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    Also known as: Butanedioic acid, 110-15-6, Amber acid, Wormwood acid, Asuccin, Dihydrofumaric acid
    Molecular Formula
    C4H6O4
    Molecular Weight
    118.09  g/mol
    InChI Key
    KDYFGRWQOYBRFD-UHFFFAOYSA-N
    FDA UNII
    AB6MNQ6J6L
    Succinic Acid
    A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
    1 2D Structure

    Succinic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid
    2.1.2 InChI
    InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    KDYFGRWQOYBRFD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    AB6MNQ6J6L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,2 Ethanedicarboxylic Acid

    2. 1,2-ethanedicarboxylic Acid

    3. 1,4 Butanedioic Acid

    4. 1,4-butanedioic Acid

    5. Ammonium Succinate

    6. Butanedioic Acid

    7. Potassium Succinate

    8. Succinate

    9. Succinate, Ammonium

    10. Succinate, Potassium

    2.3.2 Depositor-Supplied Synonyms

    1. Butanedioic Acid

    2. 110-15-6

    3. Amber Acid

    4. Wormwood Acid

    5. Asuccin

    6. Dihydrofumaric Acid

    7. Katasuccin

    8. 1,2-ethanedicarboxylic Acid

    9. Bernsteinsaure

    10. Ethylenesuccinic Acid

    11. 1,4-butanedioic Acid

    12. Wormwood

    13. Succinicum Acidum

    14. Butandisaeure

    15. Acidum Succinicum

    16. Butanedionic Acid

    17. Kyselina Jantarova

    18. Butane Diacid

    19. Ethylene Dicarboxylic Acid

    20. Spirit Of Amber

    21. Bernsteinsaure [german]

    22. Kyselina Jantarova [czech]

    23. Ammonium Succinate

    24. Hsdb 791

    25. Succinic-acid

    26. Mfcd00002789

    27. Succ

    28. Nsc 106449

    29. Ai3-06297

    30. Ab6mnq6j6l

    31. Nsc-106449

    32. Butanedioic Acid, Homopolymer

    33. E363

    34. Fema No. 4719

    35. Chebi:15741

    36. C4-beta-polymorph

    37. Nsc25949

    38. Succinicacid(industrialgrade&foodgrade)

    39. Ncgc00159372-02

    40. Ncgc00159372-04

    41. Succinellite

    42. Acide Succinique

    43. Sal Succini

    44. Acid Of Amber

    45. Dsstox_cid_3602

    46. Wln: Qv2vq

    47. Dsstox_rid_77102

    48. Dsstox_gsid_23602

    49. 26776-24-9

    50. Sin

    51. Ethylene Succinic Acid

    52. Ethanedicarboxylic Acid

    53. Bernsteinsaeure

    54. Sodium Succinate (anhydrous)

    55. Succinate, 9

    56. Acide Butanedioique

    57. Cas-110-15-6

    58. Succinic Acid [nf]

    59. Succinic Acid (8ci)

    60. Butanedioic Acid (9ci)

    61. Einecs 203-740-4

    62. Unii-ab6mnq6j6l

    63. Brn 1754069

    64. Dihydrofumarate

    65. Succinicate

    66. Butanedioic Acid Diammonium Salt

    67. Salt Of Amber

    68. 1cze

    69. Nat.succinic Acid

    70. 1,4-butanedioate

    71. Succinic Acid, 6

    72. Succinic Acid, Fcc

    73. Succinic Acide,(s)

    74. Succinic Acid (sa)

    75. 1,4-butandioic Acid

    76. Succinic Acid, 99%

    77. Succinic Acid, Natural

    78. 4lh2

    79. 1,2-ethanedicarboxylate

    80. Substrate Analogue, 11

    81. Suc

    82. Succinic Acid, Acs Grade

    83. Bmse000183

    84. Bmse000968

    85. Chembl576

    86. Ec 203-740-4

    87. Succinic Acid [ii]

    88. Succinic Acid [mi]

    89. Hooc-ch2-ch2-cooh

    90. Succinic Acid [fcc]

    91. A 12084

    92. Succinic Acid [hsdb]

    93. Succinic Acid [inci]

    94. 4-02-00-01908 (beilstein Handbook Reference)

