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Chemistry

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Also known as: Taminadenant, 1337962-47-6, Taminadenant [inn], Pbf509, Pbf-509, 5-bromo-2,6-di(pyrazol-1-yl)pyrimidin-4-amine
Molecular Formula
C10H8BrN7
Molecular Weight
306.12  g/mol
InChI Key
ATFXVNUWQOXRRU-UHFFFAOYSA-N
FDA UNII
84I5UEP321

Taminadenant
Taminadenant is an orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T-lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.
1 2D Structure

Taminadenant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-bromo-2,6-di(pyrazol-1-yl)pyrimidin-4-amine
2.1.2 InChI
InChI=1S/C10H8BrN7/c11-7-8(12)15-10(18-6-2-4-14-18)16-9(7)17-5-1-3-13-17/h1-6H,(H2,12,15,16)
2.1.3 InChI Key
ATFXVNUWQOXRRU-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CN(N=C1)C2=NC(=NC(=C2Br)N)N3C=CC=N3
2.2 Other Identifiers
2.2.1 UNII
84I5UEP321
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Taminadenant

2. 1337962-47-6

3. Taminadenant [inn]

4. Pbf509

5. Pbf-509

6. 5-bromo-2,6-di(pyrazol-1-yl)pyrimidin-4-amine

7. 84i5uep321

8. 4-pyrimidinamine, 5-bromo-2,6-di-1h-pyrazol-1-yl-

9. Taminadenant [who-dd]

10. Unii-84i5uep321

11. Schembl2546228

12. Chembl3694769

13. Gtpl10193

14. Bdbm128295

15. Mfcd30489281

16. Nsc817041

17. Pf-509

18. Zinc72317391

19. Nsc-817041

20. Ds-19509

21. Hy-109139

22. Cs-0086930

23. C72343

24. Us8796284, 1

25. A908332

2.4 Create Date
2011-10-31
3 Chemical and Physical Properties
Molecular Weight 306.12 g/mol
Molecular Formula C10H8BrN7
XLogP31.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass305.00246 g/mol
Monoisotopic Mass305.00246 g/mol
Topological Polar Surface Area87.4 Ų
Heavy Atom Count18
Formal Charge0
Complexity291
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

ABOUT THIS PAGE

Looking for 1337962-47-6 / Taminadenant API manufacturers, exporters & distributors?

Taminadenant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Taminadenant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Taminadenant manufacturer or Taminadenant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Taminadenant manufacturer or Taminadenant supplier.

PharmaCompass also assists you with knowing the Taminadenant API Price utilized in the formulation of products. Taminadenant API Price is not always fixed or binding as the Taminadenant Price is obtained through a variety of data sources. The Taminadenant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Taminadenant

Synonyms

1337962-47-6, Taminadenant [inn], Pbf509, Pbf-509, 5-bromo-2,6-di(pyrazol-1-yl)pyrimidin-4-amine, 84i5uep321

Cas Number

1337962-47-6

Unique Ingredient Identifier (UNII)

84I5UEP321

About Taminadenant

Taminadenant is an orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T-lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.

Taminadenant Manufacturers

A Taminadenant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Taminadenant, including repackagers and relabelers. The FDA regulates Taminadenant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Taminadenant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Taminadenant Suppliers

A Taminadenant supplier is an individual or a company that provides Taminadenant active pharmaceutical ingredient (API) or Taminadenant finished formulations upon request. The Taminadenant suppliers may include Taminadenant API manufacturers, exporters, distributors and traders.

Taminadenant GMP

Taminadenant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Taminadenant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Taminadenant GMP manufacturer or Taminadenant GMP API supplier for your needs.

Taminadenant CoA

A Taminadenant CoA (Certificate of Analysis) is a formal document that attests to Taminadenant's compliance with Taminadenant specifications and serves as a tool for batch-level quality control.

Taminadenant CoA mostly includes findings from lab analyses of a specific batch. For each Taminadenant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Taminadenant may be tested according to a variety of international standards, such as European Pharmacopoeia (Taminadenant EP), Taminadenant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Taminadenant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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