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    Also known as: Butanedioic acid, 110-15-6, Amber acid, Wormwood acid, Asuccin, Dihydrofumaric acid
    Molecular Formula
    C4H6O4
    Molecular Weight
    118.09  g/mol
    InChI Key
    KDYFGRWQOYBRFD-UHFFFAOYSA-N
    FDA UNII
    AB6MNQ6J6L
    Succinic Acid
    A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
    1 2D Structure

    Succinic Acid

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    butanedioic acid
    2.1.2 InChI
    InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
    2.1.3 InChI Key
    KDYFGRWQOYBRFD-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(CC(=O)O)C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    AB6MNQ6J6L
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1,2 Ethanedicarboxylic Acid

    2. 1,2-ethanedicarboxylic Acid

    3. 1,4 Butanedioic Acid

    4. 1,4-butanedioic Acid

    5. Ammonium Succinate

    6. Butanedioic Acid

    7. Potassium Succinate

    8. Succinate

    9. Succinate, Ammonium

    10. Succinate, Potassium

    2.3.2 Depositor-Supplied Synonyms

    1. Butanedioic Acid

    2. 110-15-6

    3. Amber Acid

    4. Wormwood Acid

    5. Asuccin

    6. Dihydrofumaric Acid

    7. Katasuccin

    8. 1,2-ethanedicarboxylic Acid

    9. Bernsteinsaure

    10. Ethylenesuccinic Acid

    11. 1,4-butanedioic Acid

    12. Wormwood

    13. Succinicum Acidum

    14. Butandisaeure

    15. Acidum Succinicum

    16. Butanedionic Acid

    17. Kyselina Jantarova

    18. Butane Diacid

    19. Ethylene Dicarboxylic Acid

    20. Spirit Of Amber

    21. Bernsteinsaure [german]

    22. Kyselina Jantarova [czech]

    23. Ammonium Succinate

    24. Hsdb 791

    25. Succinic-acid

    26. Mfcd00002789

    27. Succ

    28. Nsc 106449

    29. Ai3-06297

    30. Ab6mnq6j6l

    31. Nsc-106449

    32. Butanedioic Acid, Homopolymer

    33. E363

    34. Fema No. 4719

    35. Chebi:15741

    36. C4-beta-polymorph

    37. Nsc25949

    38. Succinicacid(industrialgrade&foodgrade)

    39. Ncgc00159372-02

    40. Ncgc00159372-04

    41. Succinellite

    42. Acide Succinique

    43. Sal Succini

    44. Acid Of Amber

    45. Dsstox_cid_3602

    46. Wln: Qv2vq

    47. Dsstox_rid_77102

    48. Dsstox_gsid_23602

    49. 26776-24-9

    50. Sin

    51. Ethylene Succinic Acid

    52. Ethanedicarboxylic Acid

    53. Bernsteinsaeure

    54. Sodium Succinate (anhydrous)

    55. Succinate, 9

    56. Acide Butanedioique

    57. Cas-110-15-6

    58. Succinic Acid [nf]

    59. Succinic Acid (8ci)

    60. Butanedioic Acid (9ci)

    61. Einecs 203-740-4

    62. Unii-ab6mnq6j6l

    63. Brn 1754069

    64. Dihydrofumarate

    65. Succinicate

    66. Butanedioic Acid Diammonium Salt

    67. Salt Of Amber

    68. 1cze

    69. Nat.succinic Acid

    70. 1,4-butanedioate

    71. Succinic Acid, 6

    72. Succinic Acid, Fcc

    73. Succinic Acide,(s)

    74. Succinic Acid (sa)

    75. 1,4-butandioic Acid

    76. Succinic Acid, 99%

    77. Succinic Acid, Natural

    78. 4lh2

    79. 1,2-ethanedicarboxylate

    80. Substrate Analogue, 11

    81. Suc

    82. Succinic Acid, Acs Grade

    83. Bmse000183

    84. Bmse000968

    85. Chembl576

    86. Ec 203-740-4

    87. Succinic Acid [ii]

    88. Succinic Acid [mi]

    89. Hooc-ch2-ch2-cooh

    90. Succinic Acid [fcc]

    91. A 12084

    92. Succinic Acid [hsdb]

    93. Succinic Acid [inci]

    94. 4-02-00-01908 (beilstein Handbook Reference)

    95. Succinic Acid [vandf]

    96. Succinic Acid [mart.]

    97. Gtpl3637

    98. Succinic Acid [usp-rs]

    99. Succinic Acid [who-dd]

    100. Dtxsid6023602

    101. Succinicum Acidum [hpus]

    102. Bdbm26121

    103. Succinic Acid (butanedioic Acid)

    104. Hms3885o04

    105. Zinc895030

    106. Hy-n0420

    107. Str02803

    108. Tox21_111612

    109. Tox21_201918

    110. Tox21_303247

    111. Bbl002473

    112. Lmfa01170043

    113. Nsc-25949

    114. Nsc106449

    115. S3791

    116. Stk387105

    117. Succinic Acid [usp Impurity]

    118. Succinic Acid, >=99%, Fcc, Fg

    119. Succinic Acid, Bioxtra, >=99.0%

    120. Akos000118899

    121. Tox21_111612_1

    122. Ccg-266069

    123. Db00139

    124. Ncgc00159372-03

    125. Ncgc00159372-05

    126. Ncgc00159372-06

    127. Ncgc00257092-01

    128. Ncgc00259467-01

    129. Succinic Acid, Acs Reagent, >=99.0%

    130. Bp-21128

    131. Succinic Acid, Reagentplus(r), >=99.0%

    132. Adipic Acid Impurity B [ep Impurity]

    133. Cs-0008946

    134. Ft-0652509

    135. Ft-0773657

    136. N1941

    137. S0100

    138. Succinic Acid 100 Microg/ml In Acetonitrile

    139. Succinic Acid, P.a., Acs Reagent, 99.0%

    140. Succinic Acid, Saj First Grade, >=99.0%

    141. Succinic Acid High Purity Grade 2.5kg

    142. Succinic Acid, Purum P.a., >=99.0% (t)

    143. Succinic Acid, Saj Special Grade, >=99.5%

    144. 1,4-butanedioic Acid (succinic Acid)

