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    Chemistry

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    Also known as: 577-11-7, Dioctyl sodium sulfosuccinate, Dioctyl sulfosuccinate sodium salt, Aerosol ot, Constonate, Dioctylal
    Molecular Formula
    C20H37NaO7S
    Molecular Weight
    444.6  g/mol
    InChI Key
    APSBXTVYXVQYAB-UHFFFAOYSA-M
    FDA UNII
    F05Q2T2JA0
    Docusate Sodium
    All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.
    1 2D Structure

    Docusate Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate
    2.1.2 InChI
    InChI=1S/C20H38O7S.Na/c1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h16-18H,5-15H2,1-4H3,(H,23,24,25);/q;+1/p-1
    2.1.3 InChI Key
    APSBXTVYXVQYAB-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)[O-].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    F05Q2T2JA0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aerosol Ot

    2. Colace

    3. Deh Na Ss

    4. Deh-na-ss

    5. Diethylhexyl Sodium Sulfosuccinate

    6. Dioctyl Sulfosuccinate

    7. Dioctyl Sulfosuccinate, Sodium

    8. Dioctyl Sulfosuccinates

    9. Dioctyl Sulfosuccinic Acid

    10. Dioctyl Sulfosuccinic Acid, Ammonium Salt

    11. Dioctyl Sulfosuccinic Acid, Barium Salt

    12. Dioctyl Sulfosuccinic Acid, Calcium Salt

    13. Dioctyl Sulfosuccinic Acid, Magnesium Salt

    14. Dioctyl Sulfosuccinic Acid, Potassium Salt

    15. Dioctyl Sulfosuccinic Acid, Sodium Salt

    16. Dioctylsulfosuccinate

    17. Dioctylsulphosuccinate, Sodium

    18. Docusate

    19. Docusate Calcium

    20. Docusate Potassium

    21. Doss

    22. Sodium Bis(2-ethylhexyl)sulfosuccinate

    23. Sodium Dioctyl Sulfosuccinate

    24. Sodium Dioctylsulphosuccinate

    25. Sodium Sulfosuccinate, Diethylhexyl

    26. Sulfosuccinate, Diethylhexyl Sodium

    27. Sulfosuccinate, Dioctyl

    28. Sulfosuccinates, Dioctyl

    29. Sulfosuccinic Acid Bis(2-ethylhexyl) Ester

    2.3.2 Depositor-Supplied Synonyms

    1. 577-11-7

    2. Dioctyl Sodium Sulfosuccinate

    3. Dioctyl Sulfosuccinate Sodium Salt

    4. Aerosol Ot

    5. Constonate

    6. Dioctylal

    7. Diotilan

    8. Disonate

    9. Molatoc

    10. Regutol

    11. Doxol

    12. Nevax

    13. Velmol

    14. Docusate (sodium)

    15. Doxinate

    16. Colace

    17. Dialose

    18. Molcer

    19. Soliwax

    20. Waxsol

    21. Docusate Sodium Salt

    22. Diox

    23. Manoxol Ot

    24. Adekacol Ec 8600

    25. Bis(2-ethylhexyl) Sulfosuccinate Sodium Salt

    26. Dioctyl Sulfosuccinate Sodium

    27. Comfolax

    28. Coprola

    29. Dulcivac

    30. Eurowet

    31. Jamylene

    32. Empimin Op70

    33. Sanmorin Ot 70n

    34. Airrol Ct-1

    35. Mackanate Dos-70

    36. Nikkol Otp-75

    37. Triton Gr-pg 70

    38. Gemtex Pa-70

    39. Rapisol A 30

    40. Bis(2-ethylhexyl) Sodium Sulfosuccinate

    41. Nissan Rapisol A 30

    42. Dioctyl Ester Of Sodium Sulfosuccinic Acid

    43. Ins No.480

    44. Monawet Mo 65-150

    45. Sodium 1,4-bis[(2-ethylhexyl)oxy]-1,4-dioxobutane-2-sulfonate

    46. Ins-480

    47. Butanedioic Acid, Sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt

    48. F05q2t2ja0

    49. Sodium 1,4-bis(2-ethylhexyl) Sulfosuccinate

    50. Diethylhexyl Sodium Sulfosuccinate

    51. Sodium Docusate

    52. Nsc-760404

    53. Aot

    54. Diomedicone

    55. Clestol

    56. Complemix

