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Tc-99M Tetrofosmin

Tc-99M Tetrofosmin

Synopsis, Chemistry

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Also known as: Technetium tc-99m tetrofosmin, Q7692231

Molecular Formula

C₁₈H₄₀O₄P₂Tc

Molecular Weight

479.4 g/mol

InChI Key

BDMZPZIFZPWFFW-UHFFFAOYSA-N

Technetium Tc-99m Tetrofosmin is a radiopharmaceutical consisting of tetrofosmin, composed of two bidentate diphosphine ligands chelating the metastable radioisotope technetium Tc-99 (99mTc), with potential imaging activity upon SPECT (single photon emission computed tomography). Upon administration, technetium Tc 99m tetrofosmin is preferentially taken up by, and accumulates in, myocardial cells. Upon imaging, myocardial cells can be visualized and changes in ischemia and/or perfusion can be detected.

1 2D Structure

Tc-99M Tetrofosmin

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane;technetium

2.1.2 InChI

InChI=1S/C18H40O4P2.Tc/c1-5-19-9-13-23(14-10-20-6-2)17-18-24(15-11-21-7-3)16-12-22-8-4;/h5-18H2,1-4H3;

2.1.3 InChI Key

BDMZPZIFZPWFFW-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOCCP(CCOCC)CCP(CCOCC)CCOCC.[Tc]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 99mtc-tetrafosmin

2. 99mtc-tetrofosmin

3. Myoview

4. Ppn-1011

5. Ppn1011

6. Tc-99m-ppn1011

7. Tc-99m-tetrofosmin

8. Technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

9. Technetium Tc-99m Tetrofosmin

10. Technetium(1+)-99tc, Bis(6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane-.kappa.p,.kappa.p')dioxo-, (oc-6-11)-

11. Technetium-99m-tetrofosmin

2.2.2 Depositor-Supplied Synonyms

1. Technetium Tc-99m Tetrofosmin

2. Q7692231

2.3 Create Date

2014-03-06

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₄₀O₄P₂Tc
Molecular Weight	479.4 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	19
Exact Mass	479.14654 g/mol
Monoisotopic Mass	479.14654 g/mol
Topological Polar Surface Area	36.9 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	201
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Radiopharmaceuticals

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)