Synopsis
Synopsis
0
API Suppliers
0
USDMF
0
CEP/COS
0
JDMF
0
EU WC
0
KDMF
0
NDC API
0
VMF
0
Listed Suppliers
0
EDQM
0
USP
0
JP
0
Others
0
FDF Dossiers
0
FDA Orange Book
0
Europe
0
Canada
0
Australia
0
South Africa
0
Listed Dossiers
DRUG PRODUCT COMPOSITIONS
0
US Patents
0
US Exclusivities
0
Health Canada Patents
US Medicaid
NA
Annual Reports
NA
Regulatory FDF Prices
NA
0
API
0
FDF
0
Data Compilation #PharmaFlow
0
Stock Recap #PipelineProspector
0
Weekly News Recap #Phispers
0
News #PharmaBuzz
1. Tak-981
2. 1858276-04-6
3. Subasumstat [usan]
4. Xq43h3v6m1
5. Sumoylation Inhibitor Tak-981
6. [(1r,2s,4r)-4-[[5-[[4-((1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl]carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl Sulfamate
7. 1858276-04-6 (free)
8. ((1r,2s,4r)-4-((5-(4-((r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl Sulfamate
9. ((1r,2s,4r)-4-((5-((4-((1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthien-2-yl)carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl Sulfamate
10. [(1r,2s,4r)-4-[(5-[4-[(1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl)amino]-2-hydroxycyclopentyl]methyl Sulfamate
11. [(1r,2s,4r)-4-[[5-[4-[(1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl Sulfamate
12. Tak981 Oxalate
13. Tak-981 Oxalate
14. Subasumstat [inn]
15. Subasumstat (proposed Inn)
16. Unii-xq43h3v6m1
17. Subasumstat [who-dd]
18. Tak981
19. Chembl4862901
20. Schembl17398333
21. Gtpl11305
22. Bdbm462958
23. Tak 981; Tak981
24. Bcp30806
25. Ex-a3291
26. Mfcd32062692
27. Nsc820784
28. Who 11858
29. Nsc-820784
30. Us10780090, Compound I-263a
31. Us10780090, Compound I-263b
32. Ac-35773
33. Example 133 [wo2016004136a1]
34. Hy-111789
35. Cs-0091878
36. D81004
37. A935089
38. I-263a [wo2016004136a1]
39. [(1r,2s,4r)-4-[[5-[4-[(1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-thiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxy-cyclopentyl]methyl Sulfamate
40. [(1r,2s,4r)-4-{[5-({4-[(1r)-7-chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methyl-2- Thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl Sulfamate
41. Sulfamic Acid, ((1r,2s,4r)-4-((5-((4-((1r)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl)-5-methyl-2-thienyl)carbonyl)-4-pyrimidinyl)amino)-2-hydroxycyclopentyl)methyl Ester
Molecular Weight | 578.1 g/mol |
---|---|
Molecular Formula | C25H28ClN5O5S2 |
XLogP3 | 3.5 |
Hydrogen Bond Donor Count | 4 |
Hydrogen Bond Acceptor Count | 11 |
Rotatable Bond Count | 8 |
Exact Mass | 577.1220391 g/mol |
Monoisotopic Mass | 577.1220391 g/mol |
Topological Polar Surface Area | 193 Ų |
Heavy Atom Count | 38 |
Formal Charge | 0 |
Complexity | 942 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 4 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Subasumstat binds and forms an adduct with SUMO, stopping the protein from transferring from the SUMO-activating enzyme to SUMO-conjugating enzyme UBC9. Downstream, this stops many sumoylated protein-mediated pathways from occurring in tumor cells, like DNA repair, metastasis, and proliferation. Subasumstat is also able to increase the production of type 1 interferon, which activates antitumor immune responses in cells and signals for increased tumor cell death.
ABOUT THIS PAGE
80
PharmaCompass offers a list of Subasumstat API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Subasumstat manufacturer or Subasumstat supplier for your needs.
Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Subasumstat manufacturer or Subasumstat supplier.
PharmaCompass also assists you with knowing the Subasumstat API Price utilized in the formulation of products. Subasumstat API Price is not always fixed or binding as the Subasumstat Price is obtained through a variety of data sources. The Subasumstat Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A Subasumstat manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Subasumstat, including repackagers and relabelers. The FDA regulates Subasumstat manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Subasumstat API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
A Subasumstat supplier is an individual or a company that provides Subasumstat active pharmaceutical ingredient (API) or Subasumstat finished formulations upon request. The Subasumstat suppliers may include Subasumstat API manufacturers, exporters, distributors and traders.
Subasumstat Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of Subasumstat GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Subasumstat GMP manufacturer or Subasumstat GMP API supplier for your needs.
A Subasumstat CoA (Certificate of Analysis) is a formal document that attests to Subasumstat's compliance with Subasumstat specifications and serves as a tool for batch-level quality control.
Subasumstat CoA mostly includes findings from lab analyses of a specific batch. For each Subasumstat CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
Subasumstat may be tested according to a variety of international standards, such as European Pharmacopoeia (Subasumstat EP), Subasumstat JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Subasumstat USP).