    57. Defilin

    58. Dioctlyn

    59. Diosuccin

    60. Dulsivac

    61. Laxinate

    62. Mervamine

    63. Molofac

    64. Requtol

    65. Sobital

    66. Coprol

    67. Diovac

    68. Konlax

    69. Kosate

    70. Obston

    71. Softil

    72. Revac

    73. E 480

    74. E-480

    75. Modane Soft

    76. Dsstox_cid_2959

    77. Alcopol O

    78. Alphasol Ot

    79. Manoxal Ot

    80. Sulfimel Dos

    81. Aerosol Aot

    82. Aerosol Gpg

    83. Wetaid Sr

    84. Dsstox_rid_76808

    85. Aerosol Ot-a

    86. Dsstox_gsid_22959

    87. Laxinate 100

    88. Sanmorin Ot 70

    89. Triton Gr 7

    90. Triton Gr-5

    91. Aerosol Ot 70pg

    92. Aerosol Ot 75

    93. Celanol Dos 65

    94. Celanol Dos 75

    95. Dess

    96. Humifen Wt 27g

    97. Monawet Md 70e

    98. Solusol-75%

    99. Nikkol Otp 70

    100. Aerosol A 501

    101. Alkasurf Ss-o 75

    102. Solusol-100%

    103. Nekal Wt-27

    104. Berol 478

    105. Coloxyl

    106. Dioctyl

    107. Docolace

    108. Docuprene

    109. Geriplex

    110. Silace

    111. Unilax

    112. Bloat Treatment

    113. Docusato Sodico

    114. Sodium Bis(2-ethylhexyl) Sulfosuccinate

    115. Dioctyl Sodium Sulfosuccinate (jan)

    116. Docusate Sodique

    117. Dialose Plus

    118. Natrii Dioctylsulfosuccinas

    119. Tex-wet 1001

    120. Senokot S

    121. Correctol Caplets

    122. Correctol Tablets

    123. Senokap Dss

    124. Docusatum Natricum

    125. D-s-s

    126. Doc Q Lace

    127. Cas-577-11-7

    128. Sodium Dioctyl Sulphosuccinate

    129. Feen-a-mint Pills

    130. Dioctyl Sodium Sulfosuccinate [jan]

    131. Correctol Extra Gentle Tablets

    132. Docusate Sodique [inn-french]

    133. Docusato Sodico [inn-spanish]

    134. Docusatum Natricum [inn-latin]

    135. Hsdb 3065

    136. 2-ethylhexyl Sulfosuccinate Sodium

    137. Ncgc00164140-03

    138. Einecs 209-406-4

    139. Sv 102

    140. Bis(2-ethylhexyl)sodium Sulfosuccinate

    141. Dioctyl Ester Of Sodium Sulfosuccinate

    142. Di-(2-ethylhexyl) Sodium Sulfosuccinate

    143. Sodium Di-(2-ethylhexyl) Sulfosuccinate

    144. Dioctyl Sodium Sulphosuccinat

    145. Unii-f05q2t2ja0

    146. Prenexa

    147. Purgasol

    148. Vinacol

    149. Bis(2-ethylhexyl) S-sodium Sulfosuccinate

    150. Ai3-00239

    151. Docusate Sod

    152. Sodium 1,4-bis(2-ethylhexyl)sulfosuccinate

    153. 1,4-bis(2-ethylhexyl) Sodium Sulfosuccinate

    154. Sodium Sulfodi-(2-ethylhexyl)-sulfosuccinate

    155. Senexon-s

    156. Folca[s Care Pme

    157. Folcal Dha

    158. Senna-s

    159. Di(2-ethylhexyl)sulfosuccinic Acid, Sodium Salt

    160. Bis(ethylhexyl) Ester Of Sodium Sulfosuccinic Acid

    161. Bis-2-ethylhexylester Sulfojantaranu Sodneho [czech]

    162. Colace (tn)

    163. Mfcd00012455

    164. Sodium Di(2-ethylhexyl)sulfosuccinate

    165. Sulfosuccinic Acid, Bis(2-ethylhexyl)ester Sodium Salt

    166. Docusate Sodium [usan:usp:inn:ban]

    167. Sol Sodowej Sulfobursztynianu Dwu-2-etyloheksylowego [polish]

    168. Docusate Sodium (usp)

    169. Docusate Sodium Solution

    170. Bis-2-ethylhexylester Sulfojantaranu Sodneho

    171. Chemax Doss/75e

    172. Succinic Acid, Sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt

    173. Ncgc00183136-01

    174. Ec 209-406-4

    175. Schembl4113

    176. Docusate Sodium [ii]

    177. Docusate Sodium [mi]

    178. Mls004773938

