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Chemistry

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Also known as: Spiropitan, Spiroperidol, 749-02-0, Espiperona, Spiperonum, R 5147
Molecular Formula
C23H26FN3O2
Molecular Weight
395.5  g/mol
InChI Key
DKGZKTPJOSAWFA-UHFFFAOYSA-N
FDA UNII
4X6E73CJ0Q

Spiperone
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
1 2D Structure

Spiperone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
2.1.2 InChI
InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
2.1.3 InChI Key
DKGZKTPJOSAWFA-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC12C(=O)NCN2C3=CC=CC=C3)CCCC(=O)C4=CC=C(C=C4)F
2.2 Other Identifiers
2.2.1 UNII
4X6E73CJ0Q
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Spiroperidol

2. Spiroperone

2.3.2 Depositor-Supplied Synonyms

1. Spiropitan

2. Spiroperidol

3. 749-02-0

4. Espiperona

5. Spiperonum

6. R 5147

7. [3h]spiperone

8. [3h]-spiperone

9. 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

10. E 525

11. Nsc 170983

12. Mls000028615

13. Spiroperidol;r-5147

14. 8-(3-(p-fluorobenzoyl)propyl)-1-phenyl-1,3,8-triazaspiro(4.5)decan-4-one

15. 8-(3-p-fluorobenzoyl-1-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decane

16. Nsc-170983

17. Smr000058674

18. 1,3,8-triazaspiro(4.5)decan-4-one, 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl-

19. 4x6e73cj0q

20. Chebi:9233

21. Chembl267930

22. R-5147

23. Butyrophenone, 4'-fluoro-4-(4-oxo-1-phenyl-1,3,8-triazaspiro(4,5)decan-8-yl)-

24. Nsc170983

25. Ncgc00015964-09

26. Cas-749-02-0

27. 1,3,8-triazaspiro(4.5)decan-4-one, 8-(3-(p-fluorobenzoyl)propyl)-1-phenyl-

28. 1,3,8-triazaspiro[4.5]decan-4-one, 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-

29. 8-(4-(4-fluorophenyl)-4-oxobutyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

30. 8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

31. Dsstox_cid_25205

32. Dsstox_rid_80749

33. Dsstox_gsid_45205

34. Spiroperidone

35. Spiperonum [inn-latin]

36. Espiperona [inn-spanish]

37. 1,3,8-triazaspiro[4.5]decan-4-one, 8-[3-(p-fluorobenzoyl)propyl]-1-phenyl-

38. 8-[4-(4-fluorophenyl)-4-oxo-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

