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Talinolol

Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 EU WC

1 API Suppliers
1 EU WC

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 57460-41-0, Cordanum, 1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea, Talinolol [inn], 38649-73-9, Cordanum; racemic talinolol

Molecular Formula

C₂₀H₃₃N₃O₃

Molecular Weight

363.5 g/mol

InChI Key

MXFWWQICDIZSOA-UHFFFAOYSA-N

FDA UNII

3S82268BKG

Talinolol has been investigated for the basic science of Gastrointestinal Motility Disorder.

1 2D Structure

Talinolol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea

2.1.2 InChI

InChI=1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)

2.1.3 InChI Key

MXFWWQICDIZSOA-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C)(C)NCC(COC1=CC=C(C=C1)NC(=O)NC2CCCCC2)O

2.2 Other Identifiers

2.2.1 UNII

3S82268BKG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane

2. Cordanum

3. Talinolol Acetate

4. Talinolol Benzoate

5. Talinolol Hydrochloride

6. Talinolol Monoacetate

7. Talinolol Monohydrochloride

8. Talinolol Mononitrate

9. Talinolol Monosalicylate

10. Talinolol Nitrate

11. Talinolol Oxalate

12. Talinolol Oxalate (2:1)

13. Talinolol Salicylate

14. Talinolol Sulfate

15. Talinolol Sulfate (2:1)

16. Talinolol Tartrate (2:1), L-(+)-isomer

17. Talinolol Tartrate, L-(+)-isomer

18. Talinolol, (+-)-isomer

2.3.2 Depositor-Supplied Synonyms

1. 57460-41-0

2. Cordanum

3. 1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

4. Talinolol [inn]

5. 38649-73-9

6. Cordanum; Racemic Talinolol

7. 1-{4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-3-cyclohexylurea

8. 1-[4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-3-cyclohexylurea

9. 3s82268bkg

10. Talinolol (inn)

11. Racemic Talinolol

12. ( Inverted Exclamation Marka)-talinolol

13. Ncgc00164542-01

14. Dsstox_cid_26426

15. Dsstox_rid_81604

16. Dsstox_gsid_46426

17. (+-)-talinolol

18. Talinololum

19. Rac Talinolol

20. Talinololum [inn-latin]

21. Cas-57460-41-0

22. (+/-)-talinolol

23. Unii-3s82268bkg

24. 1-(4-cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane

25. (+-)-n-cyclohexyl-n'-(4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)urea

26. 1-(4-(cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

27. Talinolol [mi]

28. 1-(3-(3-cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

29. Talinolol [mart.]

30. Talinolol [who-dd]

31. Schembl78047

32. Chembl152067

33. Gtpl4664

34. Dtxsid6046426

35. Chebi:135533

36. Bcp30483

37. Tox21_112171

38. Bdbm50502344

39. (+-)-1-(p-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

40. Akos003382147

41. Tox21_112171_1

42. At33613

43. Db11770

44. (+-)-1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff

45. Urea, N-cyclohexyl-n'-(4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-, (+-)-

46. Ncgc00164542-02

47. Db-072303

48. Ft-0674796

49. D07184

50. Sr-01000945249

51. Q7679533

52. Sr-01000945249-1

53. F1905-6534

54. N-cyclohexyl-n'-[4-(3-tert-butylamino-2-hydroxypropoxy)phenyl]urea

55. 3-{4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-1-cyclohexylurea

56. N-{4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-n'-cyclohexylurea

57. N-{4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl}-n'-cyclohexylcarbamimidic Acid

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₃₃N₃O₃
Molecular Weight	363.5 g/mol
XLogP3	2.6
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	8
Exact Mass	363.25219192 g/mol
Monoisotopic Mass	363.25219192 g/mol
Topological Polar Surface Area	82.6 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	411
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Arrhythmia Agents

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

Adrenergic beta-Antagonists

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

4.2 ATC Code

C - Cardiovascular system

C07 - Beta blocking agents

C07A - Beta blocking agents

C07AB - Beta blocking agents, selective

C07AB13 - Talinolol

API SUPPLIERS

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ABOUT THIS PAGE

Talinolol Manufacturers

A Talinolol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Talinolol, including repackagers and relabelers. The FDA regulates Talinolol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Talinolol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Talinolol Suppliers

A Talinolol supplier is an individual or a company that provides Talinolol active pharmaceutical ingredient (API) or Talinolol finished formulations upon request. The Talinolol suppliers may include Talinolol API manufacturers, exporters, distributors and traders.

click here to find a list of Talinolol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Talinolol WC

A Talinolol written confirmation (Talinolol WC) is an official document issued by a regulatory agency to a Talinolol manufacturer, verifying that the manufacturing facility of a Talinolol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Talinolol APIs or Talinolol finished pharmaceutical products to another nation, regulatory agencies frequently require a Talinolol WC (written confirmation) as part of the regulatory process.

click here to find a list of Talinolol suppliers with Written Confirmation (WC) on PharmaCompass.

Talinolol GMP

Talinolol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Talinolol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Talinolol GMP manufacturer or Talinolol GMP API supplier for your needs.

Talinolol CoA

A Talinolol CoA (Certificate of Analysis) is a formal document that attests to Talinolol's compliance with Talinolol specifications and serves as a tool for batch-level quality control.

Talinolol CoA mostly includes findings from lab analyses of a specific batch. For each Talinolol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Talinolol may be tested according to a variety of international standards, such as European Pharmacopoeia (Talinolol EP), Talinolol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Talinolol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.