    145. A14596

    146. C00042

    147. D85169

    148. Succinic Acid, Vetec(tm) Reagent Grade, 98%

    149. Ab01332192-02

    150. Q213050

    151. Sr-01000944556

    152. J-002386

    153. Sr-01000944556-2

    154. Z57127453

    155. F2191-0239

    156. 37e8fffb-70da-4399-b724-476bd8715ef0

    157. Succinic Acid, Certified Reference Material, Tracecert(r)

    158. Succinic Acid, Puriss. P.a., Acs Reagent, >=99.5% (t)

    159. Succinic Acid, United States Pharmacopeia (usp) Reference Standard

    160. Succinic Acid, Matrix Substance For Maldi-ms, >=99.5% (t), Ultra Pure

    161. Succinic Acid, Anhydrous, Free-flowing, Redi-dri(tm), Acs Reagent, >=99.0%

    162. Succinic Acid, Bioreagent, Suitable For Cell Culture, Suitable For Insect Cell Culture

    163. Succinic Acid, Pharmaceutical Secondary Standard; Certified Reference Material

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 118.09 g/mol
    Molecular Formula C4H6O4
    XLogP3-0.6
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count3
    Exact Mass118.02660867 g/mol
    Monoisotopic Mass118.02660867 g/mol
    Topological Polar Surface Area74.6 Ų
    Heavy Atom Count8
    Formal Charge0
    Complexity92.6
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    /EXPTL THER/ Succinic acid (100 mM) significantly inhibited systemic anaphylaxis induced by compound 48/80 /a potent mast cell degranulator/ in mice and dose-dependently inhibited local anaphylaxis activated by anti-dinitrophenyl IgE. Further 10 and 100 mM significantly inhibited histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-dinitrophenyl IgE. In addition succinic acid (0.1 and 1 mM) had a significant inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha secretion from rat peritoneal mast cells. The level of cyclic AMP in rat peritoneal mast cells, when succinic acid (100 mM) was added, transiently and significantly increased about 4 times compared with that of basal cells. These results suggest a possible use of succinic acid in managing mast cell-dependent anaphylaxis.

    Kim HM et al;

    4.2 Drug Indication

    For nutritional supplementation, also for treating dietary shortage or imbalance

    5 Pharmacology and Biochemistry
    5.1 Absorption, Distribution and Excretion

    Succinic acid occurs normally in human urine (1.9-8.8 mg/L).

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 758

    5.2 Metabolism/Metabolites

    Succinic acid is a normal intermediary metabolite and a constituent of the citric acid cycle. It is readily metabolized when administered to animals, but may be partly excreted unchanged in the urine if large doses are fed.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V5 757

    5.3 Mechanism of Action

    Succinate is an essential component of the Krebs or citric acid cycle and serves an electron donor in the production of fumaric acid and FADH2. It also has been shown to be a good "natural" antibiotic because of its relative acidic or caustic nature (high concentrations can even cause burns). Succinate supplements have been shown to help reduce the effects of hangovers by activating the degradation of acetaldehyde - a toxic byproduct of alcohol metabolism - into CO2 and H2O through aerobic metabolism. Succinic acid has been shown to stimulate neural system recovery and bolster the immune system. Claims have also been made that it boosts awareness, concentration and reflexes.

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Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716834600,"product":"SUCCINIC ACID CRYST., EMPROVE ESSENTIAL CHP,NF,JPE,ACS 10PCS X 5KG","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"ROTTERDAM","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"4666.8","totalValueFC":"2806.4","currency":"INR","unitRateINR":"4678.5","date":"28-May-2024","totalValueINR":"233923.15","totalValueInUsd":"2806.4","indian_port":"JNPT","hs_no":"29171930","bill_no":"3705210","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"ROTTERDAM","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717871400,"product":"SUCCINIC ACID 7X25 KG ORGANIC CHEMICALS","address":"3\/62 A SAMUDRA DWAR SALAI","city":"CHENNAI","supplier":"SORACHIM SA","supplierCountry":"SPAIN","foreign_port":"BARCELONA","customer":"BIOSYSTEMS DIAGNOSTICS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"175.00","actualQuantity":"175","unit":"KGS","unitRateFc":"10.4","totalValueFC":"2219.2","currency":"EUR","unitRateINR":"1058.6","date":"09-Jun-2024","totalValueINR":"185254.34","totalValueInUsd":"2219.2","indian_port":"Madras Air","hs_no":"29349990","bill_no":"3910119","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"BARCELONA","supplierAddress":"CHEMIN DE PRE FLEURI6, 1006 LAUSANNESDNF SWITZERLAND","customerAddress":"3\/62 A SAMUDRA DWAR SALAI"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724178600,"product":"SUCCINIC ACID CRYST., EMPROVE ESSENTIAL CHP,NF,JPE,ACS 11PCS X 5KG","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"55.00","actualQuantity":"55","unit":"KGS","unitRateFc":"5646.8","totalValueFC":"3711.9","currency":"INR","unitRateINR":"5660.9","date":"21-Aug-2024","totalValueINR":"311351.76","totalValueInUsd":"3711.9","indian_port":"Bombay Air","hs_no":"29171930","bill_no":"5165914","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"}]
    27-Jan-2021
    21-Aug-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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