Find Talazoparib manufacturers, exporters & distributors on PharmaCompass

PharmaCompass

Synopsis

Related ProductsRelated Products

Synopsis

ACTIVE PHARMA INGREDIENTS

0

USDMF

US DMFs Filed

0

CEP/COS

CEP/COS Certifications

0

JDMF

JDMFs Filed

0

EU WC

EU WC

0

KDMF

KDMF

0

VMF

NDC API

API REF. PRICE (USD/KG)

MARKET PLACE

0

API

0

FDF

FINISHED DOSAGE FORMULATIONS

0

FDA Orange Book

FDA (Orange Book)

0

Canada

Canada

0

Australia

Australia

0

South Africa

South Africa

0

Listed Dossiers

Listed Dossiers

FDF Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

0

EDQM

0

USP

0

JP

0

Others

PATENTS & EXCLUSIVITIES

0

US Patents

0

US Exclusivities

0

Health Canada Patents

DIGITAL CONTENT

0

Data Compilation #PharmaFlow

0

Stock Recap #PipelineProspector

0

Weekly News Recap #Phispers

GLOBAL SALES INFORMATION

US Medicaid

NA

Annual Reports

NA

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown
read-moreClick the button for full data set
Also known as:
Molecular Formula
C19H14F2N6O
Molecular Weight
380.4  g/mol
InChI Key
IUEWAGVJRJORLA-HZPDHXFCSA-N

Talazoparib
1 2D Structure

Talazoparib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(2-methyl-1,2,4-triazol-3-yl)-2,3,10-triazatricyclo[7.3.1.05,13]trideca-1(13),5,7,9-tetraen-4-one
2.1.2 InChI
InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,25H,1H3,(H,26,28)/t15-,16-/m1/s1
2.1.3 InChI Key
IUEWAGVJRJORLA-HZPDHXFCSA-N
2.1.4 Canonical SMILES
CN1C(=NC=N1)C2C(N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F
2.1.5 Isomeric SMILES
CN1C(=NC=N1)[C@@H]2[C@H](N=C3C=C(C=C4C3=C2NNC4=O)F)C5=CC=C(C=C5)F
2.2 Create Date
2010-03-15
3 Chemical and Physical Properties
Molecular Weight 380.4 g/mol
Molecular Formula C19H14F2N6O
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass380.11971542 g/mol
Monoisotopic Mass380.11971542 g/mol
Topological Polar Surface Area84.2 A^2
Heavy Atom Count28
Formal Charge0
Complexity826
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

API Reference Price

read-more
read-more
[{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1625509800,"product":"TALAZOPARIB TOSYLATE STANDARD","address":"HOTEL DREAMZ PARK OFFICE COMPLEX\\r\\nUNIT G, 571\/2, ANNA SALAI,\\r\\nTEYNAMPET, CHENNAI, TAMIL NADU.","city":"CHENNAI,","supplier":"FAREVA","supplierCountry":"GERMANY","foreign_port":"MUNICH","customer":"PFIZER INC","customerCountry":"INDIA","quantity":"0.10","actualQuantity":"100","unit":"GMS","unitRateFc":"0.1","totalValueFC":"12","currency":"EUR","unitRateINR":"9","date":"06-Jul-2021","totalValueINR":"898","totalValueInUsd":"12","indian_port":"MADRAS AIR","hs_no":"29339990","bill_no":"4582293","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"MUNICH","supplierAddress":"","customerAddress":"HOTEL DREAMZ PARK OFFICE COMPLEX\\r\\nUNIT G, 571\/2, ANNA SALAI,\\r\\nTEYNAMPET, CHENNAI, TAMIL NADU."}]
06-Jul-2021
06-Jul-2021
KGS
overview
Loading...

Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country Total Quantity
(KGS)
Average Price
(USD/KGS)
Number of Transactions

Upgrade, download data, analyse, strategize, subscribe with us contact

Drugs in Development

read-more
read-more

Details:

Talzenna (talazoparib) is a PARP inhibitor, which is approved for the treatment of BRCA gene mutation-positive castration-resistant prostate cancer with distant metastases.


Lead Product(s): Talazoparib

Therapeutic Area: Oncology Brand Name: Talzenna

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 05, 2024

blank

01

The Pharmacy Technology
Not Confirmed
The Pharmacy Technology
Not Confirmed

Details : Talzenna (talazoparib) is a PARP inhibitor, which is approved for the treatment of BRCA gene mutation-positive castration-resistant prostate cancer with distant metastases.

Brand Name : Talzenna

Molecule Type : Small molecule

Upfront Cash : Not Applicable

February 05, 2024

blank

Details:

Talzenna (talazoparib) combined with Xtandi (enzalutamide) is approved by EMA for treating metastatic castration-resistant prostate cancer (mCRPC).


