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Chemistry

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Also known as: 161715-24-8, Orapenem, Tbpm-pi, Me1211, L-084, Ljc 11,084
Molecular Formula
C22H31N3O6S2
Molecular Weight
497.6  g/mol
InChI Key
SNUDIPVBUUXCDG-QHSBEEBCSA-N
FDA UNII
95AK1A52I8

Tebipenem Pivoxil
Tebipenem Pivoxil is an orally available pivaloyloxymethyl ester prodrug of tebipenem, a broad-spectrum 1-beta-methylcarbapenem antibiotic with a 1-(1,3-thiazolin-2-yl) azetidin-3-ylthio group at the C-2 position. After oral administration of tebipenem pivoxil, the ester bond is cleaved, releasing active tebipenem.
1 2D Structure

Tebipenem Pivoxil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,2-dimethylpropanoyloxymethyl (4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
2.1.2 InChI
InChI=1S/C22H31N3O6S2/c1-11-15-14(12(2)26)18(27)25(15)16(19(28)30-10-31-20(29)22(3,4)5)17(11)33-13-8-24(9-13)21-23-6-7-32-21/h11-15,26H,6-10H2,1-5H3/t11-,12-,14-,15-/m1/s1
2.1.3 InChI Key
SNUDIPVBUUXCDG-QHSBEEBCSA-N
2.1.4 Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)C(C)O
2.1.5 Isomeric SMILES
C[C@@H]1[C@@H]2[C@H](C(=O)N2C(=C1SC3CN(C3)C4=NCCS4)C(=O)OCOC(=O)C(C)(C)C)[C@@H](C)O
2.2 Other Identifiers
2.2.1 UNII
95AK1A52I8
2.3 Synonyms
2.3.1 MeSH Synonyms

1. L 084

2. L-084

2.3.2 Depositor-Supplied Synonyms

1. 161715-24-8

2. Orapenem

3. Tbpm-pi

4. Me1211

5. L-084

6. Ljc 11,084

7. 2,2-dimethylpropanoyloxymethyl (4r,5s,6s)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

8. Ljc-11084

9. Me-1211

10. 95ak1a52i8

11. Tebipenempivoxil

12. Tebipenem [inn]

13. (4r,5s,6s)-(pivaloyloxy)methyl 3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

14. (1r,5s,6s)-6-[1(r)-hydroxyethyl]-1-methyl-2-[1-(2-thiazolin-2-yl)azetidin-3-ylsulfanyl]-1-carba-2-penem-3-carboxylic Acid Pivaloyloxymethyl Ester

15. Tebipenem Pivoxil (l-084)

16. Tebipenem Pivoxil [inn]

17. Tebipenem Pivoxil(l-084)

18. Unii-95ak1a52i8

19. Orapenem (tn)

20. 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid, 3-((1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (4r,5s,6s)-

21. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid, 3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-, (2,2-dimethyl-1-oxopropoxy)methyl Ester, (4r,5s,6s)-

22. Mls006011128

23. Schembl305541

24. Tebipenem Pivoxil [mi]

25. Tebipenem Pivoxil [usan:inn]

26. Tebipenem Pivoxil [jan]

27. Chembl2107486

28. Tebipenem Pivoxil [usan]

29. Gtpl10864

30. Dtxsid00167228

31. Chebi:135799

32. Tebipenem Pivoxil [who-dd]

33. Ex-a1256

34. Hy-b0396

35. Who 7924

36. Zinc4217736

37. Tebipenem Pivoxil (jan/usan/inn)

38. Ljc 11084

39. Mfcd17215369

40. S2159

41. Akos015899532

42. Ccg-269673

43. Ljc-11,084

44. Ncgc00346570-01

45. Ncgc00346570-04

46. (pivaloyloxy)methyl (4r,5s,6s)-3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

47. [(4r,5s,6s)-3-{[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl}-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carbonyloxy]methyl 2,2-dimethylpropanoate

48. Ac-22712

49. As-75334

50. L-084;me1211

51. Smr004702908

52. L 084

53. C73086

54. D09598

55. Ab01566835_01

56. A854567

57. Q1623593

58. ((2,2-dimethylpropanoyl)oxy)methyl (4r,5s,6s)-3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)sulfanyl)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylate

59. (4r,5r,6s)-3-((1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl)thio)-6-((1r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic Acid (2,2-dimethyl-1-oxopropoxy) Methyl Ester

60. (4r,5s,6s)-(pivaloyloxy)methyl3-((1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl)thio)-6-((r)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

61. 2,2-dimethylpropanoyloxymethyl (4r,5s,6s)-3-[1-(4,5-dihydrothiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 497.6 g/mol
Molecular Formula C22H31N3O6S2
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count9
Rotatable Bond Count10
Exact Mass497.16542806 g/mol
Monoisotopic Mass497.16542806 g/mol
Topological Polar Surface Area159 Ų
Heavy Atom Count33
Formal Charge0
Complexity908
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 ATC Code

J - Antiinfectives for systemic use

J01 - Antibacterials for systemic use

J01D - Other beta-lactam antibacterials

J01DH - Carbapenems

J01DH06 - Tebipenem pivoxil


INTERMEDIATES SUPPLIERS

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  • WHO-GMP

Virtual BoothJinan Tantu Chemicals offers customized R&D services & production of small molecule APIs & pharmaceutical intermediates.

CAS Number : 179337-57-6

End Use API : Tebipenem Pivoxil

About The Company : Jinan Tantu Chemicals Co., Ltd. operates as a Contract Development and Manufacturing Organization (CDMO) that serves pharmaceutical companies worldwide. Our cor...

Jinan Tantu Chemicals
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ABOUT THIS PAGE

Tebipenem Pivoxil Manufacturers

A Tebipenem Pivoxil manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Tebipenem Pivoxil, including repackagers and relabelers. The FDA regulates Tebipenem Pivoxil manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Tebipenem Pivoxil API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Tebipenem Pivoxil Suppliers

A Tebipenem Pivoxil supplier is an individual or a company that provides Tebipenem Pivoxil active pharmaceutical ingredient (API) or Tebipenem Pivoxil finished formulations upon request. The Tebipenem Pivoxil suppliers may include Tebipenem Pivoxil API manufacturers, exporters, distributors and traders.

Tebipenem Pivoxil GMP

Tebipenem Pivoxil Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Tebipenem Pivoxil GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Tebipenem Pivoxil GMP manufacturer or Tebipenem Pivoxil GMP API supplier for your needs.

Tebipenem Pivoxil CoA

A Tebipenem Pivoxil CoA (Certificate of Analysis) is a formal document that attests to Tebipenem Pivoxil's compliance with Tebipenem Pivoxil specifications and serves as a tool for batch-level quality control.

Tebipenem Pivoxil CoA mostly includes findings from lab analyses of a specific batch. For each Tebipenem Pivoxil CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Tebipenem Pivoxil may be tested according to a variety of international standards, such as European Pharmacopoeia (Tebipenem Pivoxil EP), Tebipenem Pivoxil JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Tebipenem Pivoxil USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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