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    Chemistry

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    Also known as: 14807-96-6, Pulvistalci, Magnesium silicate, hydrous, 13376-74-4, Magnesium silicate monohydrate (talc), Mfcd00792903
    Molecular Formula
    H2Mg3O12Si4
    Molecular Weight
    379.27  g/mol
    InChI Key
    FPAFDBFIGPHWGO-UHFFFAOYSA-N
    Talc API
    Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed)
    1 2D Structure

    Talc API

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dioxosilane;oxomagnesium;hydrate
    2.1.2 InChI
    InChI=1S/3Mg.4O2Si.H2O.3O/c;;;4*1-3-2;;;;/h;;;;;;;1H2;;;
    2.1.3 InChI Key
    FPAFDBFIGPHWGO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    O.O=[Mg].O=[Mg].O=[Mg].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Talc

    2. Talcum Powder

    2.2.2 Depositor-Supplied Synonyms

    1. 14807-96-6

    2. Pulvistalci

    3. Magnesium Silicate, Hydrous

    4. 13376-74-4

    5. Magnesium Silicate Monohydrate (talc)

    6. Mfcd00792903

    7. 78229-94-4

    8. Purified Talc

    9. Talc Nanoparticles

    10. Talc, Cp

    11. Talc, -350 Mesh

    12. Talc, Powder, 10 Mum

    13. Magnesiumsilicatemonohydrate325m

    14. Talc, Vetec(tm) Reagent Grade

    15. Chembl3989756

    16. Magnesium Silicate Xhydrate 800m

    17. Talc, Tested According To Ph.eur.

    18. Magnesium Silicate Monohydrate 325m

    19. Ft-0645101

    20. Ab01568263_01

    21. Talc, Meets Analytical Specification Of Ph.??eur., Bp, Powder

    22. 149925-00-8

    2.3 Create Date
    2007-07-12
    3 Chemical and Physical Properties
    Molecular Weight 379.27 g/mol
    Molecular Formula H2Mg3O12Si4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count0
    Exact Mass377.8174567 g/mol
    Monoisotopic Mass377.8174567 g/mol
    Topological Polar Surface Area189 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity20.3
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count8
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Talc intrapleural aerosol is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients. It is administered during thoracoscopy or open thoracotomy.

    Thomson.Micromedex. Drug Information for the Health Care Professional. 24th ed. Volume 1. Plus Updates. Content Reviewed by the United States Pharmacopeial Convention, Inc. Greenwood Village, CO. 2004.

    ...Talc insufflation, either as a poudrage or by using slurry, is recognized as an effective treatment /for spontaneous pneumothorax/.

    PMID:14602332 Milton R, Cale AR; Ann Thorac Surg 76 (5): 1740-1 (2003)

    4.2 Drug Warning

    ...The case of a 78 yr-old man /is presented,/ who was treated with talc pleurodesis for recurrent pleural effusion and subsequently developed a massive hemothorax, a rare complication.

    PMID:15384468 Hirota B et al; Hawaii Med J 63 (7): 208-10 (2004)

    /The case of/ ...a young woman with a large, calcified anterior mediastinal mass discovered 18 months following a left talc pleurodesis /is reported/.

    PMID:12607675 Ahmed Z, Shrager JB; Ann Thorac Surg 75 (2): 568-9 (2003)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiperspirants

    Agents that are put on the SKIN to reduce SWEATING or prevent excess sweating (HYPERHIDROSIS). (See all compounds classified as Antiperspirants.)

    5.2 Absorption, Distribution and Excretion

    Foreign body granulomas containing talc fibers are to be found in lung, pleura, diaphragm, pericardium, and gastric wall ... .

    Hamilton, A., and H. L. Hardy. Industrial Toxicology. 3rd ed. Acton, Mass.: Publishing Sciences Group, Inc., 1974., p. 441

    ...Transmission electron microscopy and energy dispersive X-ray spectroscopy /was used to analyze/ the total fibrous and nonfibrous mineral content of the lungs of a series of 14 male smokers with lung cancer but with no history of occupational dust exposure, and of a series of 14 control men matched by age, smoking history and general occupational class. The average concentration of mineral fibers and nonfiberous particles were 3.8 and 2.0 times higher in the group with cancer. Kaolinite, talc, mica, feldspars and crystalline silica comprised the majority of fibrous and nonfibrous particles in both groups.

    IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V42 208 (1987)

    Mice that received a sterile sc injection of talc were studied by measuring the incorporation of radioactive leucine and glucosamine into liver and plasma protein and the talc gramuloma at various intervals between 2 and 528 hours after injection. Incorporation into plasma proteins indicated a biphasic response with a marked increased incorporation into the perchloric acid insoluble fraction at 21 hours, a return to normal values at 45 hours, and a similar marked increase into the perchloric acid soluble fraction at 45 hours with a gradual return toward normal values. The response was dependent upon the amount of talc injected.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

    Using radioactive tracer techniques in rats, mice, guinea pigs, and hamsters, no intestinal absorption or translocation of ingested talc to the liver and kidneys was detected.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 527

    For more Absorption, Distribution and Excretion (Complete) data for TALC (7 total), please visit the HSDB record page.

