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Chemistry

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Also known as: 811471-91-7, 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one;1-[(2r,5s)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione, Lamivudine; stavudine; nevirapine, Lamivudine/nevirapine/stavudine, Stavudine, lamivudine and nevirapine, Lamivudine mixture with nevirapine and stavudine
Molecular Formula
C33H37N9O8S
Molecular Weight
719.8  g/mol
InChI Key
FEOBXHIFUYOHBP-KPTOQMEFSA-N

Stavudine, Lamivudine, Nevirapine Drug Combination
1 2D Structure

Stavudine, Lamivudine, Nevirapine Drug Combination

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one;1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C15H14N4O.C10H12N2O4.C8H11N3O3S/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10;1-6-4-12(10(15)11-9(6)14)8-3-2-7(5-13)16-8;9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h2-3,6-8,10H,4-5H2,1H3,(H,18,20);2-4,7-8,13H,5H2,1H3,(H,11,14,15);1-2,6-7,12H,3-4H2,(H2,9,10,13)/t;7-,8+;6-,7+/m.00/s1
2.1.3 InChI Key
FEOBXHIFUYOHBP-KPTOQMEFSA-N
2.1.4 Canonical SMILES
CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4.CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO.C1C(OC(S1)CO)N2C=CC(=NC2=O)N
2.1.5 Isomeric SMILES
CC1=C2C(=NC=C1)N(C3=C(C=CC=N3)C(=O)N2)C4CC4.CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@H](O2)CO.C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Stavudine - Lamivudine - Nevirapine

2. Stavudine, Lamivudine, Nevirapine Drug Combination

3. Triomune

2.2.2 Depositor-Supplied Synonyms

1. 811471-91-7

2. 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;2-cyclopropyl-7-methyl-2,4,9,15-tetrazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,12,14-hexaen-10-one;1-[(2r,5s)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

3. Lamivudine; Stavudine; Nevirapine

4. Lamivudine/nevirapine/stavudine

5. Stavudine, Lamivudine And Nevirapine

6. Lamivudine Mixture With Nevirapine And Stavudine

7. Stv & Lmv & Nvp

8. Lamivudine, Nevirapine, And Stavudine Fixed-dose Tablet

9. Nevirapine & Lamivudine & Stavudine

10. 11-cyclopropyl-4-methyl-5,11-dihydro-6h-dipyrido[2,3-e:3',2'-b][1,4]diazepin-6-one & (-)-(2'r,5's)-1-[2'-hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine & Thymidine, 2',3'-didehydro-, 3'-deoxy-

11. 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one; 11-cyclopropyl-4-methyl-5h-dipyrido[[?],[?]][1,4]diazepin-6-one; 1-[(2r,5s)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

2.3 Create Date
2007-03-19
3 Chemical and Physical Properties
Molecular Weight 719.8 g/mol
Molecular Formula C33H37N9O8S
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count12
Rotatable Bond Count5
Exact Mass719.24858035 g/mol
Monoisotopic Mass719.24858035 g/mol
Topological Polar Surface Area250 Ų
Heavy Atom Count51
Formal Charge0
Complexity1120
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameLamivudine; stavudine; nevirapine
Active Ingredientstavudine; Lamivudine; nevirapine
Dosage FormTablet; Tablet, dispersible
Routeoral
Strength100mg; 6mg; 30mg; 200mg; 150mg; 12mg; 50mg; 30mg; 40mg; 60mg
Market StatusTentative Approval
CompanyCipla

2 of 2  
Drug NameLamivudine; stavudine; nevirapine
Active Ingredientstavudine; Lamivudine; nevirapine
Dosage FormTablet; Tablet, dispersible
Routeoral
Strength100mg; 6mg; 30mg; 200mg; 150mg; 12mg; 50mg; 30mg; 40mg; 60mg
Market StatusTentative Approval
CompanyCipla

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-HIV Agents

Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)


Reverse Transcriptase Inhibitors

Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)


5.2 ATC Code

J - Antiinfectives for systemic use

J05 - Antivirals for systemic use

J05A - Direct acting antivirals

J05AR - Antivirals for treatment of hiv infections, combinations

J05AR07 - Stavudine, lamivudine and nevirapine


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Stavudine, Lamivudine, Nevirapine Drug Combination Manufacturers

A Stavudine, Lamivudine, Nevirapine Drug Combination manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Stavudine, Lamivudine, Nevirapine Drug Combination, including repackagers and relabelers. The FDA regulates Stavudine, Lamivudine, Nevirapine Drug Combination manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Stavudine, Lamivudine, Nevirapine Drug Combination API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Stavudine, Lamivudine, Nevirapine Drug Combination Suppliers

A Stavudine, Lamivudine, Nevirapine Drug Combination supplier is an individual or a company that provides Stavudine, Lamivudine, Nevirapine Drug Combination active pharmaceutical ingredient (API) or Stavudine, Lamivudine, Nevirapine Drug Combination finished formulations upon request. The Stavudine, Lamivudine, Nevirapine Drug Combination suppliers may include Stavudine, Lamivudine, Nevirapine Drug Combination API manufacturers, exporters, distributors and traders.

Stavudine, Lamivudine, Nevirapine Drug Combination GMP

Stavudine, Lamivudine, Nevirapine Drug Combination Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Stavudine, Lamivudine, Nevirapine Drug Combination GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Stavudine, Lamivudine, Nevirapine Drug Combination GMP manufacturer or Stavudine, Lamivudine, Nevirapine Drug Combination GMP API supplier for your needs.

Stavudine, Lamivudine, Nevirapine Drug Combination CoA

A Stavudine, Lamivudine, Nevirapine Drug Combination CoA (Certificate of Analysis) is a formal document that attests to Stavudine, Lamivudine, Nevirapine Drug Combination's compliance with Stavudine, Lamivudine, Nevirapine Drug Combination specifications and serves as a tool for batch-level quality control.

Stavudine, Lamivudine, Nevirapine Drug Combination CoA mostly includes findings from lab analyses of a specific batch. For each Stavudine, Lamivudine, Nevirapine Drug Combination CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Stavudine, Lamivudine, Nevirapine Drug Combination may be tested according to a variety of international standards, such as European Pharmacopoeia (Stavudine, Lamivudine, Nevirapine Drug Combination EP), Stavudine, Lamivudine, Nevirapine Drug Combination JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Stavudine, Lamivudine, Nevirapine Drug Combination USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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