Find Tacrine manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Related ProductsRelated Products

Synopsis

ACTIVE PHARMA INGREDIENTS

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

NDC API

NDC API

0

VMF

NDC API

API REF. PRICE (USD/KG)

$
$ 0

MARKET PLACE

0

API

0

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

0

Europe

Europe

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

0 DRUGS IN DEVELOPMENT

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

0

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

Finished Drug Prices

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as: 1684-40-8, Tacrine hcl, 1,2,3,4-tetrahydroacridin-9-amine hydrochloride, Cognex, Hydroaminacrine, 9-amino-1,2,3,4-tetrahydroacridine hydrochloride
Molecular Formula
C13H15ClN2
Molecular Weight
234.72  g/mol
InChI Key
ZUFVXZVXEJHHBN-UHFFFAOYSA-N
FDA UNII
4966RNG0BU

Tacrine
A cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders.
1 2D Structure

Tacrine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1,2,3,4-tetrahydroacridin-9-amine;hydrochloride
2.1.2 InChI
InChI=1S/C13H14N2.ClH/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13;/h1,3,5,7H,2,4,6,8H2,(H2,14,15);1H
2.1.3 InChI Key
ZUFVXZVXEJHHBN-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
2.2 Other Identifiers
2.2.1 UNII
4966RNG0BU
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1,2,3,4-tetrahydro-9-acridinamine

2. 1,2,3,4-tetrahydroaminoacridine

3. 9-amino-1,2,3,4-tetrahydroacridine

4. Cognex

5. Romotal

6. Tacrine

7. Tenakrin

8. Tetrahydroaminoacridine

9. Tha

2.3.2 Depositor-Supplied Synonyms

1. 1684-40-8

2. Tacrine Hcl

3. 1,2,3,4-tetrahydroacridin-9-amine Hydrochloride

4. Cognex

5. Hydroaminacrine

6. 9-amino-1,2,3,4-tetrahydroacridine Hydrochloride

7. Romotal

8. Tenakrin

9. Ci-970

10. Tacrine.hcl

11. Tacrine (hydrochloride)

12. 9-acridinamine, 1,2,3,4-tetrahydro-, Monohydrochloride

13. Nsc-72108

14. 1,2,3,4-tetrahydro-9-acridinamine Hydrochloride

15. Mls000028845

16. 4966rng0bu

17. 9-acridinamine, 1,2,3,4-tetrahydro-, Hydrochloride (1:1)

