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ACTIVE PHARMA INGREDIENTS

101 API Suppliers, 32 USDMF, 22 CEP/COS, 10 JDMF, 15 EU WC, 23 KDMF, 12 NDC API, 64 Listed Suppliers, $ API Reference Price

101 API Suppliers
32 USDMF
22 CEP/COS
10 JDMF
15 EU WC
23 KDMF
12 NDC API
64 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

INTERMEDIATES

13 Intermediates Suppliers

13 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

324 FDF Dossiers, 20 FDA Orange Book, 189 Europe, 10 Canada, 14 Australia, 8 South Africa, 83 Listed Dossiers

324 FDF Dossiers
20 FDA Orange Book
189 Europe
10 Canada
14 Australia
8 South Africa
83 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

CAPSULE;ORAL - 0.4MG, CAPSULE;ORAL - 0.5MG;0.4MG

drugProductComposition
CAPSULE;ORAL - 0.4MG
CAPSULE;ORAL - 0.5MG;0.4MG

RELATED EXCIPIENT COMPANIES

3 Evonik, 1 Rochem International Inc, 4 SPI Pharma, 2 Seqens, 11 DKSH, 4 Faran Shimi Pharmaceutical, 2 Boai NKY Pharmaceuticals Ltd, 9 Gangwal Healthcare, 5 Nanjing Well Pharmaceutical, 1 Pfanstiehl, 4 ACG Worldwide, 8 Actylis, 1 Aeon Procare, 2 Alcedo Pharmachem, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 23 BASF, 15 Corel Pharma Chem, 2 DFE Pharma, 3 Doshion Polyscience, 3 Finar, 10 Gangwal Chemicals, 1 Huzhou Sunflower Pharmaceutical, 14 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 20 Kerry, 4 Kima Chemical, 6 Lonza Capsugel, 13 Microlex e.U, 1 Nanjing Bold Chemical, 2 Nomisma Healthcare, 2 Novo Excipients, 1 Pharmatrans-Sanaq, 5 Pluviaendo, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 2 Qualicaps, 16 Roquette, 14 Seppic, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 9 Sigachi Industries, 3 The Dow Chemical Company, 2 Valens Pharmachem, 3 Vasa Pharmachem, 3 Vertellus

relatedExcipients
3 Evonik
1 Rochem International Inc
4 SPI Pharma
2 Seqens
11 DKSH
4 Faran Shimi Pharmaceutical
2 Boai NKY Pharmaceuticals Ltd
9 Gangwal Healthcare
5 Nanjing Well Pharmaceutical
1 Pfanstiehl
4 ACG Worldwide
8 Actylis
1 Aeon Procare
2 Alcedo Pharmachem
5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd
23 BASF
15 Corel Pharma Chem
2 DFE Pharma
3 Doshion Polyscience
3 Finar
10 Gangwal Chemicals
1 Huzhou Sunflower Pharmaceutical
14 Ideal Cures Pvt Ltd
2 Ingredion Pharma Solutions
20 Kerry
4 Kima Chemical
6 Lonza Capsugel
13 Microlex e.U
1 Nanjing Bold Chemical
2 Nomisma Healthcare
2 Novo Excipients
1 Pharmatrans-Sanaq
5 Pluviaendo
2 Prachin Chemical
1 Qianhao Chemical (Hebei) Co., Ltd
2 Qualicaps
16 Roquette
14 Seppic
6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
9 Sigachi Industries
3 The Dow Chemical Company
2 Valens Pharmachem
3 Vasa Pharmachem
3 Vertellus

EXCIPIENTS BY APPLICATIONS

76 Coating Systems & Additives, 51 Fillers, Diluents & Binders, 47 Controlled & Modified Release, 30 Thickeners and Stabilizers, 26 Direct Compression, 26 Solubilizers, 23 Film Formers & Plasticizers, 20 Lubricants & Glidants, 19 Taste Masking, 18 Topical, 16 Granulation, 15 Parenteral, 15 Co-Processed Excipients, 10 Emulsifying Agents, 10 Disintegrants & Superdisintegrants, 9 Empty Capsules, 6 Rheology Modifiers, 6 Chewable & Orodispersible Aids, 5 API Stability Enhancers, 5 Coloring Agents, 4 Vegetarian Capsules, 4 Surfactant & Foaming Agents, 1 Soft Gelatin

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 10 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
10 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 188 Finished Drug Prices, 5 Annual Reports

globalSalesInformation
2 US Medicaid Prescriptions
188 Finished Drug Prices
5 Annual Reports

