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Talc API

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4 API Suppliers, 2 USDMF, 2 Listed Suppliers, $ API Reference Price

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Synopsis

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Chemistry

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Also known as: 14807-96-6, Pulvistalci, Magnesium silicate, hydrous, 13376-74-4, Magnesium silicate monohydrate (talc), Mfcd00792903

Molecular Formula

H₂Mg₃O₁₂Si₄

Molecular Weight

379.27 g/mol

InChI Key

FPAFDBFIGPHWGO-UHFFFAOYSA-N

Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)

1 2D Structure

Talc API

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

dioxosilane;oxomagnesium;hydrate

2.1.2 InChI

InChI=1S/3Mg.4O2Si.H2O.3O/c;;;4*1-3-2;;;;/h;;;;;;;1H2;;;

2.1.3 InChI Key

FPAFDBFIGPHWGO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

O.O=[Mg].O=[Mg].O=[Mg].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Talc

2. Talcum Powder

2.2.2 Depositor-Supplied Synonyms

1. 14807-96-6

2. Pulvistalci

3. Magnesium Silicate, Hydrous

4. 13376-74-4

5. Magnesium Silicate Monohydrate (talc)

6. Mfcd00792903

7. 78229-94-4

8. Purified Talc

9. Talc Nanoparticles

10. Talc, Cp

11. Talc, -350 Mesh

12. Talc, Powder, 10 Mum

13. Magnesiumsilicatemonohydrate325m

14. Talc, Vetec(tm) Reagent Grade

15. Chembl3989756

16. Magnesium Silicate Xhydrate 800m

17. Talc, Tested According To Ph.eur.

18. Magnesium Silicate Monohydrate 325m

19. Ft-0645101

20. Ab01568263_01

21. Talc, Meets Analytical Specification Of Ph.??eur., Bp, Powder

22. 149925-00-8

2.3 Create Date

2007-07-12

3 Chemical and Physical Properties

Molecular Formula	H₂Mg₃O₁₂Si₄
Molecular Weight	379.27 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	0
Exact Mass	377.8174567 g/mol
Monoisotopic Mass	377.8174567 g/mol
Topological Polar Surface Area	189 Å²
Heavy Atom Count	19
Formal Charge	0
Complexity	20.3
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	8

4 Drug and Medication Information

4.1 Therapeutic Uses

Talc intrapleural aerosol is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients. It is administered during thoracoscopy or open thoracotomy.

Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004.

...Talc insufflation, either as a poudrage or by using slurry, is recognized as an effective treatment /for spontaneous pneumothorax/.

PMID:14602332 Milton R, Cale AR; Ann Thorac Surg 76 (5): 1740-1 (2003)

4.2 Drug Warning

...The case of a 78 yr-old man /is presented,/ who was treated with talc pleurodesis for recurrent pleural effusion and subsequently developed a massive hemothorax, a rare complication.

PMID:15384468 Hirota B et al; Hawaii Med J 63 (7): 208-10 (2004)

/The case of/ ...a young woman with a large, calcified anterior mediastinal mass discovered 18 months following a left talc pleurodesis /is reported/.

PMID:12607675 Ahmed Z, Shrager JB; Ann Thorac Surg 75 (2): 568-9 (2003)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiperspirants

Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS). (See all compounds classified as Antiperspirants.)

5.2 Absorption, Distribution and Excretion

Foreign body granulomas containing talc fibers are to be found in lung, pleura, diaphragm, pericardium, and gastric wall ... .

Hamilton, A., and H. L. Hardy. Industrial Toxicology. 3rd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1974., p. 441

...Transmission electron microscopy and energy dispersive X-ray spectroscopy /was used to analyze/ the total fibrous and nonfibrous mineral content of the lungs of a series of 14 male smokers with lung cancer but with no history of occupational dust exposure, and of a series of 14 control men matched by age, smoking history and general occupational class. The average concentration of mineral fibers and nonfiberous particles were 3.8 and 2.0 times higher in the group with cancer. Kaolinite, talc, mica, feldspars and crystalline silica comprised the majority of fibrous and nonfibrous particles in both groups.

IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V42 208 (1987)

Mice that received a sterile sc injection of talc were studied by measuring the incorporation of radioactive leucine and glucosamine into liver and plasma protein and the talc gramuloma at various intervals between 2 and 528 hours after injection. Incorporation into plasma proteins indicated a biphasic response with a marked increased incorporation into the perchloric acid insoluble fraction at 21 hours, a return to normal values at 45 hours, and a similar marked increase into the perchloric acid soluble fraction at 45 hours with a gradual return toward normal values. The response was dependent upon the amount of talc injected.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

Using radioactive tracer techniques in rats, mice, guinea pigs, and hamsters, no intestinal absorption or translocation of ingested talc to the liver and kidneys was detected.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 527

For more Absorption, Distribution and Excretion (Complete) data for TALC (7 total), please visit the HSDB record page.