    179. Docusate Sodium [inn]

    180. 1,4-bis(2-ethylhexyl)sulfobutanedioate, Sodium Salt

    181. Sol Sodowej Sulfobursztynianu Dwu-2-etyloheksylowego

    182. Docusate Sodium [hsdb]

    183. Docusate Sodium [usan]

    184. Chebi:4674

    185. Sulfosuccinic Acid Bis(2-ethylhexyl) Ester Sodium Salt

    186. Docusate Sodium [vandf]

    187. Chembl1905872

    188. Docusate Sodium [mart.]

    189. Dtxsid8022959

    190. Correctol Stool Softener Laxative

    191. Docusate Sodium [usp-rs]

    192. Docusate Sodium [who-dd]

    193. Sulfosuccinic Acid, Di-(2-ethylhexyl) Ester, Sodium Salt

    194. Hms3264p07

    195. Hms3885b10

    196. Sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate

    197. Bcp31325

    198. Hy-b1268

    199. 4-(4-bromophenoxymethyl)benzoicacid

    200. Aerosol™ Ot, Solid Anhydrous

    201. Sodium Dioctyl Sulfosuccinate (inn)

    202. Tox21_112087

    203. Tox21_113469

    204. Tox21_201342

    205. Tox21_300496

    206. S4588

    207. Dioctyl Disodium Sulfosuccinate

    208. Akos015901806

    209. Docusate Sodium [usp Impurity]

    210. Ccg-213234

    211. Cs-4813

    212. Docusate Sodium [usp Monograph]

    213. Nsc 760404

    214. Sodium Di(2-ethylhexyl) Sulfosuccinate

    215. Docusate Sodium Salt, Bioxtra, >=99%

    216. Docusate Sodium Solution [vandf]

    217. Dioctyl Sulfosuccinate Sodium Salt, 96%

    218. Ncgc00164140-01

    219. Ncgc00254414-01

    220. Ncgc00258894-01

    221. As-13347

    222. E480

    223. Smr001595510

    224. Aerosol™ Ot Solution, 10% (w/w)

    225. Dioctyl Sodium Sulfosuccinate [fcc]

    226. Dioctyl Sodium Sulfosuccinate With Ethanol

    227. Bis(2-ethylhexyl) Sulfosuccinatesodium Salt

    228. Dioctyl Sulfosuccinate Sodium Salt, >=97%

    229. Aec Diethylhexyl Sodium Sulfosuccinate

    230. Ft-0689234

    231. D00305

    232. Docusate Sodium Salt, P.a., 99.0-100.5%

    233. E77584

    234. Diethylhexyl Sodium Sulfosuccinate [inci]

    235. Docusate Sodium Salt, Purum, >=96.0% (tlc)

    236. Docusate Sodium Salt, Bioultra, >=99.0% (tlc)

    237. Docusate Sodium, Meets Usp Testing Specifications

    238. Dioctyl Sodium Sulfosuccinate With Diethylene Glycol

    239. Dioctyl Sodium Sulfosuccinate With Propylene Glycol

    240. Q2815334

    241. W-105447

    242. F8880-5559

    243. Docusate Sodium, British Pharmacopoeia (bp) Reference Standard

    244. Docusate Sodium, European Pharmacopoeia (ep) Reference Standard

    245. Sodium 1,4-bis(2-ethylhexyloxy)-1,4-dioxobutane-2-sulfonate

    246. Docusate Sodium, United States Pharmacopeia (usp) Reference Standard

    247. Dioctyl Sodium Sulfosuccinate With Diethylene Glycol And Glycol Ethers

    248. 1,4-bis(2-ethylhexyl)sodiumsulfosuccinate Pound>>dioctyl Sulfosuccinate Sodium Salt

    249. Butanedioic Acid, 2-sulfo-, 1,4-bis(2-ethylhexyl) Ester, Sodium Salt (1:1)

    250. Yal

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 444.6 g/mol
    Molecular Formula C20H37NaO7S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count18
    Exact Mass444.21576897 g/mol
    Monoisotopic Mass444.21576897 g/mol
    Topological Polar Surface Area118 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity546
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count3
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Cathartics; Excipients; Surface-Active Agents