39. Spiperone [usan:inn:ban:jan]

40. Einecs 212-024-0

41. Brn 0632204

42. Unii-4x6e73cj0q

43. Sr-01000000261

44. Spiperone, Solid

45. Spiropitan (tn)

46. Prestwick_624

47. [3h]-spiroperidol

48. Spectrum_001143

49. Tocris-0995

50. Spiperone [inn]

51. Spiperone [jan]

52. Spiperone [mi]

53. Spiperone (jan/usan)

54. Regid855701

55. Spiperone [usan]

56. Opera_id_1551

57. Prestwick0_000288

58. Prestwick1_000288

59. Prestwick2_000288

60. Prestwick3_000288

61. Spectrum2_001426

62. Spectrum3_001460

63. Spectrum4_000451

64. Spectrum5_000987

65. Lopac-s-7395

66. Gtpl99

67. Spiperone [mart.]

68. 4-phenyl-8-[3-(4-fluorobenzoyl)propyl]-1-oxo-2,4,8-triazaspiro[4,5]decane

69. Cid_5265

70. Spiperone [who-dd]

71. Lopac0_001069

72. Regid_for_cid_5265

73. Bspbio_000196

74. Bspbio_002959

75. Kbiogr_000862

76. Kbioss_001623

77. Mls001076321

78. Divk1c_000566

79. Schembl116031

80. Spectrum1501152

81. Spbio_001532

82. Spbio_002415

83. Bpbio1_000216

84. Gtpl3300

85. Dtxsid5045205

86. Bdbm21397

87. Hms501m08

88. Kbio1_000566

89. Kbio2_001623

90. Kbio2_004191

91. Kbio2_006759

92. Kbio3_002459

93. Tqp0726

94. Ninds_000566

95. Hms1568j18

96. Hms1921l09

97. Hms2089e16

98. Hms2092h17

99. Hms2095j18

100. Hms2235e11

101. Hms3371l01

102. Hms3712j18

103. Pharmakon1600-01501152

104. Zinc643233

105. Hy-b1371

106. Tox21_110269

107. Ccg-38975

108. Nsc757864

109. Akos024282958

110. Tox21_110269_1

111. Nsc-757864

112. Sdccgsbi-0051039.p004

113. Idi1_000566

114. Ncgc00015964-01

115. Ncgc00015964-02

116. Ncgc00015964-03

117. Ncgc00015964-04

118. Ncgc00015964-05

119. Ncgc00015964-06

120. Ncgc00015964-07

121. Ncgc00015964-08

122. Ncgc00015964-10

123. Ncgc00015964-11

124. Ncgc00015964-12

125. Ncgc00015964-13

126. Ncgc00015964-17

127. Ncgc00015964-25

128. Ncgc00016536-01

129. Ncgc00022260-02

130. Ncgc00022260-04

131. Ncgc00022260-05

132. Ncgc00022260-06

133. Ncgc00022260-07

134. Sbi-0051039.p003

135. Ab00052224

136. Cs-0013110

137. Ft-0674639

138. D01051

139. Ab00052224-15

140. Ab00052224_16

141. L000569

142. Q3077150

143. Sr-01000000261-5

144. Sr-01000000261-8

145. Brd-k55468218-001-05-5

146. Brd-k55468218-003-01-0

147. Wln: T6n Dxtj A3vr Df& D-& Ct5mvxn Ehj Dr

148. 8-[3-(p-fluorobenzoyl)propyl]-1-phenyl-1,8-triazaspiro[4.5]decan-4-one

149. 1,8-triazaspiro[4.5]decan-4-one, 8-[3-(p-fluorobenzoyl)propyl]-1-phenyl-

150. 1,8-triazaspiro[4.5]decan-4-one, 8-[4-(4-fluorophenyl)-4-oxobutyl]-1-phenyl-

151. 8-[4-(4-fluorophenyl)-4-keto-butyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

152. 8-[4-(4-fluorophenyl)-4-oxo-butyl]-4-phenyl-2,4,8-triazaspiro[4.5]decan-1-one

153. 1-(4-fluorophenyl)-4-(4-hydroxy-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-en-8-yl)-1-butanone #

154. Sip

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 395.5 g/mol
Molecular Formula C23H26FN3O2
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass395.20090524 g/mol
Monoisotopic Mass395.20090524 g/mol
Topological Polar Surface Area52.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity577
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


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Spiperone manufacturers, exporters & distributors 1

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Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Spiperone manufacturer or Spiperone supplier.

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API | Excipient name

Spiperone

Synonyms

Spiropitan, Spiroperidol, 749-02-0, Espiperona, Spiperonum, R 5147

Cas Number

749-02-0

Unique Ingredient Identifier (UNII)

4X6E73CJ0Q

About Spiperone

A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.

Spiropitan Manufacturers

A Spiropitan manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Spiropitan, including repackagers and relabelers. The FDA regulates Spiropitan manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Spiropitan API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Spiropitan Suppliers

A Spiropitan supplier is an individual or a company that provides Spiropitan active pharmaceutical ingredient (API) or Spiropitan finished formulations upon request. The Spiropitan suppliers may include Spiropitan API manufacturers, exporters, distributors and traders.

Spiropitan GMP

Spiropitan Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Spiropitan GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Spiropitan GMP manufacturer or Spiropitan GMP API supplier for your needs.

Spiropitan CoA

A Spiropitan CoA (Certificate of Analysis) is a formal document that attests to Spiropitan's compliance with Spiropitan specifications and serves as a tool for batch-level quality control.

Spiropitan CoA mostly includes findings from lab analyses of a specific batch. For each Spiropitan CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Spiropitan may be tested according to a variety of international standards, such as European Pharmacopoeia (Spiropitan EP), Spiropitan JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Spiropitan USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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