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Also known as: 594839-88-0, Vyndamax, Fx-1006, 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, 2-(3,5-dichlorophenyl)-6-benzoxazole carboxylic acid, 8fg9h9d31j
Molecular Formula
C14H7Cl2NO3
Molecular Weight
308.1  g/mol
InChI Key
TXEIIPDJKFWEEC-UHFFFAOYSA-N
FDA UNII
8FG9H9D31J

Tafamidis
Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives developed by FoldRX. Tafamidis is structurally similar to diflusinal. Tafamidis was granted an EMA market authorisation on 16 November 2011 and FDA approval on 3 May 2019.
1 2D Structure

Tafamidis

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
2.1.2 InChI
InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19)
2.1.3 InChI Key
TXEIIPDJKFWEEC-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC2=C(C=C1C(=O)O)OC(=N2)C3=CC(=CC(=C3)Cl)Cl
2.2 Other Identifiers
2.2.1 UNII
8FG9H9D31J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Fx 1006a

2. Fx-1006a

3. Fx1006a

4. Tafamidis Meglumine

5. Vyndamax

6. Vyndaqel

2.3.2 Depositor-Supplied Synonyms

1. 594839-88-0

2. Vyndamax

3. Fx-1006

4. 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic Acid

5. 2-(3,5-dichlorophenyl)-6-benzoxazole Carboxylic Acid

6. 8fg9h9d31j

7. Chebi:78538

8. 2-(3,5-dichlorophenyl)benzoxazole-6-carboxylic Acid

9. 2-(3,5-dichlorophenyl)benzo[d]oxazole-6-carboxylic Acid

10. 594839-88-0 (free Acid)

11. Fx1006

12. Mfcd16621109

13. Fx-1005

14. 6-benzoxazolecarboxylic Acid, 2-(3,5-dichlorophenyl)-

15. Tafamidis [usan]

16. Tafamidis [usan:inn]

17. Tafamidisum

18. Unii-8fg9h9d31j

19. 4his

20. Tafamidis-meglumine

21. Vyndamax (tn)

22. 3mi

23. Tafamidis [inn]

24. Tafamidis [jan]

25. Tafamidis [mi]

26. Tafamidis [mart.]

27. Tafamidis [who-dd]

28. Tafamidis (jan/usan/inn)

29. Schembl442508

30. Gtpl8378

31. Tafamidis [orange Book]

32. Chembl2103837

33. Pf-06291826(tafamidis)

34. Dtxsid00208185

35. Hms3741e09

36. Bcp29089

37. Ex-a3575

38. Bdbm50197883

39. S6465

40. Zinc43206271

41. Akos017550076

42. Db11644

43. Vs-0125

44. Ncgc00390731-01

45. 137464-18-7

46. Hy-14852

47. Sy217402

48. Db-072645

49. Ft-0674793

50. A14111

51. C75776

52. D09673

53. 839d880

54. A869196

55. Q519447

56. 2-(3,5-dichloro-phenyl)-benzooxazole-6-carboxylic Acid

57. Z2588039578

58. Discontinued Until Pfizer Approves It For Our Agreement""

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 308.1 g/mol
Molecular Formula C14H7Cl2NO3
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.9802985 g/mol
Monoisotopic Mass306.9802985 g/mol
Topological Polar Surface Area63.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity371
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Tafamidis is indicated to treat cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Tafamidis stabilizes transthyretin tetramers, reducing the amount of monomers available for amyloidogenesis. It has a long duration of action as it is given once daily, and a wide therapeutic window.


5.2 ATC Code

N07XX08

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N07 - Other nervous system drugs

N07X - Other nervous system drugs

N07XX - Other nervous system drugs

N07XX08 - Tafamidis


5.3 Absorption, Distribution and Excretion

Absorption

Tafamidis reaches a Cmax of 1430.93ng/mL with a Tmax of 1.75h fasted and 4h fed. The AUC of tafamidis is 47,864.31ng\*h/mL.


Route of Elimination

A 20mg oral dose of tafamidis is approximately 59% recovered in the feces, largely as unchanged drug. Approximately 22% of a 20mg oral dose is recovered in the urine, mostly as the glucuronide metabolite.


Volume of Distribution

The apparent volume of distribution at steady state is 18.5L.


Clearance

The oral clearance of tafamidis is 0.263L/h. The apparent total clearance is 0.44L/h.


5.4 Metabolism/Metabolites

Tafamidis is largely not subject to first pass or oxidative metabolism, being 90% unchanged after in in vitro experiments. Preclinical data suggest tafamidis is mainly metabolized through glucuronidation and excreted in bile.


5.5 Biological Half-Life

The half life of tafamidis is 49h.


5.6 Mechanism of Action

Genetic mutations or natural misfolding of transthyretin destabalizes transthyretin tetramers, leading to their dissociation and aggregation in tissues, and disrupting the normal function of these tissues. Tafamidis binds to transthyretin tetramers at the thyroxin binding sites, stabilizing the tetramer, reducing the availability of monomers for amyloidogenesis.