MARKET PLACE

25 APIs, 8 FDF Dossiers

marketPlace
25 APIs
8 FDF Dossiers

PATENTS & EXCLUSIVITIES

3 Health Canada Patents

patents
3 Health Canada Patents

REF. STANDARDS & IMPURITIES

4 EDQM , 2 USP , 3 Others

otherSolutions
4 EDQM
2 USP
3 Others

ANALYTICAL

3 BioAnalytical Methods

otherMethods
3 BioAnalytical Methods

Synopsis

ACTIVE PHARMA INGREDIENTS

101

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 108

MARKET PLACE

API

FDF

13INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

324

FDF Dossiers

FDA Orange Book

189

Europe

Canada

Australia

South Africa

Listed Dossiers

3DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

361,780,833

Annual Reports (USD Million)

1,278

Finished Drug Prices

250 RELATED EXCIPIENT COMPANIES

442EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 106463-17-6, Flomax, Tamsulosin hcl, Omnic, Pradif, Harnal

Molecular Formula

C₂₀H₂₉ClN₂O₅S

Molecular Weight

445.0 g/mol

InChI Key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

FDA UNII

11SV1951MR

A sulfonamide derivative and adrenergic alpha-1 receptor antagonist that is used to relieve symptoms of urinary obstruction caused by BENIGN PROSTATIC HYPERPLASIA.

1 2D Structure

Tamsulosin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride

2.1.2 InChI

InChI=1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

2.1.3 InChI Key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

2.1.4 Canonical SMILES

CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl

2.1.5 Isomeric SMILES

CCOC1=CC=CC=C1OCCN[C@H](C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N.Cl

2.2 Other Identifiers

2.2.1 UNII

11SV1951MR

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide

2. Flomax

3. Ly 253352

4. Ly-253352

5. Tamsulosin

6. Ym 617

7. Ym-617

2.3.2 Depositor-Supplied Synonyms

1. 106463-17-6

2. Flomax

3. Tamsulosin Hcl

4. Omnic

5. Pradif

6. Harnal

7. Urolosin

8. Secotex

9. Josir

10. Alna

11. Omic

12. Omix

13. Ym617

14. Ly253351

15. Amsulosin Hydrochloride

16. Tamsulosin (hydrochloride)

17. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

18. R-(-)-ym-12617

19. Ym 617

20. Ym-12617-1

21. Ym-617

22. Ly-253351

23. Chebi:9399

24. (-)-(r)-5-(2-((2-(o-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Monohydrochloride

25. 11sv1951mr

26. 5-[(2r)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride

27. 5-[(2r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride

28. 5-[(r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamide Hydrochloride

29. R-(-)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

30. Expros

31. Flomax (tn)

32. Dsstox_cid_26628

33. Dsstox_rid_81777

34. Dsstox_gsid_46628

35. 128332-25-2

36. Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, Monohydrochloride, (r)-

37. (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzenesulfonamide Hydrochloride

38. (-)-(r)-5-(2-((2-(o-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzene Sulfonamide Monohydrochloride

39. Cas-106463-17-6

40. Tamsulosine Hydrochloride

41. Ncgc00167442-01

42. Mfcd00922997

43. (r)-tamsulosin Hydrochloride

44. Unii-11sv1951mr

45. Tamsulosin.hcl

46. Harnalidge Ocas

47. Flomax Mr

48. Alnaocas

49. 5-[(2r)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide Hydrochloride

50. Flomax Hydrochloride

51. Harnal (tn)

52. Tamsulosin Hydrochloride [usan:usp:jan]

53. Tamsulosina Hydrochloride

54. Tamsulosinum Hydrochloride

55. (-)-ly 253352

56. Schembl23428

57. Tamsulosin Hydrochloride,(s)

58. Mls003899197

59. Racemic Tamsulosin Hydrochloride

60. Chembl1200914

61. Dtxsid2046628

62. Hy-b0661a

63. 5-[(2rs)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride (tamsulosin Racemate Hydrochloride)

