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    Chemistry

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    Also known as: 14807-96-6, Pulvistalci, Magnesium silicate, hydrous, 13376-74-4, Magnesium silicate monohydrate (talc), Mfcd00792903
    Molecular Formula
    H2Mg3O12Si4
    Molecular Weight
    379.27  g/mol
    InChI Key
    FPAFDBFIGPHWGO-UHFFFAOYSA-N
    Talc API
    Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)
    1 2D Structure

    Talc API

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dioxosilane;oxomagnesium;hydrate
    2.1.2 InChI
    InChI=1S/3Mg.4O2Si.H2O.3O/c;;;4*1-3-2;;;;/h;;;;;;;1H2;;;
    2.1.3 InChI Key
    FPAFDBFIGPHWGO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    O.O=[Mg].O=[Mg].O=[Mg].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Talc

    2. Talcum Powder

    2.2.2 Depositor-Supplied Synonyms

    1. 14807-96-6

    2. Pulvistalci

    3. Magnesium Silicate, Hydrous

    4. 13376-74-4

    5. Magnesium Silicate Monohydrate (talc)

    6. Mfcd00792903

    7. 78229-94-4

    8. Purified Talc

    9. Talc Nanoparticles

    10. Talc, Cp

    11. Talc, -350 Mesh

    12. Talc, Powder, 10 Mum

    13. Magnesiumsilicatemonohydrate325m

    14. Talc, Vetec(tm) Reagent Grade

    15. Chembl3989756

    16. Magnesium Silicate Xhydrate 800m

    17. Talc, Tested According To Ph.eur.

    18. Magnesium Silicate Monohydrate 325m

    19. Ft-0645101

    20. Ab01568263_01

    21. Talc, Meets Analytical Specification Of Ph.??eur., Bp, Powder

    22. 149925-00-8

    2.3 Create Date
    2007-07-12
    3 Chemical and Physical Properties
    Molecular Weight 379.27 g/mol
    Molecular Formula H2Mg3O12Si4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count0
    Exact Mass377.8174567 g/mol
    Monoisotopic Mass377.8174567 g/mol
    Topological Polar Surface Area189 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity20.3
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count8
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Talc intrapleural aerosol is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients. It is administered during thoracoscopy or open thoracotomy.

    Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004.

    ...Talc insufflation, either as a poudrage or by using slurry, is recognized as an effective treatment /for spontaneous pneumothorax/.

    PMID:14602332 Milton R, Cale AR; Ann Thorac Surg 76 (5): 1740-1 (2003)

    4.2 Drug Warning

    ...The case of a 78 yr-old man /is presented,/ who was treated with talc pleurodesis for recurrent pleural effusion and subsequently developed a massive hemothorax, a rare complication.

    PMID:15384468 Hirota B et al; Hawaii Med J 63 (7): 208-10 (2004)

    /The case of/ ...a young woman with a large, calcified anterior mediastinal mass discovered 18 months following a left talc pleurodesis /is reported/.

    PMID:12607675 Ahmed Z, Shrager JB; Ann Thorac Surg 75 (2): 568-9 (2003)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiperspirants

    Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS). (See all compounds classified as Antiperspirants.)

    5.2 Absorption, Distribution and Excretion

    Foreign body granulomas containing talc fibers are to be found in lung, pleura, diaphragm, pericardium, and gastric wall ... .

    Hamilton, A., and H. L. Hardy. Industrial Toxicology. 3rd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1974., p. 441

    ...Transmission electron microscopy and energy dispersive X-ray spectroscopy /was used to analyze/ the total fibrous and nonfibrous mineral content of the lungs of a series of 14 male smokers with lung cancer but with no history of occupational dust exposure, and of a series of 14 control men matched by age, smoking history and general occupational class. The average concentration of mineral fibers and nonfiberous particles were 3.8 and 2.0 times higher in the group with cancer. Kaolinite, talc, mica, feldspars and crystalline silica comprised the majority of fibrous and nonfibrous particles in both groups.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V42 208 (1987)

    Mice that received a sterile sc injection of talc were studied by measuring the incorporation of radioactive leucine and glucosamine into liver and plasma protein and the talc gramuloma at various intervals between 2 and 528 hours after injection. Incorporation into plasma proteins indicated a biphasic response with a marked increased incorporation into the perchloric acid insoluble fraction at 21 hours, a return to normal values at 45 hours, and a similar marked increase into the perchloric acid soluble fraction at 45 hours with a gradual return toward normal values. The response was dependent upon the amount of talc injected.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

    Using radioactive tracer techniques in rats, mice, guinea pigs, and hamsters, no intestinal absorption or translocation of ingested talc to the liver and kidneys was detected.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 527

    For more Absorption, Distribution and Excretion (Complete) data for TALC (7 total), please visit the HSDB record page.

    5.3 Biological Half-Life

    In hamsters, ...the biological half-life of talc deposited in the alveoli was 7-10 days, and the alveolar clearance was basically complete 4 months after exposure.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

    API Reference Price

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    04-Nov-2024
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    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    ABOUT THIS PAGE

    Talc API Manufacturers

    A Talc API manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Talc API, including repackagers and relabelers. The FDA regulates Talc API manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Talc API API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Talc API manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Talc API Suppliers

    A Talc API supplier is an individual or a company that provides Talc API active pharmaceutical ingredient (API) or Talc API finished formulations upon request. The Talc API suppliers may include Talc API API manufacturers, exporters, distributors and traders.

    click here to find a list of Talc API suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Talc API USDMF

    A Talc API DMF (Drug Master File) is a document detailing the whole manufacturing process of Talc API active pharmaceutical ingredient (API) in detail. Different forms of Talc API DMFs exist exist since differing nations have different regulations, such as Talc API USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Talc API DMF submitted to regulatory agencies in the US is known as a USDMF. Talc API USDMF includes data on Talc API's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Talc API USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Talc API suppliers with USDMF on PharmaCompass.

    Talc API GMP

    Talc API Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Talc API GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Talc API GMP manufacturer or Talc API GMP API supplier for your needs.

    Talc API CoA

    A Talc API CoA (Certificate of Analysis) is a formal document that attests to Talc API's compliance with Talc API specifications and serves as a tool for batch-level quality control.

    Talc API CoA mostly includes findings from lab analyses of a specific batch. For each Talc API CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Talc API may be tested according to a variety of international standards, such as European Pharmacopoeia (Talc API EP), Talc API JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Talc API USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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