio1_001086

72. Sperminetetrahydrochloride

73. Dtxsid9058781

74. Bdbm79403

75. Cid_5351186

76. 1, N,n'-bis(3-aminopropyl)-

77. Spermine, >=99.0% (gc)

78. Hy-b1777

79. Zinc1532734

80. Ccg-35276

81. Hsci1_000212

82. S3948

83. Akos024258603

84. Db00127

85. Sb38410

86. Sdccgsbi-0051047.p003

87. N1,n4-bis(3-aminopropyl)-butanediamine

88. Ncgc00015941-01

89. Ncgc00015941-02

90. Ncgc00015941-03

91. Ncgc00015941-04

92. Ncgc00015941-05

93. Ncgc00015941-10

94. Ncgc00024902-01

95. Ncgc00024902-02

96. Ncgc00024902-03

97. As-35114

98. Bp-21388

99. Nci60_035280

100. Db-055526

101. Cs-0013806

102. Ft-0625219

103. Ft-0631308

104. N,na?bis(3-aminopropyl)-1,4-diaminobutane

105. Spermine, Vetec(tm) Reagent Grade, >=97%

106. N,n''-bis(3-aminopropyl)butane-1,4-diamine

107. C00750

108. S-7400

109. Z-1049

110. 956s569

111. A866441

112. L001114

113. N1,n1'-(butane-1,4-diyl)dipropane-1,3-diamine

114. Q424597

115. N,n'-bis(3-aminopropyl)-1,4-tetramethylenediamine

116. N1,n1-(butane-1,4-diyl)bis(propane-1,3-diamine)

117. N1,n1'-(butane-1,4-diyl);bis(propane-1,3-diamine);

118. 2b445aed-6284-43e4-82fe-39598858d67f

119. 3-aminopropyl-[4-(3-aminopropylamino)butyl]amine;hydrochloride

120. N,n''''-bis(3-aminopropyl)butane-1,4-diamine;hydrochloride

121. N,n''''-bis(3-azanylpropyl)butane-1,4-diamine;hydrochloride

122. Spermine, Bioreagent, Amorphous Semi-solid, Suitable For Cell Culture

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 202.34 g/mol
Molecular Formula C10H26N4
XLogP3-1.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass202.21574685 g/mol
Monoisotopic Mass202.21574685 g/mol
Topological Polar Surface Area76.1 Ų
Heavy Atom Count14
Formal Charge0
Complexity86.1
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For nutritional supplementation, also for treating dietary shortage or imbalance


5 Pharmacology and Biochemistry
5.1 Pharmacology

Spermine is a polyamine. It is an organic molecule that is involved in cellular metabolism.


5.2 Mechanism of Action

Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.


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ABOUT THIS PAGE

Spermine Manufacturers

A Spermine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Spermine, including repackagers and relabelers. The FDA regulates Spermine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Spermine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Spermine Suppliers

A Spermine supplier is an individual or a company that provides Spermine active pharmaceutical ingredient (API) or Spermine finished formulations upon request. The Spermine suppliers may include Spermine API manufacturers, exporters, distributors and traders.

Spermine GMP

Spermine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Spermine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Spermine GMP manufacturer or Spermine GMP API supplier for your needs.

Spermine CoA

A Spermine CoA (Certificate of Analysis) is a formal document that attests to Spermine's compliance with Spermine specifications and serves as a tool for batch-level quality control.

Spermine CoA mostly includes findings from lab analyses of a specific batch. For each Spermine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Spermine may be tested according to a variety of international standards, such as European Pharmacopoeia (Spermine EP), Spermine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Spermine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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