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Sugammadex

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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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Asolution Sugammadex Sodium

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Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

63 API Suppliers, 29 USDMF, 8 JDMF, 12 EU WC, 23 KDMF, 26 NDC API, 49 Listed Suppliers, $ API Reference Price

63 API Suppliers
29 USDMF
8 JDMF
12 EU WC
23 KDMF
26 NDC API
49 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

42 FDF Dossiers, 15 FDA Orange Book, 3 Europe, 1 Canada, 10 South Africa, 13 Listed Dossiers

42 FDF Dossiers
15 FDA Orange Book
3 Europe
1 Canada
10 South Africa
13 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

SOLUTION;INTRAVENOUS - EQ 200MG BASE/2ML (EQ 100MG BASE/ML), SOLUTION;INTRAVENOUS - EQ 500MG BASE/5ML (EQ 100MG BASE/ML)

drugProductComposition
SOLUTION;INTRAVENOUS - EQ 200MG BASE/2ML (EQ 100MG BASE/ML)
SOLUTION;INTRAVENOUS - EQ 500MG BASE/5ML (EQ 100MG BASE/ML)

RELATED EXCIPIENT COMPANIES

1 Actylis

relatedExcipients
1 Actylis

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow, 27 NEWS #PharmaBuzz

media
3 DATA COMPILATION #PharmaFlow
27 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 Finished Drug Prices, 10 Annual Reports

globalSalesInformation
2 Finished Drug Prices
10 Annual Reports

MARKET PLACE

11 APIs, 5 FDF Dossiers

marketPlace
11 APIs
5 FDF Dossiers

PATENTS & EXCLUSIVITIES

2 US Patents, 4 US Exclusivities, 1 Health Canada Patents

patents
2 US Patents
4 US Exclusivities
1 Health Canada Patents

REF. STANDARDS & IMPURITIES

3 Others

otherSolutions
3 Others

Sugammadex

Synopsis

ACTIVE PHARMA INGREDIENTS

63

API Suppliers

29

USDMF

0

CEP/COS

CEP/COS Certifications

8

JDMF

12

EU WC

23

KDMF

26

NDC API

0

VMF

49

Listed Suppliers

API REF. PRICE (USD/KG)

$

$ 13,722

MARKET PLACE

11

API

5

FDF

2INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

42

FDF Dossiers

15

FDA Orange Book

FDA (Orange Book)

3

Europe

1

Canada

0

Australia

10

South Africa

13

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

3

Others

PATENTS & EXCLUSIVITIES

2

US Patents

4

US Exclusivities

1

Health Canada Patents

DIGITAL CONTENT

3

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

27

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

NA

Annual Reports (USD Million)

9,849

Finished Drug Prices

1 RELATED EXCIPIENT COMPANIES

1EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 343306-79-6, Bridion, Org 25969, Org-25969, Erj6x2mxv7, 343306-71-8

Molecular Formula

C₇₂H₁₀₄Na₈O₄₈S₈

Molecular Weight

2178.0 g/mol

InChI Key

KMGKABOMYQLLDJ-VKHHSAQNSA-F

FDA UNII

ERJ6X2MXV7

Sugammadex Sodium

A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE.

1 2D Structure

Sugammadex Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

octasodium;3-[[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-10,15,20,25,30,35,40-heptakis(2-carboxylatoethylsulfanylmethyl)-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecahydroxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontan-5-yl]methylsulfanyl]propanoate

2.1.2 InChI

InChI=1S/C72H112O48S8.8Na/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90;;;;;;;;/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88);;;;;;;;/q;8*+1/p-8/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-;;;;;;;;/m1......../s1

2.1.3 InChI Key

KMGKABOMYQLLDJ-VKHHSAQNSA-F

2.1.4 Canonical SMILES

C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

2.1.5 Isomeric SMILES

C(CSC[C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

ERJ6X2MXV7

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 6-perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin Sodium Salt

2. Bridion

3. Org 25969

4. Sugammadex

2.3.2 Depositor-Supplied Synonyms

1. 343306-79-6

2. Bridion

3. Org 25969

4. Org-25969

5. Erj6x2mxv7

6. 343306-71-8

7. Sugammadex Octasodium Salt

8. Sugammadex (sodium)

9. Unii-erj6x2mxv7

10. Sugammadex Sodium [usan]

11. Sugammadexsodium

12. Sugammadex Sodium [usan:jan]

13. Bridion (tn)

14. Mk-8616

15. Org25969

16. Sugammadex Sodium (jan/usan)

17. Sugammadex Sodium [jan]

18. Chebi:90952

19. Sugammadex Sodium [mart.]

20. Sugammadex Sodium [who-dd]

21. Amy12422

22. Ex-a2600

23. Sch-900616

24. Sugammadex Octasodium Salt [mi]

25. Sugammadex Sodium [orange Book]

26. Ac-30384

27. C13789

28. D05940

29. .gamma.-cyclodextrin, 6a,6b,6c,6d,6e,7f,6g,6h-octakis-s-(2-carboxyethyl)-6a,6b,6c,6d,6e,7f,6g,6h-octathio-, Octasodium Salt

30. Gamma-cyclodextrin, 6a,6b,6c,6d,6e,7f,6g,6h-octakis-s-(2-carboxyethyl)-6a,6b,6c,6d,6e,7f,6g,6h-octathio-, Octasodium Salt

31. Octasodium 6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octakis-s-(2-carboxylatoethyl)-6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octathiocyclo-alpha-(1-4)-d-octaglucopyranoside

2.4 Create Date

2006-07-28

3 Chemical and Physical Properties

Molecular Formula	C₇₂H₁₀₄Na₈O₄₈S₈
Molecular Weight	2178.0 g/mol
Hydrogen Bond Donor Count	16
Hydrogen Bond Acceptor Count	56
Rotatable Bond Count	32
Exact Mass	2176.2644287 g/mol
Monoisotopic Mass	2176.2644287 g/mol
Topological Polar Surface Area	995 Å²
Heavy Atom Count	136
Formal Charge	0
Complexity	2790
Isotope Atom Count	0
Defined Atom Stereocenter Count	40
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	9

4 Drug and Medication Information

4.1 Drug Indication

Reversal of neuromuscular blockade induced by rocuronium or vecuronium.