    95. Succinic Acid [vandf]

    96. Succinic Acid [mart.]

    97. Gtpl3637

    98. Succinic Acid [usp-rs]

    99. Succinic Acid [who-dd]

    100. Dtxsid6023602

    101. Succinicum Acidum [hpus]

    102. Bdbm26121

    103. Succinic Acid (butanedioic Acid)

    104. Hms3885o04

    105. Zinc895030

    106. Hy-n0420

    107. Str02803

    108. Tox21_111612

    109. Tox21_201918

    110. Tox21_303247

    111. Bbl002473

    112. Lmfa01170043

    113. Nsc-25949

    114. Nsc106449

    115. S3791

    116. Stk387105

    117. Succinic Acid [usp Impurity]

    118. Succinic Acid, >=99%, Fcc, Fg

    119. Succinic Acid, Bioxtra, >=99.0%

    120. Akos000118899

    121. Tox21_111612_1

    122. Ccg-266069

    123. Db00139

    124. Ncgc00159372-03

    125. Ncgc00159372-05

    126. Ncgc00159372-06

    127. Ncgc00257092-01

    128. Ncgc00259467-01

    129. Succinic Acid, Acs Reagent, >=99.0%

    130. Bp-21128

    131. Succinic Acid, Reagentplus(r), >=99.0%

    132. Adipic Acid Impurity B [ep Impurity]

    133. Cs-0008946

    134. Ft-0652509

    135. Ft-0773657

    136. N1941

    137. S0100

    138. Succinic Acid 100 Microg/ml In Acetonitrile

    139. Succinic Acid, P.a., Acs Reagent, 99.0%

    140. Succinic Acid, Saj First Grade, >=99.0%

    141. Succinic Acid High Purity Grade 2.5kg

    142. Succinic Acid, Purum P.a., >=99.0% (t)

    143. Succinic Acid, Saj Special Grade, >=99.5%

    144. 1,4-butanedioic Acid (succinic Acid)

    145. A14596

    146. C00042

    147. D85169

    148. Succinic Acid, Vetec(tm) Reagent Grade, 98%

    149. Ab01332192-02

    150. Q213050

    151. Sr-01000944556

    152. J-002386

    153. Sr-01000944556-2

    154. Z57127453

    155. F2191-0239

    156. 37e8fffb-70da-4399-b724-476bd8715ef0

    157. Succinic Acid, Certified Reference Material, Tracecert(r)

    158. Succinic Acid, Puriss. P.a., Acs Reagent, >=99.5% (t)

    159. Succinic Acid, United States Pharmacopeia (usp) Reference Standard

    160. Succinic Acid, Matrix Substance For Maldi-ms, >=99.5% (t), Ultra Pure

    161. Succinic Acid, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99.0%

    162. Succinic Acid, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture

    163. Succinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 118.09 g/mol
    Molecular Formula C4H6O4
    XLogP3-0.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass118.02660867 g/mol
    Monoisotopic Mass118.02660867 g/mol
    Topological Polar Surface Area74.6 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity92.6
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    /EXPTL THER/ Succinic acid (100 mM) significantly inhibited systemic anaphylaxis induced by compound 48/80 /a potent mast cell degranulator/ in mice and dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl IgE. Further 10 and 100 mM significantly inhibited histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-dinitrophenyl IgE. In addition succinic acid (0.1 and 1 mM) had a significant inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha secretion from rat peritoneal mast cells. The level of cyclic AMP in rat peritoneal mast cells, when succinic acid (100 mM) was added, transiently and significantly increased about 4 times compared with that of basal cells. These results suggest a possible use of succinic acid in managing mast cell-dependent anaphylaxis.

    Kim HM et al;

    4.2 Drug Indication

    For nutritional supplementation, also for treating dietary shortage or imbalance

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Succinic acid occurs normally in human urine (1.9-8.8 mg/L).

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 758

    5.2 Metabolism/Metabolites

    Succinic acid is a normal intermediary metabolite and a constituent of the citric acid cycle. It is readily metabolized when administered to animals, but may be partly excreted unchanged in the urine if large doses are fed.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 757

    5.3 Mechanism of Action

    Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes.

