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Chemistry

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Also known as: 125973-56-0, Tac-101, Am 555s, Amsilarotene [inn], Am555s,tac-101, 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid
Molecular Formula
C20H27NO3Si2
Molecular Weight
385.6  g/mol
InChI Key
VVTNSTLJOVCBDL-UHFFFAOYSA-N
FDA UNII
Q1418F39MH

Tac 101
Amsilarotene is a retinobenzoic acid with potential antineoplastic activity. Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest. This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.
1 2D Structure

Tac 101

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid
2.1.2 InChI
InChI=1S/C20H27NO3Si2/c1-25(2,3)17-11-15(12-18(13-17)26(4,5)6)19(22)21-16-9-7-14(8-10-16)20(23)24/h7-13H,1-6H3,(H,21,22)(H,23,24)
2.1.3 InChI Key
VVTNSTLJOVCBDL-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C[Si](C)(C)C1=CC(=CC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)O)[Si](C)(C)C
2.2 Other Identifiers
2.2.1 UNII
Q1418F39MH
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-(3,5-bis(trimethylsilyl)benzamido)benzoic Acid

2. Am 555s

3. Am-555s

4. Am555s

5. Tac 101

6. Tac-101

2.3.2 Depositor-Supplied Synonyms

1. 125973-56-0

2. Tac-101

3. Am 555s

4. Amsilarotene [inn]

5. Am555s,tac-101

6. 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic Acid

7. Amsilarotene; Tac 101

8. Q1418f39mh

9. 4-[3,5-bis(trimethylsilyl) Benzamido] Benzoic Acid

10. Benzoic Acid, 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]-

11. Am-555s

12. Tac 101

13. 4-(3,5-bis(trimethylsilyl)benzamido)benzoic Acid

14. Benzoic Acid, 4-((3,5-bis(trimethylsilyl)benzoyl)amino)-

15. Unii-q1418f39mh

16. Ccris 9419

17. 4-(3,5-bis(trimethylsilyl)benzamido) Benzoic Acid

18. Amsilarotene [who-dd]

19. Chembl32994

20. Schembl1133175

21. Dtxsid90155013

22. Ex-a128

23. Bcp06502

24. Akos032947226

25. Zinc169746726

26. Ac-36797

27. Da-13333

28. Hy-14653

29. Cs-0003504

30. Ft-0769431

31. A13122

32. Q27286879

33. 5-(4-methylphenyl)furan-2-carboxylicacidmethylester

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 385.6 g/mol
Molecular Formula C20H27NO3Si2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass385.15294679 g/mol
Monoisotopic Mass385.15294679 g/mol
Topological Polar Surface Area66.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity494
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API SUPPLIERS

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ABOUT THIS PAGE

Tac 101 Manufacturers

A Tac 101 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tac 101, including repackagers and relabelers. The FDA regulates Tac 101 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tac 101 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tac 101 Suppliers

A Tac 101 supplier is an individual or a company that provides Tac 101 active pharmaceutical ingredient (API) or Tac 101 finished formulations upon request. The Tac 101 suppliers may include Tac 101 API manufacturers, exporters, distributors and traders.

click here to find a list of Tac 101 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tac 101 USDMF

A Tac 101 DMF (Drug Master File) is a document detailing the whole manufacturing process of Tac 101 active pharmaceutical ingredient (API) in detail. Different forms of Tac 101 DMFs exist exist since differing nations have different regulations, such as Tac 101 USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tac 101 DMF submitted to regulatory agencies in the US is known as a USDMF. Tac 101 USDMF includes data on Tac 101's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tac 101 USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tac 101 suppliers with USDMF on PharmaCompass.

Tac 101 GMP

Tac 101 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tac 101 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tac 101 GMP manufacturer or Tac 101 GMP API supplier for your needs.

Tac 101 CoA

A Tac 101 CoA (Certificate of Analysis) is a formal document that attests to Tac 101's compliance with Tac 101 specifications and serves as a tool for batch-level quality control.

Tac 101 CoA mostly includes findings from lab analyses of a specific batch. For each Tac 101 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tac 101 may be tested according to a variety of international standards, such as European Pharmacopoeia (Tac 101 EP), Tac 101 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tac 101 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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