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Chemistry

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Also known as: 1140964-99-3, E7449, E-7449, Stenoparib, Parp inhibitor 2x-121, Unii-9x5a2qia7c
Molecular Formula
C18H15N5O
Molecular Weight
317.3  g/mol
InChI Key
JLFSBHQQXIAQEC-UHFFFAOYSA-N
FDA UNII
9X5A2QIA7C

Stenoparib
PARP/Tankyrase Inhibitor 2X-121 is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes genomic instability eventually leading to apoptosis. PARP 1/2 inhibitor E7449 may enhance the cytotoxicity of DNA-damaging agents and of radiotherapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA.
1 2D Structure

Stenoparib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
11-(1,3-dihydroisoindol-2-ylmethyl)-2,3,10,12-tetrazatricyclo[7.3.1.05,13]trideca-1,5(13),6,8,11-pentaen-4-one
2.1.2 InChI
InChI=1S/C18H15N5O/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23/h1-7H,8-10H2,(H,22,24)(H,19,20,21)
2.1.3 InChI Key
JLFSBHQQXIAQEC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1C2=CC=CC=C2CN1CC3=NC4=NNC(=O)C5=C4C(=CC=C5)N3
2.2 Other Identifiers
2.2.1 UNII
9X5A2QIA7C
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 8-(isoindolin-2-ylmethyl)-2,9-dihydro-3h-pyridazino(3,4,5-de)quinazolin-3-one

2. E-7449

3. E7449

4. Parp Inhibitor 2x-121

5. Stenoparib

2.3.2 Depositor-Supplied Synonyms

1. 1140964-99-3

2. E7449

3. E-7449

4. Stenoparib

5. Parp Inhibitor 2x-121

6. Unii-9x5a2qia7c

7. 9x5a2qia7c

8. Cid 25267262

9. 2x-121

10. 11-(1,3-dihydroisoindol-2-ylmethyl)-2,3,10,12-tetrazatricyclo[7.3.1.05,13]trideca-1(12),5(13),6,8,10-pentaen-4-one

11. 3h-pyridazino(3,4,5-de)quinazolin-3-one, 8-((1,3-dihydro-2h-isoindol-2-yl)methyl)-1,2-dihydro-

12. Stenoparib [who-dd]

13. Schembl3886731

14. Chembl3644587

15. Schembl22023558

16. Bcp19934

17. Ex-a1282

18. Nsc783107

19. Nsc798215

20. S8419

21. Zinc59277233

22. Ccg-267668

23. Cs-3479

24. Nsc-783107

25. Nsc-798215

26. Sb16888

27. 8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one

28. Ac-36842

29. Hy-12418

30. A909458

31. Q27273339

32. 8-(isoindolin-2-ylmethyl)-2,9-dihydro-3h-pyridazino[3,4,5-de]quinazolin-3-one

2.4 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 317.3 g/mol
Molecular Formula C18H15N5O
XLogP31.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass317.12766012 g/mol
Monoisotopic Mass317.12766012 g/mol
Topological Polar Surface Area69.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity586
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Stenoparib Manufacturers

A Stenoparib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Stenoparib, including repackagers and relabelers. The FDA regulates Stenoparib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Stenoparib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Stenoparib Suppliers

A Stenoparib supplier is an individual or a company that provides Stenoparib active pharmaceutical ingredient (API) or Stenoparib finished formulations upon request. The Stenoparib suppliers may include Stenoparib API manufacturers, exporters, distributors and traders.

Stenoparib GMP

Stenoparib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Stenoparib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Stenoparib GMP manufacturer or Stenoparib GMP API supplier for your needs.

Stenoparib CoA

A Stenoparib CoA (Certificate of Analysis) is a formal document that attests to Stenoparib's compliance with Stenoparib specifications and serves as a tool for batch-level quality control.

Stenoparib CoA mostly includes findings from lab analyses of a specific batch. For each Stenoparib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Stenoparib may be tested according to a variety of international standards, such as European Pharmacopoeia (Stenoparib EP), Stenoparib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Stenoparib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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