Tazobactam Sodium

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

27 API Suppliers, 17 USDMF, 8 JDMF, 4 EU WC, 2 KDMF, 10 NDC API, 6 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

INTERMEDIATES

1 Suppliers

1 Suppliers

DOSSIERs // Finished Dosage Formulations

147 Dossiers, 57 FDA Orange Book, 31 Europe, 17 Canada, 9 South Africa, 33 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - EQ 40MG BASE/ML;EQ 5MG BASE/ML, INJECTABLE;INJECTION - EQ 4GM BASE/100ML;EQ 500MG BASE/100ML, INJECTABLE;INJECTION - EQ 60MG BASE/ML;EQ 7.5MG BASE/ML

INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**
INJECTABLE;INJECTION - EQ 40MG BASE/ML;EQ 5MG BASE/ML
INJECTABLE;INJECTION - EQ 4GM BASE/100ML;EQ 500MG BASE/100ML
INJECTABLE;INJECTION - EQ 60MG BASE/ML;EQ 7.5MG BASE/ML

RELATED EXCIPIENT COMPANIES

Suppliers, 4 Roquette, 3 Actylis, 1 SPI Pharma, 1 Nanjing Well Pharmaceutical, 1 Pfanstiehl

EXCIPIENTS BY APPLICATIONS

7 Parenteral, 2 Fillers, Diluents & Binders, 1 Thickeners and Stabilizers, 1 API Stability Enhancers

GLOBAL SALES INFORMATION

29 Finished Drug Prices

29 Finished Drug Prices

MARKET PLACE

13 APIs, 5 DOSSIERS // FDF

PATENTS

28 US Patents, 3 US Exclusivities

REF. STANDARDS & IMPURITIES

1 USP, 2 Others

DIGITAL CONTENT

2 Data Compilations & Company Tracker #PharmaFlow, 42 News

API SUPPLIERS

API Suppliers

US DMFs Filed

CEP/COS Certifications

JDMFs Filed

EU WC

Listed Suppliers

API REF. PRICE (USD / KG)

139

API Market Place

INTERMEDIATES

DOSSIERS // FDF

USA (Orange Book)

Europe

Canada

Australia

South Africa

Uploaded Dossiers

GLOBAL SALES (USD Million)

U.S. Medicaid

Annual Reports

218.00

FDF Market Place

EXCIPIENTS

PATENTS & EXCLUSIVITIES

USFDA Orange Book Patents

USFDA Exclusivities

DIGITAL CONTENT

Blog #PharmaFlow

News

REF STANDARD

EDQM

USP

Other Listed Suppliers

SERVICES

Also known as: Tazobactam sodium salt, 89785-84-2, Tazobactum sodium, Tazobactam sodium [usan], Cl-307579, Tazobactam (sodium)

Molecular Formula

C₁₀H₁₁N₄NaO₅S

Molecular Weight

322.28 g/mol

InChI Key

RFMIKMMOLPNEDG-QVUDESDKSA-M

FDA UNII

UXA545ABTT

A penicillanic acid and sulfone derivative and potent BETA-LACTAMASE inhibitor that enhances the activity of other anti-bacterial agents against beta-lactamase producing bacteria.

1 2D Structure

Tazobactam Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;(2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-46-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

2.1.2 InChI

InChI=1S/C10H12N4O5S.Na/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19;/h2-3,7-8H,4-5H2,1H3,(H,16,17);/q;+1/p-1/t7-,8+,10+;/m1./s1

2.1.3 InChI Key

RFMIKMMOLPNEDG-QVUDESDKSA-M

2.1.4 Canonical SMILES

CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]

2.1.5 Isomeric SMILES

C[C@@]1([C@@H](N2[C@H](S1(=O)=O)CC2=O)C(=O)[O-])CN3C=CN=N3.[Na+]

2.2 Other Identifiers

2.2.1 UNII

UXA545ABTT

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Tazobactam

2. Ytr 830

3. Ytr 830h

4. Ytr-830

5. Ytr830

2.3.2 Depositor-Supplied Synonyms

1. Tazobactam Sodium Salt

2. 89785-84-2

3. Tazobactum Sodium

4. Tazobactam Sodium [usan]

5. Cl-307579

6. Tazobactam (sodium)

7. Ytr-830

8. Tazobactam (as Sodium)

9. Cl 307,579

10. Uxa545abtt

11. Chembl1439

12. Cl 307579

13. Chebi:85192

14. 89785-84-2 (sodium)

15. Ytr 830

16. 2-alpha-methyl-2-beta-(1,2,3-triazol-1-ylmethyl)penam-3-alpha-carboxylic Acid Sodium Salt

