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ACTIVE PHARMA INGREDIENTS

32 API Suppliers, 14 USDMF, 3 CEP/COS, 9 JDMF, 1 EU WC, 13 KDMF, 5 NDC API, 12 Listed Suppliers, $ API Reference Price

32 API Suppliers
14 USDMF
3 CEP/COS
9 JDMF
1 EU WC
13 KDMF
5 NDC API
12 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

59 FDF Dossiers, 44 FDA Orange Book, 15 Listed Dossiers

59 FDF Dossiers
44 FDA Orange Book
15 Listed Dossiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

MARKET PLACE

8 APIs, 2 FDF Dossiers

marketPlace
8 APIs
2 FDF Dossiers

PATENTS & EXCLUSIVITIES

4 US Patents, 2 US Exclusivities

patents
4 US Patents
2 US Exclusivities

REF. STANDARDS & IMPURITIES

3 EDQM

otherSolutions
3 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 134

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

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Finished Drug Prices

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Chemistry

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Also known as: 69388-84-7, Sulbactam sodium salt, Sodium sulbactam, Combactam, Sulbactam (sodium), Sulbactam (as sodium)

Molecular Formula

C₈H₁₀NNaO₅S

Molecular Weight

255.23 g/mol

InChI Key

NKZMPZCWBSWAOX-IBTYICNHSA-M

FDA UNII

DKQ4T82YE6

A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone.

1 2D Structure

Sulbactam Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(2S,5R)-3,3-dimethyl-4,4,7-trioxo-46-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

2.1.2 InChI

InChI=1S/C8H11NO5S.Na/c1-8(2)6(7(11)12)9-4(10)3-5(9)15(8,13)14;/h5-6H,3H2,1-2H3,(H,11,12);/q;+1/p-1/t5-,6+;/m1./s1

2.1.3 InChI Key

NKZMPZCWBSWAOX-IBTYICNHSA-M

2.1.4 Canonical SMILES

CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+]

2.1.5 Isomeric SMILES

CC1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])C.[Na+]

2.2 Other Identifiers

2.2.1 UNII

DKQ4T82YE6

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Btamaze

2. Combactam

3. Cp 45899

4. Cp-45899

5. Cp45899

6. Penicillanic Acid Sulfone

7. Sodium, Sulbactam

8. Sulbactam

9. Sulfone, Penicillanic Acid

2.3.2 Depositor-Supplied Synonyms

1. 69388-84-7

2. Sulbactam Sodium Salt

3. Sodium Sulbactam

4. Combactam

5. Sulbactam (sodium)

6. Sulbactam (as Sodium)

7. Dkq4t82ye6

8. Sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

9. Sodium;(2s,5r)-3,3-dimethyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

10. Cp-45899-2

11. Cp-45,899-2

12. Sodium 1,1-dioxopenicillanate

13. Cp-458992

14. Sulbactam Sodium (unasyn)

15. Sodium Penicillanate 1,1-dioxide

16. Sulbactam Natrium

17. Cp 45899 Sodium Salt

18. Penicillanic Acid Dioxide Sodium Salt

19. Penicillanic Acid Sulfone Sodium Salt

20. Unii-dkq4t82ye6

21. Cp 45899-2

22. Sulbactam Sodium [usan:usp:jan]

23. Sodium (2s,5r)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-dioxide

24. Sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-dioxide

25. Einecs 273-984-4

26. Cp 45899 Sodium

27. Penicillanic Acid 1,1-dioxide Sodium Salt

28. 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, Sodium Salt, (2s,5r)- (9ci)

29. Schembl667857

30. Sulbactam Sodium [jan]

31. Sulbactam Sodium (jp17/usp)

32. Sulbactam Sodium [usan]

33. Chembl1200944

34. Sulbactam Sodium [vandf]

35. Hy-b0334a

36. Sulbactam Sodium [mart.]

37. Chebi:157785

38. Sulbactam Sodium [who-dd]

39. Dtxsid401026661

40. Hms3651h07

41. Sulbactam Sodium Salt [mi]

42. Akos015963378

43. Sulbactam Sodium [ep Impurity]

44. Sulbactam Sodium [orange Book]

45. Ccg-267009

46. Sulbactam Sodium [ep Monograph]

47. Sulbactam Sodium [usp Impurity]

48. Sulbactam Sodium [usp Monograph]

49. Ac-20083

50. Cs-0013161

51. S2551

52. Sulperazone Component Sulbactam Sodium

53. D02223

54. Sulbactam Sodium Component Of Sulperazone

55. W-104633

56. Q27276453

57. Sulbactam Sodium, Antibiotic For Culture Media Use Only

58. (2s,5r)-3,3-dimethyl-4,4,7-trioxo-4$l^{6}-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

59. (2s,5r)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide Sodium Salt

60. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, Sodium Salt, (2s-cis)-

61. Sodium(2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate4,4-dioxide

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₈H₁₀NNaO₅S
Molecular Weight	255.23 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	255.01773788 g/mol
Monoisotopic Mass	255.01773788 g/mol
Topological Polar Surface Area	103 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	452
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. (See all compounds classified as beta-Lactamase Inhibitors.)

API SUPPLIERS

01

Qilu Tianhe Pharmaceutical Co., Lt...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

02

Istituto Biochimico Italiano Giova...

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

03

ACS DOBFAR SPA

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

04

Zhuhai United Laboratories Co ., L...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

05

Mustafa Nevzat Ilac Sanayi A S

Turkey

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

06

Mustafa Nevzat Ilac Sanayi A S

Turkey

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

07

Mustafa Nevzat Ilac Sanayi A S

Turkey

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

08

Zhejiang Hisun Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

09

Istituto Biochimico Italiano Giova...

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

10

Qilu Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Compamed

Not Confirmed

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API Reference Price

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Export","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1636396200,"product":"SULBACTAM SODIUM USP 40","address":"PLOT NO1 INDUSTRIAL AREA,CHAMBAGHT SOLAN SAPROON HP","city":"SOLAN,HIMACHAL PRADESH","supplier":"ODIN HEALTHCARE PVT.LTD.","supplierCountry":"INDIA","foreign_port":"SHANGHAI","customer":"NORTH CHINA PHARMACEUTICAL CO., LTD.","customerCountry":"CHINA","quantity":"498.00","actualQuantity":"498","unit":"KGS","unitRateFc":"94","totalValueFC":"46420.6","currency":"USD","unitRateINR":6941.7670682730923,"date":"09-Nov-2021","totalValueINR":"3457000","totalValueInUsd":"46420.6","indian_port":"JNPT","hs_no":"29419090","bill_no":"5873789","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"PLOT NO1 INDUSTRIAL AREA,CHAMBAGHT SOLAN SAPROON HP, SOLAN,HIMACHAL PRADESH","customerAddress":""},{"dataSource":"API 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