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    Oral bulk-forming, lubricant, and stool softener laxatives are indicated prophylactically in patients who should not strain during defecation, such as those with an episiotomy wound, painful thrombosed hemorrhoids, fissures or perianal abbesses, body wall and diaphragmatic hernias, anorectal stenosis, or postmyocardial infarction. /Laxatives; Included in US product labeling/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1704

    Oral laxatives are indicated for the short-term relief of constipation. Oral bulk-forming laxatives, stimulant laxatives, and carbon dioxide-releasing suppositories are indicated to facilitate defecation in geriatric patients with diminished colonic motor response. Oral bulk-forming laxatives and stool softener laxatives are preferred to treat constipation that may occur during pregnancy and postpartum to help re-establish normal bowel function or to avoid straining if hemorrhoids are present. In severe cases of constipation, such as with fecal impaction, mineral oil and stool softener laxatives administered orally or rectally are indicated to soften the impacted feces. To help complete the evacuation of the impacted colon, a rectal stimulant or saline laxative may follow. /Laxatives; Included in US product labeling/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1704

    4.2 Drug Warning

    Laxatives should not be given to young children (up to 6 years of age) unless prescribed by a physician. Since children are not usually able to describe their symptoms precisely, proper diagnosis should precede the use of a laxative. This will avoid the complication of an existing condition(e.g., appendicitis) or the appearance of more severe side effects. /Laxatives/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1705

    Side/Adverse Effects: Those indicating need for medical attention: Incidence rare: Allergies, undetermined (skin rash). /Laxatives/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1707

    Side/Adverse Effects: Those indicating need for medical attention only if they continue or are bothersome: Incidence less frequent: Stomach and/or intestinal cramping; throat irritation - with liquid forms. /Laxatives/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1707

    Because concurrent use of the docusate salts may increase the absorption of mineral oil, their concomitant administration is not recommended. /Docusate salts/

    American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 952

    For more Drug Warnings (Complete) data for BIS(2-ETHYLHEXYL) SODIUM SULFOSUCCINATE (7 total), please visit the HSDB record page.

    4.3 Minimum/Potential Fatal Human Dose

    3. 3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG, BETWEEN 1 OZ & 1 PINT FOR 70 KG PERSON (150 LB).

    Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-274

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Surface-Active Agents

    Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics. (See all compounds classified as Surface-Active Agents.)

    5.2 ATC Code

    A06AA02

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    A - Alimentary tract and metabolism

    A06 - Drugs for constipation

    A06A - Drugs for constipation

    A06AA - Softeners, emollients

    A06AA02 - Docusate sodium

    5.3 Absorption, Distribution and Excretion

    ...DRUG IS ABSORBED FROM GI TRACT & IS EXCRETED IN SIGNIFICANT CONCN IN BILE.