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    Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs) and finished dosage forms. For the past three years, the company focused on extracting alkaloid opiates, controlled substances, and narcotics. The APIs are widely used by major pharmaceutical companies nationwide and exported to the Middle East. All production adheres to local GMP standards in an SOP-driven environment with modern systems and utilities, ensuring the highest quality and safety.
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    QUALITY CHEMICALS, SL is a fine chemicals manufacturer of pure salts (mineral, metallic, organic, etc.), solvents, acids, basis and some organics. Our products are destined to a wide range of industries, among them: pharmaceutical, laboratory reagent, food and cosmetics. Customized synthesis, purification, packaging and labelling are available. All these products are produced under international standards at our two plants, one of which works on GMP conditions. Furthermore, Quality Chemicals develops and manufactures tailored made chemicals on GMP basis, under confidential agreement. We can be your GMP partner!
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(VT020PR.0C025K) (RAW MATERIAL FOR COSMETIC USE)","address":"509,SHAH NIHAR (WORLI) INDL.ESTAT","city":"WORLI, MUMBAI, MAHARASHTRA.","supplier":"QUIMIVITA PRODUCTS SL","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"VALUETREE INGREDIENTS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"6.9","totalValueFC":"434.1","currency":"EUR","unitRateINR":"1455.3","date":"28-Sep-2024","totalValueINR":"36381.9","totalValueInUsd":"434.1","indian_port":"Bombay Air","hs_no":"29171930","bill_no":"5858196","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"BALMES 245,6 PLANTA-08006BARCELONA SDNF SDNF SPAIN","customerAddress":"509,SHAH NIHAR (WORLI) INDL.ESTAT"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1728844200,"product":"SUCCINIC ACID CRYST., EMPROVE ESSENTIAL CHP,NF,JPE,ACS 1PCSX 50KG","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"3121.4","totalValueFC":"1862","currency":"INR","unitRateINR":"3129.2","date":"14-Oct-2024","totalValueINR":"156459.53","totalValueInUsd":"1862","indian_port":"JNPT","hs_no":"29171930","bill_no":"6110633","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"Frankfurter Strasse 250, 64293 Darm stadt,(BENEFICIARY MERCKFINANCIALS SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"}]
    11-Jan-2021
    14-Oct-2024
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    INTERMEDIATES SUPPLIERS

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    USV Private Limited

    India
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    Virtual BoothUSV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

    (9H-fluoren-9-yl)methyl ((2R,3R)-1,3dihydroxybutan...

    CAS Number : 176380-53-3

    End Use API : Succinic Acid

    About The Company : USV is a leading health care company with focus on Active Pharmaceutical Ingredients (marketed globally with emphasis on regulated markets of USA, European Unio...

    USV Private Limited

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    Acarpia Farmaceutici

    Italy
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    Succinic Acid; Potassium Citrate; L-Tartaric Acid; Potassium hydrogen carbonate

    Brand Name : Potassion

    Dosage Form : Granules

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    Registration Country : Italy

    Succinic Acid; Potassium Citrate; L-Tartaric Acid; Potassium hydrogen carbonate

    Brand Name : Potassion

    Dosage Form : Granules

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    Registration Country : Italy

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    Acarpia Farmaceutici

    Italy
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    Italy
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    Packaging :

    Regulatory Info :

    Succinic Acid; Potassium Citrate; L-Tartaric Acid; Potassium hydrogen carbonate

    Dosage : Granules

    Dosage Strength : 100MG; 250MG; 50MG; 50...

    Brand Name : Potassion

    Approval Date :

    Application Number :

    Registration Country : Italy

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    Excipient Market Overview: Roquette, Seqens, Evonik make strategic moves; new guidelines deal with contamination

    Excipient Market Overview: Roquette, Seqens, Evonik make strategic moves; new guidelines deal with contamination