    5.3 Biological Half-Life

    In hamsters, ...the biological half-life of talc deposited in the alveoli was 7-10 days, and the alveolar clearance was basically complete 4 months after exposure.

    Bingham, E.; Cohrssen, B.; Powell, C.H.; Patty's Toxicology Volumes 1-9 5th ed. John Wiley & Sons. New York, N.Y. (2001)., p. V1 526

    API Reference Price

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LIMITED","customerCountry":"INDIA","quantity":"29.50","actualQuantity":"29.5","unit":"KGS","unitRateFc":"453.8","totalValueFC":"13479.9","currency":"USD","unitRateINR":"37473.1","date":"16-Aug-2023","totalValueINR":"1116622.628","totalValueInUsd":"13479.9","indian_port":"HYDERABAD AIR","hs_no":"29181990","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"3-5-1037\/1,,VITTALWADI NARAYANAGUD A"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693679400,"product":"M.P.MICRO 3 70% TALCO\/ZINCO(STEARIC ACID) (RAW MATERIAL FORMANUFACTURING OF COSMETIC) (NOT FOR FOOD GRADE)","address":"A-802, Crescenzo, C\/38-39, G-Block","city":"Mumbai","supplier":"INTERCOS EUROPE S.P.A","supplierCountry":"ITALY","foreign_port":"SEGRATE AIRPRT MILAN","customer":"INTERCOS INDIA PRIVATE 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","customerCountry":"INDIA","quantity":"4.79","actualQuantity":"4.78835","unit":"KGS","unitRateFc":"780.7","totalValueFC":"3781.9","currency":"USD","unitRateINR":"65736.3","date":"27-Oct-2023","totalValueINR":"314768.23","totalValueInUsd":"3781.9","indian_port":"Hyderabad Air","hs_no":"29181990","bill_no":"8500789","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"2ND FLOOR, BUILDING 3, NO.1, MIDDLEWANGDONG ROAD, SIJING TOWN,SONGJIANG DISTRICT, SHANGHAI, 201601 CHINA CHINA","customerAddress":"3-5-1037\/1,,VITTALWADI NARAYANAGUD"},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1700591400,"product":"(RAW MATERIAL FOR PHARMACEUTICAL PRODUCTS) TALC (HI-FILLER-17)","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"MEIJI SEIKA PHARMA","supplierCountry":"JAPAN","foreign_port":"TOKYO - NARITA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"30.00","actualQuantity":"30","unit":"KGS","unitRateFc":"12.8","totalValueFC":"387.8","currency":"USD","unitRateINR":"1076.5","date":"22-Nov-2023","totalValueINR":"32294.4","totalValueInUsd":"387.8","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"8881853","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"4-16, KYOBASHI, 2-CHOME, CHUO-KUTOKYO-104-8002SDNF JAPAN","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716921000,"product":"(RAW MATERIAL FOR PHARMACEUTICAL PRODUCTS) TALC (LIS BLANC)","address":"MEDREICH HOUSE, NO12\/8,","city":"SEVA NAGAR, BANGALORE, KARNATAKA","supplier":"MEIJI SEIKA PHARMA","supplierCountry":"JAPAN","foreign_port":"TOKYO - NARITA","customer":"MEDREICH","customerCountry":"INDIA","quantity":"20.00","actualQuantity":"20","unit":"KGS","unitRateFc":"8","totalValueFC":"161.9","currency":"USD","unitRateINR":"674.8","date":"29-May-2024","totalValueINR":"13496","totalValueInUsd":"161.9","indian_port":"Bangalore Air","hs_no":"29349990","bill_no":"3713667","productDescription":"API","marketType":"REGULATED MARKET","country":"JAPAN","selfForZScoreResived":"Pharma Grade","supplierPort":"TOKYO - NARITA","supplierAddress":"4-16, KYOBASHI, 2-CHOME, CHUO-KUTOKYO-104-8002SDNF JAPAN","customerAddress":"MEDREICH HOUSE, NO12\/8,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1719685800,"product":"1042955, M.P. MICRO 3 70% TALCO\/ZINCO 132765 (CODE. B150A) STEARIC ACID (RAW MATERIAL FOR MANUFACTURING OF COSMETIC) (NO","address":"A-802, Crescenzo, C\/38-39, G-Block","city":"Mumbai","supplier":"INTERCOS EUROPE S.P.A","supplierCountry":"ITALY","foreign_port":"SEGRATE AIRPRT MILAN","customer":"INTERCOS INDIA PRIVATE LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"8.7","totalValueFC":"174.5","currency":"EUR","unitRateINR":"971.3","date":"30-Jun-2024","totalValueINR":"14569.93","totalValueInUsd":"174.5","indian_port":"Delhi Air","hs_no":"29157090","bill_no":"4261989","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"SEGRATE AIRPRT MILAN","supplierAddress":"20123 MILANO, PIAZZA DIAZ, 1 Milano, , ItalySDNF Italy","customerAddress":"A-802, Crescenzo, C\/38-39, G-Block"}]
    04-Feb-2021
    20-Sep-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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