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 922

    SINCE THE DRUG IS ABSORBED FROM GI TRACT & IS EXCRETED IN SIGNIFICANT CONCN IN BILE...

    Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 922

    5.4 Mechanism of Action

    In vitro studies suggest that these salts of dioctylsulfosuccinic acid lower the surface tension of the stool to permit water and lipids to enter more readily and thus soften the feces. ... More recent evidence indicates that they may stimulate the secretion of water and electrolytes on contact with the mucosa.

    American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 949

    Reduce surface film tension of interfacing liquid contents of the bowel, promoting permeation of additional liquid into the stool to form a softer mass. /Laxatives/

    USP Convention. USPDI-Drug Information for the Health Care Professional. 14th ed. Volume I. Rockville, MD: United States Pharmacopeial Convention, Inc., 1994. (Plus Updates)., p. 1705

    API Reference Price

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ROAD,INDL.AREA,ANEKAL TQ, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1642012200,"product":"DOCUSATE SODIUM USP 500G (PHARMA GRADE) (QTY 1PAC X 500G=500G)","address":"306, STUDIO COMPLEX, NEAR GOTA CHAR RASTA, GOTA,","city":"AHMEDABAD -","supplier":"SPECTRUM CHEMICAL","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"TEKNIRVANA TRADELINK PRIVATE ","customerCountry":"INDIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"500","totalValueFC":"295.6","currency":"USD","unitRateINR":"44039.7","date":"13-Jan-2022","totalValueINR":"22019.85","totalValueInUsd":"295.6","indian_port":"BOMBAY AIR","hs_no":"29171920","bill_no":"7068813","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"","customerAddress":"306, STUDIO COMPLEX, NEAR GOTA CHAR RASTA, GOTA,"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1648751400,"product":"DSS 100 USP DOCUSATE SODIUM USP (DOCUSATE SODIUM USP\/NF,EP)(PHARMA GRADE FOR PHARMACEUTICAL USE ONLY)","address":"A 801, CRESCENZO, C-38\/39, G-BLOCK ,BANDRA KURLA COMPLEX","city":"MUMBAI,MAHARASHTRA","supplier":"SOLVAY SPECIALTY POLYMERS","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SIGNET","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"145","totalValueFC":"88673.2","currency":"USD","unitRateINR":"11150.5","date":"01-Apr-2022","totalValueINR":"6690300","totalValueInUsd":"88673.2","indian_port":"JNPT","hs_no":"29171990","bill_no":"8103104","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A 801, CRESCENZO, C-38\/39, G-BLOCK ,BANDRA KURLA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1657823400,"product":"D1685-CONF DOCUSATE SODIUM SALT MEETS USP TESTING","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N","city":"BANGALORE","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15000","unit":"GMS","unitRateFc":"12.4","totalValueFC":"2483.7","currency":"INR","unitRateINR":"13.2","date":"15-Jul-2022","totalValueINR":"197493.04","totalValueInUsd":"2483.7","indian_port":"BANGALORE AIR","hs_no":"29171920","bill_no":"9570703","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK ROAD,INDL.AREA,ANEKAL TQ, Contact N"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1659637800,"product":"DSS 100 USP DOCUSATE SODIUM USP (DOCUSATE SODIUM USP\/NF,EP)(PHARMA GRADE FOR PHARMACEUTICAL USE ONLY)","address":"A 801, CRESCENZO, C-38\/39, G-BLOCK ,BANDRA KURLA COMPLEX","city":"MUMBAI,MAHARASHTRA","supplier":"SOLVAY SPECIALTY POLYMERS","supplierCountry":"UNITED STATES","foreign_port":"NA","customer":"SIGNET","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"156","totalValueFC":"94403.3","currency":"USD","unitRateINR":"12519","date":"05-Aug-2022","totalValueINR":"7511400","totalValueInUsd":"94403.3","indian_port":"JNPT","hs_no":"29171990","bill_no":"9879154","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"A 801, CRESCENZO, C-38\/39, G-BLOCK ,BANDRA KURLA COMPLEX"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1675362600,"product":"IA60500 DOCUSATE SODIUM USP\/EP-","address":"PLOT NO M14 TO M18,VERNA INDL ESTA TE PHASE IIIB","city":"VERNA,GOA","supplier":"COLORCON