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    Also known as: 61318-91-0, Exelderm, 82382-23-8, Sulconazole nitrate salt, 1-[2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole nitrate, Sulconazolenitrate
    Molecular Formula
    C18H16Cl3N3O3S
    Molecular Weight
    460.8  g/mol
    InChI Key
    CRKGMGQUHDNAPB-UHFFFAOYSA-N
    FDA UNII
    1T89100D5U
    Sulconazole Nitrate
    Sulconazole Nitrate is the nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA.
    1 2D Structure

    Sulconazole Nitrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric acid
    2.1.2 InChI
    InChI=1S/C18H15Cl3N2S.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)
    2.1.3 InChI Key
    CRKGMGQUHDNAPB-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC(=CC=C1CSC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl.[N+](=O)(O)[O-]
    2.2 Other Identifiers
    2.2.1 UNII
    1T89100D5U
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(beta-(4''-chlorobenzylthio)-2'4'-dichlorophenethyl)imidazole

    2. Exelderm

    3. Myk

    4. Sulconazole

    5. Sulconazole Mononitrate

    6. Sulconazole, Mononitrate, (+-)-isomer

    2.3.2 Depositor-Supplied Synonyms

    1. 61318-91-0

    2. Exelderm

    3. 82382-23-8

    4. Sulconazole Nitrate Salt

    5. 1-[2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl]-1h-imidazole Nitrate

    6. Sulconazolenitrate

    7. Sulconazole (mononitrate)

    8. Sulcosyn

    9. Rs 44872

    10. Rs-44872

    11. Sulconazole (nitrate)

    12. 1-(2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Nitrate

    13. Nsc-757849

    14. Rs-44872-00-10-3

    15. 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole;nitric Acid

    16. Mls000028611

    17. (+/-)-sulconazole (nitrate)

    18. (+/-)-sulconazole (mononitrate)

    19. 1-(2-[p-chlorobenzylthio]-2-[2,4-dichlorophenyl]ethyl)-1h-imidazole

    20. Sulconazole Mononitrate

    21. 1t89100d5u

    22. 61318-91-0 (nitrate)

    23. Smr000058734

    24. Dsstox_cid_25490

    25. Dsstox_rid_80911

    26. Dsstox_gsid_45490

    27. Sulconazle Nitrate

    28. Sr-01000000237

    29. Unii-1t89100d5u

    30. 1-(2-(4-chlorobenzylthio)-2-(2,4-dichlorophenyl)ethyl)-1h-imidazole Nitrate

    31. Exelderm (tn)

    32. Prestwick_128

    33. Mfcd00058163

    34. Sulconazole Nitrate [usan:usp:jan]

    35. Opera_id_1591

    36. Ncgc00016898-01

    37. (+-)-1-(2,4-dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate

    38. Sulconazole Nitrate (1:x)

    39. Sulconazolenitratesalt

    40. Cas-61318-91-0

    41. (+-)-1-(2,4-dichloro-beta-((p-chlorobenzyl)thio)phenethyl)imidazole Mononitrate

    42. Schembl36906

    43. Mls001146948

    44. Mls002222171

    45. Spectrum1501148

    46. Chebi:9326

    47. Sulconazole Nitrate (jan/usp)

    48. Chembl1200348

    49. Dtxsid2045490

    50. Sulconazole Nitrate [mi]

    51. Hms500k22

    52. Sulconazole Nitrate [jan]

    53. Hms1570b21

    54. Hms1921l03

    55. Hms2092h09

    56. Hms2097b21

    57. Hms2232b18

    58. Hms3370h17

    59. Hms3652c18

    60. Hms3714b21

    61. Pharmakon1600-01501148

    62. Sulconazole Nitrate [usan]

    63. Sulconazole Nitrate [vandf]

    64. Bcp15962

    65. Hy-b1460

    66. Sulconazole Nitrate [mart.]

    67. Tox21_110671

    68. Ccg-39015

    69. Nsc757849

    70. S4120

    71. Sulconazole Nitrate [usp-rs]

    72. Sulconazole Nitrate [who-dd]

    73. Akos015897482

    74. Tox21_110671_1

    75. Ks-1471

    76. Nsc 757849

    77. 1-[2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

    78. Ncgc00018250-06

    79. Ncgc00094911-01

    80. Ncgc00094911-02

    81. Ncgc00094911-03

    82. Ncgc00094911-04

    83. Sulconazole Nitrate [orange Book]

    84. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate, (+-)-

    85. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, Nitrate (9ci)

    86. Ac-26451

    87. Sulconazole Nitrate [usp Monograph]

    88. Cs-0013167

    89. Ft-0659334

    90. Sw196439-3

    91. U0112

    92. D00886

    93. Rs-44872-00-1o-3

    94. A833159

    95. A916203

    96. Sr-01000000237-2

    97. Sr-01000000237-4

    98. Q27252867

    99. (+/-)-1-(2,4-dichloro-.beta.-((p-chlorobenzyl)thio)phenethyl)imidazole Mononitrate

    100. 1-[2-[(4-chlorophenyl)methylthio]-2-(2,4-dichlorophenyl)ethyl]imidazole; Nitric Acid

    101. 1h-imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate, (+/-)-

    102. 1h-imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, Nitrate (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 460.8 g/mol
    Molecular Formula C18H16Cl3N3O3S
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count6
    Exact Mass458.997796 g/mol
    Monoisotopic Mass458.997796 g/mol
    Topological Polar Surface Area109 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity404
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameExelderm
    PubMed HealthSulconazole (Topical route)
    Drug ClassesAntifungal, Imidazole
    Drug LabelEXELDERM (sulconazole nitrate, USP) CREAM, 1.0% is a broad-spectrum antifungal agent intended for topical application. Sulconazole nitrate, USP the active ingredient in EXELDERM CREAM, is an imidazole derivative with in vitro antifungal and antiyeast...
    Active IngredientSulconazole nitrate
    Dosage FormCream; Solution
    RouteTopical
    Strength1%
    Market StatusPrescription
    CompanyRanbaxy

    2 of 2  
    Drug NameExelderm
    PubMed HealthSulconazole (Topical route)
    Drug ClassesAntifungal, Imidazole
    Drug LabelEXELDERM (sulconazole nitrate, USP) CREAM, 1.0% is a broad-spectrum antifungal agent intended for topical application. Sulconazole nitrate, USP the active ingredient in EXELDERM CREAM, is an imidazole derivative with in vitro antifungal and antiyeast...
    Active IngredientSulconazole nitrate
    Dosage FormCream; Solution
    RouteTopical
    Strength1%
    Market StatusPrescription
    CompanyRanbaxy

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antifungal Agents

    Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (See all compounds classified as Antifungal Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Azoles [CS]; Azole Antifungal [EPC]

    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - CREAM;TOPICAL - 1%

    USFDA APPLICATION NUMBER - 18737

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    DOSAGE - SOLUTION;TOPICAL - 1%

    USFDA APPLICATION NUMBER - 18738

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