    The pharmaceutical industry has long recognized the critical role excipients or inactive ingredients play in drug formulation and delivery. Excipients can comprise up to 90 percent of a medicine's total ingredients and serve crucial functions as binders, disintegrants, coatings, preservatives, colors, and flavorings. According to recent market research, the pharmaceutical excipients market was valued at US$ 9.27 billion in 2023. It is growing at a compound annual growth rate (CAGR) of 7.03 percent and is projected to reach US$ 18.48 billion by 2032. The main factors driving market growth is an increased demand for multifunctional excipients, coupled with the expanding use of generic medications. The development in the biologics sector and advancements in nanotechnology are also contributing significantly to market growth. Major excipient providers include BASF, Evonik, Merck KGaA owned MilliporeSigma, Gangwal Healthcare, Roquette Frères, DuPont, Croda International, Seqens, Boai NKY Pharmaceuticals, PMC Isochem, Minakem, Kewpie Corporation, Ashland Global, SPI Pharma, Pfanstiehl, Nanjing Well Pharmaceutical, ICE Pharma, Anhui Ribobay Pharmaceutical and Nippon Fine Chemical.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available) WHO, India’s CDSCO tighten regulations; new GMP guidelines implemented to curb contamination Last year, the World Health Organization (WHO) issued a health alert linking at least 300 child deaths in the Gambia, Uzbekistan, and Indonesia to the ingestion of contaminated cough syrups containing unacceptable levels of diethylene glycol (DEG) and ethylene glycol (EG). In response to the tragic events, the WHO released two draft appendices to its guideline on good manufacturing practices (GMPs) for excipients this year. Manufacturers are now required to use suitable risk assessment tools to identify and mitigate potential hazards.  Since India-made cough syrups had been linked to the deaths, India’s drug regulator — Central Drugs Standard Control Organization (CDSCO) — took steps to prevent contamination, and advised drugmakers to only use pharmaceutical-grade excipients from approved sources. Furthermore, the Indian Health Ministry proposed amendments to the Drugs and Cosmetics Rules, 1945 to include details of excipients on drug labels. While listing all excipients on every strip of medicine may be challenging, the ministry suggested mentioning those causing hypersensitivity on the label. Applicants now mandatorily need to submit evidence of stability and safety of excipients. These regulatory developments have significant implications for excipient manufacturers and pharmaceutical companies worldwide. Leading pharmaceutical excipient firms like Gangwal Healthcare, Sigachi Industries, and Nitika Pharmaceuticals are well-positioned to meet these heightened quality and safety standards, given their long-standing commitment to producing high-quality, compliant excipients.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Roquette buys IFF’s pharma unit for US$ 2.85 bn; Evonik opens new spray-drying facility in Darmstadt In a significant industry move, France-based Roquette entered into an agreement to acquire IFF's pharma solutions business in a deal valued at US$ 2.85 billion. This acquisition is set to rebalance family-owned Roquette’s portfolio around health and nutrition. The deal is expected to accelerate Roquette’s growth and significantly strengthen its presence in the excipients market. Evonik has opened a new facility for drying aqueous dispersions of its Eudragit polymers at its site in Darmstadt, Germany. The facility will help Evonik meet increasing demand from drugmakers for its oral drug delivery solutions. The plant uses green energy solutions. The company has also partnered University of Mainz to commercialize a new class of polyethylene glycols (PEG) lipids for nucleic acid delivery. Evonik’s Health Care business has been growing its nucleic acid drug and vaccine delivery portfolio.  Germany’s Johannes Gutenberg University of Mainz was the first to develop randomized polyethylene glycols (rPEGs). This collaboration aims to expand Evonik’s toolbox of technologies for nucleic acid-based medicines, offering an improved immunogenicity profile for lipid nanoparticle carriers used in mRNA vaccines and therapeutics. Asahi Kasei made significant strides in addressing a pressing industry concern that emerged in 2018 when potentially carcinogenic nitrosamine impurities were detected in several pharmaceuticals. Guided by regional authorities, such as the European Medicines Agency and the US Food and Drug Administration, the pharmaceutical industry has been carrying out extensive assessments and research to identify the cause of these impurities. In response to this challenge, Asahi Kasei developed its Ceolus microcrystalline cellulose with extremely low nitrite levels. The Japanese company achieved nitrite concentrations of 0.1 micrograms per gram or less, which is equivalent to 0.1 parts per million (ppm). The company also started full commercial operation of its second manufacturing facility for Ceolus in Japan, enhancing supply capacity and stability. JRS Pharma and Gujarat Microwax opened a state-of-the-art cotton-based croscarmellose sodium plant in Mehsana, Gujarat (India). This facility aims to produce high-quality excipients that meet global standards, potentially reducing India's dependency on imports and boosting its presence in the global excipient market. The Indian excipient industry accounts for less than 1 percent of the global market share.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Seqens to advance innovative polymer; biologics, personalized medicine create demand for specialized excipients Recent industry collaborations highlight the ongoing innovation in novel excipients. France’s Seqens, with over 20 years of polymer development experience, was chosen by Pleryon Therapeutics to advance its leading osteoarthritis candidate – an innovative GMP polymer. This collaboration leverages Seqens’ newly expanded and modernized cGMP plant in Aramon, France, demonstrating the industry’s commitment to investing in advanced manufacturing capabilities for novel excipients.  The rise of biologics and personalized medicine has created a demand for specialized excipients capable of stabilizing complex molecules and enabling targeted drug delivery. Roquette’s launch of Lycagel Flex, a hydroxypropyl pemix for nutraceutical and pharmaceutical softgel capsules, exemplifies this trend. Built on Roquette’s market-first Lycagel pea starch technology, this plant-based alternative to gelatin offers manufacturers the flexibility to customize formulations for a range of production and end-user needs. The innovative pea starch foundation also underscores the industry’s move towards sustainable bio-based excipients. The trend towards patient-centric drug development has also influenced excipient innovation. Excipients that can improve palatability, ease of swallowing, or enable novel dosage forms (such as orally disintegrating tablets) are in high demand. For example, IFF brought a super disintegrant Ac-Di-Sol, that supports faster disintegration and drug dissolution in oral disintegrating tablets, improving patient experience.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Our view The heightened regulatory scrutiny on excipients due to product contamination incidents has created a high risk perception and uncertainty around the regulatory acceptance of novel excipients. That said, novel excipients are central to the development of new drug modalities and therapies. Going forward, sustainability will also become an increasingly important factor in excipient selection and development. As the industry innovates towards biologics, personalized therapies, and patient-centric formulations, the role of high-quality, multifunctional excipients will only grow more vital in ensuring drug stability, bioavailability, and patient compliance. Companies that can navigate the complex regulatory landscape, invest in R&D, and offer high-quality, multifunctional excipients will be well-positioned to succeed in this evolving market.   
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    12 Sep 2024
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    NEWS #PharmaBuzz