INC","supplierCountry":"UNITED KINGDOM","foreign_port":"NA","customer":"COLORCON INC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"483.3","totalValueFC":"503.5","currency":"USD","unitRateINR":"41585.1","date":"03-Feb-2023","totalValueINR":"41585.06","totalValueInUsd":"503.5","indian_port":"BOMBAY AIR","hs_no":"29171990","bill_no":"4482413","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"PLOT NO M14 TO M18,VERNA INDL ESTA TE PHASE IIIB"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1685471400,"product":"DOCUSATE SODIUM USP DOCUSATE SODIUM DSS 100 USP NF EP PHARMA GRADE FOR PHARMACEUTICAL USE ONLY","address":"1605,16TH FLR.RUPA SOLITAIRE BLDG. MILLENNIUM BUS. PARK,MAHAPE,THANE B","city":"THANE","supplier":"SOLVAY SPECIALTY POLYMERS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"SIGNET","customerCountry":"INDIA","quantity":"900.00","actualQuantity":"900","unit":"KGS","unitRateFc":"156","totalValueFC":"142133.2","currency":"USD","unitRateINR":"12994.8","date":"31-May-2023","totalValueINR":"11695320","totalValueInUsd":"142133.2","indian_port":"JNPT","hs_no":"29171990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"United States","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"","customerAddress":"1605,16TH FLR.RUPA SOLITAIRE BLDG. MILLENNIUM BUS. PARK,MAHAPE,THANE B"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711391400,"product":"D1685-CONF DOCUSATE SODIUM SALT, MEETS USP TESTING (FOR LBAPURPOSE) (16000 GMS)","address":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK","city":"BANGALORE","supplier":"MERCK GROUP","supplierCountry":"UNITED STATES","foreign_port":"CHICAGO, IL","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"16.00","actualQuantity":"16","unit":"KGS","unitRateFc":"13187.1","totalValueFC":"2659.1","currency":"INR","unitRateINR":"13800.2","date":"26-Mar-2024","totalValueINR":"220802.74","totalValueInUsd":"2659.1","indian_port":"Bangalore Air","hs_no":"29171990","bill_no":"2733940","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO, IL","supplierAddress":"6000 N TEUTONIA AVE MILWAUKEE WI MILWAUKEE - 53209-3645, , United States United States","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1712946600,"product":"DSS 100 USP DOCUSATE SODIUM USP (DOCUSATE SODIUM USP\/NF,EP)(PHARMA GRADE FOR PHARMACEUTICAL USE ONLY)","address":"A 801, CRESCENZO, C-38\/39, G-BLOCK","city":"MUMBAI,MAHARASHTRA","supplier":"SOLVAY SPECIALTY POLYMERS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK","customer":"SIGNET","customerCountry":"INDIA","quantity":"600.00","actualQuantity":"600","unit":"KGS","unitRateFc":"162.4","totalValueFC":"98423.3","currency":"USD","unitRateINR":"13698.4","date":"13-Apr-2024","totalValueINR":"8219064","totalValueInUsd":"98423.3","indian_port":"JNPT","hs_no":"29171990","bill_no":"3006489","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"NEW YORK","supplierAddress":"1 BIOPOLIS DRIVE #03-02\/04 AMNIOS SINGAPORE 138622SDNF Singapore","customerAddress":"A 801, CRESCENZO, C-38\/39, G-BLOCK"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1718130600,"product":"DOCUSATE SODIUM USP (DOCUSATE SODIUM DSS 100 USP\/NF,EP) (PHARMA GRADE FOR PHARMACEUTICAL USE ONLY)","address":"A 801, CRESCENZO, C-38\/39, G-BLOCK","city":"MUMBAI,MAHARASHTRA","supplier":"SOLVAY SPECIALTY POLYMERS","supplierCountry":"UNITED STATES","foreign_port":"NEW YORK - JOHN F. 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M-14 TO M-18,","city":"VERNA,GOA","supplier":"JIANGXI CHIBANG PHARMACEUTICAL CO.,LTD","supplierCountry":"UNITED KINGDOM","foreign_port":"HEATHROW APT\/LONDON, HIL","customer":"COLORCON INC","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"521.2","totalValueFC":"529.8","currency":"USD","unitRateINR":"46075","date":"14-Feb-2025","totalValueINR":"46075","totalValueInUsd":"529.8","indian_port":"Bombay Air","hs_no":"29171990","bill_no":"8345481","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"HEATHROW APT\/LONDON, HIL","supplierAddress":"N\/A","customerAddress":"PLOT NO. M-14 TO M-18,"}]
    07-Jan-2021
    27-Feb-2025
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    ABOUT THIS PAGE

