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Talarozole

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 201410-53-9, Rambazole, R115866, R-115866, N-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine, Talarozole (r enantiomer)

Molecular Formula

C₂₁H₂₃N₅S

Molecular Weight

377.5 g/mol

InChI Key

SNFYYXUGUBUECJ-UHFFFAOYSA-N

FDA UNII

XKD9N5CJ6W

Talarozole has been investigated for the treatment of Psoriasis and Cutaneous Inflammation.

1 2D Structure

talarozole

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine

2.1.2 InChI

InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)

2.1.3 InChI Key

SNFYYXUGUBUECJ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCC(CC)C(C1=CC=C(C=C1)NC2=NC3=CC=CC=C3S2)N4C=NC=N4

2.2 Other Identifiers

2.2.1 UNII

XKD9N5CJ6W

2.3 Synonyms

2.3.1 MeSH Synonyms

1. N-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine

2. R 115866

3. R-115866

4. R115866

5. Rambazole

2.3.2 Depositor-Supplied Synonyms

1. 201410-53-9

2. Rambazole

3. R115866

4. R-115866

5. N-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)benzo[d]thiazol-2-amine

6. Talarozole (r Enantiomer)

7. Xkd9n5cj6w

8. 201410-66-4

9. N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine

10. Chembl459505

11. (+)-n-[4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine

12. 2-benzothiazolamine, N-[4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl]-

13. N-(4-((1rs)-2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)benzothiazol-2-amine

14. Rambazole (tn)

15. Talarozole [usan]

16. Talarozole (usan/inn)

17. Talarozole [usan:inn]

18. Unii-xkd9n5cj6w

19. 2-benzothiazolamine, N-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)-

20. N-{4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine

21. R 115866

22. N-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine

23. Talarozole [inn]

24. Talarozole [who-dd]

25. Schembl721201

26. Schembl21020998

27. Gtpl11381

28. Dtxsid70942185

29. Chebi:102167

30. Bcp21218

31. Bcp28256

32. Bia41053

33. Bdbm50253810

34. Akos005067289

35. Cs-1343

36. Db13083

37. Ncgc00378894-01

38. Ncgc00378894-02

39. Hy-14531

40. Ws-02133

41. D09385

42. D85497

43. A926099

44. Q15410180

45. Rambazole; R115866; R-115866; R 115866

46. Talarozole R Enantiomer;r115866;r 115866;r-115866

47. R115866;r-115866;r 115866

48. (+/-)-n-[4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazol-amine

49. (+/-)-n-[4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine

50. N-{4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothi Azol-2-amine

51. N-{4-[2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine

2.4 Create Date

2006-10-25

3 Chemical and Physical Properties

Molecular Formula	C₂₁H₂₃N₅S
Molecular Weight	377.5 g/mol
XLogP3	6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	377.16741693 g/mol
Monoisotopic Mass	377.16741693 g/mol
Topological Polar Surface Area	83.9 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	452
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Cytochrome P-450 Enzyme Inhibitors

Drugs and compounds which inhibit or antagonize the biosynthesis or actions of CYTOCHROME P-450 ENZYMES. (See all compounds classified as Cytochrome P-450 Enzyme Inhibitors.)

4.2 Mechanism of Action

Rambazole is a new generation all-trans retinoic acid metabolism blocking agent, highly specific against the retinoic acid 4-hydroxylase. The drug alleviates hyperproliferation and normalizes differentiation of the epidermis in animal models of psoriasis. All-trans-retinoic acid (RA) regulates epithelial differentiation and growth through activation of specific nuclear RA receptors (RARs). Rambazole acts by inhibiting the metabolic breakdown of the retinoid, increasing the biological efficacy of RA.

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ABOUT THIS PAGE

talarozole Manufacturers

A talarozole manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of talarozole, including repackagers and relabelers. The FDA regulates talarozole manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. talarozole API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

talarozole Suppliers

A talarozole supplier is an individual or a company that provides talarozole active pharmaceutical ingredient (API) or talarozole finished formulations upon request. The talarozole suppliers may include talarozole API manufacturers, exporters, distributors and traders.

click here to find a list of talarozole suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

talarozole USDMF

A talarozole DMF (Drug Master File) is a document detailing the whole manufacturing process of talarozole active pharmaceutical ingredient (API) in detail. Different forms of talarozole DMFs exist exist since differing nations have different regulations, such as talarozole USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A talarozole DMF submitted to regulatory agencies in the US is known as a USDMF. talarozole USDMF includes data on talarozole's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The talarozole USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of talarozole suppliers with USDMF on PharmaCompass.

talarozole GMP

talarozole Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of talarozole GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right talarozole GMP manufacturer or talarozole GMP API supplier for your needs.

talarozole CoA

A talarozole CoA (Certificate of Analysis) is a formal document that attests to talarozole's compliance with talarozole specifications and serves as a tool for batch-level quality control.

talarozole CoA mostly includes findings from lab analyses of a specific batch. For each talarozole CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

talarozole may be tested according to a variety of international standards, such as European Pharmacopoeia (talarozole EP), talarozole JP (Japanese Pharmacopeia) and the US Pharmacopoeia (talarozole USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.