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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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KDMF

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NDC API

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0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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Chemistry

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Also known as: Tak-733, 1035555-63-5, Tak733, Tak 733, Mek inhibitor tak-733, 5j61hsp0qj
Molecular Formula
C17H15F2IN4O4
Molecular Weight
504.23  g/mol
InChI Key
RCLQNICOARASSR-SECBINFHSA-N
FDA UNII
5J61HSP0QJ

Tak-733
MEK Inhibitor TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
1 2D Structure

Tak-733

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione
2.1.2 InChI
InChI=1S/C17H15F2IN4O4/c1-23-15-12(16(27)24(7-21-15)5-9(26)6-25)14(13(19)17(23)28)22-11-3-2-8(20)4-10(11)18/h2-4,7,9,22,25-26H,5-6H2,1H3/t9-/m1/s1
2.1.3 InChI Key
RCLQNICOARASSR-SECBINFHSA-N
2.1.4 Canonical SMILES
CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O
2.1.5 Isomeric SMILES
CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)C[C@H](CO)O
2.2 Other Identifiers
2.2.1 UNII
5J61HSP0QJ
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Tak 733

2. Tak-733

3. Tak733

2.3.2 Depositor-Supplied Synonyms

1. Tak-733

2. 1035555-63-5

3. Tak733

4. Tak 733

5. Mek Inhibitor Tak-733

6. 5j61hsp0qj

7. Chembl1615025

8. 3-[(2r)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione

9. Unii-5j61hsp0qj

10. (r)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido(2,3-d)pyrimidine-4,7(3h,8h)-dione

11. Mls006011054

12. Gtpl9911

13. Schembl1528606

14. Tak-733 [who-dd]

15. Dtxsid20648089

16. Example 18 [us8470837]

17. Bcp06625

18. Ex-a2164

19. Bdbm50337926

20. Mfcd24386349

21. Nsc761215

22. Nsc800940

23. S2617

24. Zinc43196550

25. Akos027251050

26. Ccg-264969

27. Cs-1283

28. Db12241

29. Nsc-761215

30. Nsc-800940

31. Compound 17 [pmid: 21310613]

32. Ncgc00263187-01

33. 3-[(2r)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione

34. Hy-13449

35. Smr004702846

36. Sw220152-1

37. Us8470837, 18

38. A857992

39. Q27262384

40. (r)-3-(2,3-dihydroxypropyl)-6-fluoro-5-((2-fluoro-4-iodophenyl)amino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione

41. 3-[(2r)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido [2,3-d]pyrimidine-4,7(3h,8h)-dione

42. Izg

43. Pyrido[2,3-d]pyrimidine-4,7(3h,8h)-dione,3-[(2r)-2,3-dihydroxy-propyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methyl-

2.4 Create Date
2008-10-20
3 Chemical and Physical Properties
Molecular Weight 504.23 g/mol
Molecular Formula C17H15F2IN4O4
XLogP30.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass504.01061 g/mol
Monoisotopic Mass504.01061 g/mol
Topological Polar Surface Area106 Ų
Heavy Atom Count28
Formal Charge0
Complexity772
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1035555-63-5 / Tak-733 API manufacturers, exporters & distributors?

Tak-733 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Tak-733 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Tak-733 manufacturer or Tak-733 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Tak-733 manufacturer or Tak-733 supplier.

PharmaCompass also assists you with knowing the Tak-733 API Price utilized in the formulation of products. Tak-733 API Price is not always fixed or binding as the Tak-733 Price is obtained through a variety of data sources. The Tak-733 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Tak-733

Synonyms

1035555-63-5, Tak733, Tak 733, Mek inhibitor tak-733, 5j61hsp0qj, Chembl1615025

Cas Number

1035555-63-5

Unique Ingredient Identifier (UNII)

5J61HSP0QJ

About Tak-733

MEK Inhibitor TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

TAK 733 Manufacturers

A TAK 733 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of TAK 733, including repackagers and relabelers. The FDA regulates TAK 733 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. TAK 733 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

TAK 733 Suppliers

A TAK 733 supplier is an individual or a company that provides TAK 733 active pharmaceutical ingredient (API) or TAK 733 finished formulations upon request. The TAK 733 suppliers may include TAK 733 API manufacturers, exporters, distributors and traders.

TAK 733 GMP

TAK 733 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of TAK 733 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right TAK 733 GMP manufacturer or TAK 733 GMP API supplier for your needs.

TAK 733 CoA

A TAK 733 CoA (Certificate of Analysis) is a formal document that attests to TAK 733's compliance with TAK 733 specifications and serves as a tool for batch-level quality control.

TAK 733 CoA mostly includes findings from lab analyses of a specific batch. For each TAK 733 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

TAK 733 may be tested according to a variety of international standards, such as European Pharmacopoeia (TAK 733 EP), TAK 733 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (TAK 733 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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