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Chemistry

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Also known as: 1258861-20-9, Ly2940680, Ly-2940680, 4-fluoro-n-methyl-n-(1-(4-(1-methyl-1h-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide, Ly 2940680, Qy8bwx1lj5
Molecular Formula
C26H24F4N6O
Molecular Weight
512.5  g/mol
InChI Key
SZBGQDXLNMELTB-UHFFFAOYSA-N
FDA UNII
QY8BWX1LJ5

Taladegib
Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. Taladegib inhibits signaling that is mediated by the Hh pathway protein Smo, which may result in a suppression of the Hh signaling pathway and may lead to the inhibition of the proliferation of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation and has been observed in a variety of cancers.
1 2D Structure

Taladegib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
4-fluoro-N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoromethyl)benzamide
2.1.2 InChI
InChI=1S/C26H24F4N6O/c1-34(25(37)20-8-7-16(27)15-21(20)26(28,29)30)17-10-13-36(14-11-17)24-19-6-4-3-5-18(19)23(32-33-24)22-9-12-31-35(22)2/h3-9,12,15,17H,10-11,13-14H2,1-2H3
2.1.3 InChI Key
SZBGQDXLNMELTB-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1C(=CC=N1)C2=NN=C(C3=CC=CC=C32)N4CCC(CC4)N(C)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
QY8BWX1LJ5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ly2940680

2. Taledegib

2.3.2 Depositor-Supplied Synonyms

1. 1258861-20-9

2. Ly2940680

3. Ly-2940680

4. 4-fluoro-n-methyl-n-(1-(4-(1-methyl-1h-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide

5. Ly 2940680

6. Qy8bwx1lj5

7. Taladegib (ly2940680)

8. 4-fluoro-n-methyl-n-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-2-(trifluoromethyl)benzamide

9. 4-fluoro-n-methyl-n-{1-[4-(1-methyl-1h-pyrazol-5-yl)phthalazin-1-yl]piperidin-4-yl}-2-(trifluoromethyl)benzamide

10. Benzamide, 4-fluoro-n-methyl-n-(1-(4-(1-methyl-1h-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)-

11. 4-fluoro-n-methyl-n-(1-(4-(1-methyl-1h-pyrazol-5-yl)-1-phthalazinyl)-4-piperidinyl)-2-(trifluoromethyl)benzamide

12. Benzamide, 4-fluoro-n-methyl-n-[1-[4-(1-methyl-1h-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-

13. Taladegib [usan:inn]

14. Unii-qy8bwx1lj5

15. Taladegib [inn]

16. 4-fluoro-n-methyl-n-{1-[4-(1-methyl-1h-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl}-2-(trifluoromethyl)benzamide

17. Taladegib (usan/inn)

18. Taladegib [usan]

19. Taladegib [who-dd]

20. Mls006011066

21. Ly-2940680(taladegib)

22. Schembl2128615

23. Chembl2142592

24. Gtpl10333

25. Dtxsid50154986

26. Ex-a156

27. Bcp02512

28. Bdbm50545020

29. Mfcd21609264

30. Nsc767896

31. S2157

32. Zinc68247898

33. Akos026674116

34. Bcp9000881

35. Ccg-269788

36. Cs-0459

37. Db12550

38. Nsc-767896

39. Sb16504

40. Ncgc00263170-01

41. Ncgc00263170-06

42. Ac-33096

43. As-75020

44. Hy-13242

45. Smr004702857

46. D10671

47. J-515412

48. Q27287564

49. 1ks

2.4 Create Date
2011-01-31
3 Chemical and Physical Properties
Molecular Weight 512.5 g/mol
Molecular Formula C26H24F4N6O
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass512.19477206 g/mol
Monoisotopic Mass512.19477206 g/mol
Topological Polar Surface Area67.2 Ų
Heavy Atom Count37
Formal Charge0
Complexity794
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Taladegib Manufacturers

A Taladegib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Taladegib, including repackagers and relabelers. The FDA regulates Taladegib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Taladegib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Taladegib Suppliers

A Taladegib supplier is an individual or a company that provides Taladegib active pharmaceutical ingredient (API) or Taladegib finished formulations upon request. The Taladegib suppliers may include Taladegib API manufacturers, exporters, distributors and traders.

Taladegib GMP

Taladegib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Taladegib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Taladegib GMP manufacturer or Taladegib GMP API supplier for your needs.

Taladegib CoA

A Taladegib CoA (Certificate of Analysis) is a formal document that attests to Taladegib's compliance with Taladegib specifications and serves as a tool for batch-level quality control.

Taladegib CoA mostly includes findings from lab analyses of a specific batch. For each Taladegib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Taladegib may be tested according to a variety of international standards, such as European Pharmacopoeia (Taladegib EP), Taladegib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Taladegib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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