64. Tox21_112446

65. Eu-617

66. S4729

67. (r)-tamsulosin Hydrochloride- Bio-x

68. Tamsulosin Hydrochloride (jp17/usp)

69. Tamsulosin Hydrochloride [jan]

70. Akos015895342

71. Akos015995287

72. Tox21_112446_1

73. Bs-1019

74. Ccg-269178

75. Tamsulosin Hydrochloride [usan]

76. (-)-ly253352

77. Tamsulosin Hydrochloride [mart.]

78. Tamsulosin Hydrochloride [vandf]

79. Ncgc00167442-03

80. Tamsulosin Hydrochloride [usp-rs]

81. Tamsulosin Hydrochloride [who-dd]

82. Bt164440

83. Smr002543366

84. Bcp0726000042

85. Tamsulosin Hydrochloride, >=98% (hplc)

86. T2749

87. Y-617

88. Tamsulosin Hydrochloride [orange Book]

89. A14936

90. D01024

91. Jalyn Component Tamsulosin Hydrochloride

92. Tamsulosin Hydrochloride [ep Monograph]

93. Tamsulosin Hydrochloride [usp Impurity]

94. Tamsulosin Hydrochloride [usp Monograph]

95. 463t176

96. A801444

97. Tamsulosin Hydrochloride Component Of Jalyn

98. Q-201777

99. (r)-(-)-ym12617;ly253351

100. (r)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2

101. Q27108379

102. Tamsulosin Hydrochloride, British Pharmacopoeia (bp) Reference Standard

103. Tamsulosin Hydrochloride, European Pharmacopoeia (ep) Reference Standard

104. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Hcl

105. 5-((2r)-2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxybenzene-sulfonamide Hcl

106. 5-[(r)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]]-2-methoxybenzenesulfonamidehydrochloride

107. Tamsulosin Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

108. Tamsulosin Hydrochloride, United States Pharmacopeia (usp) Reference Standard

109. (r)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide Monohydrochloride

110. 5-[(2r)-2-[[2-(-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide Hydrochloride;tamsulosin Hcl

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₉ClN₂O₅S
Molecular Weight	445.0 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	11
Exact Mass	444.1485709 g/mol
Monoisotopic Mass	444.1485709 g/mol
Topological Polar Surface Area	108 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	539
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 4
Drug Name	Flomax
PubMed Health	Tamsulosin (By mouth)
Drug Classes	Benign Prostatic Hypertrophy Agent
Drug Label	Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
Active Ingredient	Tamsulosin hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	0.4mg
Market Status	Prescription
Company	Boehringer Ingelheim

2 of 4
Drug Name	Tamsulosin hydrochloride
Drug Label	Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
Active Ingredient	Tamsulosin hydrochloride
Dosage Form	Capsule
Route	oral; Oral
Strength	0.4mg
Market Status	Tentative Approval; Prescription
Company	Synthon Pharms; Anchen Pharms; Wockhardt; Ranbaxy; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Teva Pharms; Zydus Pharms Usa; Mylan; Impax Labs

3 of 4
Drug Name	Flomax
PubMed Health	Tamsulosin (By mouth)
Drug Classes	Benign Prostatic Hypertrophy Agent
Drug Label	Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
Active Ingredient	Tamsulosin hydrochloride
Dosage Form	Capsule
Route	Oral
Strength	0.4mg
Market Status	Prescription
Company	Boehringer Ingelheim

4 of 4
Drug Name	Tamsulosin hydrochloride
Drug Label	Tamsulosin hydrochloride is an antagonist of alpha1A adrenoceptors in the prostate.Tamsulosin hydrochloride is (-)-(R)-5-[2-[[2-(o-Ethoxyphenoxy) ethyl]amino]propyl]-2-methoxybenzenesulfonamide, monohydrochloride. Tamsulosin hydrochloride is a white...
Active Ingredient	Tamsulosin hydrochloride
Dosage Form	Capsule
Route	oral; Oral
Strength	0.4mg
Market Status	Tentative Approval; Prescription
Company	Synthon Pharms; Anchen Pharms; Wockhardt; Ranbaxy; Aurobindo Pharma; Sun Pharm Inds; Sandoz; Teva Pharms; Zydus Pharms Usa; Mylan; Impax Labs

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Urological Agents

Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS. (See all compounds classified as Urological Agents.)

Adrenergic alpha-1 Receptor Antagonists

Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

alpha-Adrenergic Blocker [EPC]; Adrenergic alpha-Antagonists [MoA]

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API Reference Price

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Number of Transactions

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Quantity (KGS) & Unit rate (USD/KGS) over time

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Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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DOSAGE - CAPSULE;ORAL - 0.4MG

USFDA APPLICATION NUMBER - 20579

DOSAGE - CAPSULE;ORAL - 0.5MG;0.4MG

USFDA APPLICATION NUMBER - 22460

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CAPSULE;ORAL - 0.4MG

CAPSULE;ORAL - 0.5MG;0.4MG

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