17. Dsstox_cid_26030

18. Dsstox_rid_81299

19. Dsstox_gsid_46030

20. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, Sodium Salt, (2s,3s,5r)-

21. Sodium (2s,3s,5r)-3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate, 4,4-dioxide

22. Sodium;(2s,3s,5r)-3-methyl-4,4,7-trioxo-3-(triazol-1-ylmethyl)-4lambda6-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

23. Cas-89785-84-2

24. Unii-uxa545abtt

25. Tazobactum

26. Ncgc00159340-02

27. Schembl259991

28. Tazobactam Sodium (jan/usan)

29. Tazobactam Sodium [jan]

30. Dtxsid8046030

31. Tazobactam Sodium [vandf]

32. Tazobactam Sodium [mart.]

33. Yp-14

34. Tazobactam Sodium [who-dd]

35. Sodium (2s,3s,5r)-3-((1h-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide

36. Tazobactam Sodium Salt [mi]

37. Tox21_111584

38. Bdbm50157692

39. Mfcd00917472

40. Akos015962921

41. Akos016843926

42. Tox21_111584_1

43. Cs-w009884

44. Hy-w009168

45. Tazobactam Sodium [orange Book]

46. Zosyn Component Tazobactam Sodium

47. Ncgc00159340-05

48. Ac-18978

49. Ac-32478

50. As-56873

51. Zerbaxa Component Tazobactam Sodium

52. Tazobactam Sodium Salt, Analytical Standard

53. Tazobactam Sodium Component Of Zosyn

54. Tazobactam Sodium Component Of Zerbaxa

55. D03707

56. T-1446

57. Tazobactam Sodium Salt, Beta-lactamase Inhibitor

58. Q27158392

59. Tazobactam Sodium Salt, Antibiotic For Culture Media Use Only

60. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3-methyl-7-oxo-3-(1h-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, Sodium Salt, (2s-(2alpha,3beta,5alpha))-

61. Sodium (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[(1h-1,2,3-triazol-1-yl)methyl]-4lambda(6)-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

62. Sodium (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda6-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

63. Sodium(2s,3s,5r)-3-((1h-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate4,4-dioxide

64. Sodium; (2s,3s,5r)-3-methyl-4,4,7-trioxo-3-[1,2,3]triazol-1-ylmethyl-4lambda*6*-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₁₁N₄NaO₅S
Molecular Weight	322.28 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	3
Exact Mass	322.03478492 g/mol
Monoisotopic Mass	322.03478492 g/mol
Topological Polar Surface Area	134 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	579
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

beta-Lactamase Inhibitors

Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. (See all compounds classified as beta-Lactamase Inhibitors.)

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Tazobactam Sodium

Tazobactam Sodium

Synopsis

Chemistry

APIs // Active Pharmaceutical Ingredients

27 API Suppliers

17 USDMF

8 JDMF

4 EU WC

2 KDMF

10 NDC API

6 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price

API Exports

API Imports

FDF Exports

FDF Imports

INTERMEDIATES

1 Suppliers

DOSSIERs // Finished Dosage Formulations

147 Dossiers

57 FDA Orange Book

31 Europe

17 Canada

9 South Africa

33 Listed Dossiers

DRUG PRODUCT COMPOSITION

INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

INJECTABLE;INJECTION - EQ 40MG BASE/ML;EQ 5MG BASE/ML

INJECTABLE;INJECTION - EQ 4GM BASE/100ML;EQ 500MG BASE/100ML

INJECTABLE;INJECTION - EQ 60MG BASE/ML;EQ 7.5MG BASE/ML

RELATED EXCIPIENT COMPANIES

Suppliers

4 Roquette

3 Actylis

1 SPI Pharma

1 Nanjing Well Pharmaceutical

1 Pfanstiehl

EXCIPIENTS BY APPLICATIONS

7 Parenteral

2 Fillers, Diluents & Binders

1 Thickeners and Stabilizers

1 API Stability Enhancers

GLOBAL SALES INFORMATION

29 Finished Drug Prices

MARKET PLACE

13 APIs

5 DOSSIERS // FDF

PATENTS

28 US Patents

3 US Exclusivities

REF. STANDARDS & IMPURITIES

1 USP

2 Others

DIGITAL CONTENT

2 Data Compilations & Company Tracker #PharmaFlow

42 News

API SUPPLIERS

API REF. PRICE (USD / KG)

INTERMEDIATES

DOSSIERS // FDF

GLOBAL SALES (USD Million)

EXCIPIENTS

PATENTS & EXCLUSIVITIES

DIGITAL CONTENT

REF STANDARD

SERVICES

What are you looking for?

INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons

INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons