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Synopsis

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Chemistry

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Also known as: Spirapril hcl, 94841-17-5, Spirapril hydrochloride [usan], Sch 33844, Occ25lm897, 83647-97-6 (free base)
Molecular Formula
C22H31ClN2O5S2
Molecular Weight
503.1  g/mol
InChI Key
CLDOLNORSLLQDI-OOAIBONUSA-N
FDA UNII
OCC25LM897

Spirapril
Spirapril Hydrochloride is the hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
1 2D Structure

Spirapril

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid;hydrochloride
2.1.2 InChI
InChI=1S/C22H30N2O5S2.ClH/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27;/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27);1H/t15-,17-,18-;/m0./s1
2.1.3 InChI Key
CLDOLNORSLLQDI-OOAIBONUSA-N
2.1.4 Canonical SMILES
CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3(CC2C(=O)O)SCCS3.Cl
2.1.5 Isomeric SMILES
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2CC3(C[C@H]2C(=O)O)SCCS3.Cl
2.2 Other Identifiers
2.2.1 UNII
OCC25LM897
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Quadropril

2. Renormax

3. Renpress

4. Sch 33844

5. Sch-33844

6. Spirapril

2.3.2 Depositor-Supplied Synonyms

1. Spirapril Hcl

2. 94841-17-5

3. Spirapril Hydrochloride [usan]

4. Sch 33844

5. Occ25lm897

6. 83647-97-6 (free Base)

7. (8s)-7((s)-n-((s)-1-carboxy-3-phenylpropyl)alanyl)-1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic Acid, 1-ethyl Ester, Monohydrochloride

8. Sch-33844

9. (8s)-7-[(2s)-2-[[(2s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid;hydrochloride

10. 1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic Acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, Monohydrochloride, (8s-(7(r*(r*)),8r*))-

11. Spirapril Hydrochloride (usan)

12. (s)-7-(((s)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-l-alanyl)-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Hydrochloride

13. Unii-occ25lm897

14. Renormax (tn)

15. Spiraprilhydrochloride

16. Ncgc00182545-01

17. Dsstox_cid_24272

18. Dsstox_rid_80139

19. Dsstox_gsid_44272

20. Schembl387353

21. Spirapril For System Suitability

22. Chembl1200831

23. Dtxsid6044272

24. Spirapril Hydrochloride [mi]

25. Tox21_112981

26. Akos025311425

27. Spirapril Hydrochloride [mart.]

28. Spirapril Hydrochloride [vandf]

29. Spirapril Hydrochloride [who-dd]

30. Cas-94841-17-5

31. Spirapril Hydrochloride [orange Book]

32. D03765

33. A854716

34. Q27285573

35. (8s)-7-[(2s)-2-[[(1s)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic Acid Monohydrochloride

36. 1,4-dithia-7-azaspiro(4.4)nonane-8-carboxylic Acid, 7-((2s)-2-(((1s)-1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, Hydrochloride (1:1), (8s)-

2.4 Create Date
2006-06-06
3 Chemical and Physical Properties
Molecular Weight 503.1 g/mol
Molecular Formula C22H31ClN2O5S2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count10
Exact Mass502.1362921 g/mol
Monoisotopic Mass502.1362921 g/mol
Topological Polar Surface Area147 Ų
Heavy Atom Count32
Formal Charge0
Complexity650
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Angiotensin-Converting Enzyme Inhibitors

A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)


Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)


ABOUT THIS PAGE

Looking for 94841-17-5 / Spirapril API manufacturers, exporters & distributors?

Spirapril manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Spirapril API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Spirapril manufacturer or Spirapril supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Spirapril manufacturer or Spirapril supplier.

PharmaCompass also assists you with knowing the Spirapril API Price utilized in the formulation of products. Spirapril API Price is not always fixed or binding as the Spirapril Price is obtained through a variety of data sources. The Spirapril Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Spirapril

Synonyms

Spirapril hcl, 94841-17-5, Spirapril hydrochloride [usan], Sch 33844, Occ25lm897, 83647-97-6 (free base)

Cas Number

94841-17-5

Unique Ingredient Identifier (UNII)

OCC25LM897

About Spirapril

Spirapril Hydrochloride is the hydrochloride salt form of spirapril, a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril is converted in the body to its active metabolite spiraprilat. Spiraprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Spirapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Spirapril Manufacturers

A Spirapril manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Spirapril, including repackagers and relabelers. The FDA regulates Spirapril manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Spirapril API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Spirapril Suppliers

A Spirapril supplier is an individual or a company that provides Spirapril active pharmaceutical ingredient (API) or Spirapril finished formulations upon request. The Spirapril suppliers may include Spirapril API manufacturers, exporters, distributors and traders.

Spirapril GMP

Spirapril Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Spirapril GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Spirapril GMP manufacturer or Spirapril GMP API supplier for your needs.

Spirapril CoA

A Spirapril CoA (Certificate of Analysis) is a formal document that attests to Spirapril's compliance with Spirapril specifications and serves as a tool for batch-level quality control.

Spirapril CoA mostly includes findings from lab analyses of a specific batch. For each Spirapril CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Spirapril may be tested according to a variety of international standards, such as European Pharmacopoeia (Spirapril EP), Spirapril JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Spirapril USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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