Lead Product(s): Talazoparib,Enzalutamide

Therapeutic Area: Oncology Brand Name: Talzenna

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 08, 2024

blank

02

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Details : Talzenna (talazoparib) combined with Xtandi (enzalutamide) is approved by EMA for treating metastatic castration-resistant prostate cancer (mCRPC).

Brand Name : Talzenna

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 08, 2024

blank

Details:

Talzenna (talazoparib) is an oral inhibitor of PARP, which plays a role in DNA damage repair combination with XTANDI (enzalutamide) for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC).


Lead Product(s): Talazoparib,Enzalutamide

Therapeutic Area: Oncology Brand Name: Talzenna

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: TFS Trial Form Support

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 20, 2023

blank

03

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Details : Talzenna (talazoparib) is an oral inhibitor of PARP, which plays a role in DNA damage repair combination with XTANDI (enzalutamide) for the treatment of adult patients with homologous recombination repair (HRR) gene-mutated metastatic castration-resistan...

Brand Name : Talzenna

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 20, 2023

blank

Details:

Talzenna (talazoparib) is an oral PARP inhibitor, which plays a role in DNA damage repair. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to cancer cell apoptosis.


Lead Product(s): Talazoparib,Enzalutamide

Therapeutic Area: Oncology Brand Name: Talzenna

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 16, 2023

blank

04

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Details : Talzenna (talazoparib) is an oral PARP inhibitor, which plays a role in DNA damage repair. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to cancer cell apoptosis.

Brand Name : Talzenna

Molecule Type : Small molecule

Upfront Cash : Not Applicable

February 16, 2023

blank

Details:

CX-5461 (pidnarulex) stabilizes the DNA G-quadruplexes of cancer cells which leads to disruption of the cell's replication fork. Pidnarulex demonstrated clinically significant and lasting benefits in patients with specific tumor biomarkers, such as BRCA1/2 and PALB2 mutations.


Lead Product(s): Pidnarulex,Talazoparib

Therapeutic Area: Oncology Brand Name: CX-5461

Study Phase: Phase IProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 31, 2022

blank

05

The Pharmacy Technology
Not Confirmed
The Pharmacy Technology
Not Confirmed

Details : CX-5461 (pidnarulex) stabilizes the DNA G-quadruplexes of cancer cells which leads to disruption of the cell's replication fork. Pidnarulex demonstrated clinically significant and lasting benefits in patients with specific tumor biomarkers, such as BRCA1...

Brand Name : CX-5461

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 31, 2022

blank

Details:

TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor met its primary endpoint with a statistically significant and clinically meaningful improvement in radiographic progression-free survival (rPFS) compared with placebo plus XTANDI.


Lead Product(s): Talazoparib,Enzalutamide

Therapeutic Area: Oncology Brand Name: Talzenna

Study Phase: Phase IIIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable October 04, 2022

blank

06

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Pfizer Inc

U.S.A
arrow
The Pharmacy Technology
Not Confirmed

Details : TALZENNA® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor met its primary endpoint with a statistically significant and clinically meaningful improvement in radiographic progression-free survival (rPFS) compared with placebo plus XTAN...

Brand Name : Talzenna

Molecule Type : Small molecule

Upfront Cash : Not Applicable

October 04, 2022

blank

Details:

ART4215 is first selective, oral, small molecule inhibitor of Polθ polymerase domain to enter clinic. Polθ, a DNA polymerase, is a tumor-specific DDR target involved in MMEJ that is overexpressed in many tumors and found in low levels in healthy tissue.


Lead Product(s): ART4215,Talazoparib

Therapeutic Area: Oncology Brand Name: ART4215

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable August 10, 2022

blank

07

Artios Pharma Limited

United Kingdom
arrow
The Pharmacy Technology
Not Confirmed

Artios Pharma Limited

United Kingdom
arrow
The Pharmacy Technology
Not Confirmed

Lead Product(s) : ART4215,Talazoparib

Therapeutic Area : Oncology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : ART4215 is first selective, oral, small molecule inhibitor of Polθ polymerase domain to enter clinic. Polθ, a DNA polymerase, is a tumor-specific DDR target involved in MMEJ that is overexpressed in many tumors and found in low levels in healthy tissue...

Brand Name : ART4215

Molecule Type : Small molecule

Upfront Cash : Not Applicable

August 10, 2022

blank

Details:

ZEN-3694 (ZEN003694), orally bioavailable small molecule, in initro studies selectively binds to BET proteins with >20 fold selectivity over non-BET bromodomains inhibiting interaction of acetylated histone peptide with IC50 values in low nM range.