    Looking for 577-11-7 / Docusate Sodium API manufacturers, exporters & distributors?

    Docusate Sodium manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Docusate Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Docusate Sodium manufacturer or Docusate Sodium supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Docusate Sodium manufacturer or Docusate Sodium supplier.

    PharmaCompass also assists you with knowing the Docusate Sodium API Price utilized in the formulation of products. Docusate Sodium API Price is not always fixed or binding as the Docusate Sodium Price is obtained through a variety of data sources. The Docusate Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Docusate Sodium

    Synonyms

    577-11-7, Dioctyl sodium sulfosuccinate, Dioctyl sulfosuccinate sodium salt, Aerosol ot, Constonate, Dioctylal

    Cas Number

    577-11-7

    Unique Ingredient Identifier (UNII)

    F05Q2T2JA0

    About Docusate Sodium

    All-purpose surfactant, wetting agent, and solubilizer used in the drug, cosmetics, and food industries. It has also been used in laxatives and as cerumenolytics. It is usually administered as either the calcium, potassium, or sodium salt.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Manufacturers

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt, including repackagers and relabelers. The FDA regulates Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Suppliers

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt supplier is an individual or a company that provides Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt active pharmaceutical ingredient (API) or Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt finished formulations upon request. The Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers may include Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt API manufacturers, exporters, distributors and traders.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt USDMF

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt DMF (Drug Master File) is a document detailing the whole manufacturing process of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt active pharmaceutical ingredient (API) in detail. Different forms of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt DMFs exist exist since differing nations have different regulations, such as Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt DMF submitted to regulatory agencies in the US is known as a USDMF. Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt USDMF includes data on Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with USDMF on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Drug Master File in Japan (Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt JDMF) empowers Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt JDMF during the approval evaluation for pharmaceutical products. At the time of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with JDMF on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Drug Master File in Korea (Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt. The MFDS reviews the Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt KDMF as part of the drug registration process and uses the information provided in the Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with KDMF on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP of the European Pharmacopoeia monograph is often referred to as a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Certificate of Suitability (COS). The purpose of a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt to their clients by showing that a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP has been issued for it. The manufacturer submits a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP (COS) as part of the market authorization procedure, and it takes on the role of a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP holder for the record. Additionally, the data presented in the Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt DMF.

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with CEP (COS) on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt WC

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt written confirmation (Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt WC) is an official document issued by a regulatory agency to a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt manufacturer, verifying that the manufacturing facility of a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt APIs or Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt finished pharmaceutical products to another nation, regulatory agencies frequently require a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt WC (written confirmation) as part of the regulatory process.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with Written Confirmation (WC) on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt suppliers with NDC on PharmaCompass.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt GMP

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt GMP manufacturer or Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt GMP API supplier for your needs.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CoA

    A Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CoA (Certificate of Analysis) is a formal document that attests to Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt's compliance with Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt specifications and serves as a tool for batch-level quality control.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CoA mostly includes findings from lab analyses of a specific batch. For each Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt may be tested according to a variety of international standards, such as European Pharmacopoeia (Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt EP), Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Succinic acid, sulfo-, 1,4-bis(2-ethylhexyl) ester, sodium salt USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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