5.3 Biological Half-Life

In hamsters, ...the biological half-life of talc deposited in the alveoli was 7-10 days, and the alveolar clearance was basically complete 4 months after exposure.

Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

API SUPPLIERS

01

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

02

Country

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

03

Skotmark Speciality Chemicals

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

04

Nitika Pharmaceutical Specialities

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

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USDMF

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API Reference Price

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NARITA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"12.8","totalValueFC":"387.8","currency":"USD","unitRateINR":"1076.5","date":"22-Nov-2023","totalValueINR":"32294.4","totalValueInUsd":"387.8","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"8881853","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"4-16, KYOBASHI, 2-CHOME, CHUO-KUTOKYO-104-8002SDNF JAPAN","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1705429800,"product":"MUGUETALCOHOL","address":"140, OLD MAHABALIPURAM ROAD,","city":"CHENNAI, TAMIL NADU.","supplier":"SYMRISE","supplierCountry":"GERMANY","foreign_port":"HANNOVER","customer":"SYMRISE","customerCountry":"INDIA","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"27.3","totalValueFC":"143.2","currency":"USD","unitRateINR":"2380.6","date":"17-Jan-2024","totalValueINR":"11903.19","totalValueInUsd":"143.2","indian_port":"Madras Air","hs_no":"29062990","bill_no":"9707331","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"HANNOVER","supplierAddress":"MUEHLENFELDSTRASSE 137603 HOLZMINDENGERMANY GERMANY","customerAddress":"140, OLD MAHABALIPURAM ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1713637800,"product":"(RAW MATERIAL FOR PHARMACEUTICAL PRODUCTS) TALC (HI-FILLER17)","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"MEIJI SEIKA PHARMA","supplierCountry":"JAPAN","foreign_port":"TOKYO - NARITA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"10","totalValueFC":"302.6","currency":"USD","unitRateINR":"842.3","date":"21-Apr-2024","totalValueINR":"25269.36","totalValueInUsd":"302.6","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"3128236","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"4-16, KYOBASHI, 2-CHOME, CHUO-KUTOKYO-104-8002SDNF JAPAN","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1723746600,"product":"(RAW MATERIAL FOR PHARMACEUTICAL PRODUCTS) TALC (HI FILLER 17)","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"MEIJI SEIKA PHARMA","supplierCountry":"JAPAN","foreign_port":"TOKYO - NARITA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"10","totalValueFC":"151.4","currency":"USD","unitRateINR":"846.8","date":"16-Aug-2024","totalValueINR":"12702.04","totalValueInUsd":"151.4","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"5088769","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"4-16, KYOBASHI, 2-CHOME, CHUO-KUTOKYO-104-8002SDNF JAPAN","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726857000,"product":"TALC (RAW MATERIAL)","address":"PLOT NO.A-177,ROAD NO.16-Z,WAGLE","city":"THANE, MAHARASHTRA","supplier":"PT. VITABIOTICS HEA1THCARE","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"MEYER ORGANICS","customerCountry":"INDIA","quantity":"124.38","actualQuantity":"124.384","unit":"KGS","unitRateFc":"2.5","totalValueFC":"322.5","currency":"USD","unitRateINR":"217.3","date":"21-Sep-2024","totalValueINR":"27029.31","totalValueInUsd":"322.5","indian_port":"JNPT","hs_no":"29420090","bill_no":"5729603","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"JAKARTA","supplierAddress":"JL RAYA CARINGIN NO. 363, KEL. KER TAJAYA, KEC. PADALARANG KAB. BANDUN G BARAT, PROV. JAWA BARAT, INDONESI Indonesia","customerAddress":"PLOT NO.A-177,ROAD NO.16-Z,WAGLE"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers

2 USDMF

2 Listed Suppliers

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2 FDF Dossiers

1 Canada

1 Listed Dossiers

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EXCIPIENTS BY APPLICATIONS

32 Fillers, Diluents & Binders

22 Direct Compression

19 Thickeners and Stabilizers

13 Coating Systems & Additives

13 Co-Processed Excipients

11 Topical

10 Lubricants & Glidants

10 Disintegrants & Superdisintegrants

9 Film Formers & Plasticizers

8 Granulation

6 Taste Masking

6 Controlled & Modified Release

6 Chewable & Orodispersible Aids

5 Parenteral

5 Solubilizers

4 Rheology Modifiers

3 Coloring Agents

3 Emulsifying Agents

1 API Stability Enhancers

1 Surfactant & Foaming Agents

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API REF. PRICE (USD/KG)

$ 86

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