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TAFAMIDIS

NDC Package Code : 58159-090

Start Marketing Date : 2022-07-19

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (35kg/35kg)

Marketing Category : BULK INGREDIENT

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TAFAMIDIS

NDC Package Code : 58159-079

Start Marketing Date : 2020-06-17

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (35kg/35kg)

Marketing Category : BULK INGREDIENT

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TAFAMIDIS

NDC Package Code : 73435-031

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End Marketing Date : 2024-12-31

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TAFAMIDIS

NDC Package Code : 58032-1031

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NDC Package Code : 59651-743

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TAFAMIDIS

NDC Package Code : 69988-0039

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NDC Package Code : 66039-960

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NDC Package Code : 14501-0102

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TAFAMIDIS

NDC Package Code : 60715-0647

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NDC Package Code : 60715-4344

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SCIENCE","customerCountry":"INDIA","quantity":"0.90","actualQuantity":"0.9","unit":"KGS","unitRateFc":"39000","totalValueFC":"38321.1","currency":"EUR","unitRateINR":"3545590.8","date":"16-Nov-2023","totalValueINR":"3191031.74","totalValueInUsd":"38321.1","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"8793046","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ZAGREB","supplierAddress":"CARRER SANT GABRIEL 50 08950, ESPLUGUES DE LLOBREHAT-SPAIN CIF ES B63078075 ES","customerAddress":"206, DEVAVRATA,"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1701455400,"product":"TAFAMIDIS MEGLUMINE(FOC)","address":"206, DEVAVRATA,","city":"NAVI MUMBAI, MAHARASHTRA.","supplier":"GALENICUM","supplierCountry":"CROATIA","foreign_port":"ZAGREB","customer":"STRIDES PHARMA SCIENCE","customerCountry":"INDIA","quantity":"0.97","actualQuantity":"0.966","unit":"KGS","unitRateFc":"39000","totalValueFC":"42013.4","currency":"EUR","unitRateINR":"3620426.3","date":"02-Dec-2023","totalValueINR":"3497331.78","totalValueInUsd":"42013.4","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"9053417","productDescription":"API","marketType":"REGULATED MARKET","country":"CROATIA","selfForZScoreResived":"Pharma Grade","supplierPort":"ZAGREB","supplierAddress":"CARRER SANT GABRIEL 50 08950, ESPLUGUES DE LLOBREHAT-SPAIN CIF ES B630SDNF ES","customerAddress":"206, DEVAVRATA,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1717093800,"product":"FREE SAMPLE - TAFAMIDIS - FOR R AND D PURPOSE","address":"206, DEVAVRATA,","city":"NAVI MUMBAI, MAHARASHTRA.","supplier":"GALENICUM","supplierCountry":"SPAIN","foreign_port":"MADRID","customer":"STRIDES PHARMA SCIENCE","customerCountry":"INDIA","quantity":"8.00","actualQuantity":"8","unit":"KGS","unitRateFc":"39500","totalValueFC":"350672.3","currency":"EUR","unitRateINR":"3653750","date":"31-May-2024","totalValueINR":"29230000","totalValueInUsd":"350672.3","indian_port":"Bangalore Air","hs_no":"29420090","bill_no":"3768825","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"MADRID","supplierAddress":"Carrer Sant Gabriel 50 08950, Esplugues de Llobrehat Barcelona, , SPAIN SPAIN","customerAddress":"206, DEVAVRATA,"}]
01-Apr-2021
26-Oct-2024
KGS
overview
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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

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Patents & EXCLUSIVITIES

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US Patents

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01

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BioFlorida Conference
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TAFAMIDIS

US Patent Number : 7214695

Drug Substance Claim : Y

Drug Product Claim : Y

Application Number : 212161

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2025-12-19

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02

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BioFlorida Conference
Not Confirmed
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TAFAMIDIS

US Patent Number : 7214696

Drug Substance Claim :

Drug Product Claim :

Application Number : 212161

Patent Use Code : U-2524

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2025-12-19

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03

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BioFlorida Conference
Not Confirmed
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BioFlorida Conference
Not Confirmed

TAFAMIDIS

US Patent Number : 9770441

Drug Substance Claim : Y

Drug Product Claim : Y

Application Number : 212161

Patent Use Code : U-2524

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2035-08-31

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US Exclusivities

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01

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euroPLX 86 Munich
Not Confirmed
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euroPLX 86 Munich
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TAFAMIDIS

Exclusivity Code : NCE

Exclusivity Expiration Date : 2024-05-03

Application Number : 212161

Product Number : 1

Exclusivity Details :

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02

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euroPLX 86 Munich
Not Confirmed
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euroPLX 86 Munich
Not Confirmed

TAFAMIDIS

Exclusivity Code : ODE-237

Exclusivity Expiration Date : 2026-05-03

Application Number : 212161

Product Number : 1

Exclusivity Details :

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