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1 RELATED EXCIPIENT COMPANIES

1EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 343306-79-6, Bridion, Org 25969, Org-25969, Erj6x2mxv7, 343306-71-8
Molecular Formula
C72H104Na8O48S8
Molecular Weight
2178.0  g/mol
InChI Key
KMGKABOMYQLLDJ-VKHHSAQNSA-F
FDA UNII
ERJ6X2MXV7

Sugammadex Sodium
A gamma-cyclodextrin that functions as a reversal agent for the neuromuscular blocker ROCURONIUM BROMIDE.
1 2D Structure

Sugammadex Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
octasodium;3-[[(1S,3S,5S,6S,8S,10S,11S,13S,15S,16S,18S,20S,21S,23S,25S,26S,28S,30S,31S,33S,35S,36S,38S,40S,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-10,15,20,25,30,35,40-heptakis(2-carboxylatoethylsulfanylmethyl)-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecahydroxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontan-5-yl]methylsulfanyl]propanoate
2.1.2 InChI
InChI=1S/C72H112O48S8.8Na/c73-33(74)1-9-121-17-25-57-41(89)49(97)65(105-25)114-58-26(18-122-10-2-34(75)76)107-67(51(99)43(58)91)116-60-28(20-124-12-4-36(79)80)109-69(53(101)45(60)93)118-62-30(22-126-14-6-38(83)84)111-71(55(103)47(62)95)120-64-32(24-128-16-8-40(87)88)112-72(56(104)48(64)96)119-63-31(23-127-15-7-39(85)86)110-70(54(102)46(63)94)117-61-29(21-125-13-5-37(81)82)108-68(52(100)44(61)92)115-59-27(19-123-11-3-35(77)78)106-66(113-57)50(98)42(59)90;;;;;;;;/h25-32,41-72,89-104H,1-24H2,(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,83,84)(H,85,86)(H,87,88);;;;;;;;/q;8*+1/p-8/t25-,26-,27-,28-,29-,30-,31-,32-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-;;;;;;;;/m1......../s1
2.1.3 InChI Key
KMGKABOMYQLLDJ-VKHHSAQNSA-F
2.1.4 Canonical SMILES
C(CSCC1C2C(C(C(O1)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)OC5C(OC(C(C5O)O)OC6C(OC(C(C6O)O)OC7C(OC(C(C7O)O)OC8C(OC(C(C8O)O)OC9C(OC(O2)C(C9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
2.1.5 Isomeric SMILES
C(CSC[C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])CSCCC(=O)[O-])O)O)C(=O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
ERJ6X2MXV7
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-perdeoxy-6-per(2-carboxyethyl)thio-gamma-cyclodextrin Sodium Salt

2. Bridion

3. Org 25969

4. Sugammadex

2.3.2 Depositor-Supplied Synonyms

1. 343306-79-6

2. Bridion

3. Org 25969

4. Org-25969

5. Erj6x2mxv7

6. 343306-71-8

7. Sugammadex Octasodium Salt

8. Sugammadex (sodium)

9. Unii-erj6x2mxv7

10. Sugammadex Sodium [usan]

11. Sugammadexsodium

12. Sugammadex Sodium [usan:jan]

13. Bridion (tn)

14. Mk-8616

15. Org25969

16. Sugammadex Sodium (jan/usan)

17. Sugammadex Sodium [jan]

18. Chebi:90952

19. Sugammadex Sodium [mart.]

20. Sugammadex Sodium [who-dd]

21. Amy12422

22. Ex-a2600

23. Sch-900616

24. Sugammadex Octasodium Salt [mi]

25. Sugammadex Sodium [orange Book]

26. Ac-30384

27. C13789

28. D05940

29. .gamma.-cyclodextrin, 6a,6b,6c,6d,6e,7f,6g,6h-octakis-s-(2-carboxyethyl)-6a,6b,6c,6d,6e,7f,6g,6h-octathio-, Octasodium Salt

30. Gamma-cyclodextrin, 6a,6b,6c,6d,6e,7f,6g,6h-octakis-s-(2-carboxyethyl)-6a,6b,6c,6d,6e,7f,6g,6h-octathio-, Octasodium Salt

31. Octasodium 6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octakis-s-(2-carboxylatoethyl)-6,6',6'',6''',6'''',6''''',6'''''',6'''''''-octathiocyclo-alpha-(1-4)-d-octaglucopyranoside

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 2178.0 g/mol
Molecular Formula C72H104Na8O48S8
Hydrogen Bond Donor Count16
Hydrogen Bond Acceptor Count56
Rotatable Bond Count32
Exact Mass2176.2644287 g/mol
Monoisotopic Mass2176.2644287 g/mol
Topological Polar Surface Area995 Ų
Heavy Atom Count136
Formal Charge0
Complexity2790
Isotope Atom Count0
Defined Atom Stereocenter Count40
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count9
4 Drug and Medication Information
4.1 Drug Indication

Reversal of neuromuscular blockade induced by rocuronium or vecuronium.

For the peadiatric population: sugammadex is only recommended for routine reversal of rocuronium-induced blockade in children and adolescents.


Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults.

For the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in children and adolescents aged 2 to 17 years.


Reversal of neuromuscular blockade induced by rocuronium or vecuronium in adults.

For the paediatric population: sugammadex is only recommended for routine reversal of rocuronium induced blockade in children and adolescents aged 2 to 17 years.


5 Pharmacology and Biochemistry
5.1 ATC Code

V03AB35


V03AB35


V03AB35


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06-Jan-2021
23-Sep-2024
KGS
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DOSAGE - SOLUTION;INTRAVENOUS - EQ 200MG BASE...DOSAGE - SOLUTION;INTRAVENOUS - EQ 200MG BASE/2ML (EQ 100MG BASE/ML)

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DOSAGE - SOLUTION;INTRAVENOUS - EQ 500MG BASE...DOSAGE - SOLUTION;INTRAVENOUS - EQ 500MG BASE/5ML (EQ 100MG BASE/ML)

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01

Brand Name : Bridion

U.S.A
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Fi Europe 2024
Not Confirmed

Brand Name : Bridion

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Sugammadex Sodium

Dosage Form : Sugammadex 200Mg 2Ml 10 Units Pa...

Dosage Strength : 10 VIALS EV 2 ml 100 mg/ml

Price Per Pack (Euro) : 1,221.31

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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02

Brand Name : Bridion

U.S.A
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Brand Name : Bridion

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Sugammadex Sodium

Dosage Form : Sugammadex 500Mg 5Ml 10 Units Pa...

Dosage Strength : 10 VIALS EV 5 ml 100 mg/ml

Price Per Pack (Euro) : 3,053.24

Published in :

Country : Italy

RX/OTC/DISCN : Class H

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