18. 1,2,3,4-tetrahydro-9-aminoacridine Hydrochloride

19. 9-amino-1,2,3,4-tetrahydroacridine Monohydrochloride

20. 9-amino-1,2,3,4-tetrahydroacridine Hydrochloride Dihydrate

21. Smr000059105

22. 1,2,3,4-tetrahydroacridin-9-amine;hydrochloride

23. 1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride

24. Sr-01000075593

25. Cas-1684-40-8

26. Unii-4966rng0bu

27. Tacrine Hydrochloride [usan]

28. Ccris 7250

29. T.h.a.

30. Oros-tacrine

31. Tacrine Hydrochloride [usan:usp]

32. Tacrine Hydrochlorid

33. Tacrin Hydrochloride

34. Einecs 216-867-5

35. 1,2,3,4-tetrahydroacridin-9-amine Monohydrochloride

36. Ci 970

37. Cognex (tn)

38. Nsc 72108

39. Tha.hcl

40. Cpd000059105

41. Opera_id_296

42. Dsstox_cid_6112

43. Schembl3270

44. 1,2,3,4-tetrahydroacridin-9-aminehydrochloride

45. Chembl1677

46. Dsstox_rid_78021

47. Dsstox_gsid_26112

48. Tacrine Hydrochloride (usp)

49. Mls000758202

50. Mls001401372

51. Spectrum2300104

52. Acridine, 9-amino-1,2,3,4-tetrahydro-, Hydrochloride

53. Dtxsid1026112

54. Acridine, 9-amino-1,2,3,4-tetrahydro-, Monohydrochloride

55. Ci970

56. Pharmakon1600-02300104

57. Tacrine Hydrochloride [mi]

58. Act08745

59. Amy10870

60. Bcp29701

61. Hy-b1488

62. Nsc72108

63. Tox21_200299

64. Tox21_500036

65. Ccg-39606

66. Mfcd00012657

67. Nsc759324

68. S4357

69. Tacrine Hydrochloride [vandf]

70. Tacrine Hydrochloride [mart.]

71. Akos015913476

72. Tacrine Hydrochloride [who-dd]

73. Lp00036

74. Nc00068

75. Nsc-759324

76. Tacrine Hydrochloride; Tha Hydrochloride

77. Tetrahydroaminoacridine Monohydrochloride

78. Ncgc00024908-02

79. Ncgc00093554-01

80. Ncgc00093554-02

81. Ncgc00093554-03

82. Ncgc00093554-04

83. Ncgc00257853-01

84. Ncgc00260721-01

85. 1,2,3,4-tetrahydroacridin-9-amine Hcl

86. Ds-16390

87. Tacrine Hydrochloride [orange Book]

88. Db-043738

89. Tacrine Hydrochloride [usp Impurity]

90. B6527

91. Cs-0013186

92. Eu-0100036

93. Ft-0633768

94. Sw033163-6

95. A 3773

96. Acridine,2,3,4-tetrahydro-, Monohydrochloride

97. D02068

98. F20766

99. A810973

100. J-010457

101. Sr-01000075593-1

102. Sr-01000075593-3

103. Sr-01000075593-9

104. 9-acridinamine,2,3,4,-tetrahydro-, Monohydrochloride

105. Q27259239

106. Sr-01000075593-16

107. Acridine, 1,2,3,4-tetrahydro-9-amino-, Monohydrochloride

108. Tacrine Hcl;hydroaminacrine; Nsc72108; Nsc-72108; Nsc72108

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 234.72 g/mol
Molecular Formula C13H15ClN2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass234.0923762 g/mol
Monoisotopic Mass234.0923762 g/mol
Topological Polar Surface Area38.9 Ų
Heavy Atom Count16
Formal Charge0
Complexity229
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Cholinesterase Inhibitors

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)


Nootropic Agents

Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. (See all compounds classified as Nootropic Agents.)


Parasympathomimetics

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here. (See all compounds classified as Parasympathomimetics.)


REF. STANDARDS & IMPURITIES

Upload your portfolio for free, ask us

USP

read-more
read-more

ABOUT THIS PAGE

Tacrine Manufacturers

A Tacrine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tacrine, including repackagers and relabelers. The FDA regulates Tacrine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tacrine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Tacrine manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Tacrine Suppliers

A Tacrine supplier is an individual or a company that provides Tacrine active pharmaceutical ingredient (API) or Tacrine finished formulations upon request. The Tacrine suppliers may include Tacrine API manufacturers, exporters, distributors and traders.

click here to find a list of Tacrine suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Tacrine USDMF

A Tacrine DMF (Drug Master File) is a document detailing the whole manufacturing process of Tacrine active pharmaceutical ingredient (API) in detail. Different forms of Tacrine DMFs exist exist since differing nations have different regulations, such as Tacrine USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Tacrine DMF submitted to regulatory agencies in the US is known as a USDMF. Tacrine USDMF includes data on Tacrine's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Tacrine USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Tacrine suppliers with USDMF on PharmaCompass.

Tacrine GMP

Tacrine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tacrine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tacrine GMP manufacturer or Tacrine GMP API supplier for your needs.

Tacrine CoA

A Tacrine CoA (Certificate of Analysis) is a formal document that attests to Tacrine's compliance with Tacrine specifications and serves as a tool for batch-level quality control.

Tacrine CoA mostly includes findings from lab analyses of a specific batch. For each Tacrine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tacrine may be tested according to a variety of international standards, such as European Pharmacopoeia (Tacrine EP), Tacrine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tacrine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty