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Also known as: Sunvozertinib [inn], L1q2k5jyo8, 2370013-12-8, Dzd9008, 2-propenamide, n-(5-((4-((5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl)amino)-2-pyrimidinyl)amino)-2-((3r)-3-(dimethylamino)-1-pyrrolidinyl)-4-methoxyphenyl)-, Unii-l1q2k5jyo8

Molecular Formula

C₂₉H₃₅ClFN₇O₃

Molecular Weight

584.1 g/mol

InChI Key

BTMKEDDEMKKSEF-QGZVFWFLSA-N

FDA UNII

L1Q2K5JYO8

Sunvozertinib is an orally available, irreversible, dual kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) that shows similar activity against certain activating mutations, including exon 20 insertions (exon20ins), with potential antineoplastic activity. Upon oral administration,sunvozertinib binds to and inhibits EGFR and HER2, which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. In contrast to other agents active against exon20ins mutations, sunvozertinib appears to be more selective against mutated EGFR than wild-type (wt) EGFR. This may lessen wtEGFR-related dose-limiting toxicity and may allow for the administration of the desired therapeutic dose of sunvozertinib.

1 2D Structure

Sunvozertinib

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

2.1.2 InChI

InChI=1S/C29H35ClFN7O3/c1-7-27(39)34-22-14-23(25(41-6)15-24(22)38-11-9-17(16-38)37(4)5)35-28-32-10-8-26(36-28)33-21-13-19(30)20(31)12-18(21)29(2,3)40/h7-8,10,12-15,17,40H,1,9,11,16H2,2-6H3,(H,34,39)(H2,32,33,35,36)/t17-/m1/s1

2.1.3 InChI Key

BTMKEDDEMKKSEF-QGZVFWFLSA-N

2.1.4 Canonical SMILES

CC(C)(C1=CC(=C(C=C1NC2=NC(=NC=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CCC(C4)N(C)C)OC)Cl)F)O

2.1.5 Isomeric SMILES

CC(C)(C1=CC(=C(C=C1NC2=NC(=NC=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CC[C@H](C4)N(C)C)OC)Cl)F)O

2.2 Other Identifiers

2.2.1 UNII

L1Q2K5JYO8

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Sunvozertinib [inn]

2. L1q2k5jyo8

3. 2370013-12-8

4. Dzd9008

5. 2-propenamide, N-(5-((4-((5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl)amino)-2-pyrimidinyl)amino)-2-((3r)-3-(dimethylamino)-1-pyrrolidinyl)-4-methoxyphenyl)-

6. Unii-l1q2k5jyo8

7. Schembl21232131

8. Gtpl11672

9. Glxc-25829

10. Ex-a6612

11. Example 52 [wo2019149164a1]

12. Hy-132842

13. Cs-0204146

14. N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3r)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

2.4 Create Date

2019-11-02

3 Chemical and Physical Properties

Molecular Formula	C₂₉H₃₅ClFN₇O₃
Molecular Weight	584.1 g/mol
XLogP3	5
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	583.2473939 g/mol
Monoisotopic Mass	583.2473939 g/mol
Topological Polar Surface Area	115 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	885
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

Drugs in Development

01 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

02 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

03 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

04 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

05 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

06 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

07 Anova Enterprises

U.S.A

BIO Partnering at JPM

Not Confirmed

08 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

09 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

10 Dizal Pharmaceutical

China

BIO Partnering at JPM

Not Confirmed

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ABOUT THIS PAGE

Sunvozertinib Manufacturers

A Sunvozertinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Sunvozertinib, including repackagers and relabelers. The FDA regulates Sunvozertinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Sunvozertinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Sunvozertinib Suppliers

A Sunvozertinib supplier is an individual or a company that provides Sunvozertinib active pharmaceutical ingredient (API) or Sunvozertinib finished formulations upon request. The Sunvozertinib suppliers may include Sunvozertinib API manufacturers, exporters, distributors and traders.

Sunvozertinib GMP

Sunvozertinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Sunvozertinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Sunvozertinib GMP manufacturer or Sunvozertinib GMP API supplier for your needs.

Sunvozertinib CoA

A Sunvozertinib CoA (Certificate of Analysis) is a formal document that attests to Sunvozertinib's compliance with Sunvozertinib specifications and serves as a tool for batch-level quality control.

Sunvozertinib CoA mostly includes findings from lab analyses of a specific batch. For each Sunvozertinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Sunvozertinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Sunvozertinib EP), Sunvozertinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Sunvozertinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

Find Sunvozertinib manufacturers, exporters & distributors on PharmaCompass

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