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Chemistry

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Also known as: Proscillaridin-a, Caradrin, Caradrine, Nsc7521, Cardiovite, Proscillan
Molecular Formula
C30H42O8
Molecular Weight
530.6  g/mol
InChI Key
MYEJFUXQJGHEQK-OWBILYANSA-N

Proscillaridin
A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).
1 2D Structure

Proscillaridin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[(3S,8R,9S,10R,13R,14S,17R)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
2.1.2 InChI
InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16?,19-,20+,21-,22+,24?,25?,26?,27?,28-,29+,30-/m0/s1
2.1.3 InChI Key
MYEJFUXQJGHEQK-OWBILYANSA-N
2.1.4 Canonical SMILES
CC1C(C(C(C(O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3=C2)O)C6=COC(=O)C=C6)C)C)O)O)O
2.1.5 Isomeric SMILES
CC1C(C(C(C(O1)O[C@H]2CC[C@@]3([C@H]4CC[C@@]5([C@H](CC[C@@]5([C@@H]4CCC3=C2)O)C6=COC(=O)C=C6)C)C)O)O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Caradrin

2. Desglucotransvaaline

3. Digitalysat

4. Proscillaridin

5. Proscillaridine

6. Rhamnoside, Scillarenin

7. Sandoscill

8. Scillarenin Rhamnoside

9. Scillase

10. Talusin

2.2.2 Depositor-Supplied Synonyms

1. Proscillaridin-a

2. Caradrin

3. Caradrine

4. Nsc7521

5. Cardiovite

6. Proscillan

7. Proscillaridine

8. Proslladin

9. Sandoscill

10. Scillacrist

11. Cardion

12. Carmazon

13. Coratol

14. Procardin

15. Procilan

16. Prostosin

17. Proszin

18. Protasin

19. Solestril

20. Stellarid

21. Talusin

22. Tradenal

23. Urgilan

24. Wirnesin

25. Simeon

26. Herzo Proscillan

27. Purosin-tc

28. 466-06-8

29. Transvaalin, Degluco-

30. 5-[(3s,8r,9s,10r,13r,14s,17r)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

31. Psc-801

32. Desglucotransvaaline

33. A-32686

34. Scillarenin 3.beta.-rhamnoside

35. Scillarenin, 3.alpha.-l-rhamnopyranoside

36. Rhamnopyranoside, .alpha.-l-

37. Schembl1649544

38. Chembl1977418

39. Hbl0000188

40. Nci60_041645

41. P8334

42. 14-hydroxy-3.beta.-(rhamnosyloxy)bufa-4,22-trienolide

43. Desgluco-transvaalin3.beta.,20,22-trienolide 3-rhamnoside

44. (3beta)-3-[(6-deoxyhexopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide

45. [(6-deoxy-.alpha.-l-mannopyranosyl)oxy]-14-hydroxybufa-4,22-trienolide

46. 3.beta.-rhamnosido-14.beta.-hydroxy-.delta.(sup 4,22)-bufatrienolide

47. Wln: L E5 B666 Mutj A1 E1 Iq F- Et6ovj& O- Bt6otj Cq Dq Eq F1

48. Bufa-4,22-trienolide, 3-[(6-deoxy-.alpha.-l-mannopyranosyl)oxy]-14-hydroxy-, (3.beta.)-

49. Bufa-4,22-trienolide, 3.beta.-[(16-deoxy-.alpha.-l-mannosyl)oxy]-14-hydroxy-

50. Bufa-4,22-trienolide, 3.beta.-[(6-deoxy-.alpha.-l-mannopyranosyl)oxy]-14-hydroxy-

51. 5-[(3s,8r,9s,10r,13r,14s,17r)-14-hydroxy-10,13-dimethyl-3-(3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

2.3 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 530.6 g/mol
Molecular Formula C30H42O8
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass530.28796829 g/mol
Monoisotopic Mass530.28796829 g/mol
Topological Polar Surface Area126 Ų
Heavy Atom Count38
Formal Charge0
Complexity1070
Isotope Atom Count0
Defined Atom Stereocenter Count7
Undefined Atom Stereocenter Count5
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


Cardiotonic Agents

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). (See all compounds classified as Cardiotonic Agents.)


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Proscillaridin manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Proscillaridin API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Proscillaridin manufacturer or Proscillaridin supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Proscillaridin manufacturer or Proscillaridin supplier.

PharmaCompass also assists you with knowing the Proscillaridin API Price utilized in the formulation of products. Proscillaridin API Price is not always fixed or binding as the Proscillaridin Price is obtained through a variety of data sources. The Proscillaridin Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Proscillaridin

Synonyms

Proscillaridin-a, Caradrin, Caradrine, Nsc7521, Cardiovite, Proscillan

Cas Number

466-06-8

About Proscillaridin

A cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).

Talusin Manufacturers

A Talusin manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Talusin, including repackagers and relabelers. The FDA regulates Talusin manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Talusin API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Talusin Suppliers

A Talusin supplier is an individual or a company that provides Talusin active pharmaceutical ingredient (API) or Talusin finished formulations upon request. The Talusin suppliers may include Talusin API manufacturers, exporters, distributors and traders.

Talusin GMP

Talusin Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Talusin GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Talusin GMP manufacturer or Talusin GMP API supplier for your needs.

Talusin CoA

A Talusin CoA (Certificate of Analysis) is a formal document that attests to Talusin's compliance with Talusin specifications and serves as a tool for batch-level quality control.

Talusin CoA mostly includes findings from lab analyses of a specific batch. For each Talusin CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Talusin may be tested according to a variety of international standards, such as European Pharmacopoeia (Talusin EP), Talusin JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Talusin USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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