Lead Product(s): ZEN003694,Talazoparib

Therapeutic Area: Oncology Brand Name: ZEN-3694

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: National Cancer Institute

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable July 06, 2022

blank

08

The Pharmacy Technology
Not Confirmed
The Pharmacy Technology
Not Confirmed

Details : ZEN-3694 (ZEN003694), orally bioavailable small molecule, in initro studies selectively binds to BET proteins with >20 fold selectivity over non-BET bromodomains inhibiting interaction of acetylated histone peptide with IC50 values in low nM range.

Brand Name : ZEN-3694

Molecule Type : Small molecule

Upfront Cash : Not Applicable

July 06, 2022

blank

Details:

The combination regimen of ZEN-3694 (ZEN003694) + talazoparib has shown promising clinical activity in a mTNBC patient population with significant unmet need. This combination is active with a manageable safety profile and warrants continued clinical evaluation.


Lead Product(s): ZEN-3694,Talazoparib

Therapeutic Area: Oncology Brand Name: ZEN003694

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 21, 2022

blank

09

The Pharmacy Technology
Not Confirmed
The Pharmacy Technology
Not Confirmed

Lead Product(s) : ZEN-3694,Talazoparib

Therapeutic Area : Oncology

Highest Development Status : Phase II

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : The combination regimen of ZEN-3694 (ZEN003694) + talazoparib has shown promising clinical activity in a mTNBC patient population with significant unmet need. This combination is active with a manageable safety profile and warrants continued clinical eva...

Brand Name : ZEN003694

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 21, 2022

blank

Details:

CX-5461 (Pidnarulex) demonstrated clinically significant and persist benefits in patients with specific tumor biomarkers, such as BRCA1/2, and PALB2 mutations, and who had been exposed to platinum and other chemotherapeutics.


Lead Product(s): Pidnarulex,Talazoparib

Therapeutic Area: Oncology Brand Name: CX-5461

Study Phase: Phase IProduct Type: Small molecule

Sponsor: Pfizer Inc

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable June 06, 2022

blank

10

The Pharmacy Technology
Not Confirmed
The Pharmacy Technology
Not Confirmed

Details : CX-5461 (Pidnarulex) demonstrated clinically significant and persist benefits in patients with specific tumor biomarkers, such as BRCA1/2, and PALB2 mutations, and who had been exposed to platinum and other chemotherapeutics.

Brand Name : CX-5461

Molecule Type : Small molecule

Upfront Cash : Not Applicable

June 06, 2022

blank
click full view
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

FDF Dossiers

read-more
read-more

01

Pfizer Inc

U.S.A
Pharmtech & Ingredients
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
Pharmtech & Ingredients
Not Confirmed

Talazoparibtosylat

Brand Name : Talzenna

Dosage Form : Kapsel, hard

Dosage Strength : 0.1 mg

Packaging : Boks 30item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

blank

02

Pfizer Inc

U.S.A
Pharmtech & Ingredients
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
Pharmtech & Ingredients
Not Confirmed

Talazoparibum

Brand Name : Talzenna

Dosage Form : Caps

Dosage Strength : 0.25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

blank

03

Pfizer Inc

U.S.A
Pharmtech & Ingredients
Not Confirmed
arrow

Pfizer Inc

U.S.A
arrow
Pharmtech & Ingredients
Not Confirmed

Talazoparibum

Brand Name : Talzenna

Dosage Form : Caps

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Europe

read-more
read-more

01

Fi Europe 2024
Not Confirmed
arrow
arrow
Fi Europe 2024
Not Confirmed

Talazoparibtosylat

Brand Name : Talzenna

Dosage Form : Kapsel, hard

Dosage Strength : 0.1 mg

Packaging : Boks 30item

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Norway

blank

02

Pfizer AG

U.S.A
Fi Europe 2024
Not Confirmed
arrow

Pfizer AG

U.S.A
arrow
Fi Europe 2024
Not Confirmed

Talazoparibum

Brand Name : Talzenna

Dosage Form : Caps

Dosage Strength : 0.25mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

blank

03

Pfizer AG

U.S.A
Fi Europe 2024
Not Confirmed
arrow

Pfizer AG

U.S.A
arrow
Fi Europe 2024
Not Confirmed

Talazoparibum

Brand Name : Talzenna

Dosage Form : Caps

Dosage Strength : 1mg

Packaging :

Approval Date :

Application Number :

Regulatory Info :

Registration Country : Switzerland

blank
Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Digital Content read-more

Create Content with PharmaCompass, ask us

NEWS #PharmaBuzz

read-more
read-more

Global Sales Information

Do you need Business Intel? Ask us

ABOUT THIS PAGE

Ask Us for Pharmaceutical Supplier and Partner
Ask Us, Find A Supplier / Partner
No Commissions, No Strings Attached, Get Connected for FREE

What are you looking for?

How can we help you?

The request can't be empty

Please read our Privacy Policy carefully

You must agree to the privacy policy

The name can't be empty
The company can't be empty.
The email can't be empty Please enter a valid email.
The mobile can't be empty