For the peadiatric population: sugammadex is only recommended for routine reversal of rocuronium-induced blockade in children and adolescents.

Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults.

For the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in children and adolescents aged 2 to 17 years.

Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults.

For the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in children and adolescents aged 2 to 17 years.

5 Pharmacology and Biochemistry

5.1 ATC Code

V03AB35

V03AB35

V03AB35

API SUPPLIERS

01

Dr. Reddy's Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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India

Digital Content

USDMF

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CEP/COS JDMF

EU-WC

NDC

KDMF

VMF Others AUDIT

Dr Reddy Company Banner

Product Web Link

Digital Content

02

ASolution Pharmaceuticals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

ASolution Pharmaceuticals: Your Partner for cGMP Development & Manufacturing Services – Supplying APIs, FDFs, and Specialty Molecules.

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India

Digital Content

USDMF

CEP/COS JDMF EU-WC

NDC KDMF

VMF Others AUDIT

ASolution Pharmaceuticals

Product Web Link

Digital Content

03

Biophore India Pharmaceuticals Pvt...

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

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India

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

04

LGM Pharma

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

05

Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Suppliers Night Expo

Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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U.S.A

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

06

Seqens

France

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

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France

Digital Content

USDMF

CEP/COS JDMF EU-WC NDC

KDMF

VMF Others AUDIT

Seqens Company Banner

Product Web Link

Digital Content

07

Shandong Chenghui Shuangda Pharmac...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

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China

Digital Content

USDMF CEP/COS JDMF EU-WC

NDC KDMF

VMF Others AUDIT

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

Digital Content

08

Synnat Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Synnat Pharma is one of the leading active pharmaceutical ingredients and intermediates manufacturers.

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India

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Product Web Link

Digital Content

09

HRV Global Life Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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India

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF AU

AUDIT

HRV Global Life Sciences

Product Web Link

Digital Content

10

Medichem S.A

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Antibody Engineering

Not Confirmed

Medichem is a vertically integrated pharmaceutical company specializing in the development & manufacturing of APIs & FDFs.

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Spain

Digital Content

USDMF

CEP/COS JDMF

EU-WC NDC

KDMF

VMF Others AUDIT

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EU WC

01

Dr. Reddy's Laboratories

India

Antibody Engineering

Not Confirmed

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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India

Digital Content

Sugammadex Sodium IH

Date of Issue : 2022-06-17

Valid Till : 2025-07-07

Written Confirmation Number : WC-0067

Address of the Firm : Chemical Technical Operations Unit-VI, APIIC Industrial Estate, Pydibhimavaram V...

Dr Reddy Company Banner

Product Web Link

Digital Content

02

ASolution Pharmaceuticals

India

Antibody Engineering

Not Confirmed

ASolution Pharmaceuticals: Your Partner for cGMP Development & Manufacturing Services – Supplying APIs, FDFs, and Specialty Molecules.

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India

Digital Content

Sugammadex Sodium IH

Date of Issue : 2024-01-23

Valid Till : 2026-06-17

Written Confirmation Number : WC-476

Address of the Firm : K3/8 Anand Nagar, MIDC, Ambernath-421506 District Thane, Maharshtra

ASolution Pharmaceuticals

Product Web Link

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03

Shandong Chenghui Shuangda Pharmaceutical

China

Shuangda Pharmaceutical has a world-class first-class production line, having GMP, FDA and other regulatory certifications.

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China

Digital Content

Sugammadex Sodium

Date of Issue : 2023-04-07

Valid Till : 2026-04-06

Written Confirmation Number : SD230030

Address of the Firm : Economic Development Zone, Pingyuan County, Dezhou City, Shandong, PR China

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

Digital Content

04

Neuland Laboratories

India

Antibody Engineering

Not Confirmed

Neuland Laboratories- A dedicated 100% API provider.

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India

Digital Content

Sugammadex Sodium IH

Date of Issue : 2022-07-28

Valid Till : 2025-06-16

Written Confirmation Number : WC-0036

Address of the Firm : Sy. No. 347,473,474, 490/2 Bonthapally village, Veerabhadraswamy Temple Road, Ji...

Product Web Link

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05

USV Private Limited

India

Antibody Engineering

Not Confirmed

USV offers custom peptide synthesis ranging from gram to multi-gram to multi-kilogram quantities.

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India

Digital Content

Sugammadex Sodium IH

Date of Issue : 2022-06-27

Valid Till : 2025-06-02

Written Confirmation Number : WC-0012

Address of the Firm : MIs USV Private Limited ,B-1/8,MIDC, Lote Parshuram, Tal., Dist. Ratnagiri, Khed...

USV Private Limited

Portfolio PDF

Product Web Link

Digital Content

06

Almelo

India

Antibody Engineering

Not Confirmed

07

Azico Biophore India Pvt. Ltd

India

Antibody Engineering

Not Confirmed

08

Azico Biophore India Pvt. Ltd

India

Antibody Engineering

Not Confirmed

09

MSN Laboratories

India

Antibody Engineering

Not Confirmed

10

Natco Pharma

India

Antibody Engineering

Not Confirmed

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API Reference Price

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Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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