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    Pfanstiehl Launches Succinic Acid Excipient Grade
    Pfanstiehl Launches Succinic Acid Excipient Grade

    29 Nov 2024

    // PTECHNOLOGY

    https://www.pharmaceutical-technology.com/contractors/api-biologics/pfanstiehl/pressreleases/succinic-acid-excipient-grade/

    PTECHNOLOGY
    29 Nov 2024
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    APIs

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    Various APIs needed in Italy [ENA14114]
    A pharmaceutical company that focuses in development and manufacturing of various finished dosage formulations is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with GMP & CoA. 1. Potassium Bicarbonate (1.5 MT/ annum) API 2. Potassium Citrate (750 kg/ annum) API 3. Potassium Maleate (300 kg/ annum) API 4. Potassium Tartrate (150 kg/ annum) API 5. Potassium Succinate (300 kg/ annum) API
    27 Jun 2022

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    27 Jun 2022

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    27 Jun 2022

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    Various APIs needed in Slovakia [ENA09953]
    A company based in the US that is focused on providing its customers with the highest quality organic sesame products is looking for suppliers of Various APIs for commercial purposes. The products must be organically certified for the EU. The final market is the UK. 1. Organic Wormwood Powder 2. Organic Red Clover Extract 3. Organic Papaya Leaf Powder
    16 Mar 2021

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    16 Mar 2021

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    Enquiry// Adipic Acid and Succinic Acid (Minimum Order Quantity) needed in Bangladesh [ENA00938]
    One of the rising pharmaceutical companies in Bangladesh is looking for suppliers of Adipic Acid and Succinic Acid (Minimum Order Quantity). Interested suppliers must contact Md Ismail Hossain Mithun via Email: mithun@mbiologix.com or Tel: 01969617131. Documents required: COA, MOA, MSDS, SDS and GMP certificate.
    23 May 2018

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    23 May 2018

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    23 May 2018

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