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Chemistry

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Also known as: Antimony sodium gluconate, Solusurmin, Stibogluconate sodium, Trisodium;(4r,5s,6r)-2-[[(4r,5s,6r)-4-carboxylato-6-[(1r)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinan-2-yl]oxy]-6-[(1r)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinane-4-carboxylate;nonahydrate, Solyusurmin, Solustin
Molecular Formula
C12H36Na3O26Sb2+
Molecular Weight
908.89  g/mol
InChI Key
CUEDNFKBTFCOSV-UZVLBLASSA-L

Stibogluconate Sodium
Antimony complex where the metal may exist in either the pentavalent or trivalent states. The pentavalent gluconate is used in leishmaniasis. The trivalent gluconate is most frequently used in schistosomiasis.
1 2D Structure

Stibogluconate Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
trisodium;(4R,5S,6R)-2-[[(4R,5S,6R)-4-carboxylato-6-[(1R)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,25-dioxastibinan-2-yl]oxy]-6-[(1R)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,25-dioxastibinane-4-carboxylate;nonahydrate
2.1.2 InChI
InChI=1S/2C6H10O7.3Na.9H2O.3O.2Sb/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;;;;;;;;;;;;;;/h2*2-5,7-8,10H,1H2,(H,12,13);;;;9*1H2;;;;;/q2*-2;3*+1;;;;;;;;;;;;;2*+2/p-2/t2*2-,3-,4+,5-;;;;;;;;;;;;;;;;;/m11................./s1
2.1.3 InChI Key
CUEDNFKBTFCOSV-UZVLBLASSA-L
2.1.4 Canonical SMILES
C(C(C1C(C(O[Sb](=O)(O1)O[Sb]2(=O)OC(C(C(O2)C(=O)[O-])O)C(CO)O)C(=O)[O-])O)O)O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]
2.1.5 Isomeric SMILES
C([C@H]([C@@H]1[C@@H]([C@@H](O[Sb](=O)(O1)O[Sb]2(=O)O[C@@H]([C@@H]([C@@H](O2)C(=O)[O-])O)[C@@H](CO)O)C(=O)[O-])O)O)O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[Na+]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Antimony Gluconate Sodium

2. Antimony Gluconic Acid

3. Antimony Sodium Gluconate

4. Antimony Sodium Gluconates

5. Myostibin

6. Pentostam

7. Sodium Gluconates, Antimony

8. Sodium, Stibogluconate

9. Solustibosan

10. Stibatin

11. Stibogluconate Sodium

12. Stibogluconate, Sodium

13. Triostam

2.2.2 Depositor-Supplied Synonyms

1. Antimony Sodium Gluconate

2. Solusurmin

3. Stibogluconate Sodium

4. Trisodium;(4r,5s,6r)-2-[[(4r,5s,6r)-4-carboxylato-6-[(1r)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinan-2-yl]oxy]-6-[(1r)-1,2-dihydroxyethyl]-5-hydroxy-2-oxo-1,3,2lambda5-dioxastibinane-4-carboxylate;nonahydrate

5. Solyusurmin

6. Solustin

7. Stibogluconate Sodique

8. Estibogluconato Sodico [spanish]

9. Natrii Stibogluconas [inn-latin]

10. Estibogluconato Sodico [inn-spanish]

11. Sodium Stibogluconate [inn:ban:dcf]

12. Stibogluconate De Sodium [inn-french]

13. Antimony(v) Derivative Of Sodium Gluconate

14. Unii-apj6285y89

15. Trinatrium Bis(gluconato(3)-o2,o3,o4)hydroxooxido-oxy-bis-antimonat(v)

16. D-gluconic Acid, 2,4:2',4'-o-(oxydistibylidyne)bis-, Sb,sb'-dioxide, Trisodium Salt, Nonahydrate

2.3 Create Date
2007-08-23
3 Chemical and Physical Properties
Molecular Weight 908.89 g/mol
Molecular Formula C12H36Na3O26Sb2+
Hydrogen Bond Donor Count15
Hydrogen Bond Acceptor Count26
Rotatable Bond Count6
Exact Mass908.92682 g/mol
Monoisotopic Mass906.92641 g/mol
Topological Polar Surface Area291 Ų
Heavy Atom Count43
Formal Charge1
Complexity699
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count13
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiprotozoal Agents

Substances that are destructive to protozoans. (See all compounds classified as Antiprotozoal Agents.)


Schistosomicides

Agents that act systemically to kill adult schistosomes. (See all compounds classified as Schistosomicides.)


4.2 ATC Code

P - Antiparasitic products, insecticides and repellents

P01 - Antiprotozoals

P01C - Agents against leishmaniasis and trypanosomiasis

P01CB - Antimony compounds

P01CB02 - Sodium stibogluconate


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ABOUT THIS PAGE

Stibogluconate Sodium Manufacturers

A Stibogluconate Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Stibogluconate Sodium, including repackagers and relabelers. The FDA regulates Stibogluconate Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Stibogluconate Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Stibogluconate Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Stibogluconate Sodium Suppliers

A Stibogluconate Sodium supplier is an individual or a company that provides Stibogluconate Sodium active pharmaceutical ingredient (API) or Stibogluconate Sodium finished formulations upon request. The Stibogluconate Sodium suppliers may include Stibogluconate Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Stibogluconate Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Stibogluconate Sodium GMP

Stibogluconate Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Stibogluconate Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Stibogluconate Sodium GMP manufacturer or Stibogluconate Sodium GMP API supplier for your needs.

Stibogluconate Sodium CoA

A Stibogluconate Sodium CoA (Certificate of Analysis) is a formal document that attests to Stibogluconate Sodium's compliance with Stibogluconate Sodium specifications and serves as a tool for batch-level quality control.

Stibogluconate Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Stibogluconate Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Stibogluconate Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Stibogluconate Sodium EP), Stibogluconate Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Stibogluconate Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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